UniProtKB - A0A499FHX9 (A0A499FHX9_HUMAN)
Protein
Submitted name:
DNA replication licensing factor MCM3
Gene
MCM3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- DNA replication initiation Source: InterPro
Keywordsi
Molecular function | DNA-bindingUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Submitted name: DNA replication licensing factor MCM3Imported |
Gene namesi | Name:MCM3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6945 MCM3 |
Subcellular locationi
Other locations
- MCM complex Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 305 – 511 | MCMInterPro annotationAdd BLAST | 207 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 672 – 749 | DisorderedSequence analysisAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 692 – 717 | PolyampholyteSequence analysisAdd BLAST | 26 | |
Compositional biasi | 724 – 749 | PolyampholyteSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00960000186637 |
Family and domain databases
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR031327 MCM IPR008046 Mcm3 IPR018525 MCM_CS IPR001208 MCM_dom IPR041562 MCM_lid IPR033762 MCM_OB IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase |
PANTHERi | PTHR11630 PTHR11630, 1 hit |
Pfami | View protein in Pfam PF00493 MCM, 1 hit PF17855 MCM_lid, 1 hit PF17207 MCM_OB, 1 hit |
PRINTSi | PR01657 MCMFAMILY PR01659 MCMPROTEIN3 |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM00350 MCM, 1 hit |
SUPFAMi | SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847 MCM_1, 1 hit PS50051 MCM_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A499FHX9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLICSQGPRL FLEVTFGGGK SSEVFAPGWS HPGNLHATLV EVVLWQRAWR
60 70 80 90 100
VPWCWTMWSC GRLREITWTS WTTRLLNNAF EELVAFQRAL KDFVASIDAT
110 120 130 140 150
YAKQYEEFYV GLEGSFGSKH VSPRTLTSCF LSCVVCVEGI VTKCSLVRPK
160 170 180 190 200
VVRSVHYCPA TKKTIERRYS DLTTLVAFPS SSVYPTKDEE NNPLETEYGL
210 220 230 240 250
SVYKDHQTIT IQEMPEKAPA GQLPRSVDVI LDDDLVDKAK PGDRVQVVGT
260 270 280 290 300
YRCLPGKKGG YTSGTFRTVL IACNVKQMSK DAQPSFSAED IAKIKKFSKT
310 320 330 340 350
RSKDIFDQLA KSLAPSIHGH DYVKKAILCL LLGGVERDLE NGSHIRGDIN
360 370 380 390 400
ILLIGDPSVA KSQLLRYVLC TAPRAIPTTG RGSSGVGLTA AVTTDQETGE
410 420 430 440 450
RRLEAGAMVL ADRGVVCIDE FDKMSDMDRT AIHEVMEQGR VTIAKAGIHA
460 470 480 490 500
RLNARCSVLA AANPVYGRYD QYKTPMENIG LQDSLLSRFD LLFIMLDQMD
510 520 530 540 550
PEQDREISDH VLRMHRYRAP GEQDGDAMPL GSAVDILATD DPNFSQEDQQ
560 570 580 590 600
DTQIYEKHDN LLHGTKKKKE KMVSAAFMKK YIHVAKIIKP VLTQESATYI
610 620 630 640 650
AEEYSRLRSQ DSMSSDTART SPVTARTLET LIRLATAHAK ARMSKTVDLQ
660 670 680 690 700
DAEEAVELVQ YAYFKKVLEK EKKRKKRSED ESETEDEEEK SQEDQEQKRK
710 720 730 740 750
RRKTRQPDAK DGDSYDPYDF SDTEEEMPQV HTPKTADSQE TKESQKVELS
760 770 780 790 800
ESRLKAFKVA LLDVFREAHA QSIGMNRLTE SINRDSEEPF SSVEIQAALS
810
KMQDDNQVMV SEGIIFLI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP25205 | MCM3_HUMAN | DNA replication licensing factor MC... | MCM3 | 808 | Annotation score: | ||
J3KQ69 | J3KQ69_HUMAN | DNA replication licensing factor MC... | MCM3 | 762 | Annotation score: | ||
Q7Z6P5 | Q7Z6P5_HUMAN | DNA replication licensing factor MC... | MCM3 | 328 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034343 Genomic DNA No translation available. |
RefSeqi | NP_001257401.1, NM_001270472.1 |
Genome annotation databases
Ensembli | ENST00000229854; ENSP00000229854; ENSG00000112118 |
GeneIDi | 4172 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL034343 Genomic DNA No translation available. |
RefSeqi | NP_001257401.1, NM_001270472.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENST00000229854; ENSP00000229854; ENSG00000112118 |
GeneIDi | 4172 |
Organism-specific databases
CTDi | 4172 |
HGNCi | HGNC:6945 MCM3 |
OpenTargetsi | ENSG00000112118 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00960000186637 |
Miscellaneous databases
ChiTaRSi | MCM3 human |
Family and domain databases
InterProi | View protein in InterPro IPR003593 AAA+_ATPase IPR031327 MCM IPR008046 Mcm3 IPR018525 MCM_CS IPR001208 MCM_dom IPR041562 MCM_lid IPR033762 MCM_OB IPR012340 NA-bd_OB-fold IPR027417 P-loop_NTPase |
PANTHERi | PTHR11630 PTHR11630, 1 hit |
Pfami | View protein in Pfam PF00493 MCM, 1 hit PF17855 MCM_lid, 1 hit PF17207 MCM_OB, 1 hit |
PRINTSi | PR01657 MCMFAMILY PR01659 MCMPROTEIN3 |
SMARTi | View protein in SMART SM00382 AAA, 1 hit SM00350 MCM, 1 hit |
SUPFAMi | SSF50249 SSF50249, 1 hit SSF52540 SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00847 MCM_1, 1 hit PS50051 MCM_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A499FHX9_HUMAN | |
Accessioni | A0A499FHX9Primary (citable) accession number: A0A499FHX9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 3, 2019 |
Last sequence update: | July 3, 2019 | |
Last modified: | November 13, 2019 | |
This is version 5 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |