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Entry version 9 (10 Feb 2021)
Sequence version 1 (03 Jul 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

D915_002961

Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:D915_002961Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFasciola hepatica (Liver fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6192 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000230066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 330DisorderedSequence analysisAdd BLAST24
Regioni2053 – 2072DisorderedSequence analysisAdd BLAST20
Regioni2086 – 2109DisorderedSequence analysisAdd BLAST24
Regioni2280 – 2326DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 176Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi310 – 330PolyampholyteSequence analysisAdd BLAST21
Compositional biasi2291 – 2326PolarSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018864, Nucleoporin_Nup188

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10487, Nup188, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4E0RX58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACISALSFC VAHRDFSEED ILVRELSKVK EPLSKGLSYF NAKSSTENKQ
60 70 80 90 100
PTLKDQVQRF LTKLSTFLNL SDERCLDLLV HYLAAQNTDG PSDEDQVQNF
110 120 130 140 150
IADGRLSDLL NRIRAFYWHE RLSLLGLFRV TVCDWHESWV SQADVLFAMT
160 170 180 190 200
PFASRIELLE NMLKQYTQAA STTESLLADG YYGFMRLTQP TGMADVESQD
210 220 230 240 250
EFDLTVSQYL KEQLEMLNVI LTGVHALCDS DASPSSCFFS KLLEAFWSKS
260 270 280 290 300
FGLQPSHVQP LSKHRHLVDR ICLTQGLILI RAANLDNLAL YKNAFTKPSQ
310 320 330 340 350
GAVEALRSSK RLAKQSDPGR KIDQSSNRTK PEHKHFLYDA HLLNRLLASL
360 370 380 390 400
SGLGDSPVHG PLLLFGAVCA IAFAPSVPPD FLNRLETGDA ISCEWDPADD
410 420 430 440 450
GKASGRDGWA EVSATAHLVA GQYAHSAIDT LGVFGFLSEQ LTDLDRSVQS
460 470 480 490 500
GPETESNPSL LELPPLQADT DLNLIDFCAH VAVFDLLCLL AQHVVLWTLD
510 520 530 540 550
GPPMILSSST PTPVASVTRC AQATNRIAYV RLFARALCVV AHYAHLTPRA
560 570 580 590 600
SDSVSSSESE ASGIGQRIAG LIESLAEGFP SDLSLLHLCT ALMVPAASRS
610 620 630 640 650
SLADNGIEDA DSLVQLVSEL ITALPYLTEP FTAELQRVVQ QPPASLYPQL
660 670 680 690 700
GRGDQLVPSS NIVSLTQTRT VLSVDWRQRS GSLADRNRYA TPSFLYAGVR
710 720 730 740 750
LIAGTRGKLE SDLGWISWKQ EYPVWNVIAY EVERALILLD RIRSSIGSGH
760 770 780 790 800
SLMQQPTPSR AKTGRVMRES AYRSEESQGV IHTSLFDQLM RVQQLVQFMS
810 820 830 840 850
ACVEAQVHVS TCLYLMEDVW LLIQRITNMS TELTELWRTQ ANRISSVSIP
860 870 880 890 900
DFLLDQIVPS VLQLLGSTLS GIAATGTVKL LTEHTSLWNH VLLTEANRFF
910 920 930 940 950
PHLTLTRTAR PSEPLFSLSA SYLTGPLLSC GGNATVINVP VASSANSSPT
960 970 980 990 1000
LNSSLLPSYL KFLFGLLTGV KWMCTLTRCG LADPIPDSIE VWINQAVDLL
1010 1020 1030 1040 1050
QGGLMVTVNG VLLTISNILK PNQWLLSTSA FSSTERNRWC LELAERSFIL
1060 1070 1080 1090 1100
LTDLLTTHAP EPEMRQACTM LNTSLSSQAD GTVTRAFSDT LRVANMPHVI
1110 1120 1130 1140 1150
AALQAVLLHL LLDSPCAVHS LLAFSSVPLH CLLAQFKALD QGLSVGTPSN
1160 1170 1180 1190 1200
TIIAISGSSP QLHRTRSLAT VVWLGLTLVR RVLGLEHVML EQHAGCTSAE
1210 1220 1230 1240 1250
LLTHANALAV SRAPTPRASM LSSLIAYVDP GTRVHYLAIL LTYLRYPFHT
1260 1270 1280 1290 1300
GLCRSAVTLL KWLTQHTPVN IIDYLSPDSS VVIRDSVLDR LASSSSTLPE
1310 1320 1330 1340 1350
DPLTRIALFD LIAEAVLASP TDRSGKRTVP ILRFLIPSPT PPAGLNKTRN
1360 1370 1380 1390 1400
TKPDCLDCCM AVLAEIKSVH GSALPDQLSV LLLCSVTKLI AALYLQEANT
1410 1420 1430 1440 1450
YLVMLKSKSR FWDFLTEPMF RLLDADVKTQ NEFSQVEHEY CGHVVSILGL
1460 1470 1480 1490 1500
ELFCTQSCPG SPTQDNSFQQ IVNRLTSEDA YTSWFQLVAN ACERAQSMCD
1510 1520 1530 1540 1550
LEPDVSPADC IGPILSSLYE ATCRWKCLLM VHLDWLRQAE TRIGKATQLS
1560 1570 1580 1590 1600
QTVEPLRTKG MMDQLIRGLH QLKSSLDLTV ASDLANQLAV CLSIVVNYHH
1610 1620 1630 1640 1650
KHANDSKSAP DPDNQVRLAQ LVDFLITVRP GLDEQARHLH ADLLACASTL
1660 1670 1680 1690 1700
WQLVHTTRTQ PESGVQPSDD ALHQLQIDLS DCAFGYVAQL AIYSNLLPAD
1710 1720 1730 1740 1750
GAALRQAISL VLKLWDTTSM ASALYARLIQ AGVFNNLLIT LEQHSQSRTG
1760 1770 1780 1790 1800
AAVCHDILIL VMRVLCADGC PSSPTNCSPL TPSAEMDVEE EGHNMLGEDE
1810 1820 1830 1840 1850
VEIKRNRKQL GFHINLSSAQ VVGSYGDLLV RAFNWPPVDT LLQWIHEDEL
1860 1870 1880 1890 1900
TASQNVGPDS CGFDGSCQSV NWVHLILVEL RCLCLLHDRL GGLQQPVVAR
1910 1920 1930 1940 1950
LLDSFCTQNG TQLQALYQSW CSPLYEPDRI QRQFTPLPRT AGLMHDGILP
1960 1970 1980 1990 2000
ASRLELARAV GALYWRLLEA AQALNASPLV SGSGIPTIGT NVLYRDNVKP
2010 2020 2030 2040 2050
YLHTYGPNPS PEFGISVWKL TEWQLHCCSV LLQRFGLRFD LKPGSSIATI
2060 2070 2080 2090 2100
VSSGGNSASG TPLPSSSSGT PNKALLMPNR ATAVVASPRR SQTPSTGGTP
2110 2120 2130 2140 2150
AVRGAQDVSS PQPTVTAQFV SEPDLSEMCC GENELVCLVR HLIMCLSVLS
2160 2170 2180 2190 2200
TQLPLLGRIA LFTMEELQEL RPLVQLMFNT PSLEDNSRQL TFGVLITLAH
2210 2220 2230 2240 2250
SLSYLFLKVS RYIRNDSSAK KSACELSGLL AQAHEMTVAI MLSQATLILL
2260 2270 2280 2290 2300
HEFTSPAEKQ LLVRELTSEL KSCNLLGRSS RRRHSLGHRS SHSPSSRSSS
2310 2320 2330 2340 2350
TARALHRTTS PHPNTPTTGA SSTTAAQSNS VAVAAAADLH SVGTKLDGPD
2360 2370
MGGFGFEQAI DRFAEMLRLC M
Length:2,371
Mass (Da):259,572
Last modified:July 3, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i520ED54ACE7D9EE5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JXXN02000777 Genomic DNA Translation: THD26337.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JXXN02000777 Genomic DNA Translation: THD26337.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR018864, Nucleoporin_Nup188
PfamiView protein in Pfam
PF10487, Nup188, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4E0RX58_FASHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4E0RX58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 3, 2019
Last sequence update: July 3, 2019
Last modified: February 10, 2021
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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