UniProtKB - A0A502 (A0A502_HUMAN)
Protein
C-C chemokine receptor type 5
Gene
CCR-5
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- C-C chemokine receptor activity Source: InterPro
GO - Biological processi
- chemotaxis Source: InterPro
- immune response Source: InterPro
- inflammatory response Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 5ARBA annotation |
Gene namesi | Name:CCR-5Imported Synonyms:CMKBR5Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Plasma membrane
- Cell membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Other locations
- Membrane ARBA annotation; Multi-pass membrane protein ARBA annotation
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 36 – 56 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 68 – 87 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 107 – 129 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 141 – 161 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Keywords - PTMi
Lipoprotein, PalmitateARBA annotation, SulfationARBA annotationProteomic databases
PeptideAtlasi | A0A502 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 47 – 215 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 169 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationFamily and domain databases
InterProi | View protein in InterPro IPR002240, Chemokine_CCR5 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01110, CHEMOKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A502-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML
60 70 80 90 100
VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM
110 120 130 140 150
CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV
160 170 180 190 200
ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYIKDSHL GAGPAAACHG
210
HLLLGNPKNS ASVSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66285 Genomic DNA Translation: AAB09551.1 AF009962 Genomic DNA Translation: AAC23944.1 X99393 Genomic DNA Translation: CAA67767.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U66285 Genomic DNA Translation: AAB09551.1 AF009962 Genomic DNA Translation: AAC23944.1 X99393 Genomic DNA Translation: CAA67767.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PeptideAtlasi | A0A502 |
Family and domain databases
InterProi | View protein in InterPro IPR002240, Chemokine_CCR5 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01110, CHEMOKINER5 PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A502_HUMAN | |
Accessioni | A0A502Primary (citable) accession number: A0A502 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 28, 2006 |
Last sequence update: | November 28, 2006 | |
Last modified: | October 7, 2020 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |