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Entry version 7 (22 Apr 2020)
Sequence version 1 (31 Jul 2019)
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Protein

Endonuclease V

Gene

nfi

Organism
Salmonella enterica subsp. enterica serovar Chester
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate.UniRule annotation EC:3.1.21.7

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi35MagnesiumUniRule annotation1
Metal bindingi103MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonucleaseUniRule annotationImported, Hydrolase, Nuclease
Biological processDNA damage, DNA repairUniRule annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Endonuclease VUniRule annotation (EC:3.1.21.7UniRule annotation)
Alternative name(s):
Deoxyinosine 3'endonucleaseUniRule annotation
Deoxyribonuclease VUniRule annotation
Short name:
DNase VUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nfiUniRule annotation
ORF Names:AU949_22065Imported, AU960_21685Imported, AU983_22885Imported, AVB03_22740Imported, CB400_20150Imported, CB695_22885Imported, CC389_22475Imported, CC481_21825Imported, D4Z47_22760Imported, D5937_22370Imported, D5P46_22840Imported, D5P85_23190Imported, DLR56_22945Imported, DMO46_22375Imported, DNY88_22390Imported, DO677_21795Imported, DO716_23185Imported, DOW63_22810Imported, DQR84_16530Imported, DRL11_22890Imported, DS524_23140Imported, DS528_22205Imported, DSN31_23020Imported, E2E96_22275Imported, EHE49_22900Imported, EJJ75_22500Imported, EOV55_22480Imported, EUR09_22395Imported, GA754_22100Imported, GCH40_22130Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella enterica subsp. enterica serovar ChesterImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri149386 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000394912 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei73Interaction with target DNAUniRule annotation1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the endonuclease V family.UniRule annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06559, Endonuclease_V, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00801, Endonuclease_5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007581, Endonuclease-V

The PANTHER Classification System

More...
PANTHERi
PTHR28511, PTHR28511, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04493, Endonuclease_5, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4U8J050-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLASLRAQQ IELASSVCRE DRLDKDPPAF IGGADVGFEQ GGEVTRAAMV
60 70 80 90 100
LLKYPSLELV EYKVARIATT MPYIPGFLSF REYPALLAAW EQLSQKPDLL
110 120 130 140 150
FVDGHGISHP RRLGVASHFG LLVDVPTIGV AKKRLCGKFE PLSTEPGALS
160 170 180 190 200
PLMDKGEQLA WVWRSKARCN PLFIATGHRV STDSALAWVQ RCMKGYRLPE
210 220
PTRWADAVAS GRPAFIRWQE IQR
Length:223
Mass (Da):24,790
Last modified:July 31, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD833205154954E52
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAAGNC010000044 Genomic DNA Translation: EAC0259480.1
AAGQQG010000024 Genomic DNA Translation: EBQ9437775.1
AAGTTH010000027 Genomic DNA Translation: EBR8875520.1
AAGUAT010000030 Genomic DNA Translation: EBR9858661.1
AAHDPK010000028 Genomic DNA Translation: EBU9237816.1
AAHEIL010000040 Genomic DNA Translation: EBV1536421.1
AAHFGZ010000028 Genomic DNA Translation: EBV4520484.1
AAHFLT010000035 Genomic DNA Translation: EBV5113968.1
AAHGNC010000033 Genomic DNA Translation: EBV8409045.1
AAHGNJ010000042 Genomic DNA Translation: EBV8441759.1
AAHIGU010000026 Genomic DNA Translation: EBW4191378.1
AAHJVM010000053 Genomic DNA Translation: EBW9788617.1
AAHKSL010000035 Genomic DNA Translation: EBX2684514.1
AAHLQC010000026 Genomic DNA Translation: EBX5586697.1
AAHMCG010000030 Genomic DNA Translation: EBX7357626.1
AAHOCW010000025 Genomic DNA Translation: EBY4532443.1
AAHOUX010000026 Genomic DNA Translation: EBY7120865.1
AAHPOZ010000024 Genomic DNA Translation: EBY9550289.1
AAHPPW010000028 Genomic DNA Translation: EBY9662769.1
AAHTRM010000025 Genomic DNA Translation: ECA2383514.1
AAHVCR010000031 Genomic DNA Translation: ECA6746527.1
AAHWDY010000027 Genomic DNA Translation: ECB0003442.1
AALDFV010000062 Genomic DNA Translation: ECY4305858.1
AALDGD010000037 Genomic DNA Translation: ECY4437791.1
AALTSX010000024 Genomic DNA Translation: EDD2825266.1
AAMCMS010000025 Genomic DNA Translation: EDF9276258.1
AAMIHJ010000084 Genomic DNA Translation: EDH6377766.1
AAMIYH010000029 Genomic DNA Translation: EDH8304314.1
AAMJIT010000026 Genomic DNA Translation: EDH9534033.1
SMQV01000016 Genomic DNA Translation: TLC06422.1

NCBI Reference Sequences

More...
RefSeqi
WP_000362362.1, NZ_VDDU02000015.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAAGNC010000044 Genomic DNA Translation: EAC0259480.1
AAGQQG010000024 Genomic DNA Translation: EBQ9437775.1
AAGTTH010000027 Genomic DNA Translation: EBR8875520.1
AAGUAT010000030 Genomic DNA Translation: EBR9858661.1
AAHDPK010000028 Genomic DNA Translation: EBU9237816.1
AAHEIL010000040 Genomic DNA Translation: EBV1536421.1
AAHFGZ010000028 Genomic DNA Translation: EBV4520484.1
AAHFLT010000035 Genomic DNA Translation: EBV5113968.1
AAHGNC010000033 Genomic DNA Translation: EBV8409045.1
AAHGNJ010000042 Genomic DNA Translation: EBV8441759.1
AAHIGU010000026 Genomic DNA Translation: EBW4191378.1
AAHJVM010000053 Genomic DNA Translation: EBW9788617.1
AAHKSL010000035 Genomic DNA Translation: EBX2684514.1
AAHLQC010000026 Genomic DNA Translation: EBX5586697.1
AAHMCG010000030 Genomic DNA Translation: EBX7357626.1
AAHOCW010000025 Genomic DNA Translation: EBY4532443.1
AAHOUX010000026 Genomic DNA Translation: EBY7120865.1
AAHPOZ010000024 Genomic DNA Translation: EBY9550289.1
AAHPPW010000028 Genomic DNA Translation: EBY9662769.1
AAHTRM010000025 Genomic DNA Translation: ECA2383514.1
AAHVCR010000031 Genomic DNA Translation: ECA6746527.1
AAHWDY010000027 Genomic DNA Translation: ECB0003442.1
AALDFV010000062 Genomic DNA Translation: ECY4305858.1
AALDGD010000037 Genomic DNA Translation: ECY4437791.1
AALTSX010000024 Genomic DNA Translation: EDD2825266.1
AAMCMS010000025 Genomic DNA Translation: EDF9276258.1
AAMIHJ010000084 Genomic DNA Translation: EDH6377766.1
AAMIYH010000029 Genomic DNA Translation: EDH8304314.1
AAMJIT010000026 Genomic DNA Translation: EDH9534033.1
SMQV01000016 Genomic DNA Translation: TLC06422.1
RefSeqiWP_000362362.1, NZ_VDDU02000015.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd06559, Endonuclease_V, 1 hit
HAMAPiMF_00801, Endonuclease_5, 1 hit
InterProiView protein in InterPro
IPR007581, Endonuclease-V
PANTHERiPTHR28511, PTHR28511, 1 hit
PfamiView protein in Pfam
PF04493, Endonuclease_5, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4U8J050_SALET
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4U8J050
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 31, 2019
Last sequence update: July 31, 2019
Last modified: April 22, 2020
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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