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Entry version 8 (02 Jun 2021)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

Ras GTPase-activating protein nGAP isoform X12

Gene
N/A
Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Ras GTPase-activating protein nGAP isoform X12Imported
Submitted name:
Ras GTPase-activating protein nGAP isoform X6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaSuinaSuidaeSus

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 306PHInterPro annotationAdd BLAST232
Domaini475 – 667Ras-GAPInterPro annotationAdd BLAST193

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni133 – 235DisorderedSequence analysisAdd BLAST103
Regioni832 – 851DisorderedSequence analysisAdd BLAST20
Regioni897 – 930DisorderedSequence analysisAdd BLAST34
Regioni945 – 1103DisorderedSequence analysisAdd BLAST159
Regioni1264 – 1287DisorderedSequence analysisAdd BLAST24

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1114 – 1200Sequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi162 – 186Polar residuesSequence analysisAdd BLAST25
Compositional biasi220 – 235Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi949 – 983Polar residuesSequence analysisAdd BLAST35
Compositional biasi984 – 1002Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi1059 – 1101Polar residuesSequence analysisAdd BLAST43

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot

The PANTHER Classification System

More...
PANTHERi
PTHR10194, PTHR10194, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350, SSF48350, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A480MTD8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELSLSSGGA AEALSWPEMF PGLESDSPLP PEELEAVVPV SGAVAGGMLD
60 70 80 90 100
RILLESVCQQ QSWVRVYDVK GPPTHRLSCG QSPYTETTTW ERKYCILTDS
110 120 130 140 150
QLVLLNKEKE IPVEGGQEQP TDSTKGRCLR RTVSVPSEGQ FPEYPPEGAA
160 170 180 190 200
KLEVPAERSP RRRSISGTST SEKPNSMDTA NTSPFKVPGF FSKRLKGSIK
210 220 230 240 250
RTKSQSKLDR NTSFRLPSLR SADDRSRGLP KLKESRSHES LLSPCSAVEC
260 270 280 290 300
LDLGRGEPVS VKPLHSSILG QDFCFEVTYL SGSKCFSCNS ASERDKWMEN
310 320 330 340 350
LRRTVQPNKD NCRRAENVLR LWIIEAKDLA PKKKYFCELC LDDILFARTT
360 370 380 390 400
SKTKADNIFW GEHFEFYSLP PLHSITVHIY KDVEKKKKKD KNNYVGLVNI
410 420 430 440 450
PTASVTGRQF VEKWYPVSTP TPNKGKTGGP SIRIKSRFQT ITILPMEQYK
460 470 480 490 500
EFAEFVTSNY TMLCSVLEPV ISVRNKEELA CALVHILQST GRAKDFLTDL
510 520 530 540 550
VMSEVDRCGE HDVLIFRENT IATKSIEEYL KLVGQQYLHD ALGEFIKALY
560 570 580 590 600
ESDENCEVDP SKCSSSELID HQSNLKMCCE LAFCKIINSY CVFPRELKEV
610 620 630 640 650
FASWKQQCLN RGKQDISERL ISASLFLRFL CPAIMSPSLF NLMQEYPDDR
660 670 680 690 700
TSRTLTLIAK VIQNLANFAK FGNKEEYMAF MNDFLEYEWG GMKRFLLEIS
710 720 730 740 750
NPDTISNTPG FDGYIDLGRE LSVLHSLLWE VVSQLDKGEN SFLQATVAKL
760 770 780 790 800
GPLPRVLADI TKSLTNPTPI QQQLRRFTEH SSSPNVSGSL SSGLQKIFED
810 820 830 840 850
PTDSDLHKLK SPSQDNTDSY FRGKTLLLVQ QASSQSMTYS EKDEKESSLP
860 870 880 890 900
NGRSISLMDL QDTHAAQVEH ASVMLDVPML LTGSQLSITQ VASIKQLRET
910 920 930 940 950
QSTPQSAPQV RRPLHPALNQ PGSLQPLSFQ NPVYHLNNPI PAMPKASVDS
960 970 980 990 1000
SLENLSTASS RSQSNSEDFK LSGPSNSSME DFTKRSTQSE DFSRRHTVPD
1010 1020 1030 1040 1050
RHIPLALPRQ NSTGQAQIRK MDQAGLGARA KAPPSLPHSA SLRSTGSMSV
1060 1070 1080 1090 1100
ASAALVAEPV QNGSRSRQQS SSSRESPVPK VRAIQRQQTQ QVQSPVDSAT
1110 1120 1130 1140 1150
MSPVERTAAW VLNNGQYEED VEESEQNQDE AKHAEKYEQE ITKLKERLRV
1160 1170 1180 1190 1200
SSRRLEEYER RLLVQEQQMQ KLLLEYKARL EDSEERLRRQ QEEKDSQMKS
1210 1220 1230 1240 1250
IISRLMAVEE ELKKDHAEMQ AVIDAKQKII DAQEKRIVSL DSANTRLMSA
1260 1270 1280
LTQVKERYSM QVRNGISPTN PTKLSITENG EFKNSSC
Length:1,287
Mass (Da):144,607
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8975FF020B356A95
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQIR01133547 Transcribed RNA Translation: HDA89023.1
DQIR01256580 Transcribed RNA Translation: HDC12058.1
DQIR01316952 Transcribed RNA Translation: HDC72426.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQIR01133547 Transcribed RNA Translation: HDA89023.1
DQIR01256580 Transcribed RNA Translation: HDC12058.1
DQIR01316952 Transcribed RNA Translation: HDC72426.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR021887, DUF3498
IPR001849, PH_domain
IPR039360, Ras_GTPase
IPR023152, RasGAP_CS
IPR001936, RasGAP_dom
IPR008936, Rho_GTPase_activation_prot
PANTHERiPTHR10194, PTHR10194, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF12004, DUF3498, 1 hit
PF00616, RasGAP, 2 hits
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00233, PH, 1 hit
SM00323, RasGAP, 1 hit
SUPFAMiSSF48350, SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50003, PH_DOMAIN, 1 hit
PS00509, RAS_GTPASE_ACTIV_1, 1 hit
PS50018, RAS_GTPASE_ACTIV_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A480MTD8_PIG
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A480MTD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: June 2, 2021
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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