Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 4 (22 Apr 2020)
Sequence version 1 (03 Jul 2019)
Previous versions | rss
Add a publicationFeedback
Protein

ANK_REP_REGION domain-containing protein

Gene

D915_002811

Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:D915_002811Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFasciola hepatica (Liver fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6192 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaPlatyhelminthesTrematodaDigeneaPlagiorchiidaEchinostomataEchinostomatoideaFasciolidaeFasciola
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000230066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini606 – 707ANK_REP_REGIONInterPro annotationAdd BLAST102
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati606 – 639ANKPROSITE-ProRule annotationAdd BLAST34
Repeati640 – 668ANKPROSITE-ProRule annotationAdd BLAST29
Repeati675 – 707ANKPROSITE-ProRule annotationAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni506 – 557DisorderedSequence analysisAdd BLAST52
Regioni754 – 831DisorderedSequence analysisAdd BLAST78
Regioni894 – 925DisorderedSequence analysisAdd BLAST32
Regioni1001 – 1093DisorderedSequence analysisAdd BLAST93

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi514 – 531PolyampholyteSequence analysisAdd BLAST18
Compositional biasi532 – 557AcidicSequence analysisAdd BLAST26
Compositional biasi754 – 795PolyampholyteSequence analysisAdd BLAST42
Compositional biasi796 – 813BasicSequence analysisAdd BLAST18
Compositional biasi906 – 925PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1001 – 1054PolarSequence analysisAdd BLAST54

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
1.25.40.20, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR032675, LRR_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796, Ank_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 3 hits
SM00028, TPR, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4E0RVD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLKKQRTRA KSAKEQADIT LEIAVLHTES GEHVHALREY KKLLELWQSK
60 70 80 90 100
GDKFQCAISH RFIADCCIEL DDYDQAISHT NQYLKLATEL GNKLEQQRAF
110 120 130 140 150
VTLGRCFLNR AELMKDGDST KRNLKSAAQA LLSSIKMITE FTGELDSKQL
160 170 180 190 200
GEMRAVSLLN LGQVFRAQRE RTGALERFTQ CISLARKYQL QKLLFRACYQ
210 220 230 240 250
IADLSINMPP TQKYEPLDRA SLISLMNSTS LRNVLTILQM ALVSPMAKTN
260 270 280 290 300
LDHETKELLK SLRESMAQVY LSVGQFRKAA KVYRLLKLHN PNSSDYCRRL
310 320 330 340 350
IRKCMRLSNL MYAIPESVSS DLDSLRATSK AHEKMGDIYS ELEMHGPALR
360 370 380 390 400
HYQLMLTYAE NAFDLCTTAG ADKLALTNIV DAALVSVAET YRAMFEFGRC
410 420 430 440 450
VDTYRREIGW VTSTSLSSAD LASSWFSLAQ AQRLTCESDS TGRGAQPLLE
460 470 480 490 500
SSTTVDSLNF ALQAARSTDN IPLVMEILDE LIDYHQEHHN VEQAAQLKQD
510 520 530 540 550
RISFESIRAT SQTSSGRHDK RRRSERTATE GSPVDDDDDE AAPLATGDID
560 570 580 590 600
DEGGDDEDAV TEFTETLSSD SEIERCVGQA DVLDEFHDGH RGKRQGKALC
610 620 630 640 650
LRTNMKGETP LHVAAISGDM DHVVKLIEVL AHPVNVTDGA GWLPIHEAAF
660 670 680 690 700
HDRTEVAIYL LDHGARLDDP GCPLDASTPL FEAIHNGSLA TALVLVQRGA
710 720 730 740 750
NLWHRNKQGE CLPELLDAWQ PVRRISSTFA QQRALFERLL SVIKERLGGD
760 770 780 790 800
YDRWCNQQRD SSSRKTASRD EVDSSCSEDS ADSPRPTDNR KQRKLQSVGR
810 820 830 840 850
RGASRRGHRR RRPTGSPSLT DQNEDELEER CDSVISSNLS NRRQSRGSRP
860 870 880 890 900
IRGREWDELL VDLDENSATS DLKPESKTCK SHDTAVKSYR EAMEAVGGSA
910 920 930 940 950
SRTNKRPAED ASDAPRRGKR SRAPALIDAD DNDWLVNDEA PVANRGLKCP
960 970 980 990 1000
AFVRDQFETI GTRSSERINT VTIRDRRSNE KLRDIGNVGN ITVTEFHPSE
1010 1020 1030 1040 1050
FVSSTQMVSS KSTRSVKPSA NTPKQTKEDP LTVATTSRKQ AAVRTVSQTS
1060 1070 1080 1090 1100
PKVAIPPPRE SAVSTHIKAT EPLLPPPASQ PITGSSGNTG SHGSHCSVKV
1110 1120 1130 1140 1150
AFADISVLVP VDDSSRSVAW LADEAYRRRQ ILTGRCATSS TNFSGSVGFR
1160 1170 1180 1190 1200
GADAVRLSTR DGALLLHTDR LRSVLPVLGQ TPGTVIELLA ELLHPESGAS
1210 1220 1230 1240 1250
GSEPLLRPTT VSNSTAASVQ PGSGTHVTPA HATNTVTAPL SQDHAGHILP
1260 1270 1280 1290 1300
RIVQTRQFKS LLEQARRTGI ADLSYLALGD QDCAIICDHL LAQGQLRAIT
1310 1320 1330 1340 1350
ELCLSGNALT TIVPSKTDSM SGILAILVQM APHLTSLQLA GNFFELNEML
1360 1370 1380 1390 1400
RTLDVLSRHL HPTDDELPVN RILLPRLQQL NISHNTLTAS PIHCDDNSFM
1410 1420 1430 1440 1450
LEASTGKAST VHWTELIQRF SVVFPKLSKL QLVGCSLDAG QKDTSSTSLS
1460 1470 1480 1490 1500
IPGSRVVGPS VSALSDLDLS WNSQLSASSL STLLSTTSLA GLRALHLRGC
1510 1520 1530 1540 1550
SCHIGPLSIP ISLPVDQITL ASCAWSDHHM DKSVSPMTTR TTNNTTGFSA
1560 1570 1580 1590 1600
GDQLVLTLAQ VMSKGHFHLQ SLDLGYCQLT THCLDSLRSI FGTPGTSLTT
1610 1620 1630 1640 1650
VQLDHNPDLF KSAPTIFPRG SSNSGWIEVI RATAQTASAV ASLTIDLPDV
1660 1670 1680 1690 1700
DGDDDALSTA LAAVEAKLLP GLSSTPLQEL VLIGAPDLPE GSELGSATVD
1710 1720 1730 1740
AWTLGTERQL SNAERFCQHL VTLFRSRFGT LARVRRVSKG NGVCYGIV
Length:1,748
Mass (Da):191,419
Last modified:July 3, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2CEA57B054935074
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
JXXN02000789 Genomic DNA Translation: THD26298.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JXXN02000789 Genomic DNA Translation: THD26298.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.25.40.10, 1 hit
1.25.40.20, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR032675, LRR_dom_sf
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
SMARTiView protein in SMART
SM00248, ANK, 3 hits
SM00028, TPR, 4 hits
SUPFAMiSSF48403, SSF48403, 1 hit
SSF48452, SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4E0RVD8_FASHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4E0RVD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 3, 2019
Last sequence update: July 3, 2019
Last modified: April 22, 2020
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again