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Entry version 9 (17 Jun 2020)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

Protein TALPID3

Gene

KIAA0586

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein TALPID3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIAA0586Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19960, KIAA0586

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000100578

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
A0A494C0M8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A494C0M8, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni47 – 72DisorderedSequence analysisAdd BLAST26
Regioni324 – 354DisorderedSequence analysisAdd BLAST31
Regioni392 – 415DisorderedSequence analysisAdd BLAST24
Regioni561 – 590DisorderedSequence analysisAdd BLAST30
Regioni1117 – 1144DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili197 – 227Sequence analysisAdd BLAST31
Coiled coili484 – 511Sequence analysisAdd BLAST28
Coiled coili898 – 918Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 72PolarSequence analysisAdd BLAST20
Compositional biasi392 – 414PolarSequence analysisAdd BLAST23
Compositional biasi561 – 578PolyampholyteSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012397

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029246, TALPID3

The PANTHER Classification System

More...
PANTHERi
PTHR15721, PTHR15721, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15324, TALPID3, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 12 potential isoforms that are computationally mapped.Show allAlign All

A0A494C0M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGSEVSLEK KKKIKMPVKR LREVVSQNHG DHLVLLKDEL PCVPPALSAN
60 70 80 90 100
KRLPVGTGTS LNGTSRGSSD LTSARNCYQP LLENPMVSES DFSKDVAVQV
110 120 130 140 150
LPLDKIEENN KQKANDIFIS QYTMGQKDAL RTVLKQKAQS MPVFKEVKVH
160 170 180 190 200
LLEDAGIEKD AVTQETRISP SGIDSATTVA AATAAAIATA APLIKVQSDL
210 220 230 240 250
EAKVNSVTEL LSKLQETDKH LQRVTEQQTS IQRKQEKLHC HDHEKQMNVF
260 270 280 290 300
MEQHIRHLEK LQQQQIDIQT HFISAALKTS SFQPVSMPSS RAVEKYSVKP
310 320 330 340 350
EHPNLGSCNP SLYNTFASKQ APLKEVEDTS FDKQKSPLET PAPRRFAPVP
360 370 380 390 400
VSRDDELSKR ENLLEEKENM EVSCHRGNVR LLEQILNNND SLTRKSESSN
410 420 430 440 450
TTSLTRSKIG WTPEKTNRFP SCEELETTKV TMQKSDDVLH DLGQKEKETN
460 470 480 490 500
SMVQPKESLS MLKLPDLPQN SVKLQTTNTT RSVLKDAEKI LRGVQNNKKV
510 520 530 540 550
LEENLEAIIR AKDGAAMYSL INALSTNREM SEKIRIRKTV DEWIKTISAE
560 570 580 590 600
IQDELSRTDY EQKRFDQKNQ RTKKGQNMTK DIRTNTQDKT VNKSVIPRKH
610 620 630 640 650
SQKQIEEHFR NLPMRGMPAS SLQKERKEGL LKATTVIQDE DYMLQVYGKP
660 670 680 690 700
VYQGHRSTLK KGPYLRFNSP SPKSRPQRPK VIERVKGTKV KSIRTQTDFY
710 720 730 740 750
ATKPKKMDSK MKHSVPVLPH GDQQYLFSPS REMPTFSGTL EGHLIPMAIL
760 770 780 790 800
LGQTQSNSDT MPPAGVIVSK PHPVTVTTSI PPSSRKVETG VKKPNIAIVE
810 820 830 840 850
MKSEKKDPPQ LTVQVLPSVD IDSISNSSAD VLSPLSSPKE ASLPPVQTWI
860 870 880 890 900
KEEEKCDEIP DSEPILEFNR SVKADSTKYN GPPFPPVAST FQPTADILDK
910 920 930 940 950
VIERKETLEN SLIQWVEQEI MSRIISGLFP VQQQIAPSIS VSVSETSEPL
960 970 980 990 1000
TSDIVEGTSS GALQLFVDAG VPVNSNVIKH FVNEALAETI AVMLGDREAK
1010 1020 1030 1040 1050
KQGPVATGVS GDASTNETYL PARVCTPLPT PQPTPPCSPS SPAKECVLVK
1060 1070 1080 1090 1100
TPDSSPCDSD HDMAFPVKEI CAEKGDDMPA IMLVNTPTVT PTTTPPPAAA
1110 1120 1130 1140 1150
VFTPTLSDIS IDKLKVSSPE LPKPWGDGDL PLEEENPNSP QEELHPRAIV
1160 1170 1180 1190 1200
MSVAKDEEPE SMDFPAQPPP PEPVPFMPFP AGTKAPSPSQ MPGSDSSTLE
1210 1220 1230 1240 1250
STLSVTVTET ETLDKPISEG EILFSCGQKL APKILEDIGL YLTNLNDSLS
1260 1270 1280 1290 1300
STLHDAVEME DDPPSEGQVI RMSHKKFHAD AILSFAKQNQ ESAVSQQAVY
1310 1320 1330 1340 1350
HSEDLENSVG ELSEGQRPQL TAAAENILMG HSLYMQPPVT NTQSLDQQCD
1360 1370 1380 1390 1400
PKPLSRQFDT VSGSIYEDSC ASHGPMSLGE LELEPNSKLV LPTTLLTAQE
1410 1420 1430 1440 1450
NDVNLPVAAE DFSQYQLKQN QDVKQVEHKP SQSYLRVRNK SDIAPSQQQV
1460 1470 1480 1490 1500
SPGDMDRTQI ELNPYLTCVF SGGKAVPLSA SQMPPAKMSV MLPSVNLEDC
1510 1520
SQSLSLSTMQ EDMESSGADT F
Length:1,521
Mass (Da):167,903
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC3506CF0D3380881
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9BVV6TALD3_HUMAN
Protein TALPID3
KIAA0586 TALPID3
1,533Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WYM5A0A087WYM5_HUMAN
Protein TALPID3
KIAA0586
1,463Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C075A0A494C075_HUMAN
Protein TALPID3
KIAA0586
958Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C0Z1A0A494C0Z1_HUMAN
Protein TALPID3
KIAA0586
570Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJF0H0YJF0_HUMAN
Protein TALPID3
KIAA0586
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C058A0A494C058_HUMAN
Protein TALPID3
KIAA0586
854Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C1C3A0A494C1C3_HUMAN
Protein TALPID3
KIAA0586
764Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A494C133A0A494C133_HUMAN
Protein TALPID3
KIAA0586
254Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2T5G3V2T5_HUMAN
Protein TALPID3
KIAA0586
234Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4J0G3V4J0_HUMAN
Protein TALPID3
KIAA0586
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL135752 Genomic DNA No translation available.
AL139021 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000650904; ENSP00000498606; ENSG00000100578

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135752 Genomic DNA No translation available.
AL139021 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PeptideAtlasiA0A494C0M8

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
21, 13 antibodies

Genome annotation databases

EnsembliENST00000650904; ENSP00000498606; ENSG00000100578

Organism-specific databases

HGNCiHGNC:19960, KIAA0586
OpenTargetsiENSG00000100578

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000012397

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KIAA0586, human

Gene expression databases

ExpressionAtlasiA0A494C0M8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR029246, TALPID3
PANTHERiPTHR15721, PTHR15721, 1 hit
PfamiView protein in Pfam
PF15324, TALPID3, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A494C0M8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A494C0M8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: June 17, 2020
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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