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Entry version 8 (10 Feb 2021)
Sequence version 1 (05 Jun 2019)
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Protein
Submitted name:

AF4/FMR2 family member 1 isoform X1

Gene

AFF1

Organism
Physeter macrocephalus (Sperm whale) (Physeter catodon)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
AF4/FMR2 family member 1 isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPhyseter macrocephalus (Sperm whale) (Physeter catodon)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9755 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaWhippomorphaCetaceaOdontocetiPhyseteridaePhyseter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000248484 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini975 – 1198AF-4_CInterPro annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20
Regioni28 – 60DisorderedSequence analysisAdd BLAST33
Regioni80 – 343DisorderedSequence analysisAdd BLAST264
Regioni381 – 783DisorderedSequence analysisAdd BLAST403
Regioni795 – 984DisorderedSequence analysisAdd BLAST190
Regioni1119 – 1154DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 19PolarSequence analysisAdd BLAST19
Compositional biasi80 – 94PolyampholyteSequence analysisAdd BLAST15
Compositional biasi107 – 133PolarSequence analysisAdd BLAST27
Compositional biasi176 – 199PolyampholyteSequence analysisAdd BLAST24
Compositional biasi221 – 249PolarSequence analysisAdd BLAST29
Compositional biasi283 – 298Pro-richSequence analysisAdd BLAST16
Compositional biasi326 – 343PolyampholyteSequence analysisAdd BLAST18
Compositional biasi405 – 441PolarSequence analysisAdd BLAST37
Compositional biasi483 – 508PolarSequence analysisAdd BLAST26
Compositional biasi562 – 589PolyampholyteSequence analysisAdd BLAST28
Compositional biasi605 – 629PolarSequence analysisAdd BLAST25
Compositional biasi667 – 705PolyampholyteSequence analysisAdd BLAST39
Compositional biasi753 – 767PolyampholyteSequence analysisAdd BLAST15
Compositional biasi805 – 857PolyampholyteSequence analysisAdd BLAST53
Compositional biasi889 – 906PolarSequence analysisAdd BLAST18
Compositional biasi918 – 933PolarSequence analysisAdd BLAST16
Compositional biasi934 – 950PolyampholyteSequence analysisAdd BLAST17
Compositional biasi952 – 971PolarSequence analysisAdd BLAST20
Compositional biasi1137 – 1154PolarSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AF4 family.ARBA annotation

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int

The PANTHER Classification System

More...
PANTHERi
PTHR10528, PTHR10528, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

A0A455BG02-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFTERVNSS GNSSLYNEDR NLLRIREKER RNQEAHQEKE AFSEKIPLFG
60 70 80 90 100
EPYKTEKGDE LSSRIQNMLG NYEEVKEFLN TKSHPQRLDA SENRLGKPRY
110 120 130 140 150
PSFPEKGSSI PSHSFHTSVH HQPINTPASG PLPIGTISHN PKMAQPRMEP
160 170 180 190 200
MPSLHVKSYG PPDSQHMTQD RLGQEGYSSS HHKKGDRRAD GDHCASMTDS
210 220 230 240 250
APERELSPLF SLPSPVPPLS PVHSNQQTLP RTQGSNKVHS SNSNNKGYCP
260 270 280 290 300
AKSPKDLPVK VHDKETLQDS SVAVASLAVA PPQPPSQTFP PPPLPSKSLA
310 320 330 340 350
MQQKPTAYVR PMDGQDQAPS ESPELKPLPE DYRQQSFEKT DLKVPAKAKL
360 370 380 390 400
TKLKMPSQSV EQTYSSEVHC VEEILKEMTH SWPPPLTAIH TPSTAEPSKF
410 420 430 440 450
PFPAKDSQHI SSATLNQKQY DTSSKTHSNS QQGTSVSIPA CSSMLKDDLQ
460 470 480 490 500
LSDSEDSDSD QTPEKPPPAS APPSAPQALP AAAASAHSSS AESESTSDSD
510 520 530 540 550
SSSDSESESS SSDSEENEPR ETPAPEPEPP TTNKWQLDNW LTKVSQPAPP
560 570 580 590 600
AEAPGSAEPP ARHPDSKGKG GDGATGGHER SESKEPPPKS SSKAPRLPSE
610 620 630 640 650
GPHAGKRSSQ KSPAQQEPPQ RQTVGSKQPK KPVKASAPGH ADAHADARAS
660 670 680 690 700
LLVESEPGLP PQASKDQPSK DKPKVKTKGR PRAAESREPK PVAPTPSERK
710 720 730 740 750
KHRSGPPAPP KAPPKDAAGD RSPEHFALVP LTQSQGPARS GGARTSGCRL
760 770 780 790 800
AVVVQEDRRK DKPLVPLRDT KLLSPLRDTP LPQSLMVKIT LDLLSRIPQP
810 820 830 840 850
PGKGSRPKKP EDKQPSAAKK ADSEKRSSEN SSKLAKKRKG EAERDHDSKK
860 870 880 890 900
IRLEKEVKSQ SSPSSSHKES SKSKTPKPSS EPSKKEMLPP SLVSSSSASS
910 920 930 940 950
QKPAKPAQKR SRQEADPSGQ DPPKSASSTK GNHRDSSVSK HRKVEGKGSG
960 970 980 990 1000
SSAEHKGSSG DTANRFPVPS LPNGNSKPGK PHMKLDKQQA DFHMKEAKRL
1010 1020 1030 1040 1050
KDKAELVTDK VGKAFKYLEA ALSFIECGIA MELESPASKS ACSIYAETLD
1060 1070 1080 1090 1100
LIKFIMSLKS FSDATTPTQE KIFAVLCMRC QSILNMAMFR CKKDIAIKYS
1110 1120 1130 1140 1150
RTLNEHFFKT SSKVAQAPSP CIARSTGTPS PLSPMPSPAS SIGSQSSAGS
1160 1170 1180 1190 1200
VGSGGMPATI STPVTIQNMT SSYVTITSHV LTAFDLWEQA EVLTRKNKVG
1210 1220 1230 1240 1250
GLLPMSLQFL LLVSQVFEET PPPAGRTWYT RSQPRTLQAS QGSISHSTGV
1260 1270 1280 1290
NLYAKRCEYI KWMRSEAQKL GVTMMHLQGL SKSHSQPTRS
Length:1,290
Mass (Da):139,684
Last modified:June 5, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC1AF67D45F2FBBE8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2Y9S5R3A0A2Y9S5R3_PHYMC
AF4/FMR2 family member 1 isoform X6
AFF1
1,222Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455BFC8A0A455BFC8_PHYMC
AF4/FMR2 family member 1 isoform X4
AFF1
1,261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455BFV5A0A455BFV5_PHYMC
AF4/FMR2 family member 1 isoform X3
AFF1
1,261Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455BIF0A0A455BIF0_PHYMC
AF4/FMR2 family member 1 isoform X2
AFF1
1,289Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A455BV22A0A455BV22_PHYMC
AF4/FMR2 family member 1 isoform X5
AFF1
1,230Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_028347677.1, XM_028491876.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_028347677.1, XM_028491876.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

InterProiView protein in InterPro
IPR007797, AF4/FMR2
IPR043640, AF4/FMR2_CHD
IPR043639, AF4_int
PANTHERiPTHR10528, PTHR10528, 1 hit
PfamiView protein in Pfam
PF18876, AF-4_C, 1 hit
PF18875, AF4_int, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A455BG02_PHYMC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A455BG02
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 5, 2019
Last sequence update: June 5, 2019
Last modified: February 10, 2021
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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