SOCS1

Functionⁱ

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functionⁱ

insulin-like growth factor receptor binding Source: Ensembl
kinase inhibitor activity Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to amino acid stimulus Source: Ensembl
cytokine-mediated signaling pathway Source: Ensembl
fat cell differentiation Source: Ensembl
intracellular signal transduction Source: InterPro
negative regulation of CD8-positive, alpha-beta T cell differentiation Source: Ensembl
negative regulation of insulin receptor signaling pathway Source: Ensembl
negative regulation of tyrosine phosphorylation of STAT protein Source: Ensembl
positive regulation of CD4-positive, alpha-beta T cell differentiation Source: Ensembl
positive regulation of regulatory T cell differentiation Source: Ensembl
protein ubiquitination Source: UniProtKB-UniPathway
receptor signaling pathway via JAK-STAT Source: Ensembl
regulation of activation of Janus kinase activity Source: Ensembl
regulation of cytokine production Source: Ensembl
regulation of growth Source: UniProtKB-KW
regulation of interferon-gamma-mediated signaling pathway Source: InterPro

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Signal transduction inhibitorARBA annotation
Biological process	Growth regulationARBA annotation, Ubl conjugation pathwayARBA annotation

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:SOCS1Imported
Organismⁱ	Callithrix jacchus (White-tufted-ear marmoset)Imported
Taxonomic identifierⁱ	9483 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Platyrrhini › Cebidae › Callitrichinae › Callithrix › Callithrix
Proteomesⁱ	UP000008225 Componentⁱ: Unplaced

Subcellular locationⁱ

GO - Cellular component

Interactionⁱ

GO - Molecular functionⁱ

insulin-like growth factor receptor binding Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	79 – 174	SH2InterPro annotationAdd BLAST		96
Domainⁱ	161 – 210	SOCS boxInterPro annotationAdd BLAST		50

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 52	DisorderedSequence analysisAdd BLAST		52

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	21 – 37	PolarSequence analysisAdd BLAST		17

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000161164
OMAⁱ	ETFDCLF

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10382, SH2_SOCS1, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028411, SOCS1 IPR035861, SOCS1_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf
PANTHERⁱ	PTHR10155:SF4, PTHR10155:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit
SUPFAMⁱ	SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A5F4W0R1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVAHNQVAAD NAVSTAAEPR RRPEPSSSSS SSSAAPARQR PCPAAPAPVP 
        60         70         80         90        100
GDTHFRTFRS HADYRRITRA SALLDACGFY WGPLSVHGAH ERLRAEPVGT 
       110        120        130        140        150
FLVRDSRQRN CFFALSVKMA SGPTSIRVHF QAGRFHLDGS RESFDCLFEL 
       160        170        180        190        200
LEHYVAAPRR MLGAPLRQRR VRPLQELCRQ RIVATVGREN LARIPLNPVL 
       210 
RDYLSSFPFQ I

Length:211

Mass (Da):23,572

Last modified:December 11, 2019 - v1

Checksum:ⁱCA5FAE9CE116C9D2

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_017834240.1, XM_017978751.1

RefSeqⁱ

XP_017834240.1, XM_017978751.1

Genome annotation databases

Ensemblⁱ	ENSCJAT00000092729; ENSCJAP00000071401; ENSCJAG00000062700
GeneIDⁱ	100402275
KEGGⁱ	cjc:100402275

Protein	Similar proteins		Species	Score	Length	Source
A0A5F4W0R1	Suppressor of cytokine signaling 1		MOUSE		212	UniRef90_O35716
Suppressor of cytokine signaling 1		RAT		212
Suppressor of cytokine signaling 1		HUMAN		211
Uncharacterized protein		PROCO		223
Suppressor of cytokine signaling 1		HORSE		222
+103

Protein	Similar proteins		Species	Score	Length	Source
A0A5F4W0R1	Suppressor of cytokine signaling 1		MOUSE		212	UniRef50_O35716
Suppressor of cytokine signaling 1		RAT		212
Suppressor of cytokine signaling 1		HUMAN		211
Uncharacterized protein		PROCO		223
Suppressor of cytokine signaling 1		HORSE		222
+231

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_017834240.1, XM_017978751.1

RefSeqⁱ

XP_017834240.1, XM_017978751.1

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSCJAT00000092729; ENSCJAP00000071401; ENSCJAG00000062700
GeneIDⁱ	100402275
KEGGⁱ	cjc:100402275

Organism-specific databases

CTDⁱ	8651

CTDⁱ

8651

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000161164
OMAⁱ	ETFDCLF

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Family and domain databases

CDDⁱ	cd10382, SH2_SOCS1, 1 hit
Gene3Dⁱ	3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR000980, SH2 IPR036860, SH2_dom_sf IPR028411, SOCS1 IPR035861, SOCS1_SH2 IPR001496, SOCS_box IPR036036, SOCS_box-like_dom_sf
PANTHERⁱ	PTHR10155:SF4, PTHR10155:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF00017, SH2, 1 hit
SMARTⁱ	View protein in SMART SM00252, SH2, 1 hit SM00253, SOCS, 1 hit SM00969, SOCS_box, 1 hit
SUPFAMⁱ	SSF158235, SSF158235, 1 hit SSF55550, SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001, SH2, 1 hit PS50225, SOCS, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A5F4W0R1_CALJA
Accessionⁱ	A0A5F4W0R1Primary (citable) accession number: A0A5F4W0R1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	December 11, 2019
	Last sequence update:	December 11, 2019
	Last modified:	February 10, 2021
	This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB - A0A5F4W0R1 (A0A5F4W0R1_CALJA)

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Uncharacterized protein

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Enzyme and pathway databases

Names & Taxonomyⁱ

Subcellular locationⁱ

Nucleus

Other locations

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A5F4W0R1 (A0A5F4W0R1_CALJA)

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Uncharacterized protein

SOCS1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ