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UniProtKB - A0A4E0RX58 (A0A4E0RX58_FASHE)

Entry version 9 (10 Feb 2021)
Sequence version 1 (03 Jul 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

D915_002961

Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, TranslocationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:D915_002961Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFasciola hepatica (Liver fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6192 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Plagiorchiida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000230066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni307 – 330DisorderedSequence analysisAdd BLAST24
Regioni2053 – 2072DisorderedSequence analysisAdd BLAST20
Regioni2086 – 2109DisorderedSequence analysisAdd BLAST24
Regioni2280 – 2326DisorderedSequence analysisAdd BLAST47

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili156 – 176Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi310 – 330PolyampholyteSequence analysisAdd BLAST21
Compositional biasi2291 – 2326PolarSequence analysisAdd BLAST36

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR018864, Nucleoporin_Nup188

Pfam protein domain database

More...Pfami		View protein in Pfam
PF10487, Nup188, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4E0RX58-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACISALSFC VAHRDFSEED ILVRELSKVK EPLSKGLSYF NAKSSTENKQ 
        60         70         80         90        100
PTLKDQVQRF LTKLSTFLNL SDERCLDLLV HYLAAQNTDG PSDEDQVQNF 
       110        120        130        140        150
IADGRLSDLL NRIRAFYWHE RLSLLGLFRV TVCDWHESWV SQADVLFAMT 
       160        170        180        190        200
PFASRIELLE NMLKQYTQAA STTESLLADG YYGFMRLTQP TGMADVESQD 
       210        220        230        240        250
EFDLTVSQYL KEQLEMLNVI LTGVHALCDS DASPSSCFFS KLLEAFWSKS 
       260        270        280        290        300
FGLQPSHVQP LSKHRHLVDR ICLTQGLILI RAANLDNLAL YKNAFTKPSQ 
       310        320        330        340        350
GAVEALRSSK RLAKQSDPGR KIDQSSNRTK PEHKHFLYDA HLLNRLLASL 
       360        370        380        390        400
SGLGDSPVHG PLLLFGAVCA IAFAPSVPPD FLNRLETGDA ISCEWDPADD 
       410        420        430        440        450
GKASGRDGWA EVSATAHLVA GQYAHSAIDT LGVFGFLSEQ LTDLDRSVQS 
       460        470        480        490        500
GPETESNPSL LELPPLQADT DLNLIDFCAH VAVFDLLCLL AQHVVLWTLD 
       510        520        530        540        550
GPPMILSSST PTPVASVTRC AQATNRIAYV RLFARALCVV AHYAHLTPRA 
       560        570        580        590        600
SDSVSSSESE ASGIGQRIAG LIESLAEGFP SDLSLLHLCT ALMVPAASRS 
       610        620        630        640        650
SLADNGIEDA DSLVQLVSEL ITALPYLTEP FTAELQRVVQ QPPASLYPQL 
       660        670        680        690        700
GRGDQLVPSS NIVSLTQTRT VLSVDWRQRS GSLADRNRYA TPSFLYAGVR 
       710        720        730        740        750
LIAGTRGKLE SDLGWISWKQ EYPVWNVIAY EVERALILLD RIRSSIGSGH 
       760        770        780        790        800
SLMQQPTPSR AKTGRVMRES AYRSEESQGV IHTSLFDQLM RVQQLVQFMS 
       810        820        830        840        850
ACVEAQVHVS TCLYLMEDVW LLIQRITNMS TELTELWRTQ ANRISSVSIP 
       860        870        880        890        900
DFLLDQIVPS VLQLLGSTLS GIAATGTVKL LTEHTSLWNH VLLTEANRFF 
       910        920        930        940        950
PHLTLTRTAR PSEPLFSLSA SYLTGPLLSC GGNATVINVP VASSANSSPT 
       960        970        980        990       1000
LNSSLLPSYL KFLFGLLTGV KWMCTLTRCG LADPIPDSIE VWINQAVDLL 
      1010       1020       1030       1040       1050
QGGLMVTVNG VLLTISNILK PNQWLLSTSA FSSTERNRWC LELAERSFIL 
      1060       1070       1080       1090       1100
LTDLLTTHAP EPEMRQACTM LNTSLSSQAD GTVTRAFSDT LRVANMPHVI 
      1110       1120       1130       1140       1150
AALQAVLLHL LLDSPCAVHS LLAFSSVPLH CLLAQFKALD QGLSVGTPSN 
      1160       1170       1180       1190       1200
TIIAISGSSP QLHRTRSLAT VVWLGLTLVR RVLGLEHVML EQHAGCTSAE 
      1210       1220       1230       1240       1250
LLTHANALAV SRAPTPRASM LSSLIAYVDP GTRVHYLAIL LTYLRYPFHT 
      1260       1270       1280       1290       1300
GLCRSAVTLL KWLTQHTPVN IIDYLSPDSS VVIRDSVLDR LASSSSTLPE 
      1310       1320       1330       1340       1350
DPLTRIALFD LIAEAVLASP TDRSGKRTVP ILRFLIPSPT PPAGLNKTRN 
      1360       1370       1380       1390       1400
TKPDCLDCCM AVLAEIKSVH GSALPDQLSV LLLCSVTKLI AALYLQEANT 
      1410       1420       1430       1440       1450
YLVMLKSKSR FWDFLTEPMF RLLDADVKTQ NEFSQVEHEY CGHVVSILGL 
      1460       1470       1480       1490       1500
ELFCTQSCPG SPTQDNSFQQ IVNRLTSEDA YTSWFQLVAN ACERAQSMCD 
      1510       1520       1530       1540       1550
LEPDVSPADC IGPILSSLYE ATCRWKCLLM VHLDWLRQAE TRIGKATQLS 
      1560       1570       1580       1590       1600
QTVEPLRTKG MMDQLIRGLH QLKSSLDLTV ASDLANQLAV CLSIVVNYHH 
      1610       1620       1630       1640       1650
KHANDSKSAP DPDNQVRLAQ LVDFLITVRP GLDEQARHLH ADLLACASTL 
      1660       1670       1680       1690       1700
WQLVHTTRTQ PESGVQPSDD ALHQLQIDLS DCAFGYVAQL AIYSNLLPAD 
      1710       1720       1730       1740       1750
GAALRQAISL VLKLWDTTSM ASALYARLIQ AGVFNNLLIT LEQHSQSRTG 
      1760       1770       1780       1790       1800
AAVCHDILIL VMRVLCADGC PSSPTNCSPL TPSAEMDVEE EGHNMLGEDE 
      1810       1820       1830       1840       1850
VEIKRNRKQL GFHINLSSAQ VVGSYGDLLV RAFNWPPVDT LLQWIHEDEL 
      1860       1870       1880       1890       1900
TASQNVGPDS CGFDGSCQSV NWVHLILVEL RCLCLLHDRL GGLQQPVVAR 
      1910       1920       1930       1940       1950
LLDSFCTQNG TQLQALYQSW CSPLYEPDRI QRQFTPLPRT AGLMHDGILP 
      1960       1970       1980       1990       2000
ASRLELARAV GALYWRLLEA AQALNASPLV SGSGIPTIGT NVLYRDNVKP 
      2010       2020       2030       2040       2050
YLHTYGPNPS PEFGISVWKL TEWQLHCCSV LLQRFGLRFD LKPGSSIATI 
      2060       2070       2080       2090       2100
VSSGGNSASG TPLPSSSSGT PNKALLMPNR ATAVVASPRR SQTPSTGGTP 
      2110       2120       2130       2140       2150
AVRGAQDVSS PQPTVTAQFV SEPDLSEMCC GENELVCLVR HLIMCLSVLS 
      2160       2170       2180       2190       2200
TQLPLLGRIA LFTMEELQEL RPLVQLMFNT PSLEDNSRQL TFGVLITLAH 
      2210       2220       2230       2240       2250
SLSYLFLKVS RYIRNDSSAK KSACELSGLL AQAHEMTVAI MLSQATLILL 
      2260       2270       2280       2290       2300
HEFTSPAEKQ LLVRELTSEL KSCNLLGRSS RRRHSLGHRS SHSPSSRSSS 
      2310       2320       2330       2340       2350
TARALHRTTS PHPNTPTTGA SSTTAAQSNS VAVAAAADLH SVGTKLDGPD 
      2360       2370 
MGGFGFEQAI DRFAEMLRLC M
Length:2,371
Mass (Da):259,572
Last modified:July 3, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i520ED54ACE7D9EE5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
JXXN02000777 Genomic DNA Translation: THD26337.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JXXN02000777 Genomic DNA Translation: THD26337.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR018864, Nucleoporin_Nup188
PfamiView protein in Pfam
PF10487, Nup188, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4E0RX58_FASHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4E0RX58
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 3, 2019
Last sequence update: July 3, 2019
Last modified: February 10, 2021
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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