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Entry version 2 (11 Dec 2019)
Sequence version 1 (13 Nov 2019)
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Protein

tRNA-dihydrouridine(16) synthase

Gene

dusC

Organism
Escherichia coli O16:H48
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U16 in tRNAs.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FMNUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei35Interacts with tRNA; defines subfamily-specific binding signatureUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei68FMNUniRule annotation1
Sitei95Interacts with tRNAUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei98Proton donorUniRule annotation1
Binding sitei139FMNUniRule annotation1
Sitei176Interacts with tRNAUniRule annotation1
Sitei272Interacts with tRNA; defines subfamily-specific binding signatureUniRule annotation1
Sitei274Interacts with tRNA; defines subfamily-specific binding signatureUniRule annotation1
Sitei279Interacts with tRNAUniRule annotation1
Sitei295Interacts with tRNA; defines subfamily-specific binding signatureUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi200 – 202FMNUniRule annotation3
Nucleotide bindingi224 – 225FMNUniRule annotation2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported, RNA-binding, tRNA-bindingUniRule annotation
Biological processtRNA processingUniRule annotation
LigandFlavoprotein, FMNUniRule annotation, NADPUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA-dihydrouridine(16) synthaseUniRule annotation (EC:1.3.1.-UniRule annotation)
Alternative name(s):
U16-specific dihydrouridine synthaseUniRule annotation
Short name:
U16-specific DusUniRule annotation
tRNA-dihydrouridine synthase CUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dusCUniRule annotationImported
ORF Names:FYA04_13410Imported, FYA05_09200Imported, FYA06_07870Imported, FYA07_07870Imported, FYA08_07870Imported, FYA09_07870Imported, FYA10_07870Imported, FYA11_16030Imported, FYA12_17520Imported, FYA13_09205Imported, FYA14_07870Imported, FYA15_07870Imported, FYA16_07870Imported, FYA17_07870Imported, FYA18_04835Imported, FYA19_07870Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O16:H48Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri2605619 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Dus family. DusC subfamily.UniRule annotation
Belongs to the dus family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02801 DUS_like_FMN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.20.225.30, 1 hit
3.20.20.70, 1 hit

HAMAP database of protein families

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HAMAPi
MF_02043 DusC_subfam, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR032886 DusC
IPR042270 DusC_C
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS

The PANTHER Classification System

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PANTHERi
PTHR11082:SF26 PTHR11082:SF26, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01207 Dus, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF006621 Dus, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01136 UPF0034, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A5C0KZE1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVLLAPMEG VLDSLVRELL TEVNDYDLCI TEFVRVVDQL LPVKVFHRIC
60 70 80 90 100
PELQNASRTP SGTLVRVQLL GQFPQWLAEN AARAVELGSW GVDLNCGCPS
110 120 130 140 150
KTVNGSGGGA TLLKDPELIY QGAKAMREAV PAHLPVSVKV RLGWDSGEKK
160 170 180 190 200
FEIADAVQQA GATELVVHGR TKEQGYRAEH IDWQAIGDIR QRLNIPVIAN
210 220 230 240 250
GEIWDWQSAQ QCMAISGCDA VMIGRGALNI PNLSRVVKYN EPRMPWPEVV
260 270 280 290 300
ALLQKYTRLE KQGDTGLYHV ARIKQWLSYL RKEYDEATEL FQHVRVLNNS
310
PDIARAIQAI DIEKL
Length:315
Mass (Da):35,199
Last modified:November 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83B33E5034E53565
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP043185 Genomic DNA Translation: QEI87686.1
CP043183 Genomic DNA Translation: QEI92527.1
CP043187 Genomic DNA Translation: QEI96838.1
CP043189 Genomic DNA Translation: QEJ01140.1
CP043191 Genomic DNA Translation: QEJ05601.1
CP043193 Genomic DNA Translation: QEJ10056.1
CP043195 Genomic DNA Translation: QEJ14639.1
CP043197 Genomic DNA Translation: QEJ20471.1
CP043201 Genomic DNA Translation: QEJ23017.1
CP043199 Genomic DNA Translation: QEJ28769.1
CP043205 Genomic DNA Translation: QEJ31715.1
CP043203 Genomic DNA Translation: QEJ36024.1
CP043207 Genomic DNA Translation: QEJ40364.1
CP043209 Genomic DNA Translation: QEJ44676.1
CP043211 Genomic DNA Translation: QEJ49226.1
CP043213 Genomic DNA Translation: QEJ54227.1

NCBI Reference Sequences

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RefSeqi
WP_001264861.1, NZ_CP043213.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP043185 Genomic DNA Translation: QEI87686.1
CP043183 Genomic DNA Translation: QEI92527.1
CP043187 Genomic DNA Translation: QEI96838.1
CP043189 Genomic DNA Translation: QEJ01140.1
CP043191 Genomic DNA Translation: QEJ05601.1
CP043193 Genomic DNA Translation: QEJ10056.1
CP043195 Genomic DNA Translation: QEJ14639.1
CP043197 Genomic DNA Translation: QEJ20471.1
CP043201 Genomic DNA Translation: QEJ23017.1
CP043199 Genomic DNA Translation: QEJ28769.1
CP043205 Genomic DNA Translation: QEJ31715.1
CP043203 Genomic DNA Translation: QEJ36024.1
CP043207 Genomic DNA Translation: QEJ40364.1
CP043209 Genomic DNA Translation: QEJ44676.1
CP043211 Genomic DNA Translation: QEJ49226.1
CP043213 Genomic DNA Translation: QEJ54227.1
RefSeqiWP_001264861.1, NZ_CP043213.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di1.20.225.30, 1 hit
3.20.20.70, 1 hit
HAMAPiMF_02043 DusC_subfam, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR032886 DusC
IPR042270 DusC_C
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PANTHERiPTHR11082:SF26 PTHR11082:SF26, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PIRSFiPIRSF006621 Dus, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5C0KZE1_ECOLX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5C0KZE1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2019
Last sequence update: November 13, 2019
Last modified: December 11, 2019
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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