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Entry version 10 (25 May 2022)
Sequence version 1 (18 Sep 2019)
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Protein
Submitted name:

Sorbin and SH3 domain-containing protein 2

Gene

SORBS2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sorbin and SH3 domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SORBS2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15
  • UP000694721 Componenti: Unassembled WGS sequence
  • UP000694728 Componenti: Unplaced
  • UP000694724 Componenti: Unplaced
  • UP000694570 Componenti: Unplaced
  • UP000694725 Componenti: Unplaced
  • UP000694727 Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

CytoplasmARBA annotation, MembraneARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini152 – 213SoHoInterPro annotationAdd BLAST62
Domaini944 – 1003SH3InterPro annotationAdd BLAST60
Domaini1019 – 1080SH3InterPro annotationAdd BLAST62
Domaini1159 – 1218SH3InterPro annotationAdd BLAST60

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni58 – 80DisorderedSequence analysisAdd BLAST23
Regioni221 – 398DisorderedSequence analysisAdd BLAST178
Regioni912 – 945DisorderedSequence analysisAdd BLAST34
Regioni1128 – 1148DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 80Polar residuesSequence analysisAdd BLAST18
Compositional biasi221 – 247Polar residuesSequence analysisAdd BLAST27
Compositional biasi253 – 268Pro residuesSequence analysisAdd BLAST16
Compositional biasi269 – 299Basic and acidic residuesSequence analysisAdd BLAST31
Compositional biasi312 – 332Polar residuesSequence analysisAdd BLAST21
Compositional biasi366 – 392Polar residuesSequence analysisAdd BLAST27
Compositional biasi916 – 931Polar residuesSequence analysisAdd BLAST16
Compositional biasi1129 – 1148Polar residuesSequence analysisAdd BLAST20

Keywords - Domaini

SH3 domainPROSITE-ProRule annotationARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type

The PANTHER Classification System

More...
PANTHERi
PTHR14167:SF56, PTHR14167:SF56, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452, SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044, SSF50044, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4X1VRJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVTLTSVKR VQSSPNLLAT GRDSQSPDSA WRCYNDRNQE TLNGDATYSS
60 70 80 90 100
LAAKGFRSVR PNLQEKKSPT QSQITVNGNS GGTVSPMSYY QRPFSPSAYS
110 120 130 140 150
LPGSFNSSII MQHGRSLDST DTYPQHAQSL DGTMGSSIPL YRSSEEEKRV
160 170 180 190 200
TVIKAPHYPG IGPVDESGIP TAIRTTVDRP KDWYKTMFKQ IHMVHKPDDD
210 220 230 240 250
TDMYNTPYTY NAGLYNSPYS AQSHPAAKTQ TYRPLSKSHS DNGTDAFKDA
260 270 280 290 300
SSPVPPPHVP PPVPPLRPRD RSSTEKHDWD PPDRKVDTRK FRSEPRSIFE
310 320 330 340 350
YEPGKSSILQ HERPASLYQS SIDRSLERPA SSASMASDFR KRRKSEPAVG
360 370 380 390 400
QPRGLGDPSA SRTSPGRADL PGSSTTLTKS FISSSPSSPS RAKGGDDSKM
410 420 430 440 450
CPSLCSYSGL NGNPSHELDY CNTYRQHLDV PHDSQRAIAF KNGWQMARQN
460 470 480 490 500
AEVWSSTEET VSPKIKSRSC DDLLNDDCDS FPDPKTKSES MGSLLCEEDS
510 520 530 540 550
KESCPIPWAS PYIQEGRSRL RYRSAHNAPG FLKMYKKMHR INRKDLMNSE
560 570 580 590 600
VICSVKSRIM QYEKEQQHKG LLHGWSQSST EEVPRDMVPT RISEFEKLIQ
610 620 630 640 650
KSKSMPNLGD EMLSPVTLEP QQNGLCPKRR FSIESLLEEE NQSRHPSQVQ
660 670 680 690 700
RSYTSKTLVP IHIEVTSDEQ PRTHMEFSDS DQDGVVSDHS DYIHVEGSSF
710 720 730 740 750
CSESDFDHFS FTSSESFYGS SHHHHHHHHH HHRHLISTCK GRCPASYTRF
760 770 780 790 800
TTMLKHERAK HENTEEPRRQ EMDPGLSKLA FLVSPVPFRR KKNSTPKKQT
810 820 830 840 850
EKAKCKASVF EALDSALKDI CDQIKAEKRR GSLPDNSILH RLISELLPDI
860 870 880 890 900
PERNSSLKAL KRSPMHQPFH PLPQDGAIHC PLYQNDCGRL PHSASFPDDT
910 920 930 940 950
NNNYHQDHDS ALSLQDHESP RSYSSTLTDL GRSTSRERRV TPEKEKLPAK
960 970 980 990 1000
AVYDFKAQTS KELSFKKGDT VYILRKIDQN WYEGEHHGRV GIFPISYVEK
1010 1020 1030 1040 1050
LTPPEKAQPA RPPPPAQLGE IGEAVAKYNF SADTNVELSL RKGDRVILLK
1060 1070 1080 1090 1100
RVDQNWYEGK IPGTNRQGIF PVSYVEVVKK NTTKGAEEYP DPPIPHSYSS
1110 1120 1130 1140 1150
DRIHSLSSNK ADLKNELFVL GKPPRSPVMS RRSCSSPVRG LSSSHRPQRP
1160 1170 1180 1190 1200
VFTHENIQGG GEPFQALYNY TPRNEDELEL RESDVIDVME KCDDGWFVGT
1210
SRRTKFFGTF PGNYVKRL
Length:1,218
Mass (Da):137,386
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i72240ED1C1D680F5
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00005057687.1; ENSSSCP00005035550.1; ENSSSCG00005035670.1
ENSSSCT00025060753.1; ENSSSCP00025025775.1; ENSSSCG00025040139.1
ENSSSCT00030103498.1; ENSSSCP00030047813.1; ENSSSCG00030072897.1
ENSSSCT00045040606.1; ENSSSCP00045028253.1; ENSSSCG00045022893.1
ENSSSCT00055028730.1; ENSSSCP00055022895.1; ENSSSCG00055013835.1
ENSSSCT00065096815.1; ENSSSCP00065042395.1; ENSSSCG00065070389.1
ENSSSCT00070054490.1; ENSSSCP00070046219.1; ENSSSCG00070027173.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSSCT00005057687.1; ENSSSCP00005035550.1; ENSSSCG00005035670.1
ENSSSCT00025060753.1; ENSSSCP00025025775.1; ENSSSCG00025040139.1
ENSSSCT00030103498.1; ENSSSCP00030047813.1; ENSSSCG00030072897.1
ENSSSCT00045040606.1; ENSSSCP00045028253.1; ENSSSCG00045022893.1
ENSSSCT00055028730.1; ENSSSCP00055022895.1; ENSSSCG00055013835.1
ENSSSCT00065096815.1; ENSSSCP00065042395.1; ENSSSCG00065070389.1
ENSSSCT00070054490.1; ENSSSCP00070046219.1; ENSSSCG00070027173.1

Family and domain databases

InterProiView protein in InterPro
IPR036028, SH3-like_dom_sf
IPR001452, SH3_domain
IPR003127, SoHo_dom
IPR028506, Sorbin_SH3
IPR013087, Znf_C2H2_type
PANTHERiPTHR14167:SF56, PTHR14167:SF56, 1 hit
PfamiView protein in Pfam
PF00018, SH3_1, 2 hits
PF14604, SH3_9, 1 hit
PF02208, Sorb, 1 hit
PRINTSiPR00452, SH3DOMAIN
SMARTiView protein in SMART
SM00326, SH3, 3 hits
SM00459, Sorb, 1 hit
SUPFAMiSSF50044, SSF50044, 3 hits
PROSITEiView protein in PROSITE
PS50002, SH3, 3 hits
PS50831, SOHO, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4X1VRJ2_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4X1VRJ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: May 25, 2022
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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