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Entry version 6 (02 Jun 2021)
Sequence version 1 (11 Dec 2019)
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Protein
Submitted name:

Treacle ribosome biogenesis factor 1

Gene

TCOF1

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Treacle ribosome biogenesis factor 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCOF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:55517, TCOF1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A5F5Q165

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 38LisHInterPro annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni56 – 1422DisorderedSequence analysisAdd BLAST1367
Regioni1459 – 1616DisorderedSequence analysisAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi57 – 74Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi103 – 117Polar residuesSequence analysisAdd BLAST15
Compositional biasi159 – 178Polar residuesSequence analysisAdd BLAST20
Compositional biasi319 – 338Polar residuesSequence analysisAdd BLAST20
Compositional biasi389 – 413Polar residuesSequence analysisAdd BLAST25
Compositional biasi527 – 544Polar residuesSequence analysisAdd BLAST18
Compositional biasi587 – 601Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi840 – 869Polar residuesSequence analysisAdd BLAST30
Compositional biasi1117 – 1132Polar residuesSequence analysisAdd BLAST16
Compositional biasi1139 – 1162Polar residuesSequence analysisAdd BLAST24
Compositional biasi1220 – 1253Polar residuesSequence analysisAdd BLAST34
Compositional biasi1286 – 1302Polar residuesSequence analysisAdd BLAST17
Compositional biasi1329 – 1374Polar residuesSequence analysisAdd BLAST46
Compositional biasi1389 – 1403Polar residuesSequence analysisAdd BLAST15
Compositional biasi1459 – 1501Basic and acidic residuesSequence analysisAdd BLAST43
Compositional biasi1516 – 1544Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi1569 – 1590Basic residuesSequence analysisAdd BLAST22
Compositional biasi1601 – 1616Basic residuesSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom

The PANTHER Classification System

More...
PANTHERi
PTHR20787, PTHR20787, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03546, Treacle, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00667, LisH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50896, LISH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A5F5Q165-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEARKRREL LPLIYQHLLQ AGYVRAAREV KEQSGQKSFP TQPVTLLDIY
60 70 80 90 100
THWQQTSEVG RKRKAEEDAA LQAKKTRVSD PISSSESSEE EEEEEAEAET
110 120 130 140 150
SKATPRLAST NSSVVGAVLP ASMKEKATAK TAKASKTVNS TLRPASGKAV
160 170 180 190 200
AHLSGMASAG RADSSSEDTS TSSDETYVEV KPSVKPPQVK ASPAAAKESA
210 220 230 240 250
GRRAAPTPGK AGAVTPQVRG GAVTPAGRAK KPEEDSESSE EESESEEGAP
260 270 280 290 300
EGTPSQGKAA EKSVWVKAAS GSAEGTPGKG ATPALTGKTG PAAAQAKAGR
310 320 330 340 350
PEEDSESSSE ESDSEEETPA AKTPLQPSGK TPQVKAASVP TKESPRKGTT
360 370 380 390 400
PAPPGKAGPV AAQAKAGRPE EDSESSSGES DSDGEAPAAR PLTSSSAQAK
410 420 430 440 450
PLGKNSQVRA ASTVGMGPSG KGAVPAPPGK AASTATLVLV GKQEEDSESS
460 470 480 490 500
SEESDSEREA PAQAKSSGKI LQVKSATGPA KGPPQKTGPV ATQIKVERSK
510 520 530 540 550
EDSESSEDES ESEEEVAAAV TPAQAKPAMK TPQTKASPTK GSPVTPASAK
560 570 580 590 600
VPAARVGTPA PWKAEAVTSP ACASSPAVAR GTQRPEQDSS SSEESESEEE
610 620 630 640 650
KAPAVAVGQA KSVRKNPPAK AASAPTKGPS GQGNAPLLPG KAGPAVAQVK
660 670 680 690 700
AEMHDDSESS EEESDSEEVA ATPAQVKPSV KTPQTKASPA SARAALAPGP
710 720 730 740 750
SSAVRKVVTA AAQAKQGSPA KVKPPARTPQ SSAISVRGQV SVLAGGKADA
760 770 780 790 800
AAARAQPGPV RGSQEDSESS SEEDSDSEGA APVPAQAKPP GKTPQLRTAS
810 820 830 840 850
APTKGSPRKG AASAPPGKTG PTATQVGKQK EDSESSSQEE SESEGAAPSQ
860 870 880 890 900
AKPSGKTPQV RTASAPTKGS PQKGAAPAPP GKTGPTASQA AKREENSESS
910 920 930 940 950
SEDDSDSEGV APAQAKPSGK TTQVRTASAP IKGSPRKGAA PPPPGKTGPT
960 970 980 990 1000
ATGPTATQAG KQEEDSESSS EEESDSEGAA PAQAKPSGKT AQVRTASAPT
1010 1020 1030 1040 1050
KGSPRKGAAP APPGKTGPTA TQAGKREENS ESSSEEESDS EGAVPAAVTP
1060 1070 1080 1090 1100
AQKEGASQTA RSKTLGPALP EKKAQGSSES SDEELPAGQV IKFPLIFVDP
1110 1120 1130 1140 1150
NRSPAGPAAT PAQAQAASAP RKAQASESTA RSSSSESEDE DVVPATQCST
1160 1170 1180 1190 1200
PAVRTNVVSV PPANPRTALR AGAVGASSGE EAGRASEGRK QEAQVTKKNP
1210 1220 1230 1240 1250
AHLPLTQAAL KVLVQKASEA QPPTARTPSS SGVDSALGTL PVTSPQSTPV
1260 1270 1280 1290 1300
PAKVTNRLGK PKVPEVQRAV ATSLGRPKAK ASGTSDDSED SSSCSSGSKE
1310 1320 1330 1340 1350
DAEATQRLVG AALSRRETLV EETTAESSEE EVVAPSQSLL SGYATPGLTP
1360 1370 1380 1390 1400
ANSQASKATP RPDPKPSVSS TPATKDALDG KREVEPQQPA ATMSPQTGRR
1410 1420 1430 1440 1450
DPGTTPQKPR KGAGSPQASM LALQSDITRR LLSEPWPLSE AQVQASVVKV
1460 1470 1480 1490 1500
LTELLEQERK KAVDAAKESS RKGRVGRKRK LSEDQPAART PKSKKKKQLA
1510 1520 1530 1540 1550
AGEVGEGAVS PEKGPRTLKG KSKKDRASGD IKKKEKESLG QGAKEKPEGE
1560 1570 1580 1590 1600
PAMVSIVGED PGNPKSKKEK KKTDKRKKDK EKKEKKKKAK KASTKAPDSL
1610
IQKKRKKKKK AAEQTV
Length:1,616
Mass (Da):164,693
Last modified:December 11, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i315755B04F7E071D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CZ04F7CZ04_HORSE
Treacle ribosome biogenesis factor ...
TCOF1
1,578Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I793A0A3Q2I793_HORSE
Treacle ribosome biogenesis factor ...
TCOF1
1,547Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F5PJW6A0A5F5PJW6_HORSE
Treacle ribosome biogenesis factor ...
TCOF1
1,552Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000075444; ENSECAP00000054264; ENSECAG00000014261

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiA0A5F5Q165
ModBaseiSearch...

Genome annotation databases

EnsembliENSECAT00000075444; ENSECAP00000054264; ENSECAG00000014261

Organism-specific databases

VGNCiVGNC:55517, TCOF1

Phylogenomic databases

GeneTreeiENSGT00730000111382

Family and domain databases

InterProiView protein in InterPro
IPR006594, LisH
IPR017859, Treacle
IPR003993, Treacle_dom
PANTHERiPTHR20787, PTHR20787, 5 hits
PfamiView protein in Pfam
PF03546, Treacle, 6 hits
SMARTiView protein in SMART
SM00667, LisH, 1 hit
PROSITEiView protein in PROSITE
PS50896, LISH, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5F5Q165_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5F5Q165
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 11, 2019
Last sequence update: December 11, 2019
Last modified: June 2, 2021
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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