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UniProtKB - A0A590UK28 (A0A590UK28_HUMAN)
Protein
Submitted name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Gene
GNAS
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- G-protein beta/gamma-subunit complex binding Source: InterPro
- GTPase activity Source: InterPro
- GTP binding Source: InterPro
GO - Biological processi
Keywordsi
Molecular function | TransducerARBA annotation |
Ligand | Metal-bindingARBA annotation, Nucleotide-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortImported |
Gene namesi | Name:GNASImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4392, GNAS |
VEuPathDBi | HostDB:ENSG00000087460 |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 19 – 39 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000156300 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 24 potential isoforms that are computationally mapped.Show allAlign All
A0A590UK28-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRILHVNGFN GDSEKATKVQ DIKNNLKEAI ETIVAAMSNL VPPVELANPE
60 70 80 90 100
NQFRVDYILS VMNVPDFDFP PEFYEHAKAL WEDEGVRACY ERSNEYQLID
110 120 130 140 150
CAQYFLDKID VIKQADYVPS DQDLLRCRVL TSGIFETKFQ VDKVNFHMFD
160 170 180 190 200
VGGQRDERRK WIQCFNDVTA IIFVVASSSY NMVIREDNQT NRLQEALNLF
210 220 230 240 250
KSIWNNRWLR TISVILFLNK QDLLAEKVLA GKSKIEDYFP EFARYTTPED
260 270 280 290 300
ATPEPGEDPR VTRAKYFIRD EFLRISTASG DGRHYCYPHF TCAVDTENIR
310 320
RVFNDCRDII QRMHLRQYEL L
Computationally mapped potential isoform sequencesi
There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP63092 | GNAS2_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1, GSP | 394 | Annotation score: | ||
Q5JWF2 | GNAS1_HUMAN | Guanine nucleotide-binding protein ... | GNAS GNAS1 | 1,037 | Annotation score: | ||
P84996 | ALEX_HUMAN | Protein ALEX | GNAS GNAS1 | 626 | Annotation score: | ||
O95467 | GNAS3_HUMAN | Neuroendocrine secretory protein 55 | GNAS GNAS1 | 245 | Annotation score: | ||
Q5JWE9 | Q5JWE9_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 1,022 | Annotation score: | ||
A0A590UJS2 | A0A590UJS2_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 368 | Annotation score: | ||
A0A7I2V5R6 | A0A7I2V5R6_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 1,038 | Annotation score: | ||
B0AZR9 | B0AZR9_HUMAN | GNAS complex locus, isoform CRA_b | GNAS hCG_1788380 | 335 | Annotation score: | ||
A0A0A0MR13 | A0A0A0MR13_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 362 | Annotation score: | ||
A0A590UJQ9 | A0A590UJQ9_HUMAN | Guanine nucleotide-binding protein ... | GNAS | 336 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. |
Genome annotation databases
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL109840 Genomic DNA No translation available. AL121917 Genomic DNA No translation available. AL132655 Genomic DNA No translation available. KF456967 Genomic DNA No translation available. |
3D structure databases
SMRi | A0A590UK28 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | A0A590UK28 |
Genome annotation databases
Organism-specific databases
HGNCi | HGNC:4392, GNAS |
OpenTargetsi | ENSG00000087460 |
VEuPathDBi | HostDB:ENSG00000087460 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156300 |
Family and domain databases
CDDi | cd00066, G-alpha, 1 hit |
Gene3Di | 1.10.400.10, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR000367, Gprotein_alpha_S IPR001019, Gprotein_alpha_su IPR011025, GproteinA_insert IPR027417, P-loop_NTPase |
PANTHERi | PTHR10218, PTHR10218, 1 hit |
Pfami | View protein in Pfam PF00503, G-alpha, 1 hit |
PRINTSi | PR00318, GPROTEINA PR00443, GPROTEINAS |
SMARTi | View protein in SMART SM00275, G_alpha, 1 hit |
SUPFAMi | SSF47895, SSF47895, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51882, G_ALPHA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A590UK28_HUMAN | |
Accessioni | A0A590UK28Primary (citable) accession number: A0A590UK28 Secondary accession number(s): A0A590UJA5 A0A590UKB4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 13, 2019 |
Last sequence update: | September 29, 2021 | |
Last modified: | January 19, 2022 | |
This is version 11 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |