UniProtKB - A0A4S5B2B3 (A0A4S5B2B3_ECOLI)
Protein
Biotin carboxylase
Gene
accC
Organism
Escherichia coli (strain K12)
Status
Functioni
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.UniRule annotationARBA annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- ATP + hydrogencarbonate + N6-biotinyl-L-lysyl-[protein] = ADP + H+ + N6-carboxybiotinyl-L-lysyl-[protein] + phosphateUniRule annotationARBA annotationEC:6.3.4.14UniRule annotationARBA annotation
- acetyl-CoA + ATP + hydrogencarbonate = ADP + H+ + malonyl-CoA + phosphateUniRule annotationARBA annotationEC:6.4.1.2UniRule annotationARBA annotation
: malonyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationARBA annotationProteins known to be involved in this subpathway in this organism are:
- Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Biotin carboxylase (accC), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD), Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Biotin carboxylase (accC)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-UniRule
- biotin carboxylase activity Source: UniProtKB-EC
- metal ion binding Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
- malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | LigaseUniRule annotationImported |
Biological process | Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-bindingUniRule annotationARBA annotation, BiotinUniRule annotationARBA annotation, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:accCImported ORF Names:FAZ83_05065Imported |
Organismi | Escherichia coli (strain K12)Imported |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Interactioni
Subunit structurei
Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
UniRule annotationARBA annotationChemistry databases
BindingDBi | A0A4S5B2B3 |
Family & Domainsi
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR004549, Acetyl_CoA_COase_biotin_COase IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR005481, BC-like_N IPR011764, Biotin_carboxylation_dom IPR005482, Biotin_COase_C IPR005479, CbamoylP_synth_lsu-like_ATP-bd IPR016185, PreATP-grasp_dom_sf IPR011054, Rudment_hybrid_motif |
Pfami | View protein in Pfam PF02785, Biotin_carb_C, 1 hit PF00289, Biotin_carb_N, 1 hit PF02786, CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878, Biotin_carb_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit |
TIGRFAMsi | TIGR00514, accC, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS50979, BC, 1 hit PS00866, CPSASE_1, 1 hit PS00867, CPSASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A4S5B2B3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLDKIVIANR GEIALRILRA CKELGIKTVA VHSSADRDLK HVLLADETVC
60 70 80 90 100
IGPAPSVKSY LNIPAIISAA EITGAVAIHP GYGFLSENAN FAEQVERSGF
110 120 130 140 150
IFIGPKAETI RLMGDKVSAI AAMKKAGVPC VPGSDGPLGD DMDKNRAIAK
160 170 180 190 200
RIGYPVIIKA SGGGGGRGMR VVRGDAELAQ SISMTRAEAK AAFSNDMVYM
210 220 230 240 250
EKYLENPRHV EIQVLADGQG NAIYLAERDC SMQRRHQKVV EEAPAPGITP
260 270 280 290 300
ELRRYIGERC AKACVDIGYR GAGTFEFLFE NGEFYFIEMN TRIQVEHPVT
310 320 330 340 350
EMITGVDLIK EQLRIAAGQP LSIKQEEVHV RGHAVECRIN AEDPNTFLPS
360 370 380 390 400
PGKITRFHAP GGFGVRWESH IYAGYTVPPY YDSMIGKLIC YGENRDVAIA
410 420 430 440
RMKNALQELI IDGIKTNVDL QIRIMNDENF QHGGTNIHYL EKKLGLQEK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | SSUU01000003 Genomic DNA Translation: THJ15044.1 |
RefSeqi | WP_000884639.1, NZ_STEB01000012.1 |
Genome annotation databases
GeneIDi | 58460262 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | SSUU01000003 Genomic DNA Translation: THJ15044.1 |
RefSeqi | WP_000884639.1, NZ_STEB01000012.1 |
3D structure databases
SMRi | A0A4S5B2B3 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A4S5B2B3 |
Genome annotation databases
GeneIDi | 58460262 |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR004549, Acetyl_CoA_COase_biotin_COase IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR005481, BC-like_N IPR011764, Biotin_carboxylation_dom IPR005482, Biotin_COase_C IPR005479, CbamoylP_synth_lsu-like_ATP-bd IPR016185, PreATP-grasp_dom_sf IPR011054, Rudment_hybrid_motif |
Pfami | View protein in Pfam PF02785, Biotin_carb_C, 1 hit PF00289, Biotin_carb_N, 1 hit PF02786, CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878, Biotin_carb_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit |
TIGRFAMsi | TIGR00514, accC, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS50979, BC, 1 hit PS00866, CPSASE_1, 1 hit PS00867, CPSASE_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A4S5B2B3_ECOLI | |
Accessioni | A0A4S5B2B3Primary (citable) accession number: A0A4S5B2B3 Secondary accession number(s): A0A4S5AMJ7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 26, 2020 |
Last sequence update: | February 26, 2020 | |
Last modified: | February 10, 2021 | |
This is version 7 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |