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Entry version 2 (05 Jun 2019)
Sequence version 1 (08 May 2019)
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Protein
Submitted name:

Disintegrin and metalloproteinase domain-containing protein B

Gene

AAWM_06517

Organism
Aspergillus awamori (Black koji mold)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Disintegrin and metalloproteinase domain-containing protein BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AAWM_06517Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAspergillus awamori (Black koji mold)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri105351 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286921 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei700 – 721HelicalSequence analysisAdd BLAST22

    Keywords - Cellular componenti

    Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501917080325 – 791Sequence analysisAdd BLAST767

    Keywords - PTMi

    Disulfide bondSAAS annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini275 – 487Peptidase M12BInterPro annotationAdd BLAST213
    Domaini512 – 601DisintegrinInterPro annotationAdd BLAST90

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni735 – 791DisorderedSequence analysisAdd BLAST57

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi735 – 756Pro-richSequence analysisAdd BLAST22
    Compositional biasi764 – 783Pro-richSequence analysisAdd BLAST20

    Keywords - Domaini

    SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04271 ZnMc_ADAM_fungal, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.390.10, 1 hit
    4.10.70.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR041645 ADAM_CR_2
    IPR006586 ADAM_Cys-rich
    IPR001762 Disintegrin_dom
    IPR036436 Disintegrin_dom_sf
    IPR024079 MetalloPept_cat_dom_sf
    IPR001590 Peptidase_M12B
    IPR034028 ZnMc_ADAM_fungal

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF17771 ADAM_CR_2, 1 hit
    PF00200 Disintegrin, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00608 ACR, 1 hit
    SM00050 DISIN, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF57552 SSF57552, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50215 ADAM_MEPRO, 1 hit
    PS50214 DISINTEGRIN_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    A0A401KWJ9-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRFLTYSLPF IASAISLFGV NVQARSQAPS AIRHVSTLDQ PTIKTPSQRV
    60 70 80 90 100
    DHLDHFDITF NIHDKHQRIK LELEPNHDIL AEDASVQYLD ADGNVRRHEP
    110 120 130 140 150
    IARHEHKVFK GRSLLGRGKG MWDPVGWARI YLKQDGSEPL FEGVFSIDGD
    160 170 180 190 200
    NHHVQLKSAY MEKKRPVDVD LPDSATDYMI FYRDSDMVRL HTELKRSSLG
    210 220 230 240 250
    STSCQADQLG FNTNPNHPVL QPYGQAETDT WGAISLNSLF GLNKRQSDIG
    260 270 280 290 300
    SVSGNAGGVN LASTIGDTSG CPSTKQVALI GVATDCAFTG SFNNETAAKE
    310 320 330 340 350
    WVISTVNSAS NVYEKSFNIT IGLRNLTITD SSCPDNPPAA TAWNMPCSSG
    360 370 380 390 400
    NLTSRLDLFS KWRGEQSDDN AYWTLMSDCA TGNEVGLSWL GQLCNSDASS
    410 420 430 440 450
    DGSSTVSGTN VVVRSSGSDW QIFAHESGHT FGAVHDCDSQ TCAEDLEASS
    460 470 480 490 500
    QCCPLTSSTC NANGKYIMNP TTGTDITAFS QCTIGNICAA LGRNSVKSSC
    510 520 530 540 550
    LSANRDVTTY TGSQCGNGIV ESGEDCDCGG EDGCGDNNCC DAKTCKFKSG
    560 570 580 590 600
    AVCDDSNDSC CSSCQFSSAG TVCRASRGDC DVAETCSGNS STCPTDSFKK
    610 620 630 640 650
    DGTSCGSSGS GLACASGQCT SRDYQCRSVM GSLLHSNDTY ACSSFSSSCE
    660 670 680 690 700
    LVCTSPKIGT CYSVNQNFLD GTPCGSGGYC SNGDCKGQNV ESWIKNHKGI
    710 720 730 740 750
    VIGVACAVGA LILLALMTCI VNRCRRARAP KPVPRPVPYG PWPGARPPPP
    760 770 780 790
    PPMNQWPARG YQGLGNEPPP PYPGVPGQPV PQHMPPQGRY A
    Length:791
    Mass (Da):84,369
    Last modified:May 8, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i51A59768B747CE66
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BDHI01000015 Genomic DNA Translation: GCB23632.1

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BDHI01000015 Genomic DNA Translation: GCB23632.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Family and domain databases

    CDDicd04271 ZnMc_ADAM_fungal, 1 hit
    Gene3Di3.40.390.10, 1 hit
    4.10.70.10, 1 hit
    InterProiView protein in InterPro
    IPR041645 ADAM_CR_2
    IPR006586 ADAM_Cys-rich
    IPR001762 Disintegrin_dom
    IPR036436 Disintegrin_dom_sf
    IPR024079 MetalloPept_cat_dom_sf
    IPR001590 Peptidase_M12B
    IPR034028 ZnMc_ADAM_fungal
    PfamiView protein in Pfam
    PF17771 ADAM_CR_2, 1 hit
    PF00200 Disintegrin, 1 hit
    SMARTiView protein in SMART
    SM00608 ACR, 1 hit
    SM00050 DISIN, 1 hit
    SUPFAMiSSF57552 SSF57552, 1 hit
    PROSITEiView protein in PROSITE
    PS50215 ADAM_MEPRO, 1 hit
    PS50214 DISINTEGRIN_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A401KWJ9_ASPAW
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A401KWJ9
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 8, 2019
    Last sequence update: May 8, 2019
    Last modified: June 5, 2019
    This is version 2 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported
    UniProt is an ELIXIR core data resource
    Main funding by: National Institutes of Health

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