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Entry version 2 (03 Jul 2019)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

Phosphotidylinositol phosphatase

Gene

LYPA_23C004395

Organism
Lynx pardinus (Iberian lynx) (Felis pardina)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei2303Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Phosphotidylinositol phosphataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LYPA_23C004395Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLynx pardinus (Iberian lynx) (Felis pardina)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri191816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2009 – 2031HelicalSequence analysisAdd BLAST23

    Keywords - Cellular componenti

    Membrane

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 69Fibronectin type-IIIInterPro annotationAdd BLAST69
    Domaini71 – 161Fibronectin type-IIIInterPro annotationAdd BLAST91
    Domaini162 – 257Fibronectin type-IIIInterPro annotationAdd BLAST96
    Domaini261 – 356Fibronectin type-IIIInterPro annotationAdd BLAST96
    Domaini412 – 500Fibronectin type-IIIInterPro annotationAdd BLAST89
    Domaini503 – 595Fibronectin type-IIIInterPro annotationAdd BLAST93
    Domaini671 – 766Fibronectin type-IIIInterPro annotationAdd BLAST96
    Domaini771 – 860Fibronectin type-IIIInterPro annotationAdd BLAST90
    Domaini865 – 955Fibronectin type-IIIInterPro annotationAdd BLAST91
    Domaini960 – 1049Fibronectin type-IIIInterPro annotationAdd BLAST90
    Domaini1054 – 1154Fibronectin type-IIIInterPro annotationAdd BLAST101
    Domaini1159 – 1251Fibronectin type-IIIInterPro annotationAdd BLAST93
    Domaini1253 – 1343Fibronectin type-IIIInterPro annotationAdd BLAST91
    Domaini1348 – 1441Fibronectin type-IIIInterPro annotationAdd BLAST94
    Domaini1445 – 1531Fibronectin type-IIIInterPro annotationAdd BLAST87
    Domaini1535 – 1639Fibronectin type-IIIInterPro annotationAdd BLAST105
    Domaini1644 – 1742Fibronectin type-IIIInterPro annotationAdd BLAST99
    Domaini1747 – 1848Fibronectin type-IIIInterPro annotationAdd BLAST102
    Domaini2106 – 2362Tyrosine-protein phosphataseInterPro annotationAdd BLAST257
    Domaini2282 – 2353TYR_PHOSPHATASE_2InterPro annotationAdd BLAST72

    Keywords - Domaini

    Transmembrane, Transmembrane helixSequence analysisSAAS annotation

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00063 FN3, 16 hits

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.10, 15 hits
    3.90.190.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR003961 FN3_dom
    IPR036116 FN3_sf
    IPR013783 Ig-like_fold
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR000242 PTPase_domain
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00041 fn3, 13 hits
    PF00102 Y_phosphatase, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00700 PRTYPHPHTASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00060 FN3, 17 hits
    SM00194 PTPc, 1 hit
    SM00404 PTPc_motif, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF49265 SSF49265, 11 hits
    SSF52799 SSF52799, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50853 FN3, 18 hits
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit
    PS50055 TYR_PHOSPHATASE_PTP, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A485PHI6-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MWNPTETNFT HYKIYISNRT FAEEYLIWGV ITEHTVTDLS PGGIYNITVH
    60 70 80 90 100
    RVRDNVEGSG TFIRVVAEPE RPEKLKAFNI SARSFSLYWS LPSGHVERFH
    110 120 130 140 150
    VDLVPDSGFV TIKDLGGGEY QVDVSNAVPG TRYDVTISSI SATTYSSPVS
    160 170 180 190 200
    RTVTTNVTKP GPPVFLAGER VGSAGILLSW NTPPNPNGRI ISYIVKYKEV
    210 220 230 240 250
    CPWMQTEYTQ VRTKPDGLEV LLTNLNPGTT YEIKVAAENS AGIGVFSDPF
    260 270 280 290 300
    LFQTAESAPG KVVNLTVEAF NHSAVNLIWY LPWQPNGKIT SFKISVKHAR
    310 320 330 340 350
    SGIVVKDVSI RVEDILTGKL PECNENNESF LWSTTSPSPT LGRITPPSRT
    360 370 380 390 400
    TYSLSTLARS KISSVWKEPI SFVVTHLKPY TTYLFEVSAV TTEAGYIDST
    410 420 430 440 450
    IVRTPESVPE GPPQNCVTGN ITGKSFSISW DPPSVITGKF SYRVELYGPS
    460 470 480 490 500
    GRILDNSTKD LKFAFTNLTP FTVYDVYVAA ETSAGIGPKS NISVFTPPEV
    510 520 530 540 550
    PGAIFDLQVA EVEATQIRIT WKRPRQPNGI INQYRVKVLV SETGVILENT
    560 570 580 590 600
    LLTGKDEYIN DPMAPETVNI VESMAELFEG SAEISSDLYS LASAIYNSHP
    610 620 630 640 650
    HNFPVRNRAE DQHSTVGTAR NLYITDVSAE QLSYVIRRLV PFTEHMISVS
    660 670 680 690 700
    AFTIMGEGPP TVLNVRTHEQ VPSSIQIINY KNISSSSILL YWDPPKYPNG
    710 720 730 740 750
    KITHYTIYAM ELDTNRAFQM TTTENSFLIT GLKKYTKYKM RVAASTHVGE
    760 770 780 790 800
    SSLSEENDIF VRTPEDEPES SPQDVKVIDV TASEINLKWS PPEKPNGIIV
    810 820 830 840 850
    AYEVLYKNRD TLFMKNTSTT NIILKDLKPY TLYNISVRSY TRFGHGNQLS
    860 870 880 890 900
    SFLSVRTSET VPDSAPENVT YKNISSGEIE LSFLPPSSPN GIIQKYTIYI
    910 920 930 940 950
    RRSSGNEERA INTTSLTQSI KGLKKYTQYK IEVSASTLRG EGVRSAPISI
    960 970 980 990 1000
    LTEEDAPDSP PQGFSVKQLS GVTVKLSWQP PLEPNGIILY YTVYVWDRSS
    1010 1020 1030 1040 1050
    LKTINVTETS LEFSDLDYNV EYSAYVTAST RFGDGKMRSS IINFRTPEGA
    1060 1070 1080 1090 1100
    PSDPPKDVRY ANLSSSSIML FWMPPSKPNG IIQYYSVYYR NTSGTFVQNF
    1110 1120 1130 1140 1150
    TLHEVTNDFD NMTVSAVIDK LAIFSYYTFW VTASTSVGNG NKSSDIVQVY
    1160 1170 1180 1190 1200
    TDQDIPEGFV GNLTYESISS TAINVSWSPP SHPNGLVFYY VSLSLQQTPR
    1210 1220 1230 1240 1250
    HVRPLLVTYE RSIYFDNLEK YTDYILKITP STEKGFSDTY TAQLHIKTEE
    1260 1270 1280 1290 1300
    DVPETSPIIN TFKNLSSTSV LLSWDPPVKP NGAIISYDLT LQGPNENNSF
    1310 1320 1330 1340 1350
    ITSDNYLILE ELSPFTLYSF FAAARTIKGL GPSSTLFFYT DESVPLAPPQ
    1360 1370 1380 1390 1400
    NLTLINYTSD LVWLKWSPSP VPGGIVKIYS LKIHEHETDT IFYKNISGVQ
    1410 1420 1430 1440 1450
    TEAQLVGLEP VSTYSISISA FTKVGNGNQY SNVVKFTTQE SVPDVVQNVQ
    1460 1470 1480 1490 1500
    CMATSWQSAV VKWDPPKKAN GIIIHYMITV GRNSTKVSPQ DDMYTFVKLL
    1510 1520 1530 1540 1550
    ANTSYIFKIR ASTSAGEGDE KTCNISTLPE AVPSVPTNIA FSNVQSTSAT
    1560 1570 1580 1590 1600
    LTWMRPDSVL GYFQNYKITT QLRAQKCIEW DSEECVEYQK TQYLYEANLT
    1610 1620 1630 1640 1650
    EETVYGLKKF RWYRFQVAAS TNAGYGNASN WISTQTLPGP PDGPPENVYV
    1660 1670 1680 1690 1700
    VATSPFSINI SWSEPATITG PTFYLIDVKS VDSDEFNISF IKSNEENKTI
    1710 1720 1730 1740 1750
    EIKDLKIFTR YSVVITAFTG NISAAYAEGK SSAEVIVTTL ESVPNDPPNN
    1760 1770 1780 1790 1800
    MTFWKIPDEV TKFQLTFLPP SQPNGNIQVY QALVYREDDP TAVQIHNLSI
    1810 1820 1830 1840 1850
    IQKTDTSVIA MLEGLKGGHT YNISVYAINS AGAGPNVQMR ITMDIKAPAR
    1860 1870 1880 1890 1900
    PKTKPTPIYD ATGKLLVTST TITIRMPICY YNDDHGPIKN VQVLVTEAGA
    1910 1920 1930 1940 1950
    QHDGNVTKWY DAYFNKPRPY FTNEGFPNPP CTEAKTKFSG NEEIYIIGAD
    1960 1970 1980 1990 2000
    NACMIPGNED RICNGPLKPK KQYLFKFRAT NVMGQFTDSD YSDPVKTLGE
    2010 2020 2030 2040 2050
    GLSERTVEII LSVTLCILSI ILLGTAIFAF ARIRQKQKEG GTYSPRDAEI
    2060 2070 2080 2090 2100
    IDTKFKLDQL ITVADLELKG ERLTRLLSYR KSIKPVSKKS FLQHVEELCT
    2110 2120 2130 2140 2150
    NNNLKFQEEF SELPKFLQDL SSTDADLPWN RAKNRFPNIK PYNNNRVKLI
    2160 2170 2180 2190 2200
    ADASIPGSDY INASYVSGYL CPNEFIATQG PLPGTVGDFW RMVWETRAKT
    2210 2220 2230 2240 2250
    LVMLTQCFEK GRIRCHQYWP EDNKPVTVFG DIVITKLMED VQIDWTIRDL
    2260 2270 2280 2290 2300
    KIERHGDCMT VRQCNFTAWP EHGVPENSAP LVHFVKLVRA SRAHDTTPMI
    2310 2320 2330 2340 2350
    VHCSAGVGRT GVFIALDHLT QHINDHDFVD IYGLVAELRS ERMCMVQNLA
    2360 2370 2380 2390 2400
    QYIFLYQCIL DLLSSKGSNQ PICFVNYSAL QKMDSLDAME GDVELEWEET

    TM
    Length:2,402
    Mass (Da):268,423
    Last modified:June 5, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA62C355D329BC138
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    CAAGRJ010035559 Genomic DNA Translation: VFV44287.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    CAAGRJ010035559 Genomic DNA Translation: VFV44287.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Family and domain databases

    CDDicd00063 FN3, 16 hits
    Gene3Di2.60.40.10, 15 hits
    3.90.190.10, 1 hit
    InterProiView protein in InterPro
    IPR003961 FN3_dom
    IPR036116 FN3_sf
    IPR013783 Ig-like_fold
    IPR029021 Prot-tyrosine_phosphatase-like
    IPR000242 PTPase_domain
    IPR016130 Tyr_Pase_AS
    IPR003595 Tyr_Pase_cat
    IPR000387 TYR_PHOSPHATASE_dom
    PfamiView protein in Pfam
    PF00041 fn3, 13 hits
    PF00102 Y_phosphatase, 1 hit
    PRINTSiPR00700 PRTYPHPHTASE
    SMARTiView protein in SMART
    SM00060 FN3, 17 hits
    SM00194 PTPc, 1 hit
    SM00404 PTPc_motif, 1 hit
    SUPFAMiSSF49265 SSF49265, 11 hits
    SSF52799 SSF52799, 1 hit
    PROSITEiView protein in PROSITE
    PS50853 FN3, 18 hits
    PS00383 TYR_PHOSPHATASE_1, 1 hit
    PS50056 TYR_PHOSPHATASE_2, 1 hit
    PS50055 TYR_PHOSPHATASE_PTP, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A485PHI6_LYNPA
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A485PHI6
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
    Last sequence update: June 5, 2019
    Last modified: July 3, 2019
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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