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Entry version 5 (11 Dec 2019)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

GRB10-interacting GYF protein 1 isoform X2

Gene

GIGYF1

Organism
Ursus arctos horribilis
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GRB10-interacting GYF protein 1 isoform X2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GIGYF1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUrsus arctos horribilisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri116960 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeUrsus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286642 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini477 – 525GYFInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni104 – 425DisorderedSequence analysisAdd BLAST322
Regioni642 – 662DisorderedSequence analysisAdd BLAST21
Regioni692 – 722DisorderedSequence analysisAdd BLAST31
Regioni782 – 880DisorderedSequence analysisAdd BLAST99

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili428 – 448Sequence analysisAdd BLAST21
Coiled coili954 – 974Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi143 – 229PolyampholyteSequence analysisAdd BLAST87
Compositional biasi238 – 290PolyampholyteSequence analysisAdd BLAST53
Compositional biasi291 – 305AcidicSequence analysisAdd BLAST15
Compositional biasi328 – 346AcidicSequence analysisAdd BLAST19
Compositional biasi643 – 662PolarSequence analysisAdd BLAST20
Compositional biasi851 – 868PolarSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00072 GYF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.1490.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02213 GYF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00444 GYF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55277 SSF55277, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50829 GYF, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q7XBV5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAETLNFGP EWLRALSSGG SVASPPPSPA MPKYKLADYR YGREEMLALY
60 70 80 90 100
VKENKVPDEL QDKEFAAVLQ EEPLQPLALE PLTEEEQRNF SLSVNSVAVL
110 120 130 140 150
RLMGKGAGPP LSGTSRGRGS TRSRGRGRGD SCFYQRSIEE GDGAFGRNPR
160 170 180 190 200
EIQRSQSWDD RGERRFEKSA RRDGARSGFE EGGAGPRKEH ARSDSENWRS
210 220 230 240 250
LREEQEEEEE GSWRLGAGPR RDGDRWRSAS PDGGPRSAGW REHGDRRRKF
260 270 280 290 300
EFDLRGDRGG CSEEEGRGGG GSSHLRRCRG PDGFEEDKDG LPEWCLDDED
310 320 330 340 350
EEMGTFDASG AFLPLKKGPK EPIPEEQELD FQGLEEEEEE PSEGLEEGGP
360 370 380 390 400
EAGGKELTPL PPQEEKSSSP SPLPTLGPLW GANGEGDDTA DKDLPAAAAE
410 420 430 440 450
DDGRGMPLSP GVGSPSGPPG DLEDDEGLKH LQQEAEKLVA SLQDSSLEEE
460 470 480 490 500
QFTAAMQAQG LRHSAAATAL PLSHGAARKW FYKDPQGEIQ GPFTTQEMAE
510 520 530 540 550
WFQAGYFSMA LLVKRGCDEG FQPLGEVIKM WGRVPFAPGP SPPPLLGNMD
560 570 580 590 600
QERLKKQQEL AAAALYQQLQ HQQFLQLVGS RPLPQCALRE KATLGDLSPP
610 620 630 640 650
QQQQLTAFLQ QLQALKPPRG GDQNLLPTMN RSLSVPDSGP LWDIHTSASS
660 670 680 690 700
QSGGEASLWD IPINSSTQGP ILEQLQLQHK FQERREVELR AKREEEERKR
710 720 730 740 750
REEKRRQQQQ EEQKRRQEEE ELFRRKQVRQ QELLLKLLQQ QQAAAAVPVP
760 770 780 790 800
PAPSSPPPLW AGLAKQGLSM KTLLELQLEG ERQLHKQPPP REPSRAQAPN
810 820 830 840 850
HRALGGLGSA PVNQWVSEAG PLWGGPDKSG GGSGGPGLWE DTLKSGGSLA
860 870 880 890 900
RSLGLKNSRS SPSLSDSYGH LSGRPVRKKT EEEEKLLKLL QGIPRPQDGF
910 920 930 940 950
TQWCEQMLHT LSTTGSLDVP MAVAILKEVE SPYDVHDYIR SCLGDTLEAK
960 970 980 990 1000
EFAKQFLERR AKQKASQQRQ QQQEAWLSSG SLQTAFQTNH STKLGPGEGS
1010 1020 1030 1040 1050
KAKRRALMLH SDPSILGEFG GVAMKEAVYS VGARSLGRAQ TQLLPGFRVL

PARTFW
Length:1,056
Mass (Da):116,430
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF6C590258EABA69B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q7WFR1A0A3Q7WFR1_URSAR
GRB10-interacting GYF protein 1 iso...
GIGYF1
1,057Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7WFR7A0A3Q7WFR7_URSAR
GRB10-interacting GYF protein 1 iso...
GIGYF1
955Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7X3N3A0A3Q7X3N3_URSAR
GRB10-interacting GYF protein 1 iso...
GIGYF1
1,034Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7XXM6A0A3Q7XXM6_URSAR
GRB10-interacting GYF protein 1 iso...
GIGYF1
1,047Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_026371898.1, XM_026516113.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_026371898.1, XM_026516113.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00072 GYF, 1 hit
Gene3Di3.30.1490.40, 1 hit
InterProiView protein in InterPro
IPR003169 GYF
IPR035445 GYF-like_dom_sf
PfamiView protein in Pfam
PF02213 GYF, 1 hit
SMARTiView protein in SMART
SM00444 GYF, 1 hit
SUPFAMiSSF55277 SSF55277, 1 hit
PROSITEiView protein in PROSITE
PS50829 GYF, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7XBV5_URSAR
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7XBV5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: December 11, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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