UniProtKB - A0A3S1BA26 (A0A3S1BA26_ELYCH)
Protein
Elongator complex protein 3
Gene
EGW08_012919
Organism
Elysia chlorotica (Eastern emerald elysia) (Sea slug)
Status
Functioni
Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation.UniRule annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Catalytic activityi
- acetyl-CoA + H2O + S-adenosyl-L-methionine + uridine34 in tRNA = 5'-deoxyadenosine + carboxymethyluridine34 in tRNA + CoA + 2 H+ + L-methionineUniRule annotation
Cofactori
[4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation
: 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis Pathwayi
This protein is involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis, which is part of tRNA modification.ARBA annotationView all proteins of this organism that are known to be involved in the pathway 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis and in tRNA modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 102 | Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation | 1 | |
Metal bindingi | 112 | Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation | 1 | |
Metal bindingi | 115 | Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation | 1 |
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- N-acetyltransferase activity Source: InterPro
- tRNA binding Source: UniProtKB-KW
GO - Biological processi
- tRNA processing Source: UniProtKB-KW
Keywordsi
Molecular function | AcyltransferaseUniRule annotationARBA annotation, RNA-binding, Transferase, tRNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotation, tRNA processingARBA annotation |
Ligand | 4Fe-4SARBA annotation, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation |
Enzyme and pathway databases
UniPathwayi | UPA00988 |
Names & Taxonomyi
Protein namesi | Recommended name: Elongator complex protein 3UniRule annotationARBA annotation (EC:2.3.1.-UniRule annotation) |
Gene namesi | ORF Names:EGW08_012919Imported |
Organismi | Elysia chlorotica (Eastern emerald elysia) (Sea slug)Imported |
Taxonomic identifieri | 188477 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Heterobranchia › Euthyneura › Panpulmonata › Sacoglossa › Placobranchoidea › Plakobranchidae › Elysia |
Proteomesi |
|
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 399 – 550 | N-acetyltransferaseInterPro annotationAdd BLAST | 152 |
Sequence similaritiesi
Family and domain databases
Gene3Di | 3.80.30.20, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR039661, ELP3 IPR034687, ELP3-like IPR006638, Elp3/MiaB/NifB IPR000182, GNAT_dom IPR032432, Radical_SAM_C IPR007197, rSAM IPR023404, rSAM_horseshoe |
PANTHERi | PTHR11135, PTHR11135, 1 hit PTHR11135:SF7, PTHR11135:SF7, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit PF04055, Radical_SAM, 1 hit PF16199, Radical_SAM_C, 1 hit |
PIRSFi | PIRSF005669, Hist_AcTrfase_ELP3, 1 hit |
SFLDi | SFLDF00344, ELP3-like, 1 hit SFLDS00029, Radical_SAM, 1 hit |
SMARTi | View protein in SMART SM00729, Elp3, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR01211, ELP3, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A3S1BA26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKNKKKVVN DLSKEEIMVM AVAEIVSELV KAVRENKDVD LNKLKTKIAS
60 70 80 90 100
RYNMSSQPRL VDIIAAVPQE YKKMLLPKLK AKPVRTASGI AVVAVMCKPH
110 120 130 140 150
RCPHIAMTGN ICVYCPGGPD SDFEYSTQSY TGYEPTSMRA IRARYNPYLQ
160 170 180 190 200
TRHRVEQLQQ LGHSVDKVEF IVMGGTFMSL PDDYRDYFIR NLHDALSGHT
210 220 230 240 250
SSNVQEAVKY SERSTTKCIG ITIETRPDYC LKKHLSDMLK YGCTRLEIGV
260 270 280 290 300
QSVYEDVARD TNRGHTVKAV CESFQMSKDA GFKVVSHMMP DLPNVGWERD
310 320 330 340 350
IEQFIEFFEN PAFRADGLKI YPTLVIRGTG LYELWKTGRY KSYPPSQLVD
360 370 380 390 400
LIARILALVP PWTRVYRVQR DIPMPLVTSG VEHGNLRELA LARMADLGTQ
410 420 430 440 450
CRDVRTREVG IQEIHHKVKP DQAELIRRDY VANGGWETFL SYEDPEQDIL
460 470 480 490 500
IGLLRLRKCS ADTFRAELRG GCSIVRELHV YGSVVPVHAR DPRKFQHQGF
510 520 530 540 550
GILLMEEAAR IAKEEHGAKK IAVISGVGTR NYYRKLGYEL EGPYMVKGLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | RQTK01000459 Genomic DNA Translation: RUS79301.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | RQTK01000459 Genomic DNA Translation: RUS79301.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Enzyme and pathway databases
UniPathwayi | UPA00988 |
Family and domain databases
Gene3Di | 3.80.30.20, 1 hit |
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR039661, ELP3 IPR034687, ELP3-like IPR006638, Elp3/MiaB/NifB IPR000182, GNAT_dom IPR032432, Radical_SAM_C IPR007197, rSAM IPR023404, rSAM_horseshoe |
PANTHERi | PTHR11135, PTHR11135, 1 hit PTHR11135:SF7, PTHR11135:SF7, 1 hit |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit PF04055, Radical_SAM, 1 hit PF16199, Radical_SAM_C, 1 hit |
PIRSFi | PIRSF005669, Hist_AcTrfase_ELP3, 1 hit |
SFLDi | SFLDF00344, ELP3-like, 1 hit SFLDS00029, Radical_SAM, 1 hit |
SMARTi | View protein in SMART SM00729, Elp3, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
TIGRFAMsi | TIGR01211, ELP3, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3S1BA26_ELYCH | |
Accessioni | A0A3S1BA26Primary (citable) accession number: A0A3S1BA26 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 10, 2019 |
Last sequence update: | April 10, 2019 | |
Last modified: | February 10, 2021 | |
This is version 11 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |