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Entry version 9 (10 Feb 2021)
Sequence version 1 (08 May 2019)
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Capra hircus (Goat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCapra hircus (Goat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9925 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeCaprinaeCapra
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000291000 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 794ANK_REP_REGIONInterPro annotationAdd BLAST784
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati44 – 76ANKPROSITE-ProRule annotationAdd BLAST33
Repeati77 – 109ANKPROSITE-ProRule annotationAdd BLAST33
Repeati110 – 142ANKPROSITE-ProRule annotationAdd BLAST33
Repeati213 – 245ANKPROSITE-ProRule annotationAdd BLAST33
Repeati246 – 278ANKPROSITE-ProRule annotationAdd BLAST33
Repeati279 – 311ANKPROSITE-ProRule annotationAdd BLAST33
Repeati312 – 344ANKPROSITE-ProRule annotationAdd BLAST33
Repeati345 – 377ANKPROSITE-ProRule annotationAdd BLAST33
Repeati378 – 410ANKPROSITE-ProRule annotationAdd BLAST33
Repeati411 – 443ANKPROSITE-ProRule annotationAdd BLAST33
Repeati444 – 476ANKPROSITE-ProRule annotationAdd BLAST33
Repeati477 – 509ANKPROSITE-ProRule annotationAdd BLAST33
Repeati510 – 542ANKPROSITE-ProRule annotationAdd BLAST33
Repeati543 – 575ANKPROSITE-ProRule annotationAdd BLAST33
Repeati576 – 608ANKPROSITE-ProRule annotationAdd BLAST33
Repeati609 – 641ANKPROSITE-ProRule annotationAdd BLAST33
Repeati642 – 674ANKPROSITE-ProRule annotationAdd BLAST33
Repeati675 – 707ANKPROSITE-ProRule annotationAdd BLAST33
Repeati708 – 740ANKPROSITE-ProRule annotationAdd BLAST33
Repeati741 – 773ANKPROSITE-ProRule annotationAdd BLAST33
Domaini949 – 1104ZU5InterPro annotationAdd BLAST156
Domaini1106 – 1252ZU5InterPro annotationAdd BLAST147
Domaini3500 – 3584DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1516 – 1537DisorderedSequence analysisAdd BLAST22
Regioni1589 – 2070DisorderedSequence analysisAdd BLAST482
Regioni2128 – 2420DisorderedSequence analysisAdd BLAST293
Regioni2443 – 2699DisorderedSequence analysisAdd BLAST257
Regioni2712 – 2806DisorderedSequence analysisAdd BLAST95
Regioni2829 – 2892DisorderedSequence analysisAdd BLAST64
Regioni2928 – 2954DisorderedSequence analysisAdd BLAST27
Regioni3000 – 3038DisorderedSequence analysisAdd BLAST39
Regioni3067 – 3174DisorderedSequence analysisAdd BLAST108
Regioni3195 – 3393DisorderedSequence analysisAdd BLAST199
Regioni3619 – 3642DisorderedSequence analysisAdd BLAST24
Regioni3654 – 3767DisorderedSequence analysisAdd BLAST114
Regioni3832 – 3854DisorderedSequence analysisAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3409 – 3429Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1599 – 1632PolyampholyteSequence analysisAdd BLAST34
Compositional biasi1657 – 1684PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1711 – 1749PolyampholyteSequence analysisAdd BLAST39
Compositional biasi1760 – 1774PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1775 – 1840PolarSequence analysisAdd BLAST66
Compositional biasi1908 – 1922PolarSequence analysisAdd BLAST15
Compositional biasi1945 – 1978PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2009 – 2052PolyampholyteSequence analysisAdd BLAST44
Compositional biasi2189 – 2218PolyampholyteSequence analysisAdd BLAST30
Compositional biasi2294 – 2308PolarSequence analysisAdd BLAST15
Compositional biasi2456 – 2490PolarSequence analysisAdd BLAST35
Compositional biasi2499 – 2557PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2565 – 2580PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2628 – 2655PolarSequence analysisAdd BLAST28
Compositional biasi2656 – 2683PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2712 – 2732PolarSequence analysisAdd BLAST21
Compositional biasi2747 – 2764PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2770 – 2784PolarSequence analysisAdd BLAST15
Compositional biasi2829 – 2844PolarSequence analysisAdd BLAST16
Compositional biasi2860 – 2875PolarSequence analysisAdd BLAST16
Compositional biasi2929 – 2954PolarSequence analysisAdd BLAST26
Compositional biasi3003 – 3034PolarSequence analysisAdd BLAST32
Compositional biasi3128 – 3174PolarSequence analysisAdd BLAST47
Compositional biasi3225 – 3253PolarSequence analysisAdd BLAST29
Compositional biasi3316 – 3346PolyampholyteSequence analysisAdd BLAST31
Compositional biasi3373 – 3389PolarSequence analysisAdd BLAST17
Compositional biasi3668 – 3682PolarSequence analysisAdd BLAST15
Compositional biasi3696 – 3718PolarSequence analysisAdd BLAST23
Compositional biasi3835 – 3851PolarSequence analysisAdd BLAST17

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155279

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLCSITX

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A452F4Q6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VVALFCFSQS DSNASFLRAA RAGNLDKVVE YLKGGIDINT CNQNGLNALH
60 70 80 90 100
LAAKEGHVGL VQELLGRGSA VDSATKKGNT ALHIASLAGQ AEVVKVLVKE
110 120 130 140 150
GANINAQSQN GFTPLYMAAQ ENHIDVVKYL LENGANQSTA TEDGFTPLAV
160 170 180 190 200
ALQQGHNQAV AILLENDTKG KVRLPALHIA ARKDDTKSAA LLLQNDHNAD
210 220 230 240 250
VQSKMMVNRT TESGFTPLHI AAHYGNVNVA TLLLNRGAAV DFTARNGITP
260 270 280 290 300
LHVASKRGNT NMVKLLLDRG GQIDAKTRDG LTPLHCAARS GHDQVVELLL
310 320 330 340 350
ERGAPLLART KNGLSPLHMA AQGDHVECVK HLLQHKAPVD DVTLDYLTAL
360 370 380 390 400
HVAAHCGHYR VTKLLLDKRA NPNARALNGF TPLHIACKKN RIKVMELLVK
410 420 430 440 450
YGASIQAITE SGLTPIHVAA FMGHLNIVLL LLQNGASPDV TNIRGETALH
460 470 480 490 500
MAARAGQVEV VRCLLRNGAL VDARAREEQT PLHIASRLGK TEIVQLLLQH
510 520 530 540 550
MAHPDAATTN GYTPLHISAR EGQVDVASVL LEAGAAHSLA TKKGFTPLHV
560 570 580 590 600
AAKYGSLDVA KLLLQRRAAA DSAGKNGLTP LHVAAHYDNQ KVALLLLEKG
610 620 630 640 650
ASPHATAKNG YTPLHIAAKK NQMQIASTLL SYGAETNIVT KQGVTPLHLA
660 670 680 690 700
SQEGHTDMVT LLLDKGANIH MSTKSGLTSL HLAAQEDKVN VADILTKHGA
710 720 730 740 750
DQDAHTKLGY TPLIVACHYG NVKMVNFLLK QGANVNAKTK NGYTPLHQAA
760 770 780 790 800
QQGHTHIINV LLQHGAKPNA TTANGNTALA IAKRLGYISV VDTLKVVTEE
810 820 830 840 850
VTTTTTTITE KHKLNVPETM TEVLDVSDEE GDDTMTGDGG EYLRPEDLKE
860 870 880 890 900
LGDDSLPSSQ FLDGMNYLRY SLEGGRSDSL RSFSSDRSHT LSHASYLRDS
910 920 930 940 950
AMIDDTVVIP SHQVTTLAKE AERNSYRLSW GTENLDNVAL SSSPIHSGFL
960 970 980 990 1000
VSFMVDARGG AMRGCRHNGL RIIIPPRKCT APTRVTCRLV KRHRLATMPP
1010 1020 1030 1040 1050
MVEGEGLASR LIEVGPSGAQ FLGPVIVEIP HFAALRGKER ELVVLRSENG
1060 1070 1080 1090 1100
DSWKEHYCEY TEEELNEILN GMDEVLDTPE DLEKKRVCRI ITRDFPQYFA
1110 1120 1130 1140 1150
VVSRIKQDSN LIGPEGGVLS STVVPQVQAV FPEGALTKRI RVGLQAQPMH
1160 1170 1180 1190 1200
SELVKKILGN KATFSPIVTL EPRRRKFHKP ITMTIPVPKA SSDVMLNGFG
1210 1220 1230 1240 1250
GDAPTLRLLC SITGGTTPAQ WEDITGTTPL TFVNECVSFT TNVSARFWLI
1260 1270 1280 1290 1300
DCRQIQESVT FASQVYREII CVPYMAKFVV FAKSHDPIEA RLRCFCMTDD
1310 1320 1330 1340 1350
KVDKTLEQQE NFAEVARSRD VEVLEGKPIY VDCFGNLVPL TKSGQHHIFS
1360 1370 1380 1390 1400
FFAFKENRLP LFVKVRDTTQ EPCGRLSFMK EPKSTRGLVH QAICNLNITL
1410 1420 1430 1440 1450
PIYTKESESD QEQEEEVIIW PCHDETESTE TSVLKSHLVN EVPVLASPDL
1460 1470 1480 1490 1500
LSEVSEMKQD LIKMTAILTT DGSDRAGSIK VKELVKAAEE EPGEPFEIVE
1510 1520 1530 1540 1550
RVKEDLEKVN EILRSGTCTG DEGSVPRSQP EKELEEEEWV IVSEEEIEEA
1560 1570 1580 1590 1600
KQKASSEITE YPCIEIRLDK ETKAEVEKDS TGLVNYLTED LNSYVPPHEE
1610 1620 1630 1640 1650
QPQKERGMVG EKREAQGPSR RSESEGKDAP SEETQSTQKQ PKPSLGIKKP
1660 1670 1680 1690 1700
VRRKLKEKQK QKEDSSQASA EKTELKKGSS EESLDEDTGS APEPLPAVKA
1710 1720 1730 1740 1750
TSPLIEETPI GSIKDKVKAL QKRVEDEQKG RSKLPVRVKG KEDVPKKITQ
1760 1770 1780 1790 1800
RTHLAASPSL KSERTERHTS LSSSAKTERH PPVSPSSKNE KHSPVSPSAK
1810 1820 1830 1840 1850
TERHSPVSSS SKTEKHSPVS PSTKTERHSP VSSSAKTERH PPVSPSGKTD
1860 1870 1880 1890 1900
KRPPGSPSGR TEKHPPVSPG RTEKRLLVSP AGRMEKHSPA SSSGKTEKHL
1910 1920 1930 1940 1950
PVSPSGKTDK QPPVSPTSKT ERIEETMSVR ELMKAFQSGQ DPSKHKTGLF
1960 1970 1980 1990 2000
EHKSAKQKQP QEKGRGRLEK ERGPIVTPRE VQKMESQTIK RGQRFLVTGL
2010 2020 2030 2040 2050
SEPRRAVRAS STGLKREDGA GEKEKSLNHK TPEPVQPVPE EESHKDSELA
2060 2070 2080 2090 2100
DDQGDMDLQI SPDRKTSTDF SDVIKQELED NDKYQQFRMT EEPEKAQLHL
2110 2120 2130 2140 2150
DQVLTSPFNT TFPLDYMKDE FLPALSLQSG TLPGSSESLK PEGVADSPCG
2160 2170 2180 2190 2200
SLMEGTPQIS SEESYKHEGL AETPETSPES LSFSPKKSEE QIGETHETTK
2210 2220 2230 2240 2250
LETAPESHSE KGHPSTKDVA DGSEGQGAAV TEAAESSAEC QLTEATPDPS
2260 2270 2280 2290 2300
KDMCPPQEGD SLGGQSVSLA KETPEGPTEE ATCDEGPVAH ISPSHEPQTD
2310 2320 2330 2340 2350
TEAQESIATK PSEEAEASPL SEAAVKAGSG TEPKPQAAIR SPQGLELALP
2360 2370 2380 2390 2400
SRESEVFSPG ADESFAVSHK DSLEASPVLE DNSSHKTPDS LEPSPLKESP
2410 2420 2430 2440 2450
CRDSLESSPV EPKMKAGILP SHFPLPSAVA KTELFTEVAS VRSRLLRDPD
2460 2470 2480 2490 2500
GSAEDDSLEQ TSLMESSGKS PLSPDTPSSE EVSYEVTPKT TDTPKPAVIP
2510 2520 2530 2540 2550
ECAEEDDSEN GEKKRFTPEE EMFKMVTKVK TFDELEQEAK QKRDYKREPK
2560 2570 2580 2590 2600
QEESSSSSDA DVDCSADTDE PKHTESVEDE SDAPVVVTAE GRKASSSSES
2610 2620 2630 2640 2650
EPELTQLKKG ADSGLLAEPV IRVQPPSPLP SSIDSNSSPE EIQFQPIVSK
2660 2670 2680 2690 2700
QYTFKMNEDA QEDSDKSEEE KDYKSRLPED SHALPIDGPE ISYDDLNGDT
2710 2720 2730 2740 2750
YQPKLCDSLG CEIGSPTNSA APVSSGLRSS PGDDVSEQLV IHKESLALQD
2760 2770 2780 2790 2800
TSEKDLEEEL DVPGVKSPQA DPPSESSPSF SSLPLCPASE AKELDEDVVS
2810 2820 2830 2840 2850
TASATEMEVA KTDQAFESLP EDCSIQDSLI TTQTDRSSLD VPVSDPTETD
2860 2870 2880 2890 2900
EIYEPQVISP YENVPSQSFF SGEESKTQTD TRHTSFHSSE EYSVTITSSV
2910 2920 2930 2940 2950
EDVVETSSSD KTVSSKEANF EDQVLEVESK QESTLQEVQS DGASSSLETT
2960 2970 2980 2990 3000
VQKTSTVVSE QISKVIITKT DVDSDSWSEI REDDEAFEAR VKEEEQKIFG
3010 3020 3030 3040 3050
LMVDRQSQGT TPDTTPARTP TEEGTPTSEQ NPFLFQEGKL FEMTRSGAID
3060 3070 3080 3090 3100
MTKRSYADES FHFFQIGQES REETLSQDMK EGGTGAEAPQ VETSAESLTL
3110 3120 3130 3140 3150
SESKETVDDE AELLPDDLSE EVEEIHTSDT PLSSQIDISA SIETSMKEAT
3160 3170 3180 3190 3200
STGLEDLPTR QMGDSLPLSS VKQTTCPDFP EQVVQVQLDF STVTRSIYSD
3210 3220 3230 3240 3250
RGDDSPDSSP EEQKSVIEIP TAPMENVPST ESKSKIPVRT IPTSTSIPPS
3260 3270 3280 3290 3300
VEYESSLSED FLPGLDEESK EDEAKPKSKI PVKAPAQRVE QQPSHLDSPL
3310 3320 3330 3340 3350
KKTDGPQGQD LTSSAPDDRS KSESDASLGM KTKCRVETRS YIETETESMG
3360 3370 3380 3390 3400
EEEELELESE EGATRPKIFT SRLPVKSKST TSSCRGPTSP TKDNKEHFFD
3410 3420 3430 3440 3450
LYRNSIEFFE EISDEASKLV DRLTQSEREQ DLVSDDESSS ALEVSVIENL
3460 3470 3480 3490 3500
PPVETENSIP EDIFDTRPIW DESIETLIER IPDENGHDRA EDQQDEQERI
3510 3520 3530 3540 3550
EERLAYIADH LGFSWTELAR ELDFTEEQIH QIRIENPNSL QDQSHALLKY
3560 3570 3580 3590 3600
WLERDGKHAT DTSLIECLTK INRMDIVHLM ETSTESLQER IGHSYAEIEQ
3610 3620 3630 3640 3650
TITLDHSEGF SVLQEELCTA QHKQKEEHAA SKEDEASDHP PIVSEEDISV
3660 3670 3680 3690 3700
GYSTFQDGIP KSEGDGSATE LLPQTQKEQV QRDFSGKMQD LPEDVTTPGT
3710 3720 3730 3740 3750
EMSETQKATG TSGSPAKTPE EIVTPPEEER LYLQTPTSSE RGGSPVVQEP
3760 3770 3780 3790 3800
EEPPESREES SPRKTSLVIV ESAEDQPQAF EKLDEDAAFQ KGDDMPDIPP
3810 3820 3830 3840 3850
ETVTEEEYID EHGHTVVKKV TRKIIRRFIS SDGTEKEEIT MQGTPQDSVS
3860 3870
VEEGDGYSKV IKRIVLKSDT EQSEVSP
Length:3,877
Mass (Da):424,695
Last modified:May 8, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DB7A75F973E69DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A452F4F3A0A452F4F3_CAPHI
Uncharacterized protein
ANK2
3,933Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LWLT01000006 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCHIT00000026957; ENSCHIP00000019141; ENSCHIG00000018205

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWLT01000006 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Genome annotation databases

EnsembliENSCHIT00000026957; ENSCHIP00000019141; ENSCHIG00000018205

Phylogenomic databases

GeneTreeiENSGT00940000155279
OMAiLLCSITX

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 23 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 20 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A452F4Q6_CAPHI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A452F4Q6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 8, 2019
Last sequence update: May 8, 2019
Last modified: February 10, 2021
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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