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Entry version 4 (18 Sep 2019)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

Nuclear receptor corepressor 1 isoform

Gene

LYPA_23C019782

Organism
Lynx pardinus (Iberian lynx) (Felis pardina)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Nuclear receptor corepressor 1 isoformImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LYPA_23C019782Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLynx pardinus (Iberian lynx) (Felis pardina)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri191816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini157 – 208SANTInterPro annotationAdd BLAST52
Domaini345 – 396SANTInterPro annotationAdd BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni219 – 353DisorderedSequence analysisAdd BLAST135
Regioni399 – 636DisorderedSequence analysisAdd BLAST238
Regioni745 – 766DisorderedSequence analysisAdd BLAST22
Regioni1161 – 1180DisorderedSequence analysisAdd BLAST20
Regioni1190 – 1258DisorderedSequence analysisAdd BLAST69
Regioni1413 – 1483DisorderedSequence analysisAdd BLAST71
Regioni1571 – 1590DisorderedSequence analysisAdd BLAST20
Regioni1602 – 1639DisorderedSequence analysisAdd BLAST38
Regioni1660 – 1683DisorderedSequence analysisAdd BLAST24
Regioni1716 – 1757DisorderedSequence analysisAdd BLAST42
Regioni1783 – 1872DisorderedSequence analysisAdd BLAST90
Regioni1992 – 2083DisorderedSequence analysisAdd BLAST92

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili30 – 50Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi226 – 292PolyampholyteSequence analysisAdd BLAST67
Compositional biasi327 – 342Pro-richSequence analysisAdd BLAST16
Compositional biasi399 – 420PolyampholyteSequence analysisAdd BLAST22
Compositional biasi434 – 448AcidicSequence analysisAdd BLAST15
Compositional biasi458 – 511PolarSequence analysisAdd BLAST54
Compositional biasi552 – 579PolyampholyteSequence analysisAdd BLAST28
Compositional biasi589 – 605PolarSequence analysisAdd BLAST17
Compositional biasi1203 – 1250PolarSequence analysisAdd BLAST48
Compositional biasi1430 – 1449PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1624 – 1639PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1737 – 1757PolarSequence analysisAdd BLAST21
Compositional biasi1783 – 1831PolarSequence analysisAdd BLAST49
Compositional biasi1841 – 1858PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2019 – 2059PolarSequence analysisAdd BLAST41

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00249 Myb_DNA-binding, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293 SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A485PNW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKNQVMRKK LILFFKRRNH ARKQREQKIC QRYDQLMEAW EKKVDRIENN
60 70 80 90 100
PRRKAKESKT REYYEKQFPE IRKQREQQER FQRVGQRGAG LSATIARSEH
110 120 130 140 150
EISEIIDGLS EQENNEKQMR QLSVIPPMMF DAEQRRVKFI NMNGLMEDPM
160 170 180 190 200
KVYKDRQFMN VWTDHEKEIF KDKFIQHPKN FGLIASYLER KSVPDCVLYY
210 220 230 240 250
YLTKKNENYK ALVRRNYGKR RGRNQQIARP SQEEKVEEKE EDKAEKTEKK
260 270 280 290 300
EEEKKDEEEK DDKEDSKENT KEKDKTEGAT EETEEREQAT PRGRKTANSQ
310 320 330 340 350
GRRKGRITRS MTNEAAAASA AAAAATEEPP PPLPPPPEPI STEPVETSRW
360 370 380 390 400
TEEEMEVAKK GLVEHGRNWA AIAKMVGTKS EAQCKNFYFN YKRRHNLDNL
410 420 430 440 450
LQQHKQKTSR KPREERDVSQ CESVASTVSA QEDEDIEASN EEENPEDSEV
460 470 480 490 500
EAVKPGEDST ENASSRGNTE PVAELGSTSE PAPGASPSSA VPSSKPVENE
510 520 530 540 550
SAETQANDSI TVEAAEPMDV DRQEPSAEVT SVLDLPATTR TDSVDVDMRV
560 570 580 590 600
PENNPSKVEG DTKERDLERA GEKTEPGDED LVGAQQIGAQ RPEPQSDNDS
610 620 630 640 650
SATCSADEDV DGEPERQRMF PMDSKPSLLN PPGSILVSSP IKPNPLDLPQ
660 670 680 690 700
LQHRAAVIPP MVSCTPCNIP IGTPVSGYAL YQRHIKAMHE SALLEEQRQR
710 720 730 740 750
QEQIDLECRS STSPCGTSKS PNREWEVLQP APHQVITNLP EAVRLPTTRP
760 770 780 790 800
TRPPPPLIPS SKTTVASEKP SFILGGSISQ GTPGTYLTSH NQTSYTQETA
810 820 830 840 850
KPSVGSISLG LPRQQESAKS ATVPYIKQEE FSPRSQNSQP EGLLVRAQHE
860 870 880 890 900
GVVRGTPGAI QEGSITRGTP TSKISLEGIP SLRGSITQGT PALSQAGIPA
910 920 930 940 950
EALVKGSISR MPIEENSPEK GREEAASKGH VIYEGKSGHI LSYDNIKNAR
960 970 980 990 1000
EGTRSPRTAH EISLKRSYES VEGNIKQGLS MRESPVSAPL EGLICRALPR
1010 1020 1030 1040 1050
GSPHSDLKER TVLSGSIMQG TPRATTESFE DGLKYPKQIK RESPPIRAFE
1060 1070 1080 1090 1100
GAITKGKPYD GITTIKEMGR SIHEIPRQDI LTQESRKTPE VVQSTRPIIE
1110 1120 1130 1140 1150
GSISQGTPIK FDSNSGQSAI KHNVKSLITG PNKLPRGMPP LEIVPENIKV
1160 1170 1180 1190 1200
VERGKYEDVK AGEPVRSRHT SVVSSGPSVL RSTLHEAPKA QLSPGIYDDS
1210 1220 1230 1240 1250
SARRTPVSYQ STMSRGSPMM NRTSDVTISS SKSTNHERKS TLTPTQRESI
1260 1270 1280 1290 1300
PAKSPVPGVD PVVSHSPFDP HHRGSTTGEV YRSHLPTHLD PAMPFHRALD
1310 1320 1330 1340 1350
PAAAAYLFQR QLSPTPAYPS QYQLYAMENT RQTILNDYIT SQQMQVNLRP
1360 1370 1380 1390 1400
DVARGLSPRE QQLGLPYPAT RGIIDLTNMP PAILVPHPGG TSTPPMDRIT
1410 1420 1430 1440 1450
YIPGTQITFP PRPYNSASMS PGHSTHLAAA ASAERERERE KERERIAAAS
1460 1470 1480 1490 1500
SDLYLRSGSE QPGRPGSHGY VRSPSPSVRA QEPMLQQRPS VFQGTNGTSV
1510 1520 1530 1540 1550
ITPLDPSAQL RIMPLPAGGP SISQGLPASR YSTAADALAA LVDAAASAPQ
1560 1570 1580 1590 1600
MEVSKTKESK HEASRLEETL RSRSAAVSEQ QQLEQKSLEA EKRSVQCLYT
1610 1620 1630 1640 1650
SAAFPSGKPQ PHSSVVYSEA GKDKGPPPKS RYEEELRTRG KTTITAANFI
1660 1670 1680 1690 1700
DVIITRQIAS DKDARERGSQ SSDSSSSLSS HRYEAPGDAI EVISPASSPA
1710 1720 1730 1740 1750
PPQEKLQAYQ PEVVKANQAE SEASRPYEGP LHHYRPQQES LSPQQQLPPS
1760 1770 1780 1790 1800
SQADGVGQVP RTHRLITLAD HICQIITQDF ARNQVSSQPP QQPPTSTFQN
1810 1820 1830 1840 1850
SPSALVSTPV RTKTSNRYSP ESQSQSVHHQ RPGPRVSPEN LVDKSRGRPG
1860 1870 1880 1890 1900
KSPERSHVSS ESYEPISPPQ VPVVHEKQDS VLLLSQRGAE PAEQRNDSRS
1910 1920 1930 1940 1950
PGSISYLPSF FTKLENTSPM VKSKKQEIFP AAQPGTEIFN LPAVTTSGSV
1960 1970 1980 1990 2000
SSRGHSFADP ASNLGLEDII RKALMGSFDD KVEEHGVVMS QPVGVVPGGT
2010 2020 2030 2040 2050
STSVVPSGET RREEGDPSPH SGSTQFPYNP LTMRMLSSTP PTPIACAPSS
2060 2070 2080
VNQAAPHQQS RIWEREPAPL LSAQYETLSD SDD
Length:2,083
Mass (Da):229,409
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD54AD37160CB8692
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CAAGRJ010038382 Genomic DNA Translation: VFV46088.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAGRJ010038382 Genomic DNA Translation: VFV46088.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00167 SANT, 2 hits
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 2 hits
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A485PNW3_LYNPA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A485PNW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: September 18, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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