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Entry version 4 (18 Sep 2019)
Sequence version 1 (05 Jun 2019)
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Protein

Nuclear receptor coactivator

Gene

LYPA_23C014853

Organism
Lynx pardinus (Iberian lynx) (Felis pardina)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivatorUniRule annotation, ReceptorImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear receptor coactivatorUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LYPA_23C014853Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLynx pardinus (Iberian lynx) (Felis pardina)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri191816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeLynx

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 83BHLHInterPro annotationAdd BLAST58
Domaini118 – 181PASInterPro annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 34DisorderedSequence analysisAdd BLAST34
Regioni383 – 520DisorderedSequence analysisAdd BLAST138
Regioni538 – 619DisorderedSequence analysisAdd BLAST82
Regioni631 – 675DisorderedSequence analysisAdd BLAST45
Regioni706 – 800DisorderedSequence analysisAdd BLAST95
Regioni913 – 942DisorderedSequence analysisAdd BLAST30
Regioni1001 – 1047DisorderedSequence analysisAdd BLAST47
Regioni1244 – 1335DisorderedSequence analysisAdd BLAST92

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi398 – 412PolarSequence analysisAdd BLAST15
Compositional biasi421 – 494PolarSequence analysisAdd BLAST74
Compositional biasi504 – 520PolarSequence analysisAdd BLAST17
Compositional biasi538 – 573PolarSequence analysisAdd BLAST36
Compositional biasi591 – 605PolyampholyteSequence analysisAdd BLAST15
Compositional biasi725 – 760PolyampholyteSequence analysisAdd BLAST36
Compositional biasi763 – 780PolarSequence analysisAdd BLAST18
Compositional biasi1001 – 1031PolarSequence analysisAdd BLAST31
Compositional biasi1244 – 1280PolarSequence analysisAdd BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00083 HLH, 1 hit
cd00130 PAS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.1070, 1 hit
4.10.280.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL

The PANTHER Classification System

More...
PANTHERi
PTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF038181 Nuclear_receptor_coactivator, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A485NI95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGLGENSLD PLAPDSRKRK LPCDTPGQGL TCSGEKWRRE QESKYIEELA
60 70 80 90 100
ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKAI SNDDDVQKAD
110 120 130 140 150
VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ
160 170 180 190 200
EDLVNTSVYS ILHEEDRKDF LKNLPKSTVN GVAWTNETQR QKSHTFNCRM
210 220 230 240 250
LMKTPHDILE DINTNPEMRQ RYETMQCFAL SQPRAMMEEG EDLQSCMICV
260 270 280 290 300
ARRITTGERA FPSNPESFIT RHDLSGKVVN IDTNSLRSSM RPGFEDIIRR
310 320 330 340 350
CIQRFFSLND GQSWSQKRHY QEAYIHGHAE TPVYRFSLAD GTIVTAQTKS
360 370 380 390 400
KLFRNPVTND RHGFVSTHFL QREQNGYRPN ANPVGQGIRP PAAGCNSSVG
410 420 430 440 450
GMSMSPNQGL QMLSGRPYGL ADPSSTGQMS GPRYGASSTI ASMNAGPGMQ
460 470 480 490 500
SPSSYQNSTY GLNMSSPPHG SPGLGSNQQN IMISPRNRGS PKMASHQFSP
510 520 530 540 550
VAGVHSPMGS SGNTGSHSFS SSSLSALQAI SEGVGTSLLS TLSSPGPKLD
560 570 580 590 600
NSPNMNISQP SKVNSQDSKS PLGLYCDQNP AESSMCPSNS RDHLSDKESK
610 620 630 640 650
ESSIEGAENQ RGPLESKGHK KLLQLLTCSS DDRGHSSLTN SPLDSSCKDS
660 670 680 690 700
SVSVTSPSGV SSSTSGGVSS TSNMHGSLLQ EKHRILHKLL QNGNSPAEVA
710 720 730 740 750
KITAEATGKD TGSAASGVEG SVKQEQLSPK KKENNALLRY LLDRDDPSDP
760 770 780 790 800
LSKELQPKVE GVDSKGSQCS SSAVPSSSQE KDSKIKTEAN EEGSGDLDNL
810 820 830 840 850
DAILGDLTSS DFYNNSVSTN GSNLGTKQQM FQGTNSLGLR SPQSVQSIRP
860 870 880 890 900
PYNRAVSLDS PVSVGSSPPV KNISAFPMLP KQPMLGGNPR MMDSQENYGS
910 920 930 940 950
TMGGPNRNVT VNQTASSGDW GLPSSKTSRM EPLSSNSMGR PGADYSASLP
960 970 980 990 1000
RPAVSGSMPT LPLRSAGIPG ARPALPPQQQ MLQMRPGEIP MGMGVSPYGQ
1010 1020 1030 1040 1050
AAPSNQPGSW PDGMLSVEQG SHGTQNRPLL RNSLDDLLGP PSNLEGQSDE
1060 1070 1080 1090 1100
RALLDQLHTL LSNTDATGLE EIDRALGIPE LVNQGQALES KPDAFQGQEA
1110 1120 1130 1140 1150
AVMMDQKAAL YGQTYAAQGP PMQGGFNLQG QSPSFNSMMN QMSQQGSFPL
1160 1170 1180 1190 1200
QGMHPRANIM RPRTNTPKQL RMQLQQRLQG QQFLNQSRQA LEMKMENPTA
1210 1220 1230 1240 1250
GGAAVMRPMM QPQVNPQQGF LNAQMVAQRS RELLSHHFRQ QRVAMMMQQQ
1260 1270 1280 1290 1300
QQQQQQQQQQ QQQQQQQQTQ AFSPPPNVTA SPSMDGVLAG PVMPQAPPQQ
1310 1320 1330 1340 1350
FPYPPNYGMG QQPDPAFGRV SSPPNAMMPS RMGPSQNPMM QHPQTAPMYQ
1360 1370 1380 1390 1400
SSEIKGWPSG NLARNSSFPQ QPFAHQGNPA AYGMVHMNGS SGPMGQVNVN
1410 1420 1430
PMPMSGMPMG PDQVWGSSLN FSQKIFPFLL REPKLQL
Length:1,437
Mass (Da):155,753
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i70E66D59CA2B0C31
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CAAGRJ010016368 Genomic DNA Translation: VFV32043.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CAAGRJ010016368 Genomic DNA Translation: VFV32043.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 1 hit
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A485NI95_LYNPA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A485NI95
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: September 18, 2019
This is version 4 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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