DVL1

Functionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
frizzled binding Source: Ensembl
identical protein binding Source: Ensembl
protein kinase binding Source: Ensembl

GO - Biological processⁱ

axon extension Source: Ensembl
axon guidance Source: Ensembl
canonical Wnt signaling pathway Source: Ensembl
cochlea morphogenesis Source: Ensembl
collateral sprouting Source: Ensembl
convergent extension involved in neural plate elongation Source: Ensembl
cytoplasmic microtubule organization Source: Ensembl
dendrite morphogenesis Source: Ensembl
intracellular signal transduction Source: InterPro
negative regulation of protein binding Source: Ensembl
negative regulation of protein kinase activity Source: Ensembl
neurotransmitter secretion Source: Ensembl
planar cell polarity pathway involved in neural tube closure Source: Ensembl
positive regulation of neuron projection development Source: Ensembl
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: Ensembl
positive regulation of protein phosphorylation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prepulse inhibition Source: Ensembl
presynapse assembly Source: Ensembl
protein localization to microtubule Source: Ensembl
protein localization to nucleus Source: Ensembl
protein stabilization Source: Ensembl
regulation of cellular protein localization Source: Ensembl
regulation of synaptic vesicle exocytosis Source: Ensembl
skeletal muscle acetylcholine-gated channel clustering Source: Ensembl
social behavior Source: Ensembl

Keywordsⁱ

Molecular function	Developmental proteinARBA annotation
Biological process	Wnt signaling pathwayPROSITE-ProRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Uncharacterized proteinImported
Gene namesⁱ	Name:DVL1Imported
Organismⁱ	Sus scrofa (Pig)Imported
Taxonomic identifierⁱ	9823 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Suina › Suidae › Sus
Proteomesⁱ	UP000314985 Componentⁱ: Chromosome 6

Subcellular locationⁱ

GO - Cellular component

Keywords - Cellular componentⁱ

NucleusARBA annotation

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A4X1WAB8, baseline and differential

ExpressionAtlasⁱ

A0A4X1WAB8, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

beta-catenin binding Source: Ensembl
frizzled binding Source: Ensembl
identical protein binding Source: Ensembl
protein kinase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 85	DIXInterPro annotationAdd BLAST	85
Domainⁱ	251 – 323	PDZInterPro annotationAdd BLAST	73
Domainⁱ	425 – 499	DEPInterPro annotationAdd BLAST	75

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	89 – 238	DisorderedSequence analysisAdd BLAST		150
Regionⁱ	543 – 672	DisorderedSequence analysisAdd BLAST		130

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	120 – 137	PolarSequence analysisAdd BLAST	18
Compositional biasⁱ	138 – 173	PolyampholyteSequence analysisAdd BLAST	36
Compositional biasⁱ	215 – 229	BasicSequence analysisAdd BLAST	15
Compositional biasⁱ	560 – 585	PolarSequence analysisAdd BLAST	26
Compositional biasⁱ	626 – 640	PolarSequence analysisAdd BLAST	15

Sequence similaritiesⁱ

Belongs to the DSH family.ARBA annotation

Phylogenomic databases

OMAⁱ	WWERPVS

OMAⁱ

WWERPVS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
PANTHERⁱ	PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit
PRINTSⁱ	PR01760, DISHEVELLED
SMARTⁱ	View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A4X1WAB8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAETKIIYHM DEEETPYLVK LPVAPERVTL ADFKNVLSNR PVHAYKFFFK 
        60         70         80         90        100
SMDQDFGVVK EEISDDNAKL PCFNGRVVSW LVLAEGAHSD AGSQGTDGHA 
       110        120        130        140        150
DLPPPLERTG GIGDSRPPSF HPNVASSRDG MDNETGTESV VSHRRERARR 
       160        170        180        190        200
RNREEAARTN GHPRGDRRRD LGLPPDSAST VLSSELESSS FIDSDEDDNT 
       210        220        230        240        250
SRLSSSTEQS TSSRLIRKHK RRRRKQRMRQ TDRASSFSSI TDSTMSLNII 
       260        270        280        290        300
TVTLNMERHH FLGISIVGQS NDRGDGGIYI GSIMKGGAVA ADGRIEPGDM 
       310        320        330        340        350
LLQVNDVNFE NMSNDDAVRV LREIVSQTGP ISLTVAKCWD PSPRSYFTIP 
       360        370        380        390        400
RADPVRPIDP AAWLSHTAAL TGALPRYGTS PCSSAVTRTS SSSLTSSVPG 
       410        420        430        440        450
APQLEEAPLT VKSDMGAVVR VMQLPDSGLE IRDRMWLKIT IANAVIGADV 
       460        470        480        490        500
VDWLYTHLEG FRERREARRY ASSMLKRGFL RHTVNKVTFS EQCYYVFGDL 
       510        520        530        540        550
CSNLAALNLN SGSSGASDQD TLAPLPHPAA PWPLGQGYPY QYPGPPPCFP 
       560        570        580        590        600
PAYQDPGFSY GSGSAGSQQS EGSKSSGSTR SAGGSSRRAL GREKESRSAG 
       610        620        630        640        650
AGGSGSESDH TAPSGAGGSG WRERPASQLS RGSSPRSQAS AAAPGLPPLH 
       660        670        680        690        700
PLTKAYSVVG GPPGGPPVRE LAAVPPELTG SRQSFQKAMG NPCEFFVDIM

Length:700

Mass (Da):75,459

Last modified:September 18, 2019 - v1

Checksum:ⁱC7DAA7EF1BEA88EC

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_003127548.3, XM_003127500.5

RefSeqⁱ

XP_003127548.3, XM_003127500.5

Genome annotation databases

Ensemblⁱ	ENSSSCT00070059593; ENSSSCP00070050760; ENSSSCG00070029648
GeneIDⁱ	100525170
KEGGⁱ	ssc:100525170

Protein	Similar proteins		Species	Score	Length	Source
A0A4X1WAB8	Dishevelled segment polarity protein 1		PIG		700	UniRef100_F1RJE5

Protein	Similar proteins		Species	Score	Length	Source
A0A4X1WAB8	Segment polarity protein dishevelled homolog DVL-1	)	HUMAN		695	UniRef90_O14640
Segment polarity protein dishevelled homolog DVL-1		PANTR		670
Uncharacterized protein		wild yak		726
segment polarity protein dishevelled homolog DVL-1 isoform X3		SHEEP		723
segment polarity protein dishevelled homolog DVL-1 isoform X2		BOSIN		723
+176

Protein	Similar proteins		Species	Score	Length	Source
A0A4X1WAB8	Segment polarity protein dishevelled homolog DVL-1	)	HUMAN		695	UniRef50_O14640
Segment polarity protein dishevelled homolog DVL-1		PANTR		670
Uncharacterized protein		wild yak		726
segment polarity protein dishevelled homolog DVL-1 isoform X3		SHEEP		723
segment polarity protein dishevelled homolog DVL-1 isoform X2		BOSIN		723
+405

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_003127548.3, XM_003127500.5

RefSeqⁱ

XP_003127548.3, XM_003127500.5

3D structure databases

ModBaseⁱ	Search...
SWISS-MODEL-Workspaceⁱ	Submit a new modelling project...

Genome annotation databases

Ensemblⁱ	ENSSSCT00070059593; ENSSSCP00070050760; ENSSSCG00070029648
GeneIDⁱ	100525170
KEGGⁱ	ssc:100525170

Organism-specific databases

CTDⁱ	1855

CTDⁱ

1855

Phylogenomic databases

OMAⁱ	WWERPVS

OMAⁱ

WWERPVS

Gene expression databases

ExpressionAtlasⁱ	A0A4X1WAB8, baseline and differential

ExpressionAtlasⁱ

A0A4X1WAB8, baseline and differential

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit 2.30.42.10, 1 hit 3.10.20.380, 1 hit
InterProⁱ	View protein in InterPro IPR000591, DEP_dom IPR024580, Dishevelled_C-dom IPR008339, Dishevelled_fam IPR003351, Dishevelled_protein_dom IPR001158, DIX IPR038207, DIX_dom_sf IPR015506, Dsh/Dvl-rel IPR008340, DVL-1 IPR001478, PDZ IPR036034, PDZ_sf IPR029071, Ubiquitin-like_domsf IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf
PANTHERⁱ	PTHR10878, PTHR10878, 1 hit PTHR10878:SF5, PTHR10878:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF00610, DEP, 1 hit PF02377, Dishevelled, 1 hit PF00778, DIX, 1 hit PF12316, Dsh_C, 1 hit PF00595, PDZ, 1 hit
PRINTSⁱ	PR01760, DISHEVELLED
SMARTⁱ	View protein in SMART SM00021, DAX, 1 hit SM00049, DEP, 1 hit SM00228, PDZ, 1 hit
SUPFAMⁱ	SSF46785, SSF46785, 1 hit SSF50156, SSF50156, 1 hit SSF54236, SSF54236, 1 hit
PROSITEⁱ	View protein in PROSITE PS50186, DEP, 1 hit PS50841, DIX, 1 hit PS50106, PDZ, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A4X1WAB8_PIG
Accessionⁱ	A0A4X1WAB8Primary (citable) accession number: A0A4X1WAB8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	September 18, 2019
	Last sequence update:	September 18, 2019
	Last modified:	February 10, 2021
	This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

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Supporting data

UniProtKB - A0A4X1WAB8 (A0A4X1WAB8_PIG)

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Uncharacterized protein

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ