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Entry version 6 (16 Oct 2019)
Sequence version 1 (08 May 2019)
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Protein

ANK_REP_REGION domain-containing protein

Gene

CTTNBP2

Organism
Capra hircus (Goat)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ANK_REP_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTTNBP2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCapra hircus (Goat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9925 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000291000 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini702 – 927ANK_REP_REGIONInterPro annotationAdd BLAST226
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati736 – 768ANKPROSITE-ProRule annotationAdd BLAST33
Repeati769 – 801ANKPROSITE-ProRule annotationAdd BLAST33
Repeati802 – 834ANKPROSITE-ProRule annotationAdd BLAST33
Repeati835 – 860ANKPROSITE-ProRule annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 27DisorderedSequence analysisAdd BLAST27
Regioni201 – 222DisorderedSequence analysisAdd BLAST22
Regioni362 – 433DisorderedSequence analysisAdd BLAST72
Regioni446 – 471DisorderedSequence analysisAdd BLAST26
Regioni491 – 589DisorderedSequence analysisAdd BLAST99
Regioni1442 – 1468DisorderedSequence analysisAdd BLAST27
Regioni1544 – 1641DisorderedSequence analysisAdd BLAST98

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili122 – 166Sequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi383 – 408PolarSequence analysisAdd BLAST26
Compositional biasi496 – 510Pro-richSequence analysisAdd BLAST15
Compositional biasi532 – 550Pro-richSequence analysisAdd BLAST19
Compositional biasi560 – 589PolarSequence analysisAdd BLAST30
Compositional biasi1452 – 1468PolarSequence analysisAdd BLAST17
Compositional biasi1550 – 1593PolarSequence analysisAdd BLAST44
Compositional biasi1605 – 1641PolarSequence analysisAdd BLAST37

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158293

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00248 ANK, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48403 SSF48403, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A452EPC3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATDGASCEP DFSRAPEDAA GAPAEAAKKE FDVDTLSKSE LRMLLSVMEG
60 70 80 90 100
ELEARDLVIE ALRARRKEVF IQERYGRFNL NDPFLALQRD YEAGASDKEK
110 120 130 140 150
KPVCTNPLSI LEAVMAHCRK MQERMSTQLA AAESRQKKLE MEKLQLQALE
160 170 180 190 200
QEHKKLAARL EEERGKNKHV VLMLVKECKQ LSGKVLEEAQ KLEEVMAKLE
210 220 230 240 250
EEKKKTSALE EELATEKQRS TEMEAQMEKQ LSEFDTEREQ LRAKLHREEA
260 270 280 290 300
HTTDLKEEID KMKKMIEQLK RGNDSKPSLS LPRKTKDRRL VSVSVATEGP
310 320 330 340 350
VTRSVACQTD LVTETAEPLK KLPLTVPVKP AAGSPLVSAS AKGNACASAA
360 370 380 390 400
SVRPGIERQV SHGDLIGSSL PTVPPPSADR IEENGPSTGS TPDLTSSPTP
410 420 430 440 450
LPSTVSPASG HTPTPPPHSL HSPCANAPLH PGLNPRIQAA RFRFQGSNAN
460 470 480 490 500
DPDQNGNTTQ SPPSRDVSPT SRDNLVAKQL ARNTVTQALS RFTSPPAGAP
510 520 530 540 550
PRPGAPPTGD VGTYPPVGRT SLKTPGGARV DRGNPPPIPP KKPGLSQTPS
560 570 580 590 600
PPHPQLKVIM DSSRASSTGI KADNKTVASP PSSLPQGNRV INEENLSKSS
610 620 630 640 650
SPQLPPKPSI DLTVAPAGCA VSALATSQVG AWPAETPGLN QPACPESSLV
660 670 680 690 700
IPTTTAFRSS INPVSASSRR AGASDSLLVT ASGWSPSLTP LLMSGGPAPL
710 720 730 740 750
AGRPTLLQQA AAQGNVTLLS MLLNEEGLDI NYSCEDGHSA LYSAAKNGHT
760 770 780 790 800
DCVRLLLNAE AQVNAADKNG FTPLCAAAAQ GHFKCVELLI AYDANVNHAA
810 820 830 840 850
DGGQTPLYLA CKNGNEECIK LLLEAGTDRS VKTRDGWTPI HAAVDTGNVD
860 870 880 890 900
SLKLLMYHGA PAHGNKLQEE PGLAIFDLDQ EEHHEGTSKP VVPADLINHA
910 920 930 940 950
DSEGWTAAHI AASKGFKNCL EVLCRHGGLE PERRDKCNRT AHDVATDDCK
960 970 980 990 1000
HLLENLNALK IPLRISVGEI EPGNYGADDF ECENTICALN IRKQTSWDDF
1010 1020 1030 1040 1050
SKAVSQALTN HFQAISSDGW WSLEDMTFNS TTDSSIGLSA SSVRSITLGS
1060 1070 1080 1090 1100
VPWSAGQSFT QSPWDFMRTN KAEQVTVLLS GPQEGCLSSV TYASMIPLQM
1110 1120 1130 1140 1150
LQNYLRLVEQ YHNVIFHGPE GSLQDYIAHQ LALCLKHRQM AAGFPCEIVR
1160 1170 1180 1190 1200
AEVDADFSKE QLVDLFISSA CLIPVKQSPA NKKIIVILEN LEKSSLSELL
1210 1220 1230 1240 1250
GDFLGPLENH STESPCTFQK GNGMSECYYF HENCFLMGTI AKACLQGSDL
1260 1270 1280 1290 1300
LVQQHFRWVQ LRWDSEPMQG LLQRFLRRKV VNKFRGQVPS PCDPVCKTVD
1310 1320 1330 1340 1350
WALAVWRQLN SCLARLGTPE ALLGPKYFLS CPVIPGHAQA TVKWMSKLWN
1360 1370 1380 1390 1400
AVIAPRVQEA ILSRASVKRQ PGLGQTTKNP SQGQQAVVRA ALSILLNKAV
1410 1420 1430 1440 1450
LHGCPLQRAE LDQHTADFKG GSFPLSIVSS YSSCSKKRES GAWRKVSTSP
1460 1470 1480 1490 1500
RKKSGRFSSP TWNKPDLSEE GIKSNTILQL NCNRNASLSN QKSLENDLSL
1510 1520 1530 1540 1550
TLNLDQRLSL GSDDEADLVK ELQSMCSSKS ESDISKIADS RDDLRRFDSS
1560 1570 1580 1590 1600
GNNPVFSATV NNPRMPVSQK EVSPLSSHQM TERSNSKSKT ELGVSRVKSF
1610 1620 1630 1640
LPVPRSKVTQ CSQNTKRSSS SSNTRQIEIN NNSRDLEPTQ K
Length:1,641
Mass (Da):178,204
Last modified:May 8, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD39777A41432C33
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A452EPR6A0A452EPR6_CAPHI
ANK_REP_REGION domain-containing pr...
CTTNBP2
1,605Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A452ENM2A0A452ENM2_CAPHI
ANK_REP_REGION domain-containing pr...
CTTNBP2
1,607Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A452ENR3A0A452ENR3_CAPHI
ANK_REP_REGION domain-containing pr...
CTTNBP2
1,632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LWLT01000003 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_017902683.1, XM_018047194.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSCHIT00000021523; ENSCHIP00000013730; ENSCHIG00000014972

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102175739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
chx:102175739

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWLT01000003 Genomic DNA No translation available.
RefSeqiXP_017902683.1, XM_018047194.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSCHIT00000021523; ENSCHIP00000013730; ENSCHIG00000014972
GeneIDi102175739
KEGGichx:102175739

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
83992

Phylogenomic databases

GeneTreeiENSGT00940000158293

Family and domain databases

Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR019131 Cortactin-binding_p2_N
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF09727 CortBP2, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A452EPC3_CAPHI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A452EPC3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 8, 2019
Last sequence update: May 8, 2019
Last modified: October 16, 2019
This is version 6 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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