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Entry version 2 (16 Oct 2019)
Sequence version 1 (18 Sep 2019)
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Protein

Dynactin domain-containing protein

Gene

DCTN1

Organism
Bos indicus x Bos taurus (Hybrid cattle)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynactin domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCTN1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos indicus x Bos taurus (Hybrid cattle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30522 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314981 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini393 – 671DynactinInterPro annotationAdd BLAST279

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 89DisorderedSequence analysisAdd BLAST89
Regioni932 – 952DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili226 – 249Sequence analysisAdd BLAST24
Coiled coili254 – 406Sequence analysisAdd BLAST153
Coiled coili818 – 909Sequence analysisAdd BLAST92
Coiled coili1054 – 1074Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi25 – 54PolarSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027663 DCTN1
IPR022157 Dynactin

The PANTHER Classification System

More...
PANTHERi
PTHR18916:SF75 PTHR18916:SF75, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12455 Dynactin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4W2HGM4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMRQAPTARK TTTRRPKPTR PASTGVAGAS GSLGPSGSAS AGELSSSEPS
60 70 80 90 100
TPAQTPLAAP IIPTPALTSP GAALPLPSPS KEEEGLRAQV RDLEEKLETL
110 120 130 140 150
RLKRAEDKAK LKELEKHKIQ LEQVQEWKSK MQEQQADLQR RLKEARKEAK
160 170 180 190 200
EALEAKERYM EEMADTADAI EMATLDKEMA EERAESLQQE AEVLRERVEE
210 220 230 240 250
LTTDLEILKA EIEEKGSDGA ASSYQLKQLE EQNARLKDAL VRMRDLSSSE
260 270 280 290 300
KQEHVKLQKL MEKKNQELEV VRQQRERLQE ELSQAERTID ELKEQVDAAL
310 320 330 340 350
GAEEMVETLT DRNLDLEEKV RKLKETVGDL EAINEMNDEL QENARETELE
360 370 380 390 400
LREQLDMAGA QVRDAQKRVE AAQETVADYQ QTIKKYRQLT AHLQDVNRAL
410 420 430 440 450
TNQQEASVER QQQPPPETFD FKIKFAETKA HAKAIEMELR QMEVAQANRH
460 470 480 490 500
MSLLTAFMPD SFLRPGGDHD CVLVLLLMPR LICKAELIRK QAQEKFELSE
510 520 530 540 550
SCSERPGLRG AAGEQLSFAA GLVYSLSLLQ ATLHRYEHAL SQCSVDVYKK
560 570 580 590 600
VGSLYPEMSA HERSLDFLIE LLHKDQLDET VNVEPLTKAI KYYQHLYSIH
610 620 630 640 650
LAEQPEDSTM QLADHIKFTQ SALDCMSVEV GRLRAFLQGG QEASDIALLL
660 670 680 690 700
RDLETSCSDT RQFCKKIRRR MPGTDAPGIP AALAFGPQVS DTLLDCRKHL
710 720 730 740 750
TWVVAVLQEV AAAAAQLIAP LAENEGLPVA ALEELAFKAS EQIYGTPSSN
760 770 780 790 800
PYECLRQSCS LLISTMNKLA TAMQEGEYDA ERPPSKPPPV ELRAAALRAE
810 820 830 840 850
ITDAEGLGLK LEDRETVIKE LKKSLKIKGE ELSEANVRLS LLEKKLDSAA
860 870 880 890 900
KDADERIEKV QTRLEETQTL LRKKEKEFEE TMDALQADID QLEAEKAELK
910 920 930 940 950
QRLNSQSKRT IEGLRGPPPS GIATLVSGIA GEEQQRGGAP GQAPGSVPGP
960 970 980 990 1000
GLVKDSPLLL QQISAMRLHI SQLQHENSTL KGAQMKASLA ALPPLHVAKL
1010 1020 1030 1040 1050
SLPPHEGPGS ELAAGALYRK TNQLLETLNQ LSACTHVVDI TRSNPAAKSP
1060 1070 1080 1090 1100
SAQLLEQVAQ LKSLSDTIEK LKDEVLKETV SQRPGATVPT DFATFPSSAF
1110 1120 1130 1140
LRAKEEQQDD TVYMGKVTFS CAAGLGQRHR LVLTQEQLHQ LHDRLIS
Length:1,147
Mass (Da):127,377
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DBB08C1BC967FB6
GO

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBIXT00005007989; ENSBIXP00005030405; ENSBIXG00005000588

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSBIXT00005007989; ENSBIXP00005030405; ENSBIXG00005000588

Family and domain databases

InterProiView protein in InterPro
IPR027663 DCTN1
IPR022157 Dynactin
PANTHERiPTHR18916:SF75 PTHR18916:SF75, 1 hit
PfamiView protein in Pfam
PF12455 Dynactin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4W2HGM4_BOBOX
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4W2HGM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: October 16, 2019
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health

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