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Entry version 3 (13 Nov 2019)
Sequence version 1 (18 Sep 2019)
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Protein
Submitted name:

PHD finger protein 12

Gene

PHF12

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PHD finger protein 12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHF12Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314985 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini74 – 123PHD-typeInterPro annotationAdd BLAST50
Domaini289 – 339PHD-typeInterPro annotationAdd BLAST51
Domaini833 – 887FHAInterPro annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 23DisorderedSequence analysisAdd BLAST23
Regioni49 – 78DisorderedSequence analysisAdd BLAST30
Regioni131 – 160DisorderedSequence analysisAdd BLAST30
Regioni173 – 199DisorderedSequence analysisAdd BLAST27
Regioni252 – 275DisorderedSequence analysisAdd BLAST24
Regioni549 – 598DisorderedSequence analysisAdd BLAST50
Regioni663 – 682DisorderedSequence analysisAdd BLAST20
Regioni913 – 941DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 23PolyampholyteSequence analysisAdd BLAST17
Compositional biasi50 – 78PolyampholyteSequence analysisAdd BLAST29
Compositional biasi142 – 157PolarSequence analysisAdd BLAST16
Compositional biasi181 – 196PolarSequence analysisAdd BLAST16
Compositional biasi258 – 275PolyampholyteSequence analysisAdd BLAST18
Compositional biasi566 – 582PolarSequence analysisAdd BLAST17
Compositional biasi926 – 941PolarSequence analysisAdd BLAST16

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155713

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.1860, 1 hit
1.20.920.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036427 Bromodomain-like_sf
IPR000253 FHA_dom
IPR042163 PHF12
IPR031966 PHF12_MRG-bd
IPR038098 PHF12_MRG-bd_sf
IPR008984 SMAD_FHA_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR46309 PTHR46309, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00628 PHD, 2 hits
PF16737 PHF12_MRG_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00249 PHD, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4X1TQ20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGRRTKGGR RVGDREAAPG GRRTARELRV CTHAICMCVQ QIQALLAPPK
60 70 80 90 100
ADEAEKRSRK PEKEPRRSGR ATNHDSCDSC KEGGDLLCCD HCPAAFHLQC
110 120 130 140 150
CNPPLSEEML PPGEWMCHRC TVRRKKREQK KELGHVNGLV DKSGKRTTSP
160 170 180 190 200
SSDTDLLDRS ASKTELKAIA HARILERRAS RPGTPTSNAS TETPTSEQND
210 220 230 240 250
VDEDIIDVDE EPVAAEPDCV QPQLRRPFEL LIAAAMERNP TQFQLPNELT
260 270 280 290 300
CTTALPGSSK RRRKEETTGK NVKKTQHELD HNGLVPLPVK VCFTCNRSCR
310 320 330 340 350
VAPLIQCDYC PLLFHMDCLE PPLTAMPLGR WMCPNHIEHV VLNQKNMTLS
360 370 380 390 400
NRCQVFDRFQ DTISQHVVKV DFLNRIHKKH PPNRRVLQSV KRRSLKVPDA
410 420 430 440 450
IKSQYQFPPP LIAPAAIRDG ELICNGIPEE SQTHLLNSEH LATQAEQQEW
460 470 480 490 500
LCSVVALQCS ILKHLSAKQM PSHWDSEQTE KADIKPVIVT DSSITNSLQT
510 520 530 540 550
ADKAPTPSHY PLSCPSGLST QNSLSCSPPH QPPTLEDISC SSCAEKSKKA
560 570 580 590 600
PCGTANGPVN TEVKANGPHL YSSPTDSTDP RRLPGANTPL PGLSHRQGWP
610 620 630 640 650
RPLTPPAAGG LQNHTVGIIV KTENATGPSS CPQRSLVPVP SLPPSIPSSC
660 670 680 690 700
ASIENTSTLQ RKTVQSQIGP PLTDSRPLGS PPNATRVLTP PQAAGDGILA
710 720 730 740 750
TGANQRFCSP APSSDGKVSP GTLSIGSALT VPSFPANSTA MVDLTNSLRA
760 770 780 790 800
FMDVNGEIEI NMLDEKLIKF LALQRIHQLF PSRVQASPGS VGAHPLASGG
810 820 830 840 850
HHTEVQRREV QARAVFYPLL GLGGAVNMCY RTLYIGTGAD MDVCLTNYGH
860 870 880 890 900
CNYVSGKHAC IFYDENTKHY ELLNYSEHGT TVDNVLYSCD FSEKTPPTPP
910 920 930 940 950
SSIVAKVQSV IRRRRHQKQD EEPSEEAAMM SSQAQGPQRR PCNCKASSSS
960 970 980 990 1000
LIGGSGAGWE GTALLHHGSY IKLGCLQFVF SITEFATKQP KGDASLLQDG
1010 1020
VLAEKLSLKP HQGPVLRSNS VP
Length:1,022
Mass (Da):111,349
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD91488B3E3831673
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00070023216; ENSSSCP00070019201; ENSSSCG00070011896

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSSSCT00070023216; ENSSSCP00070019201; ENSSSCG00070011896

Phylogenomic databases

GeneTreeiENSGT00940000155713

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di1.10.10.1860, 1 hit
1.20.920.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR036427 Bromodomain-like_sf
IPR000253 FHA_dom
IPR042163 PHF12
IPR031966 PHF12_MRG-bd
IPR038098 PHF12_MRG-bd_sf
IPR008984 SMAD_FHA_dom_sf
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR46309 PTHR46309, 1 hit
PfamiView protein in Pfam
PF00628 PHD, 2 hits
PF16737 PHF12_MRG_bd, 1 hit
SMARTiView protein in SMART
SM00249 PHD, 2 hits
SUPFAMiSSF49879 SSF49879, 1 hit
SSF57903 SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50006 FHA_DOMAIN, 1 hit
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4X1TQ20_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4X1TQ20
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: November 13, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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