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Entry version 10 (07 Apr 2021)
Sequence version 1 (18 Sep 2019)
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Protein
Submitted name:

Polybromo 1

Gene

PBRM1

Organism
Bos indicus x Bos taurus (Hybrid cattle)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Polybromo 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PBRM1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos indicus x Bos taurus (Hybrid cattle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri30522 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000314981 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini230 – 300BromoInterPro annotationAdd BLAST71
Domaini366 – 436BromoInterPro annotationAdd BLAST71
Domaini565 – 635BromoInterPro annotationAdd BLAST71
Domaini703 – 762BromoInterPro annotationAdd BLAST60
Domaini830 – 900BromoInterPro annotationAdd BLAST71
Domaini971 – 1016BromoInterPro annotationAdd BLAST46
Domaini1111 – 1385BAHInterPro annotationAdd BLAST275
Domaini1492 – 1560HMG boxInterPro annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 205DisorderedSequence analysisAdd BLAST58
Regioni321 – 343DisorderedSequence analysisAdd BLAST23
Regioni472 – 491DisorderedSequence analysisAdd BLAST20
Regioni652 – 682DisorderedSequence analysisAdd BLAST31
Regioni779 – 800DisorderedSequence analysisAdd BLAST22
Regioni1056 – 1096DisorderedSequence analysisAdd BLAST41
Regioni1221 – 1246DisorderedSequence analysisAdd BLAST26
Regioni1467 – 1491DisorderedSequence analysisAdd BLAST25
Regioni1544 – 1573DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi171 – 187PolarSequence analysisAdd BLAST17
Compositional biasi472 – 488PolarSequence analysisAdd BLAST17
Compositional biasi779 – 793PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1056 – 1087PolyampholyteSequence analysisAdd BLAST32

Keywords - Domaini

BromodomainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003017

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05515, Bromo_polybromo_V, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 6 hits
2.30.30.490, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo

The PANTHER Classification System

More...
PANTHERi
PTHR16062, PTHR16062, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503, BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51038, BAH, 1 hit
PS00633, BROMODOMAIN_1, 4 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A4W2DQ68-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRPDLHPW GRRSILVGSS TIRHKRPLHA RPLTTLTRPL HSGSRKNCAR
60 70 80 90 100
SYTSAYKVQR VSAGATCELR PPPSVTHSRC CRKARGRWPV CARTQCRAEP
110 120 130 140 150
GSLDGRGTGF AAVPGGVRAV RAAGAGATAA AAAGGAIAAA VASTGRGAAV
160 170 180 190 200
GGRGCRRRSG WKKLDSMGSK RRRATSPSSS VSGDFDDGHH SVSTPGPSRK
210 220 230 240 250
RRRLSSLPTV DPIAVCHELY NTIRDYKDEQ GRLLCELFIR APKRRNQPDY
260 270 280 290 300
YEVVSQPIDL MKIQQKLKME EYDDVNLLTA DFQLLFNNAK AYYKPDSPEY
310 320 330 340 350
KAACKLWDLY LRTRNEFVQK GEADDEDDDE DGQDSQGAVT EGSSPGYLKE
360 370 380 390 400
ILEQLLEAIV VATNPSGRLI SELFQKLPSK VQYPDYYAII KEPIDLKTIA
410 420 430 440 450
QRIQNGSYKS IHAMAKDIDL LAKNAKTYNE PGSQVFKDAN SIKKIFYMKK
460 470 480 490 500
AEIEHEMTKS SLRMRTSSNL AATRLTGPSH SKGSLGEERN PTSKYYRNKR
510 520 530 540 550
AVQGGRLSAI TMALQYGSES EEDAALAAAR YEEGESEAES ITSFMDVSNP
560 570 580 590 600
FYQLYDTVRS CRNNQGQLIA EPFFHLPSKK KYPDYYQQIK TPISLQQIRT
610 620 630 640 650
KLKNQEYETL DHLECDLNLM FENAKRYNVP NSAIYKRVLK LQQVMQAKKK
660 670 680 690 700
ELARRDDIED GDSMISSATS DTGSAKRKSK KNIRKQRMKI LFNVVLEARE
710 720 730 740 750
PGSGRRLCDL FMVKPSKKDY PDYYKIILEP MDLKIIEHNI RNDKYLMFRN
760 770 780 790 800
ARHYNEEGSQ VYNDAHILEK LLKDKRKELG PLPDDDDMAS PKLKLSRKSG
810 820 830 840 850
ISPKKSKYMT PMQQKLNEVY EAVKNYTDKR GRRLSAIFLR LPSRSELPDY
860 870 880 890 900
YLTIKKPMDM EKIRSHMMAN KYQDIDSMVE DFVMMFNNAC TYNEPESLIY
910 920 930 940 950
KDALVLHKVL LETRRDLEGD EDSHVPNVTL LIQELIHNLF VSVMSHQDDE
960 970 980 990 1000
GRCYSDSLAE IPAVDPSFPN KPPLTFDIIR KNVENNRYRR LDLFQEHMFE
1010 1020 1030 1040 1050
VLERARRMNR TDSEIYEDAV ELQQFFIKIR DELCKNGEIL LSPALSYTTK
1060 1070 1080 1090 1100
HLHNDVEKEK KEKLPKEIEE DKLKREEEKE VKAEKSEDSS GAAGLSGLHR
1110 1120 1130 1140 1150
TYSQDCSFKN SMYHVGDYVY VEPSEVNLQP HIVCIERLWE DSAGEKWLYG
1160 1170 1180 1190 1200
CWFYRPNETF HLATRKFLEK EVFKSDYYNK VPVSKILGKC VVMFVKEYFK
1210 1220 1230 1240 1250
LYVPLPVVRV ASVFANADKA DDEKNTDNSE DSRTEDSCNL EKEKEDVPVE
1260 1270 1280 1290 1300
MSNGEPGCHY FEQLRYNDMW LKVGDCVFIK SHGLVRPRVG RIEKVWVRDG
1310 1320 1330 1340 1350
AAYFYGPIFI HPEETEHEPT KMFYKKEVFL SNLEETCPMT CILGKCAVLS
1360 1370 1380 1390 1400
FKDFLSCRPT EIPENDILLC ESRYNESDKQ MKKFKGLKRF SLSAKVVDDE
1410 1420 1430 1440 1450
IYYFRKPIVP QKEPSPLLEK KIQLLEAKFA ELEGGDDDIE EMGEEDSEVI
1460 1470 1480 1490 1500
EPPSLPQLQT PLASELDLMP YTPPQSTPKS AKGSAKKEGS KRKINMSGYI
1510 1520 1530 1540 1550
LFSSEMRAVI KAQHPDYSFG ELSRLVGTEW RNLETAKKAE YEERAAKVAE
1560 1570 1580 1590 1600
QQERERAAQQ QQPSASPRAG TPVGALMGVV PPPTPMGMLN QQLTPVAGMM
1610 1620 1630 1640 1650
GGYPPGLPPL QGPVDGLVSM GSMQPLHPGG PPPHHLPPGV PGLPGIPPPG
1660 1670 1680 1690 1700
VMNQGVAPMV GTPAPGGSPY GQQVGVLGPP GQQAPPPYPG PHPAGPPVIQ
1710 1720 1730 1740 1750
QPTTPMFVAP PPKTQRLLHS EAYLKYIEGL SAESNSISKW DQTLAARRRD
1760 1770 1780 1790 1800
VHLSKEQESR LPSHWLKSKG AHTTMADALW RLRDLMLRDT LNIRQAYNLE

NL
Length:1,802
Mass (Da):203,899
Last modified:September 18, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6859432EF57DD95F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A4W2BJT8A0A4W2BJT8_BOBOX
Polybromo 1
PBRM1
1,581Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W2BJU1A0A4W2BJU1_BOBOX
Polybromo 1
PBRM1
1,636Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W2BM61A0A4W2BM61_BOBOX
Polybromo 1
PBRM1
1,599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W2DIY5A0A4W2DIY5_BOBOX
Polybromo 1
PBRM1
1,544Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W2DJ88A0A4W2DJ88_BOBOX
Polybromo 1
PBRM1
1,784Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSBIXT00000053890; ENSBIXP00000026288; ENSBIXG00000030305

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSBIXT00000053890; ENSBIXP00000026288; ENSBIXG00000030305

Phylogenomic databases

GeneTreeiENSGT00390000003017

Family and domain databases

CDDicd05515, Bromo_polybromo_V, 1 hit
Gene3Di1.20.920.10, 6 hits
2.30.30.490, 2 hits
InterProiView protein in InterPro
IPR001025, BAH_dom
IPR043151, BAH_sf
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR018359, Bromodomain_CS
IPR009071, HMG_box_dom
IPR036910, HMG_box_dom_sf
IPR037968, PBRM1_BD5
IPR037382, Rsc/polybromo
PANTHERiPTHR16062, PTHR16062, 3 hits
PfamiView protein in Pfam
PF01426, BAH, 2 hits
PF00439, Bromodomain, 6 hits
PF00505, HMG_box, 1 hit
PRINTSiPR00503, BROMODOMAIN
SMARTiView protein in SMART
SM00439, BAH, 2 hits
SM00297, BROMO, 6 hits
SM00398, HMG, 1 hit
SUPFAMiSSF47095, SSF47095, 1 hit
SSF47370, SSF47370, 6 hits
PROSITEiView protein in PROSITE
PS51038, BAH, 1 hit
PS00633, BROMODOMAIN_1, 4 hits
PS50014, BROMODOMAIN_2, 6 hits
PS50118, HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4W2DQ68_BOBOX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4W2DQ68
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 18, 2019
Last sequence update: September 18, 2019
Last modified: April 7, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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