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Entry version 9 (10 Feb 2021)
Sequence version 1 (18 Sep 2019)
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Protein
Submitted name:

E3 ubiquitin-protein ligase TRIM56

Gene

EWB00_007983

Organism
Schistosoma japonicum (Blood fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase TRIM56Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:EWB00_007983Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchistosoma japonicum (Blood fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6182 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000311919 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei677 – 699HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_502120218220 – 1438Sequence analysisAdd BLAST1419

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini323 – 406Ig-likeInterPro annotationAdd BLAST84
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1414 – 1438NHLPROSITE-ProRule annotationAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1156 – 1187Sequence analysisAdd BLAST32

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis, Zinc-fingerARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00021, BBOX, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR026966, Neurofascin/L1/NrCAM_C
IPR001258, NHL_repeat
IPR013017, NHL_repeat_subgr
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR017907, Znf_RING_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13882, Bravo_FIGEY, 1 hit
PF01436, NHL, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184, RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51125, NHL, 1 hit
PS00518, ZF_RING_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A4Z2CS03-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIMLIGLIIL TFKIPHGLSA KEQYLQFIPV NGVSHGTYFY EHPGLRNPIE
60 70 80 90 100
VDATVQQQVR IRIVEHLNEL PVLRIHCIVA PLDSTHELVS AYLCRRKSVH
110 120 130 140 150
DSDECIDPKT RNVVFGRVEF SAIGNRSSGY TFSSRLPVRD ELLDGFYSCK
160 170 180 190 200
FHNQNGELIS NFIEIQDAYY YHKRMVRRPV KQTEFLPPLS INNLPLSLEC
210 220 230 240 250
GQTQVSEELP SWADAAFPSP FMWSFCDVDI PDGIQSAGCM RRVRQTSIHV
260 270 280 290 300
TNYFESYVSP NGTLVLYKRT ASAWKDMGLV CWSHLDSSAV YSTYFGGSLE
310 320 330 340 350
RPRLLTYDSN IPFIGNEITV LSPLIQKITV RIGPRTGLKL VTKYRSNPKH
360 370 380 390 400
TTVRWTKDGK KIPSDFPRHN DYLLKFPDLI HRNHSGMYNL LVENEHNRVN
410 420 430 440 450
FQFSVSVVGP PEVIRAPPPL ILVMEGENVT FSCHLDSFIT ESLEINGLPY
460 470 480 490 500
QPNAANFRTE LRDQYPYLKD VLIQPLQKNG HILTYSAYNL FFTPGSKIGP
510 520 530 540 550
THTVSLVGKN EYGLARVSTV VRVLPRLNIL KAPKDYSCTT DCLNTASHIF
560 570 580 590 600
DCVINTDSYE SAYIVQTWEL NGIAVSKMTK DYQQSKFLKT EGTKLIITPV
610 620 630 640 650
DDPSLTVLFR KVNVTCRWRI FYPHVTSRIA DLDTRLLEPN MKVYDSHDDV
660 670 680 690 700
KIHSLMTAAF NLQVDHDPAP ASANISWITA VIIGILVIIA IGVLTACLVM
710 720 730 740 750
RFRGETYMLD REERALGNDP EKELREKEAF QTYERVEEPP LRGSRCSLND
760 770 780 790 800
DSAEIGSDAD GELDDYNLDP ENSNRTPSIE IASISLSTVN TTDHGLLSTK
810 820 830 840 850
SMDSSCNKQE ELINLLNSNF LSCSFCHTRD GVIKLLPCLH TICESCATSL
860 870 880 890 900
SNLRSNNQNN NSLAECKACF VSSLQLRKQY SPHINNDNCS IDESIENNNE
910 920 930 940 950
SHISIQQCIN STSDSNFKVA NEKTITANEV HLPNAIFIEN LRDLANLLQT
960 970 980 990 1000
DTQHECDYCM FENQNSKAQC RCIECGDNLC EPCAQAHKRT RITRLHTLLS
1010 1020 1030 1040 1050
YKDILVNGYL LRMREAPPTQ CTDHGFSSEM ISNKQKLSDN TVRTSPPTTA
1060 1070 1080 1090 1100
TTINCTKGTV RTGHQCNWPS PSACFYCKQC RRLLCAECSG HFSMSPGSKG
1110 1120 1130 1140 1150
HENHVVLPLE TVIRDAKVEI NEQTVRVKQN NLQFENYLHH LVEYGHELIE
1160 1170 1180 1190 1200
TKSNITDQIQ NRVGQLKKEI DQIAKKLINQ LDEQIENELK LIDNCVWSLY
1210 1220 1230 1240 1250
PLIVRCEVAC RYANALKDYG RPEEILHCFD QVNEQMRYLG QEKIEYLEVR
1260 1270 1280 1290 1300
IKPHFKVGGF NYEEDEIQTN NQQFNSSYLF GSIEYEKIVE EYLKNEIANH
1310 1320 1330 1340 1350
LSKKQQNELK LELNNLCLNP DQISVGVNTS PRELTALSSF NMNNQFNIID
1360 1370 1380 1390 1400
RLQLINSDDH FKTNDNFLTP RNAYITDNGK YKPTLKGYEN LLMCQITNEL
1410 1420 1430
EFDARVSTDL RDVWPTGLAV NQSNGDIYVV DRDNSRIK
Length:1,438
Mass (Da):163,640
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDA45A58BA4597EEE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1438Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
SKCS01000441 Genomic DNA Translation: TNN07051.1

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
SKCS01000441 Genomic DNA Translation: TNN07051.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00021, BBOX, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR026966, Neurofascin/L1/NrCAM_C
IPR001258, NHL_repeat
IPR013017, NHL_repeat_subgr
IPR000315, Znf_B-box
IPR001841, Znf_RING
IPR017907, Znf_RING_CS
PfamiView protein in Pfam
PF13882, Bravo_FIGEY, 1 hit
PF01436, NHL, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51125, NHL, 1 hit
PS00518, ZF_RING_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4Z2CS03_SCHJA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4Z2CS03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: February 10, 2021
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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