TP53

Functionⁱ

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.UniRule annotation

Cofactorⁱ

Zn²⁺UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functionⁱ

ATP binding Source: Ensembl
chaperone binding Source: Ensembl
copper ion binding Source: Ensembl
core promoter sequence-specific DNA binding Source: Ensembl
disordered domain specific binding Source: Ensembl
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
histone acetyltransferase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
identical protein binding Source: Ensembl
mRNA 3'-UTR binding Source: Ensembl
p53 binding Source: Ensembl
promoter-specific chromatin binding Source: Ensembl
protease binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
protein self-association Source: Ensembl
receptor tyrosine kinase binding Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor binding Source: Ensembl
TFIID-class transcription factor complex binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy Source: Ensembl
bone marrow development Source: Ensembl
cell cycle arrest Source: Ensembl
cellular response to actinomycin D Source: Ensembl
cellular response to drug Source: Ensembl
cellular response to gamma radiation Source: Ensembl
cellular response to glucose starvation Source: Ensembl
cellular response to hypoxia Source: Ensembl
cellular response to UV Source: Ensembl
chromatin assembly Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Ensembl
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
DNA strand renaturation Source: Ensembl
ER overload response Source: Ensembl
hematopoietic stem cell differentiation Source: Ensembl
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
mRNA transcription Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of cell growth Source: Ensembl
negative regulation of fibroblast proliferation Source: Ensembl
negative regulation of pentose-phosphate shunt Source: Ensembl
negative regulation of telomerase activity Source: Ensembl
negative regulation of transcription, DNA-templated Source: Ensembl
nucleotide-excision repair Source: Ensembl
oligodendrocyte apoptotic process Source: Ensembl
oxidative stress-induced premature senescence Source: Ensembl
positive regulation of execution phase of apoptosis Source: Ensembl
positive regulation of intrinsic apoptotic signaling pathway Source: Ensembl
positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
positive regulation of production of miRNAs involved in gene silencing by miRNA Source: Ensembl
positive regulation of reactive oxygen species metabolic process Source: Ensembl
positive regulation of release of cytochrome c from mitochondria Source: Ensembl
positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: Ensembl
positive regulation of transcription from RNA polymerase II promoter in response to stress Source: Ensembl
protein localization Source: Ensembl
protein tetramerization Source: InterPro
Ras protein signal transduction Source: Ensembl
regulation of transcription from RNA polymerase II promoter in response to DNA damage Source: Ensembl
replicative senescence Source: Ensembl
rhythmic process Source: UniProtKB-KW
tumor necrosis factor-mediated signaling pathway Source: Ensembl
viral process Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	ActivatorUniRule annotationARBA annotation, DNA-bindingUniRule annotation, RepressorARBA annotation
Biological process	ApoptosisUniRule annotationARBA annotation, Biological rhythmsARBA annotation, Cell cycleUniRule annotationARBA annotation, NecrosisARBA annotation, Transcription, Transcription regulationUniRule annotation
Ligand	Metal-bindingUniRule annotationARBA annotation, ZincUniRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cellular tumor antigen p53UniRule annotationARBA annotation
Gene namesⁱ	Name:TP53Imported
Organismⁱ	Physeter macrocephalus (Sperm whale) (Physeter catodon)Imported
Taxonomic identifierⁱ	9755 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Artiodactyla › Whippomorpha › Cetacea › Odontoceti › Physeteridae › Physeter
Proteomesⁱ	UP000248484 Componentⁱ: Genome assembly

Keywords - Cellular componentⁱ

Cytoplasm, CytoskeletonARBA annotation, Endoplasmic reticulumARBA annotation, NucleusUniRule annotation

PTM / Processingⁱ

Keywords - PTMⁱ

Isopeptide bondARBA annotation

Interactionⁱ

Subunit structureⁱ

Binds DNA as a homotetramer.

UniRule annotation

GO - Molecular functionⁱ

chaperone binding Source: Ensembl
disordered domain specific binding Source: Ensembl
histone acetyltransferase binding Source: Ensembl
histone deacetylase binding Source: Ensembl
identical protein binding Source: Ensembl
p53 binding Source: Ensembl
protease binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
protein N-terminus binding Source: Ensembl
protein phosphatase 2A binding Source: Ensembl
protein self-association Source: Ensembl
receptor tyrosine kinase binding Source: Ensembl
RNA polymerase II transcription factor binding Source: Ensembl
TFIID-class transcription factor complex binding Source: Ensembl
ubiquitin protein ligase binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A455C1G1
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	7 – 30	P53_TADInterPro annotationAdd BLAST	24
Domainⁱ	93 – 282	P53InterPro annotationAdd BLAST	190
Domainⁱ	313 – 351	P53_tetramerInterPro annotationAdd BLAST	39

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	58 – 79	DisorderedSequence analysisAdd BLAST	22
Regionⁱ	277 – 320	DisorderedSequence analysisAdd BLAST	44
Regionⁱ	344 – 387	DisorderedSequence analysisAdd BLAST	44

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	63 – 79	Pro-richSequence analysisAdd BLAST		17
Compositional biasⁱ	344 – 362	PolyampholyteSequence analysisAdd BLAST		19

Sequence similaritiesⁱ

Belongs to the p53 family.UniRule annotationARBA annotation

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08367, P53, 1 hit
Gene3Dⁱ	2.60.40.720, 1 hit 4.10.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor
PANTHERⁱ	PTHR11447, PTHR11447, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF07710, P53_tetramer, 1 hit
PRINTSⁱ	PR00386, P53SUPPRESSR
SUPFAMⁱ	SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS00348, P53, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A455C1G1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEESQAELGV EPPLSQETFS DLWKLLPENN LLSSELSPAV DDLLLSPEDV 
        60         70         80         90        100
ANWLDERPDE APQMPESPAP AAPAPAAPAP ATSWPLSSFV PSQKTYPGSY 
       110        120        130        140        150
EFRLGFLHSG TAKSVTCTYS PALNKLFCQL AKTCPVQLWV SSPPPPGTRV 
       160        170        180        190        200
RAMAIYKKSE YMTEVVRRCP HHERCSDYSD GLAPPQHLIR VEGNLRAEYL 
       210        220        230        240        250
DDRNTFRHSV VVPYEPPEVG SDCTTIHYNF MCNSSCMGGM NRRPILTIIT 
       260        270        280        290        300
LEDSNGNLLG RNSFEVRVCA CPGRDRRTEE ENFRKKGQSC PEPPPGSAKR 
       310        320        330        340        350
ALPTSTSSSP PQKKKPLDGE YFTLQIRGRE RFEMFRELNE ALELKDAQAG 
       360        370        380 
KEPGESRAHS SHLKSKKGQS PSRHKKLMFK REGPDSD

Length:387

Mass (Da):43,114

Last modified:June 5, 2019 - v1

Checksum:ⁱ3F48B72E765CE1BD

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_007100699.1, XM_007100637.1 XP_028355209.1, XM_028499408.1

RefSeqⁱ

XP_007100699.1, XM_007100637.1
XP_028355209.1, XM_028499408.1

Genome annotation databases

Ensemblⁱ	ENSPCTT00005022239; ENSPCTP00005020186; ENSPCTG00005014301
KEGGⁱ	pcad:102985658

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A455C1G1	Cellular tumor antigen p53		SHEEP		382	UniRef90_P51664
Cellular tumor antigen p53		DELLE		387
Cellular tumor antigen p53 (Fragment)		HORSE		280
Cellular tumor antigen p53 (Fragment)		ESCRO		439
Cellular tumor antigen p53		TURTR		400
+34

Protein	Similar proteins		Species	Score	Length	Source
A0A455C1G1	Cellular tumor antigen p53	)	HUMAN		393	UniRef50_P04637
Cellular tumor antigen p53		MACFA		393
Cellular tumor antigen p53		MACFU		393
Cellular tumor antigen p53		MACMU		393
Cellular tumor antigen p53		CHLAE		393
+240

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_007100699.1, XM_007100637.1 XP_028355209.1, XM_028499408.1

RefSeqⁱ

XP_007100699.1, XM_007100637.1
XP_028355209.1, XM_028499408.1

3D structure databases

SMRⁱ	A0A455C1G1
ModBaseⁱ	Search...

Genome annotation databases

Ensemblⁱ	ENSPCTT00005022239; ENSPCTP00005020186; ENSPCTG00005014301
KEGGⁱ	pcad:102985658

Family and domain databases

CDDⁱ	cd08367, P53, 1 hit
Gene3Dⁱ	2.60.40.720, 1 hit 4.10.170.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR011615, p53_DNA-bd IPR036674, p53_tetramer_sf IPR010991, p53_tetrameristn IPR013872, p53_transactivation_domain IPR002117, p53_tumour_suppressor
PANTHERⁱ	PTHR11447, PTHR11447, 1 hit
Pfamⁱ	View protein in Pfam PF00870, P53, 1 hit PF08563, P53_TAD, 1 hit PF07710, P53_tetramer, 1 hit
PRINTSⁱ	PR00386, P53SUPPRESSR
SUPFAMⁱ	SSF47719, SSF47719, 1 hit SSF49417, SSF49417, 1 hit
PROSITEⁱ	View protein in PROSITE PS00348, P53, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A455C1G1_PHYMC
Accessionⁱ	A0A455C1G1Primary (citable) accession number: A0A455C1G1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 5, 2019
	Last sequence update:	June 5, 2019
	Last modified:	February 10, 2021
	This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A455C1G1 (A0A455C1G1_PHYMC)

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Cellular tumor antigen p53

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Cytoskeleton

Nucleus

Endoplasmic reticulum

Cytoskeleton

Cytosol

Endoplasmic reticulum

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ