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Entry version 2 (26 Feb 2020)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Proteasome subunit beta 8

Gene

PSMB8

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi598 – 605ATPPROSITE-ProRule annotation8

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Proteasome subunit beta 8Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PSMB8Imported
Synonyms:TAP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMacaca mulatta (Rhesus macaque)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9544 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006718 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:76446 PSMB8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei74 – 95HelicalSequence analysisAdd BLAST22
    Transmembranei115 – 140HelicalSequence analysisAdd BLAST26
    Transmembranei247 – 267HelicalSequence analysisAdd BLAST21
    Transmembranei288 – 309HelicalSequence analysisAdd BLAST22
    Transmembranei369 – 401HelicalSequence analysisAdd BLAST33

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini249 – 530ABC transmembrane type-1InterPro annotationAdd BLAST282
    Domaini563 – 802ABC transporterInterPro annotationAdd BLAST240

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni16 – 58DisorderedSequence analysisAdd BLAST43

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili440 – 460Sequence analysisAdd BLAST21

    Keywords - Domaini

    Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

    Phylogenomic databases

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000159023

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.20.1560.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003593 AAA+_ATPase
    IPR011527 ABC1_TM_dom
    IPR036640 ABC1_TM_sf
    IPR013305 ABC_Tap-like
    IPR003439 ABC_transporter-like
    IPR017871 ABC_transporter_CS
    IPR027417 P-loop_NTPase
    IPR013306 Tap1/ABCB2
    IPR039421 Type_I_exporter

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR24221 PTHR24221, 1 hit
    PTHR24221:SF249 PTHR24221:SF249, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00664 ABC_membrane, 1 hit
    PF00005 ABC_tran, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00382 AAA, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52540 SSF52540, 1 hit
    SSF90123 SSF90123, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00958 3a01208, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50929 ABC_TM1F, 1 hit
    PS00211 ABC_TRANSPORTER_1, 1 hit
    PS50893 ABC_TRANSPORTER_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

    A0A5F8A097-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAALLASAGS DCSWDFPRAP PSLPTPAASR GGLRGTQSLR PRRSTESPRA
    60 70 80 90 100
    GRDLNGVGVP MASSRCPAPR GCRCLPGASL AWLGTVLLLL TDWVLLRTAL
    110 120 130 140 150
    PRIFSLLVPT ALPLLQVWAV GLSRWAVLWL GACGVLRATV GSKSENAGAQ
    160 170 180 190 200
    GWLAALEPLA AALGLALPGL ALFRELISWG APGAADSTRL LHWGSHPSAF
    210 220 230 240 250
    VVSYATALPA AALWHKLGSL WVTGGQGVSG DPVRRLLGCL GSEMRRLSLF
    260 270 280 290 300
    LVLVILSSLG EMAIPFFTGR ITDWILQDGS ADTFTRNLTL MSILTIASAV
    310 320 330 340 350
    LEFMGDGIYN TTMGHVHSHL QGEVFGAVLR QETEFFQQNQ TGNITSRVTE
    360 370 380 390 400
    DTSTLSDALS ENLSLFLWYL VRGLCLLGIM LWGSVSLTMV TLVTLPLLFL
    410 420 430 440 450
    LPKKVGKWYQ LLAVQVQESL AKSSQVAIEA LSAMPTVRSF ANEEGEVQKF
    460 470 480 490 500
    REKLQEIKTL NQKEAVAYAV NSWTTSISGM LLKVGILYIG GQLVTSGAVS
    510 520 530 540 550
    SGNLVTFVLY QMQFTVAVEV LLSVYPRVQK AVGSSEKIFE YLDRTPRCPP
    560 570 580 590 600
    SGLLTPLHLE GLVQFQDVSF AYPNRPDVLV LQGLTFTLRP GEVTALVGPN
    610 620 630 640 650
    GSGKSTVAAL LQNLYQPTGG QLLLDGKPLP QYEHRYLHKQ VAAVGQEPQV
    660 670 680 690 700
    FGRSLQENIA YGLTQKPTME EITAAAVKSG AHSFISGLPR GYDTEVGEAG
    710 720 730 740 750
    SQLSGGQRQA VALARALIRK PCVLILDDAT SALDANSQLR VEQLLYESPE
    760 770 780 790 800
    RYSRSVLLIT QNLSLVEQAD HILFLEGGTI REGGTHQQLM EKKGCYWAMV

    QAPADAPE
    Length:808
    Mass (Da):87,050
    Last modified:December 11, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCE5D8EEBA2598A21
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    F7GFK7F7GFK7_MACMU
    Proteasome subunit beta
    PSMB8 TAP1
    308Annotation score:

    Annotation score:3 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A5F7ZQM9A0A5F7ZQM9_MACMU
    Proteasome subunit beta 8
    PSMB8 TAP1
    907Annotation score:

    Annotation score:1 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMMUT00000109425; ENSMMUP00000070340; ENSMMUG00000011301

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Genome annotation databases

    EnsembliENSMMUT00000109425; ENSMMUP00000070340; ENSMMUG00000011301

    Organism-specific databases

    VGNCiVGNC:76446 PSMB8

    Phylogenomic databases

    GeneTreeiENSGT00940000159023

    Family and domain databases

    Gene3Di1.20.1560.10, 1 hit
    InterProiView protein in InterPro
    IPR003593 AAA+_ATPase
    IPR011527 ABC1_TM_dom
    IPR036640 ABC1_TM_sf
    IPR013305 ABC_Tap-like
    IPR003439 ABC_transporter-like
    IPR017871 ABC_transporter_CS
    IPR027417 P-loop_NTPase
    IPR013306 Tap1/ABCB2
    IPR039421 Type_I_exporter
    PANTHERiPTHR24221 PTHR24221, 1 hit
    PTHR24221:SF249 PTHR24221:SF249, 1 hit
    PfamiView protein in Pfam
    PF00664 ABC_membrane, 1 hit
    PF00005 ABC_tran, 1 hit
    SMARTiView protein in SMART
    SM00382 AAA, 1 hit
    SUPFAMiSSF52540 SSF52540, 1 hit
    SSF90123 SSF90123, 1 hit
    TIGRFAMsiTIGR00958 3a01208, 1 hit
    PROSITEiView protein in PROSITE
    PS50929 ABC_TM1F, 1 hit
    PS00211 ABC_TRANSPORTER_1, 1 hit
    PS50893 ABC_TRANSPORTER_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F8A097_MACMU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F8A097
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
    Last sequence update: December 11, 2019
    Last modified: February 26, 2020
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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