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Entry version 2 (31 Jul 2019)
Sequence version 1 (03 Jul 2019)
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Protein
Submitted name:

E3 ubiquitin-protein ligase MYCBP2

Gene

MYCBP2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
E3 ubiquitin-protein ligase MYCBP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYCBP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 13

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23386 MYCBP2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000005810

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati563 – 618RCC1PROSITE-ProRule annotationAdd BLAST56
Repeati921 – 971RCC1PROSITE-ProRule annotationAdd BLAST51
Repeati972 – 1029RCC1PROSITE-ProRule annotationAdd BLAST58
Repeati2303 – 2396FilaminPROSITE-ProRule annotationAdd BLAST94
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3680 – 3858DOCInterPro annotationAdd BLAST179
Domaini4390 – 4441RING-typeInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni49 – 89DisorderedSequence analysisAdd BLAST41
Regioni134 – 154DisorderedSequence analysisAdd BLAST21
Regioni571 – 590DisorderedSequence analysisAdd BLAST20
Regioni860 – 890DisorderedSequence analysisAdd BLAST31
Regioni1955 – 1974DisorderedSequence analysisAdd BLAST20
Regioni2283 – 2302DisorderedSequence analysisAdd BLAST20
Regioni2671 – 2893DisorderedSequence analysisAdd BLAST223
Regioni2905 – 2925DisorderedSequence analysisAdd BLAST21
Regioni2941 – 2982DisorderedSequence analysisAdd BLAST42
Regioni3028 – 3048DisorderedSequence analysisAdd BLAST21
Regioni3567 – 3593DisorderedSequence analysisAdd BLAST27
Regioni3877 – 3896DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3155 – 3180Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi64 – 83BasicSequence analysisAdd BLAST20
Compositional biasi576 – 590PolyampholyteSequence analysisAdd BLAST15
Compositional biasi870 – 886PolyampholyteSequence analysisAdd BLAST17
Compositional biasi2676 – 2697PolarSequence analysisAdd BLAST22
Compositional biasi2698 – 2719PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2745 – 2777PolarSequence analysisAdd BLAST33
Compositional biasi2785 – 2818PolarSequence analysisAdd BLAST34
Compositional biasi2822 – 2852PolyampholyteSequence analysisAdd BLAST31
Compositional biasi2863 – 2885PolarSequence analysisAdd BLAST23
Compositional biasi3881 – 3895PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155756

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR017868 Filamin/ABP280_repeat-like
IPR008979 Galactose-bd-like_sf
IPR014756 Ig_E-set
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003646 SH3-like_bac-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03256 ANAPC10, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF08239 SH3_3, 1 hit
PF13639 zf-RING_2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01337 APC10, 1 hit
SM00184 RING, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51284 DOC, 1 hit
PS50194 FILAMIN_REPEAT, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 3 hits
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A499FJI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVPDGSVAA AGLGLGLPAA DSRGHYQLLL SGRALADRYR RIYTAALNDR
60 70 80 90 100
DQGGGSAGHP ASRNKKILNK KKLKRKQKSK SKVKTRSKSE NLENTVIIPD
110 120 130 140 150
IKLHSNPSAF NIYCNVRHCV LEWQKKEISL AAASKNSVQS GESDSDEEEE
160 170 180 190 200
SKEPPIKLPK IIEVGLCEVF ELIKETRFSH PSLCLRSLQA LLNVLQGQQP
210 220 230 240 250
EGLQSEPPEV LESLFQLLLE ITVRSTGMND STGQSLTALS CACLFSLVAS
260 270 280 290 300
WGETGRTLQA ISAILTNNGS HACQTIQVPT ILNSLQRSVQ AVLVGKIQIQ
310 320 330 340 350
DWFSNGIKKA ALMHKWPLKE ISVDEDDQCL LQNDGFFLYL LCKDGLYKIG
360 370 380 390 400
SGYSGTVRGH IYNSTSRIRN RKEKKSWLGY AQGYLLYRDV NNHSMTAIRI
410 420 430 440 450
SPETLEQDGT VMLPDCHTEG QNILFTDGEY INQIAASRDD GFVVRIFATS
460 470 480 490 500
TEPVLQQELQ LKLARKCLHA CGISLFDLEK DLHIISTGFD EESAILGAGR
510 520 530 540 550
EFALMKTANG KIYYTGKYQS LGIKQGGPSA GKWVELPITK SPKIVHFSVG
560 570 580 590 600
HDGSHALLVA EDGSIFFTGS ASKGEDGEST KSRRQSKPYK PKKIIKMEGK
610 620 630 640 650
IVVYTACNNG SSSVISKDGE LYMFGKDAIY SDSSSLVTDL KGHFVTQVAM
660 670 680 690 700
GKAHTCVLMK NGEVWTFGVN NKGQCGRDTG AMNQGGKGFG VENMATAMDE
710 720 730 740 750
DLEEELDEKD EKSMMCPPGM HKWKLEQCMV CTVCGDCTGY GASCVSSGRP
760 770 780 790 800
DRVPGGICGC GSGESGCAVC GCCKACAREL DGQEARQRGI LDAVKEMIPL
810 820 830 840 850
DLLLAVPVPG VNIEEHLQLR QEEKRQRVIR RHRLEEGRGP LVFAGPIFMN
860 870 880 890 900
HREQALARLR SHPAQLKHKR DKHKDGSGER GEKDASKITT YPPGSVRFDC
910 920 930 940 950
ELRAVQVSCG FHHSVVLMEN GDVYTFGYGQ HGQLGHGDVN SRGCPTLVQA
960 970 980 990 1000
LPGPSTQVTA GSNHTAVLLM DGQVFTFGSF SKGQLGRPIL DVPYWNAKPA
1010 1020 1030 1040 1050
PMPNIGSKYG RKATWIGASG DQTFLRIDEA LINSHVLATS EIFASKHIIG
1060 1070 1080 1090 1100
LVPASISEPP PFKCLLINKV DGSCKTFNDS EQEDLQGFGV CLDPVYDVIW
1110 1120 1130 1140 1150
RFRPNTRELW CYNAVVADAR LPSAADMQSR CSILSPELAL PTGSRALTTR
1160 1170 1180 1190 1200
SHAALHILGC LDTLAAMQDL KMGVASTEEE TQAVMKVYSK EDYSVVNRFE
1210 1220 1230 1240 1250
SHGGGWGYSA HSVEAIRFSA DTDILLGGLG LFGGRGEYTA KIKLFELGPD
1260 1270 1280 1290 1300
GGDHETDGDL LAETDVLAYD CAAREKYAMM FDEPVLLQAG WWYVAWARVS
1310 1320 1330 1340 1350
GPSSDCGSHG QASITTDDGV VFQFKSSKKS NNGTDVNAGQ IPQLLYRLPT
1360 1370 1380 1390 1400
SDGSASKGKQ QTSEPVHILK RSFARTVSVE CFESLLSILH WSWTTLVLGV
1410 1420 1430 1440 1450
EELRGLKGFQ FTATLLDLER LRFVGTCCLR LLRVYTCEIY PVSATGKAVV
1460 1470 1480 1490 1500
EETSKLAECI GKTRTLLRKI LSEGVDHCMV KLDNDPQGYL SQPLSLLEAV
1510 1520 1530 1540 1550
LQECHNTFTA CFHSFYPTPA LQWACLCDLL NCLDQDIQEA NFKTSSSRLL
1560 1570 1580 1590 1600
AAVMSALCHT SVKLTSIFPI AYDGEVLLRS IVKQVSTEND STLVHRFPLL
1610 1620 1630 1640 1650
VAHMEKLSQS EENISGMTSF REVLEKMLVI VVLPVRNSLR RENELFSSHL
1660 1670 1680 1690 1700
VSNTCGLLAS IVSELTASAL GSEVDGLNSL HSVKASANRF TKTSQGRSWN
1710 1720 1730 1740 1750
TGNGSPDAIC FSVDKPGIVV VGFSVYGGGG IHEYELEVLV DDSEHAGDST
1760 1770 1780 1790 1800
HSHRWTSLEL VKGTYTTDDS PSDIAEIRLD KVVPLKENVK YAVRLRNYGS
1810 1820 1830 1840 1850
RTANGDGGMT TVQCPDGVTF TFSTCSLSSN GTNQTRGQIP QILYYRSEFD
1860 1870 1880 1890 1900
GDLQSQLLSK ANEEDKNCSR ALSVVSTVVR ASKDLLHRAL AVDADDIPEL
1910 1920 1930 1940 1950
LSSSSLFSML LPLIIAYIGP VAAAIPKVAV EVFGLVQQLL PSVAILNQKY
1960 1970 1980 1990 2000
APPAFNPNQS TDSTTGNQPE QGLSACTTSS HYAVIESEHP YKPACVMHYK
2010 2020 2030 2040 2050
VTFPECVRWM TIEFDPQCGT AQSEDVLRLL IPVRTVQNSG YGPKLTSVHE
2060 2070 2080 2090 2100
NLNSWIELKK FSGSSGWPTM VLVLPGNEAL FSLETASDYV KDDKASFYGF
2110 2120 2130 2140 2150
KCFAIGYEFS PGPDEGVIQL EKELANLGGV CAAALMKKDL ALPIGNELEE
2160 2170 2180 2190 2200
DLEILEEAAL QVCKTHSGIL GKGLALSHSP TILEALEGNL PLQIQSNEQS
2210 2220 2230 2240 2250
FLDDFIACVP GSSGGRLARW LQPDSYADPQ KTSLILNKDD IRCGWPTTIT
2260 2270 2280 2290 2300
VQTKDQYGDV VHVPNMKVEV KAVPVSQKKM SLQQDQAKKP QRIPGSPAVT
2310 2320 2330 2340 2350
AASSNTDMTY GGLASPKLDV SYEPMIVKEA RYIAITMMKV YENYSFEELR
2360 2370 2380 2390 2400
FASPTPKRPS ENMLIRVNND GTYCANWTPG AIGLYTLHVT IDGIEIDAGL
2410 2420 2430 2440 2450
EVKVKDPPKG MIPPGTQLVK PKSEPQPNKV RKFVAKDSAG LRIRSHPSLQ
2460 2470 2480 2490 2500
SEQIGIVKVN GTITFIDEIH NDDGVWLRLN DETIKKYVPN MNGYTEAWCL
2510 2520 2530 2540 2550
SFNQHLGKSL LVPVDESKTN TDDFFKDINS CCPQEATMQE QDMPFLRGGP
2560 2570 2580 2590 2600
GMYKVVKTGP SGHNIRSCPN LRGIPIGMLV LGNKVKAVGE VTNSEGTWVQ
2610 2620 2630 2640 2650
LDQNSMVEFC ESDEGEAWSL ARDRGGNQYL RHEDEQALLD QNSQTPPPSP
2660 2670 2680 2690 2700
FSVQAFNKGA SCSAQGFDYG LGNSKGDRGN ISTSSKPAST SGKSELSSKH
2710 2720 2730 2740 2750
SRSLKPDGRM SRTTADQKKP RGTESLSASE SLILKSDAAK LRSDSHSRSL
2760 2770 2780 2790 2800
SPNHNTLQTL KSDGRMPSSS RAESPGPGSR LSSPKPKTLP ANRSSPSGAS
2810 2820 2830 2840 2850
SPRSSSPHDK NLPQKSTAPV KTKLDPPRER SKSDSYTLDP DTLRKKKMPL
2860 2870 2880 2890 2900
TEPLRGRSTS PKPKSVPKDS TDSPGSENRA PSPHVVQENL HSEVVEVCTS
2910 2920 2930 2940 2950
STLKTNSLTD STCDDSSEFK SVDEGSNKVH FSIGKAPLKD EQEMRASPKI
2960 2970 2980 2990 3000
SRKCANRHTR PKKEKSSFLF KGDGSKPLEP AKQAMSPSVA ECARAVFASF
3010 3020 3030 3040 3050
LWHEGIVHDA MACSSFLKFH PELSKEHAPI RSSLNSQQPT EEKETKLKNR
3060 3070 3080 3090 3100
HSLEISSALN MFNIAPHGPD ISKMGSINKN KVLSMLKEPP LHEKCEDGKT
3110 3120 3130 3140 3150
ETTFEMSMHN TMKSKSPLPL TLQHLVAFWE DISLATIKAA SQNMIFPSPG
3160 3170 3180 3190 3200
SCAVLKKKEC EKENKKSKKE KKKKEKAEVR PRGNLFGEMA QLAVGGPEKD
3210 3220 3230 3240 3250
TICELCGESH PYPVTYHMRQ AHPGCGRYAG GQGYNSIGHF CGGWAGNCGD
3260 3270 3280 3290 3300
GGIGGSTWYL VCDRCREKYL REKQAAAREK VKQSRRKPMQ VKTPRALPTM
3310 3320 3330 3340 3350
EAHQVIKANA LFLLSLSSAA EPSILCYHPA KPFQSQLPSV KEGISEDLPV
3360 3370 3380 3390 3400
KMPCLYLQTL ARHHHENFVG YQDDNLFQDE MRYLRSTSVP APYISVTPDA
3410 3420 3430 3440 3450
SPNVFEEPES NMKSMPPSLE TSPITDTDLA KRTVFQRSYS VVASEYDKQH
3460 3470 3480 3490 3500
SILPARVKAI PRRRVNSGDT EVGSSLLRHP SPELSRLISA HSSLSKGERN
3510 3520 3530 3540 3550
FQWPVLAFVI QHHDLEGLEI AMKQALRKSA CRVFAMEAFN WLLCNVIQTT
3560 3570 3580 3590 3600
SLHDILWHFV ASLTPAPVEP EEEEDEENKT SKENSEQEKD TRVCEHPLSD
3610 3620 3630 3640 3650
IVIAGEAAHP LPHTFHRLLQ TISDLMMSLP SGSSLQQMAL RCWSLKFKQS
3660 3670 3680 3690 3700
DHQFLHQSNV FHHINNILSK SDDGDSEESF SISIQSGFEA MSQELCIVMC
3710 3720 3730 3740 3750
LKDLTSIVDI KTSSRPAMIG SLTDGSTETF WESGDEDKNK TKNITINCVK
3760 3770 3780 3790 3800
GINARYVSVH VDNSRDLGNK VTSMTFLTGK AVEDLCRIKQ VDLDSRHIGW
3810 3820 3830 3840 3850
VTSELPGGDN HIIKIELKGP ENTLRVRQVK VLGWKDGEST KIAGQISASV
3860 3870 3880 3890 3900
AQQRNCEAET LRVFRLITSQ VFGKLISGDA EPTPEQEEKA LLSSPEGEEK
3910 3920 3930 3940 3950
VYNATSDADL KEHMVGIIFS RSKLTNLQKQ VCAHIVQAIR MEATRVREEW
3960 3970 3980 3990 4000
EHAISSKENA NSQPNDEDAS SDAYCFELLS MVLALSGSNV GRQYLAQQLT
4010 4020 4030 4040 4050
LLQDLFSLLH TASPRVQRQV TSLLRRVLPE VTPSRLASII GVKSLPPADI
4060 4070 4080 4090 4100
SDIIHSTEKG DWNKLGILDM FLGCIAKALT VQLKAKGTTI TGTAGTTVGK
4110 4120 4130 4140 4150
GVTTVTLPMI FNSSYLRRGE SHWWMKGSTP TQISEIIIKL IKDMAAGHLS
4160 4170 4180 4190 4200
EAWSRVTKNA IAETIIALTK MEEEFRSPVR CIATTRLWLA LASLCVLDQD
4210 4220 4230 4240 4250
HVDRLSSGRW MGKDGQQKQM PMCDNHDDGE TAAIILCNVC GNLCTDCDRF
4260 4270 4280 4290 4300
LHLHRRTKTH QRQVFKEEEE AIKVDLHEGC GRTKLFWLMA LADSKTMKAM
4310 4320 4330 4340 4350
VEFREHTGKP TTSSSEACRF CGSRSGTELS AVGSVCSDAD CQEYAKIACS
4360 4370 4380 4390 4400
KTHPCGHPCG GVKNEEHCLP CLHGCDKSAT SLKQDADDMC MICFTEALSA
4410 4420 4430 4440 4450
APAIQLDCSH IFHLQCCRRV LENRWLGPRI TFGFISCPIC KNKINHIVLK
4460 4470 4480 4490 4500
DLLDPIKELY EDVRRKALMR LEYEGLHKSE AITTPGVRFY NDPAGYAMNR
4510 4520 4530 4540 4550
YAYYVCYKCR KAYFGGEARC DAEAGRGDDY DPRELICGAC SDVSRAQMCP
4560 4570 4580 4590 4600
KHGTDFLEYK CRYCCSVAVF FCFGTTHFCN ACHDDFQRMT SIPKEELPHC
4610 4620 4630 4640
PAGPKGKQLE GTECPLHVVH PPTGEEFALG CGVCRNAHTF
Length:4,640
Mass (Da):510,084
Last modified:July 3, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0557ADF6D26472D6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O75592MYCB2_HUMAN
E3 ubiquitin-protein ligase MYCBP2
MYCBP2 KIAA0916, PAM
4,678Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3U4H7C3U4_HUMAN
E3 ubiquitin-protein ligase MYCBP2
MYCBP2
1,061Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WY34A0A087WY34_HUMAN
E3 ubiquitin-protein ligase MYCBP2
MYCBP2
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGY7A0A0C4DGY7_HUMAN
E3 ubiquitin-protein ligase MYCBP2
MYCBP2
275Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC001226 Genomic DNA No translation available.
AL159154 Genomic DNA No translation available.
AL159158 Genomic DNA No translation available.
AL359257 Genomic DNA No translation available.
KF455798 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000357337; ENSP00000349892; ENSG00000005810

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC001226 Genomic DNA No translation available.
AL159154 Genomic DNA No translation available.
AL159158 Genomic DNA No translation available.
AL359257 Genomic DNA No translation available.
KF455798 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357337; ENSP00000349892; ENSG00000005810

Organism-specific databases

HGNCiHGNC:23386 MYCBP2
OpenTargetsiENSG00000005810

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000155756

Family and domain databases

Gene3Di2.130.10.30, 2 hits
2.60.120.260, 1 hit
2.60.120.820, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR004939 APC_su10/DOC_dom
IPR017868 Filamin/ABP280_repeat-like
IPR008979 Galactose-bd-like_sf
IPR014756 Ig_E-set
IPR012983 PHR
IPR038648 PHR_sf
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003646 SH3-like_bac-type
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF03256 ANAPC10, 1 hit
PF08005 PHR, 2 hits
PF00415 RCC1, 1 hit
PF08239 SH3_3, 1 hit
PF13639 zf-RING_2, 1 hit
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM01337 APC10, 1 hit
SM00184 RING, 1 hit
SUPFAMiSSF49785 SSF49785, 1 hit
SSF50985 SSF50985, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS51284 DOC, 1 hit
PS50194 FILAMIN_REPEAT, 1 hit
PS00626 RCC1_2, 2 hits
PS50012 RCC1_3, 3 hits
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A499FJI4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A499FJI4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 3, 2019
Last sequence update: July 3, 2019
Last modified: July 31, 2019
This is version 2 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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