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Entry version 2 (11 Dec 2019)
Sequence version 1 (13 Nov 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

E5288_WYG001453

Organism
Bos mutus (wild yak)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:E5288_WYG001453Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos mutus (wild yak)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri72004 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000322234 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei231 – 255HelicalSequence analysisAdd BLAST25
    Transmembranei267 – 287HelicalSequence analysisAdd BLAST21
    Transmembranei318 – 337HelicalSequence analysisAdd BLAST20
    Transmembranei344 – 364HelicalSequence analysisAdd BLAST21
    Transmembranei384 – 408HelicalSequence analysisAdd BLAST25
    Transmembranei420 – 442HelicalSequence analysisAdd BLAST23
    Transmembranei454 – 477HelicalSequence analysisAdd BLAST24

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini138 – 222G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST85
    Domaini232 – 478G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST247

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the G-protein coupled receptor 2 family.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSequence analysisSAAS annotation

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    4.10.1240.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003287 GCPR_2_calcitonin_rcpt_fam
    IPR017981 GPCR_2-like
    IPR001688 GPCR_2_calcitonin_rcpt
    IPR036445 GPCR_2_extracell_dom_sf
    IPR001879 GPCR_2_extracellular_dom
    IPR000832 GPCR_2_secretin-like
    IPR017983 GPCR_2_secretin-like_CS

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR45620:SF8 PTHR45620:SF8, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00002 7tm_2, 1 hit
    PF02793 HRM, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00361 CALCITONINR
    PR01350 CTRFAMILY
    PR00249 GPCRSECRETIN

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00008 HormR, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF111418 SSF111418, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
    PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
    PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
    PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A5A9QV01-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRDVLGPAVA VRQKWGQLTA REKMSSCPAW ESGAAAFPAA RHEMNHEQRE
    60 70 80 90 100
    ITDHRSVETC NTIFKVFEIA NRVVLKDRFQ RPKMKFTLTR WCLTLFIFLN
    110 120 130 140 150
    RPLPVLPTSS DSTYSPTLEP EPFLFLVGKQ KLLQAQHKCF DRMQKLPPYQ
    160 170 180 190 200
    GEGLYCNRTW DGWACWDDTP AGTLAEQHCP GYFPDFDVEE KVTKYCEEDG
    210 220 230 240 250
    VWYTHPESNI SWSNYTMCNA FTPEKMQSAY ILYYLAIVGH SMSMVTLVIS
    260 270 280 290 300
    LVIFMRVRSL SCQRVTLHKN MFLTYVLNSI IIIIHLVEVV PNGELVKRDP
    310 320 330 340 350
    PMCKVLHFFH QYMMSCNYFW MLCEGLYLHT LIVVSVFAEG QRMWWYYLLG
    360 370 380 390 400
    WGLPLLPSTA HAIARALLFN DNCWLSVDTN LLYIIHGPVM GALVLNFFFL
    410 420 430 440 450
    LNIIRVLVKK IKESQEDSYI YLKAVRATLI LVPLLGVQFV ILPWRPSHPV
    460 470 480 490 500
    LGKIYDFVMH SLIHFQGFFV AIIYCFCNHE VQAALKRQWN QYQARRWNGR
    510 520 530 540 550
    RRAHRAANAA AATAAAAAAL AETPPIYICH QEPQNEPADN LGEEAAEVIP
    560 570 580 590 600
    MEGGEVISMK GAEVIAVEGA AEVIAVEGAA EVIAVEGSAE VITVEGAEVV
    610
    AMEIIEQESS A
    Length:611
    Mass (Da):69,387
    Last modified:November 13, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6043C1464120378
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    VBQZ02000016 Genomic DNA Translation: KAA0737583.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    VBQZ02000016 Genomic DNA Translation: KAA0737583.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein family/group databases

    Information system for G protein-coupled receptors (GPCRs)

    More...
    GPCRDBi
    Search...

    Family and domain databases

    Gene3Di4.10.1240.10, 1 hit
    InterProiView protein in InterPro
    IPR003287 GCPR_2_calcitonin_rcpt_fam
    IPR017981 GPCR_2-like
    IPR001688 GPCR_2_calcitonin_rcpt
    IPR036445 GPCR_2_extracell_dom_sf
    IPR001879 GPCR_2_extracellular_dom
    IPR000832 GPCR_2_secretin-like
    IPR017983 GPCR_2_secretin-like_CS
    PANTHERiPTHR45620:SF8 PTHR45620:SF8, 1 hit
    PfamiView protein in Pfam
    PF00002 7tm_2, 1 hit
    PF02793 HRM, 1 hit
    PRINTSiPR00361 CALCITONINR
    PR01350 CTRFAMILY
    PR00249 GPCRSECRETIN
    SMARTiView protein in SMART
    SM00008 HormR, 1 hit
    SUPFAMiSSF111418 SSF111418, 1 hit
    PROSITEiView protein in PROSITE
    PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
    PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
    PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
    PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A5A9QV01_9CETA
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A5A9QV01
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2019
    Last sequence update: November 13, 2019
    Last modified: December 11, 2019
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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