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Entry version 6 (10 Feb 2021)
Sequence version 1 (31 Jul 2019)
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Protein

DUF4549 domain-containing protein

Gene

CRM22_007481

Organism
Opisthorchis felineus
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUF4549 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CRM22_007481Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOpisthorchis felineusImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri147828 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaOpisthorchiidaOpisthorchiataOpisthorchiidaeOpisthorchis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000308267 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 139DUF4549InterPro annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni282 – 306DisorderedSequence analysisAdd BLAST25
Regioni1765 – 1839DisorderedSequence analysisAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2066 – 2086Sequence analysisAdd BLAST21
Coiled coili2099 – 2126Sequence analysisAdd BLAST28
Coiled coili2165 – 2185Sequence analysisAdd BLAST21
Coiled coili2268 – 2313Sequence analysisAdd BLAST46
Coiled coili2353 – 2377Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi286 – 300PolarSequence analysisAdd BLAST15
Compositional biasi1777 – 1839PolarSequence analysisAdd BLAST63

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040401, CCDC162
IPR029376, DUF4549

The PANTHER Classification System

More...
PANTHERi
PTHR33331, PTHR33331, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15082, DUF4549, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A4S2LFV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDEDVLKT QEDGLRSDIL ELRAQIEENE LIHGIPSKGM SSVYIPKDPD
60 70 80 90 100
YFRRERKLIL QRTLQVLEPQ PIMLQAELMM QELDACNQRE FTERTLPILL
110 120 130 140 150
HQYFIDRIHQ IVLLKHGYLL RWKRYCSSTA AVETIQSEYL NRLEYLTNEY
160 170 180 190 200
LDASSRAHRL ASTREGILAN SDNGVEDVTV EDYQIYLRYH LSHLQSLSYT
210 220 230 240 250
NQLLNIIKWL PYSHRDRIKD SLIKQYPYIL CEDVTNVAPR GGFEAGGTEA
260 270 280 290 300
ATVNLTKAQG AVEREMSVHS SADEGEALVA EETETLRSGQ RASSEKGESG
310 320 330 340 350
APPSQPVEAS VILDELKAME QAHAVNESMF DETNTATTAC SSPSSIKKKS
360 370 380 390 400
VQRKSLTNVE DFDEPLQGRG SEITPAPHPQ SHFRFSEQAP QPPAMMHATV
410 420 430 440 450
FGANAPLQPT KANFDLASSG GGIVTNDKVA APPLHSNDLE TLRPHLVYFC
460 470 480 490 500
HAYGIQMNIQ AIRSSADEME LFAVINRKFR QIFSRQEEML TFKTYDSAKS
510 520 530 540 550
ASERWGLDSW VRAVRKPSNW LPYVKLRPKR HEYLVKLTME LRSGTVVDDL
560 570 580 590 600
LKASANFLKV KSPEKVQDSL RHHAMLVQHP PIVHSASVVS HRQGQSTAEI
610 620 630 640 650
FKKIYNNSDF FGKASADSDE PGKRQDDYDF TQAMQMLGLD DATNAKDDPS
660 670 680 690 700
SVQGAYLSYL HLRHLKLRDV MRTCISVLNY FRSIERTLTI NDQGLSMNSR
710 720 730 740 750
GGVERTSPPN HRVGTEAQGH KGGGNTIDGH GYLFNSPQEF KIKETEFMQF
760 770 780 790 800
AEIDNHDDFY FHEEGRIHVR DQVGFWIIYD AALEDFNKLE QDLLLLATAF
810 820 830 840 850
IQKDRQLRTS SNTKKKGVDQ EAQPSDLDIA RYAHRDVDRF GVLYDIWINE
860 870 880 890 900
CAFQQAKQKL MDVYMEVYGH IISRDSRRRL AQIMTNLMYQ RPRLDLNESY
910 920 930 940 950
FVLAYRYECA ILRQRTEIMR CILNHQILNQ REYLKKIHVD KPEFGMPPPL
960 970 980 990 1000
LERFPIAVHS DETLLTPVYL LEFHPSLSCA PSLAAAMDRS VQQLYELFTP
1010 1020 1030 1040 1050
DQPMQEIVLE KRFYDFLRYE VETLKPLGGS YTAQLQRDLF SSYFVEDAIQ
1060 1070 1080 1090 1100
MCELSNQHLA AIQNRNSRGD KKTRQMYLLN ELGRLLDLVT LRHRLIDCMW
1110 1120 1130 1140 1150
ECEVLSKIYL TVAHEMGFDD FHLFIRPLQF EAAKYKEGAD DLRPPIYITA
1160 1170 1180 1190 1200
VQDDDSMLDK FLPSALPLAI HELDETHVGK FSFRGKVTIM EMLETRGVEN
1210 1220 1230 1240 1250
MLTILKVQTA HKNALTASVM LAYNARPSFY SMHAPKTKTG ILRPSNTGAN
1260 1270 1280 1290 1300
LISYTGLSGT QVGPTPLALE RSKHQLNADY HPEAFFSIQL EKSPSRDRTQ
1310 1320 1330 1340 1350
NAFIKRTQGG GIASSKSSVE SEKMKREFIS QFCMDFGQRT QHISLRAQII
1360 1370 1380 1390 1400
STYSSILTIL EKVPTVTEDF FVIGYAFEKK NPEDDLDVQV TDPRTLRTRP
1410 1420 1430 1440 1450
RRVLSTDGTK LYNFWFIPHF IEVLFIFRHL DDLSCTKALQ RMARLACVLH
1460 1470 1480 1490 1500
DILHYLIAYA RLGISSAKIT PEQRQQVIAG SQKHGGQQWR TAIRGALPTA
1510 1520 1530 1540 1550
AEVASNIAGT TSAETFVAQL SSAGTIPSMN MALSSPALSV TPLDLSVHGR
1560 1570 1580 1590 1600
SLVVDQIIED LSDFDGGPMS MLATELREIQ YQINRLPDPT DPEQVIQMLE
1610 1620 1630 1640 1650
LRRDVMFLQF DVCMRTILRE TFLAAGNVEA YKEVVENSHF PLSELSDVQR
1660 1670 1680 1690 1700
PCLNAIEMNV PEPLEARDDQ AKAIFPWRSL MNSCGPFLLF CFGPSTIEYN
1710 1720 1730 1740 1750
IRLCLAGLKP VDRPTVHGEL LAMNLCLEDV LDVGDIPEAK AGEPMPIQQA
1760 1770 1780 1790 1800
ENMHCMLGKR TRDRRREIPP PNAASPTGTG GPASTPGSVA GTTNPVNATG
1810 1820 1830 1840 1850
TSINTINITH SSETQGQKSS THGGAGGTGP LTTTADKTPK LSTLDSPVAA
1860 1870 1880 1890 1900
YTLLKKFLIL WKRVELLKYA WGRRRLGVEA INNPNLFKTF CSIYKREKLY
1910 1920 1930 1940 1950
PLIRSLAIQY RQPDMYALGP LDATDIIVMP KGIPEMVVRQ RQLLKLIEAF
1960 1970 1980 1990 2000
EFYMIADLRK LLVRQTDLVI KERNREEGNL PLELWKRPAM KETLSVKRPG
2010 2020 2030 2040 2050
LADEFLVELM SHLEKNAKND TYTITKDKLN EVLQTVAISV MRTQRESYEN
2060 2070 2080 2090 2100
YSMYYENLLK NQHSLLYAKE REIETLKETL RQNELETNVT VQFQMSEQAH
2110 2120 2130 2140 2150
NLLLEVTALR AKIAELEEIN LKTESKVRNR VRREFSVAMR KLFGLSFEQK
2160 2170 2180 2190 2200
SRIDQYRDHL HAITLQRIAE VREEASAEMA RIKERSGARA SAEDELAERN
2210 2220 2230 2240 2250
LRLSREVNTL HQRNIALQQM MSRLRVMAHW QQTTLRCAFE KQISGVEEQR
2260 2270 2280 2290 2300
NQSKSQVTRL GILSEQRVRM LNEEMSKLRD HLSNTEKHLN DMRKALDKEM
2310 2320 2330 2340 2350
SDKVEKRHAA ERKAATDKQM AMVKQMHIDQ LMAEIAEKNA TLEKMGSLLD
2360 2370 2380 2390 2400
ASAKSKKQEA DKSVREVDLL RKQLREERKL KKSAIHKVDD LMSQLYEFET
2410 2420 2430 2440 2450
AYSSGQNRPG VNLPTMTPKG EAAAGGARKL SAEIQRPVTY EDLVAKKSGP
2460 2470 2480 2490
YTSKHYLRFR QETARVPQLR ERLVQQILKN GSYQTHMHFL RMHDDSERE
Length:2,499
Mass (Da):284,836
Last modified:July 31, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i221EFE98A7C95AA0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A4V3SDX3A0A4V3SDX3_OPIFE
DUF4549 domain-containing protein
CRM22_007481
2,485Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
SJOL01007572 Genomic DNA Translation: TGZ62343.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
SJOL01007572 Genomic DNA Translation: TGZ62343.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR040401, CCDC162
IPR029376, DUF4549
PANTHERiPTHR33331, PTHR33331, 2 hits
PfamiView protein in Pfam
PF15082, DUF4549, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4S2LFV1_OPIFE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4S2LFV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 31, 2019
Last sequence update: July 31, 2019
Last modified: February 10, 2021
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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