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UniProtKB - A0A590UJG2 (A0A590UJG2_HUMAN)

Entry version 12 (19 Jan 2022)
Sequence version 1 (13 Nov 2019)
Previous versions | rss
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Protein
Submitted name:

Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5

Gene

MACF1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi5045 – 5056PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi5081 – 5092PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandCalciumPROSITE-ProRule annotation, Metal-bindingPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MACF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13664, MACF1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000127603

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000127603

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...PeptideAtlasi		A0A590UJG2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A590UJG2

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 130Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini143 – 247Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini817 – 874SH3InterPro annotationAdd BLAST58
Domaini5032 – 5067EF-handInterPro annotationAdd BLAST36
Domaini5068 – 5103EF-handInterPro annotationAdd BLAST36
Domaini5108 – 5180GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni3574 – 3594DisorderedSequence analysisAdd BLAST21
Regioni4942 – 4972DisorderedSequence analysisAdd BLAST31
Regioni5196 – 5379DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili194 – 214Sequence analysisAdd BLAST21
Coiled coili426 – 446Sequence analysisAdd BLAST21
Coiled coili451 – 478Sequence analysisAdd BLAST28
Coiled coili770 – 790Sequence analysisAdd BLAST21
Coiled coili995 – 1015Sequence analysisAdd BLAST21
Coiled coili1352 – 1382Sequence analysisAdd BLAST31
Coiled coili1446 – 1466Sequence analysisAdd BLAST21
Coiled coili1471 – 1498Sequence analysisAdd BLAST28
Coiled coili1578 – 1612Sequence analysisAdd BLAST35
Coiled coili1742 – 1772Sequence analysisAdd BLAST31
Coiled coili2136 – 2163Sequence analysisAdd BLAST28
Coiled coili2183 – 2203Sequence analysisAdd BLAST21
Coiled coili2241 – 2261Sequence analysisAdd BLAST21
Coiled coili2346 – 2366Sequence analysisAdd BLAST21
Coiled coili2506 – 2526Sequence analysisAdd BLAST21
Coiled coili2565 – 2585Sequence analysisAdd BLAST21
Coiled coili2606 – 2640Sequence analysisAdd BLAST35
Coiled coili2757 – 2777Sequence analysisAdd BLAST21
Coiled coili2878 – 2919Sequence analysisAdd BLAST42
Coiled coili3082 – 3102Sequence analysisAdd BLAST21
Coiled coili3193 – 3213Sequence analysisAdd BLAST21
Coiled coili3846 – 3866Sequence analysisAdd BLAST21
Coiled coili4082 – 4109Sequence analysisAdd BLAST28
Coiled coili4294 – 4314Sequence analysisAdd BLAST21
Coiled coili4861 – 4881Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3578 – 3593Polar residuesSequence analysisAdd BLAST16
Compositional biasi5215 – 5294Polar residuesSequence analysisAdd BLAST80
Compositional biasi5326 – 5379Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155824

Family and domain databases

Conserved Domains Database

More...CDDi		cd00014, CH, 2 hits
cd00051, EFh, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...PANTHERi		PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 21 potential isoforms that are computationally mapped.Show allAlign All

A0A590UJG2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPSYQDEHE FNAHLVCRMC CMDERDRVQK KTFTKWVNKH LMKVRKHIND 
        60         70         80         90        100
LYEDLRDGHN LISLLEVLSG IKLPREKGRM RFHRLQNVQI ALDFLKQRQV 
       110        120        130        140        150
KLVNIRNDDI TDGNPKLTLG LIWTIILHFQ ISDIYISGES GDMSAKEKLL 
       160        170        180        190        200
LWTQKVTAGY TGIKCTNFSS CWSDGKMFNA LIHRYRPDLV DMERVQIQSN 
       210        220        230        240        250
RENLEQAFEV AERLGVTRLL DAEDVDVPSP DEKSVITYVS SIYDAFPKVP 
       260        270        280        290        300
EGGEGISATE VDSRWQEYQS RVDSLIPWIK QHTILMSDKT FPQNPVELKA 
       310        320        330        340        350
LYNQYIHFKE TEILAKEREK GRIEELYKLL EVWIEFGRIK LPQGYHPNDV 
       360        370        380        390        400
EEEWGKLIIE MLEREKSLRP AVERLELLLQ IANKIQNGAL NCEEKLTLAK 
       410        420        430        440        450
NTLQADAAHL ESGQPVQCES DVIMYIQECE GLIRQLQVDL QILRDENYYQ 
       460        470        480        490        500
LEELAFRVMR LQDELVTLRL ECTNLYRKGH FTSLELVPPS TLTTTHLKAE 
       510        520        530        540        550
PLTKATHSSS TSWFRKPMTR AELVAISSSE DEGNLRFVYE LLSWVEEMQM 
       560        570        580        590        600
KLERAEWGND LPSVELQLET QQHIHTSVEE LGSSVKEARL YEGKMSQNFH 
       610        620        630        640        650
TSYAETLGKL ETQYCKLKET SSFRMRHLQS LHKFVSRATA ELIWLNEKEE 
       660        670        680        690        700
EELAYDWSDN NSNISAKRNY FSELTMELEE KQDVFRSLQD TAELLSLENH 
       710        720        730        740        750
PAKQTVEAYS AAVQSQLQWM KQLCLCVEQH VKENTAYFQF FSDARELESF 
       760        770        780        790        800
LRNLQDSIKR KYSCDHNTSL SRLEDLLQDS MDEKEQLIQS KSSVASLVGR 
       810        820        830        840        850
SKTIVQLKPR SPDHVLKNTI SVKAVCDYRQ IEITICKNDE CVLEDNSQRT 
       860        870        880        890        900
KWKVISPTGN EAMVPSVCFL IPPPNKDAIE MASRVEQSYQ KVMALWHQLH 
       910        920        930        940        950
VNTKSLISWN YLRKDLDLVQ TWNLEKLRSS APGECHQIMK NLQAHYEDFL 
       960        970        980        990       1000
QDSRDSVLFS VADRLRLEEE VEACKARFQH LMKSMENEDK EETVAKMYIS 
      1010       1020       1030       1040       1050
ELKNIRLRLE EYEQRVVKRI QSLASSRTDR DAWQDNALRI AEQEHTQEDL 
      1060       1070       1080       1090       1100
QQLRSDLDAV SMKCDSFLHQ SPSSSSVPTL RSELNLLVEK MDHVYGLSTV 
      1110       1120       1130       1140       1150
YLNKLKTVDV IVRSIQDAEL LVKGYEIKLS QEEVVLADLS ALEAHWSTLR 
      1160       1170       1180       1190       1200
HWLSDVKDKN SVFSVLDEEI AKAKVVAEQM SRLTPERNLD LERYQEKGSQ 
      1210       1220       1230       1240       1250
LQERWHRVIA QLEIRQSELE SIQEVLGDYR ACHGTLIKWI EETTAQQEMM 
      1260       1270       1280       1290       1300
KPGQAEDSRV LSEQLSQQTA LFAEIERNQT KLDQCQKFSQ QYSTIVKDYE 
      1310       1320       1330       1340       1350
LQLMTYKAFV ESQQKSPGKR RRMLSSSDAI TQEFMDLRTR YTALVTLTTQ 
      1360       1370       1380       1390       1400
HVKYISDALR RLEEEEKVVE EEKQEHVEKV KELLGWVSTL ARNTQGKATS 
      1410       1420       1430       1440       1450
SETKESTDIE KAILEQQVLS EELTTKKEQV SEAIKTSQIF LAKHGHKLSE 
      1460       1470       1480       1490       1500
KEKKQISEQL NALNKAYHDL CDGSANQLQQ LQSQLAHQTE QKTLQKQQNT 
      1510       1520       1530       1540       1550
CHQQLEDLCS WVGQAERALA GHQGRTTQQD LSALQKNQSD LKDLQDDIQN 
      1560       1570       1580       1590       1600
RATSFATVVK DIEGFMEENQ TKLSPRELTA LREKLHQAKE QYEALQEETR 
      1610       1620       1630       1640       1650
VAQKELEEAV TSALQQETEK SKAAKELAEN KKKIDALLDW VTSVGSSGGQ 
      1660       1670       1680       1690       1700
LLTNLPGMEQ LSGASLEKGA LDTTDGYMGV NQAPEKLDKQ CEMMKARHQE 
      1710       1720       1730       1740       1750
LLSQQQNFIL ATQSAQAFLD QHGHNLTPEE QQMLQQKLGE LKEQYSTSLA 
      1760       1770       1780       1790       1800
QSEAELKQVQ TLQDELQKFL QDHKEFESWL ERSEKELENM HKGGSSPETL 
      1810       1820       1830       1840       1850
PSLLKRQGSF SEDVISHKGD LRFVTISGQK VLDMENSFKE GKEPSEIGNL 
      1860       1870       1880       1890       1900
VKDKLKDATE RYTALHSKCT RLGSHLNMLL GQYHQFQNSA DSLQAWMQAC 
      1910       1920       1930       1940       1950
EANVEKLLSD TVASDPGVLQ EQLATTKQLQ EELAEHQVPV EKLQKVARDI 
      1960       1970       1980       1990       2000
MEIEGEPAPD HRHVQETTDS ILSHFQSLSY SLAERSSLLQ KAIAQSQSVQ 
      2010       2020       2030       2040       2050
ESLESLLQSI GEVEQNLEGK QVSSLSSGVI QEALATNMKL KQDIARQKSS 
      2060       2070       2080       2090       2100
LEATREMVTR FMETADSTTA AVLQGKLAEV SQRFEQLCLQ QQEKESSLKK 
      2110       2120       2130       2140       2150
LLPQAEMFEH LSGKLQQFME NKSRMLASGN QPDQDITHFF QQIQELNLEM 
      2160       2170       2180       2190       2200
EDQQENLDTL EHLVTELSSC GFALDLCQHQ DRVQNLRKDF TELQKTVKER 
      2210       2220       2230       2240       2250
EKDASSCQEQ LDEFRKLVRT FQKWLKETEG SIPPTETSMS AKELEKQIEH 
      2260       2270       2280       2290       2300
LKSLLDDWAS KGTLVEEINC KGTSLENLIM EITAPDSQGK TGSILPSVGS 
      2310       2320       2330       2340       2350
SVGSVNGYHT CKDLTEIQCD MSDVNLKYEK LGGVLHERQE SLQAILNRME 
      2360       2370       2380       2390       2400
EVHKEANSVL QWLESKEEVL KSMDAMSSPT KTETVKAQAE SNKAFLAELE 
      2410       2420       2430       2440       2450
QNSPKIQKVK EALAGLLVTY PNSQEAENWK KIQEELNSRW ERATEVTVAR 
      2460       2470       2480       2490       2500
QRQLEESASH LACFQAAESQ LRPWLMEKEL MMGVLGPLSI DPNMLNAQKQ 
      2510       2520       2530       2540       2550
QVQFMLKEFE ARRQQHEQLN EAAQGILTGP GDVSLSTSQV QKELQSINQK 
      2560       2570       2580       2590       2600
WVELTDKLNS RSSQIDQAIV KSTQYQELLQ DLSEKVRAVG QRLSVQSAIS 
      2610       2620       2630       2640       2650
TQPEAVKQQL EETSEIRSDL EQLDHEVKEA QTLCDELSVL IGEQYLKDEL 
      2660       2670       2680       2690       2700
KKRLETVALP LQGLEDLAAD RINRLQAALA STQQFQQMFD ELRTWLDDKQ 
      2710       2720       2730       2740       2750
SQQAKNCPIS AKLERLQSQL QENEEFQKSL NQHSGSYEVI VAEGESLLLS 
      2760       2770       2780       2790       2800
VPPGEEKRTL QNQLVELKNH WEELSKKTAD RQSRLKDCMQ KAQKYQWHVE 
      2810       2820       2830       2840       2850
DLVPWIEDCK AKMSELRVTL DPVQLESSLL RSKAMLNEVE KRRSLLEILN 
      2860       2870       2880       2890       2900
SAADILINSS EADEDGIRDE KAGINQNMDA VTEELQAKTG SLEEMTQRLR 
      2910       2920       2930       2940       2950
EFQESFKNIE KKVEGAKHQL EIFDALGSQA CSNKNLEKLR AQQEVLQALE 
      2960       2970       2980       2990       3000
PQVDYLRNFT QGLVEDAPDG SDASQLLHQA EVAQQEFLEV KQRVNSGCVM 
      3010       3020       3030       3040       3050
MENKLEGIGQ FHCRVREMFS QLADLDDELD GMGAIGRDTD SLQSQIEDVR 
      3060       3070       3080       3090       3100
LFLNKIHVLK LDIEASEAEC RHMLEEEGTL DLLGLKRELE ALNKQCGKLT 
      3110       3120       3130       3140       3150
ERGKARQEQL ELTLGRVEDF YRKLKGLNDA TTAAEEAEAL QWVVGTEVEI 
      3160       3170       3180       3190       3200
INQQLADFKM FQKEQVDPLQ MKLQQVNGLG QGLIQSAGKD CDVQGLEHDM 
      3210       3220       3230       3240       3250
EEINARWNTL NKKVAQRIAQ LQEALLHCGK FQDALEPLLS WLADTEELIA 
      3260       3270       3280       3290       3300
NQKPPSAEYK VVKAQIQEQK LLQRLLDDRK ATVDMLQAEG GRIAQSAELA 
      3310       3320       3330       3340       3350
DREKITGQLE SLESRWTELL SKAAARQKQL EDILVLAKQF HETAEPISDF 
      3360       3370       3380       3390       3400
LSVTEKKLAN SEPVGTQTAK IQQQIIRHKA LEEDIENHAT DVHQAVKIGQ 
      3410       3420       3430       3440       3450
SLSSLTSPAE QGVLSEKIDS LQARYSEIQD RCCRKAALLD QALSNARLFG 
      3460       3470       3480       3490       3500
EDEVEVLNWL AEVEDKLSSV FVKDFKQDVL HRQHADHLAL NEEIVNRKKN 
      3510       3520       3530       3540       3550
VDQAIKNGQA LLKQTTGEEV LLIQEKLDGI KTRYADITVT SSKALRTLEQ 
      3560       3570       3580       3590       3600
ARQLATKFQS TYEELTGWLR EVEEELATSG GQSPTGEQIP QFQQRQKELK 
      3610       3620       3630       3640       3650
KEVMEHRLVL DTVNEVSRAL LELVPWRARE GLDKLVSDAN EQYKLVSDTI 
      3660       3670       3680       3690       3700
GQRVDEIDAA IQRSQQYEQA ADAELAWVAE TKRKLMALGP IRLEQDQTTA 
      3710       3720       3730       3740       3750
QLQVQKAFSI DIIRHKDSMD ELFSHRSEIF GTCGEEQKTV LQEKTESLIQ 
      3760       3770       3780       3790       3800
QYEAISLLNS ERYARLERAQ VLVNQFWETY EELSPWIEET RALIAQLPSP 
      3810       3820       3830       3840       3850
AIDHEQLRQQ QEEMRQLRES IAEHKPHIDK LLKIGPQLKE LNPEEGEMVE 
      3860       3870       3880       3890       3900
EKYQKAENMY AQIKEEVRQR ALALDEAVSQ STQITEFHDK IEPMLETLEN 
      3910       3920       3930       3940       3950
LSSRLRMPPL IPAEVDKIRE CISDNKSATV ELEKLQPSFE ALKRRGEELI 
      3960       3970       3980       3990       4000
GRSQGADKDL AAKEIQDKLD QMVFFWEDIK ARAEEREIKF LDVLELAEKF 
      4010       4020       4030       4040       4050
WYDMAALLTT IKDTQDIVHD LESPGIDPSI IKQQVEAAET IKEETDGLHE 
      4060       4070       4080       4090       4100
ELEFIRILGA DLIFACGETE KPEVRKSIDE MNNAWENLNK TWKERLEKLE 
      4110       4120       4130       4140       4150
DAMQAAVQYQ DTLQAMFDWL DNTVIKLCTM PPVGTDLNTV KDQLNEMKEF 
      4160       4170       4180       4190       4200
KVEVYQQQIE MEKLNHQGEL MLKKATDETD RDIIREPLTE LKHLWENLGE 
      4210       4220       4230       4240       4250
KIAHRQHKLE GALLALGQFQ HALEELMSWL THTEELLDAQ RPISGDPKVI 
      4260       4270       4280       4290       4300
EVELAKHHVL KNDVLAHQAT VETVNKAGNE LLESSAGDDA SSLRSRLEAM 
      4310       4320       4330       4340       4350
NQCWESVLQK TEEREQQLQS TLQQAQGFHS EIEDFLLELT RMESQLSASK 
      4360       4370       4380       4390       4400
PTGGLPETAR EQLDTHMELY SQLKAKEETY NQLLDKGRLM LLSRDDSGSG 
      4410       4420       4430       4440       4450
SKTEQSVALL EQKWHVVSSK MEERKSKLEE ALNLATEFQN SLQEFINWLT 
      4460       4470       4480       4490       4500
LAEQSLNIAS PPSLILNTVL SQIEEHKVFA NEVNAHRDQI IELDQTGNQL 
      4510       4520       4530       4540       4550
KFLSQKQDVV LIKNLLVSVQ SRWEKVVQRS IERGRSLDDA RKRAKQFHEA 
      4560       4570       4580       4590       4600
WKKLIDWLED AESHLDSELE ISNDPDKIKL QLSKHKEFQK TLGGKQPVYD 
      4610       4620       4630       4640       4650
TTIRTGRALK EKTLLPEDSQ KLDNFLGEVR DKWDTVCGKS VERQHKLEEA 
      4660       4670       4680       4690       4700
LLFSGQFMDA LQALVDWLYK VEPQLAEDQP VHGDLDLVMN LMDAHKVFQK 
      4710       4720       4730       4740       4750
ELGKRTGTVQ VLKRSGRELI ENSRDDTTWV KGQLQELSTR WDTVCKLSVS 
      4760       4770       4780       4790       4800
KQSRLEQALK QAEVFRDTVH MLLEWLSEAE QTLRFRGALP DDTEALQSLI 
      4810       4820       4830       4840       4850
DTHKEFMKKV EEKRVDVNSA VAMGEVILAV CHPDCITTIK HWITIIRARF 
      4860       4870       4880       4890       4900
EEVLTWAKQH QQRLETALSE LVANAELLEE LLAWIQWAET TLIQRDQEPI 
      4910       4920       4930       4940       4950
PQNIDRVKAL IAEHQTFMEE MTRKQPDVDR VTKTYKRKNI EPTHAPFIEK 
      4960       4970       4980       4990       5000
SRSGGRKSLS QPTPPPMPIL SQSEAKNPRI NQLSARWQQV WLLALERQRK 
      5010       5020       5030       5040       5050
LNDALDRLEE LKEFANFDFD VWRKKYMRWM NHKKSRVMDF FRRIDKDQDG 
      5060       5070       5080       5090       5100
KITRQEFIDG ILASKFPTTK LEMTAVADIF DRDGDGYIDY YEFVAALHPN 
      5110       5120       5130       5140       5150
KDAYRPTTDA DKIEDEVTRQ VAQCKCAKRF QVEQIGENKY RFGDSQQLRL 
      5160       5170       5180       5190       5200
VRILRSTVMV RVGGGWMALD EFLVKNDPCR ARGRTNIELR EKFILPEGAS 
      5210       5220       5230       5240       5250
QGMTPFRSRG RRSKPSSRAA SPTRSSSSAS QSNHSCTSMP SSPATPASGT 
      5260       5270       5280       5290       5300
KVIPSSGSKL KRPTPTFHSS RTSLAGDTSN SSSPASTGAK TNRADPKKSA 
      5310       5320       5330       5340       5350
SRPGSRAGSR AGSRASSRRG SDASDFDLLE TQSACSDTSE SSAAGGQGNS 
      5360       5370 
RRGLNKPSKI PTMSKKTTTA SPRTPGPKR
Length:5,379
Mass (Da):614,901
Last modified:November 13, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAF9D7438726705BB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UPN3MACF1_HUMAN
Microtubule-actin cross-linking fac...
MACF1 ABP620, ACF7, KIAA0465, KIAA1251
7,388Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPE1H3BPE1_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQK9H3BQK9_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,592Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0MQR8A0A7P0MQR8_HUMAN
Microtubule-actin cross-linking fac...
MACF1
7,385Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y390H0Y390_HUMAN
Microtubule-actin cross-linking fac...
MACF1
4,434Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A6YYJ5A0A0A6YYJ5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
1,668Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y314H0Y314_HUMAN
Microtubule-actin cross-linking fac...
MACF1
543Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A5F9ZGX0A0A5F9ZGX0_HUMAN
Microtubule-actin cross-linking fac...
MACF1
2,146Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y4F5H0Y4F5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
455Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y6T5H0Y6T5_HUMAN
Microtubule-actin cross-linking fac...
MACF1
368Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000671089; ENSP00000499399; ENSG00000127603

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137853 Genomic DNA No translation available.
AL355477 Genomic DNA No translation available.
AL356055 Genomic DNA No translation available.
AL365277 Genomic DNA No translation available.
AL442071 Genomic DNA No translation available.
KF495921 Genomic DNA No translation available.

3D structure databases

SMRiA0A590UJG2
ModBaseiSearch...

Proteomic databases

PeptideAtlasiA0A590UJG2

Genome annotation databases

EnsembliENST00000671089; ENSP00000499399; ENSG00000127603

Organism-specific databases

HGNCiHGNC:13664, MACF1
OpenTargetsiENSG00000127603
VEuPathDBiHostDB:ENSG00000127603

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155824

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A590UJG2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A590UJG2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 13, 2019
Last sequence update: November 13, 2019
Last modified: January 19, 2022
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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