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UniProtKB - A0A4E0RNW5 (A0A4E0RNW5_FASHE)

Entry version 4 (22 Apr 2020)
Sequence version 1 (03 Jul 2019)
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Protein

DUF4042 domain-containing protein

Gene

D915_006336

Organism
Fasciola hepatica (Liver fluke)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DUF4042 domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:D915_006336Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFasciola hepatica (Liver fluke)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6192 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Platyhelminthes › Trematoda › Digenea › Plagiorchiida › Echinostomata › Echinostomatoidea › Fasciolidae › Fasciola
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000230066 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini546 – 692DUF4042InterPro annotationAdd BLAST147

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni350 – 398DisorderedSequence analysisAdd BLAST49
Regioni448 – 474DisorderedSequence analysisAdd BLAST27

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016024, ARM-type_fold
IPR025283, DUF4042

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13251, DUF4042, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A4E0RNW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRNAVLQLS ECCEGVTYPE IMRDLSHLLT MYYRVAKSSN QKSCVDRSAF 
        60         70         80         90        100
SKGKWKHDIT VCLTWDEAAK VYNWISKIIC EGISQKKNDI PELGRFVSSL 
       110        120        130        140        150
SSITTLFREL KLFPQSESGS CLNIQPYKEA LNILLDQLRN LMLLFESGCS 
       160        170        180        190        200
DAQSSYSTIF ESFNKISHMV GNLVLGNLNQ IDADVLTSLA EQLMRELQSR 
       210        220        230        240        250
RTVLDPLQSV TIYATLSHLT YLHPVWDKLQ ENADVSNEAS CQIHATDILA 
       260        270        280        290        300
PSSALYHSVL DALVDGLKRC DPYMLRTASQ GSDEDRSTVI RQVVLSCLNG 
       310        320        330        340        350
LAQLLLRRTS RSNTTNLTTV VRVLWTHVLT FGCQYGTNKR LNQAVVGHDG 
       360        370        380        390        400
AASSSMSSGQ SSPSSSLPTT SDEEGALKPS SGQCSKDRHQ PSSRSCRNSS 
       410        420        430        440        450
SCILASASMA SGPLCSSSSE DERNTSGAWF GTTRSIACGL LAGSPGGTIP 
       460        470        480        490        500
RTSHRQHLDA SGFRGPHSRT HTSGFTNQLK PYALSVFCLK RLLEGCRSSS 
       510        520        530        540        550
ALDLWPTLMC GDGWAGMIPL SSTIRTVSNQ SSSPYSETDR PNVALTPDLL 
       560        570        580        590        600
TLVYKTSDMR IRKMLVEILI SLLAAVGKRF VIAEDLTPHS ASFVPYSVRL 
       610        620        630        640        650
AVELRHLHRR LMLALYGEKS VVLRGLLLKA LTTLVLITPY PRLQPGLLTS 
       660        670        680        690        700
LLPGLHQLLH LIESQNRMVD LRAGCLNLLG CILGRVPGPL MEVCQILSDD 
       710        720        730        740        750
VSSTGLNDPW TVIPNLRSTP STSRTSCDRL AWPVQSRDRP RGPGCWFSLQ 
       760        770        780        790        800
SQDPFQPCWL VQVCLRLIHP DVSTFAWDSA TQPACPEVAN FGGTVDQFTV 
       810        820        830        840        850
GTGCQSTKQC QPPPVRVQAL TVLRNMVPNY AAFLRPSLPL LKKTLLFCLQ 
       860        870        880        890        900
DYKKNKLLWA PTLKFLLVFL PYLQIVPTAT NDPSTDTISQ GESLAWWCDF 
       910        920        930        940        950
IPPIVGILRN SKLMSERSYC CKVLALLDTK TVEAIQKQEQ FAGLIGSVIE 
       960        970        980        990       1000
VMQSIVEDGD DVLRARCIRT LGSLVTLRPL QTNLSLLCYI IDRAPAIWNR 
      1010       1020       1030       1040       1050
AVNQSIELDV AWSLASCLEV VVAHRVGLIP DSPKWSSVLH ELSGAGVSWT 
      1060       1070       1080       1090       1100
KLVQTCCELC TVCTTETCSL GSEAQSQIGG SGFCESKNPS TDEQSNPVRP 
      1110       1120       1130       1140       1150
TLKPVAERSV SVKLNTEASK TPDAHRCENG ARALGYLLRI LEPGLIREQN 

VISQLFEVC
Length:1,159
Mass (Da):127,404
Last modified:July 3, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i815BCACAF3DA5635
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
JXXN02002524 Genomic DNA Translation: THD22788.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JXXN02002524 Genomic DNA Translation: THD22788.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR025283, DUF4042
PfamiView protein in Pfam
PF13251, DUF4042, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A4E0RNW5_FASHE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A4E0RNW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 3, 2019
Last sequence update: July 3, 2019
Last modified: April 22, 2020
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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