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Entry version 11 (02 Dec 2020)
Sequence version 1 (10 Apr 2019)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Ursus arctos horribilis
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3870S-adenosyl-L-methionineUniRule annotation1
Binding sitei3872S-adenosyl-L-methionineUniRule annotation1
Binding sitei3914S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3940ZincUniRule annotation1
Metal bindingi3988ZincUniRule annotation1
Binding sitei3989S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3990ZincUniRule annotation1
Metal bindingi3995ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1180 – 1228CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotationImportedARBA annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUrsus arctos horribilisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri116960 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaUrsidaeUrsus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286642 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1180 – 1228CXXC-typeInterPro annotationAdd BLAST49
Domaini1464 – 1515PHD-typeInterPro annotationAdd BLAST52
Domaini1512 – 1566PHD-typeInterPro annotationAdd BLAST55
Domaini1599 – 1663PHD-typeInterPro annotationAdd BLAST65
Domaini1739 – 1784BromoInterPro annotationAdd BLAST46
Domaini1906 – 2014PHD-typeInterPro annotationAdd BLAST109
Domaini2054 – 2110FYR N-terminalInterPro annotationAdd BLAST57
Domaini3697 – 3778FYR C-terminalInterPro annotationAdd BLAST82
Domaini3860 – 3976SETInterPro annotationAdd BLAST117
Domaini3984 – 4000Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 80DisorderedSequence analysisAdd BLAST80
Regioni188 – 265DisorderedSequence analysisAdd BLAST78
Regioni357 – 377DisorderedSequence analysisAdd BLAST21
Regioni478 – 641DisorderedSequence analysisAdd BLAST164
Regioni746 – 978DisorderedSequence analysisAdd BLAST233
Regioni1071 – 1100DisorderedSequence analysisAdd BLAST30
Regioni1138 – 1198DisorderedSequence analysisAdd BLAST61
Regioni1233 – 1424DisorderedSequence analysisAdd BLAST192
Regioni1698 – 1740DisorderedSequence analysisAdd BLAST43
Regioni1842 – 1905DisorderedSequence analysisAdd BLAST64
Regioni2118 – 2166DisorderedSequence analysisAdd BLAST49
Regioni2181 – 2208DisorderedSequence analysisAdd BLAST28
Regioni2312 – 2366DisorderedSequence analysisAdd BLAST55
Regioni2410 – 2494DisorderedSequence analysisAdd BLAST85
Regioni2529 – 2653DisorderedSequence analysisAdd BLAST125
Regioni2682 – 2710DisorderedSequence analysisAdd BLAST29
Regioni2748 – 2854DisorderedSequence analysisAdd BLAST107
Regioni2998 – 3078DisorderedSequence analysisAdd BLAST81
Regioni3203 – 3280DisorderedSequence analysisAdd BLAST78
Regioni3503 – 3674DisorderedSequence analysisAdd BLAST172
Regioni3816 – 3839DisorderedSequence analysisAdd BLAST24
Regioni3937 – 3938S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili406 – 426Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 58Pro-richSequence analysisAdd BLAST22
Compositional biasi217 – 236PolarSequence analysisAdd BLAST20
Compositional biasi237 – 259PolyampholyteSequence analysisAdd BLAST23
Compositional biasi358 – 377PolyampholyteSequence analysisAdd BLAST20
Compositional biasi478 – 528PolarSequence analysisAdd BLAST51
Compositional biasi568 – 588PolarSequence analysisAdd BLAST21
Compositional biasi589 – 609Pro-richSequence analysisAdd BLAST21
Compositional biasi746 – 764PolarSequence analysisAdd BLAST19
Compositional biasi780 – 843PolarSequence analysisAdd BLAST64
Compositional biasi857 – 878PolarSequence analysisAdd BLAST22
Compositional biasi879 – 931PolyampholyteSequence analysisAdd BLAST53
Compositional biasi957 – 978PolarSequence analysisAdd BLAST22
Compositional biasi1079 – 1094PolarSequence analysisAdd BLAST16
Compositional biasi1282 – 1305PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1311 – 1334PolarSequence analysisAdd BLAST24
Compositional biasi1335 – 1350Pro-richSequence analysisAdd BLAST16
Compositional biasi1402 – 1424PolarSequence analysisAdd BLAST23
Compositional biasi1867 – 1883Pro-richSequence analysisAdd BLAST17
Compositional biasi2132 – 2166PolarSequence analysisAdd BLAST35
Compositional biasi2312 – 2355PolarSequence analysisAdd BLAST44
Compositional biasi2439 – 2453PolarSequence analysisAdd BLAST15
Compositional biasi2454 – 2480PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2563 – 2594PolarSequence analysisAdd BLAST32
Compositional biasi2604 – 2629PolarSequence analysisAdd BLAST26
Compositional biasi2756 – 2781PolarSequence analysisAdd BLAST26
Compositional biasi2782 – 2819PolyampholyteSequence analysisAdd BLAST38
Compositional biasi2822 – 2854PolarSequence analysisAdd BLAST33
Compositional biasi3046 – 3078PolarSequence analysisAdd BLAST33
Compositional biasi3203 – 3218PolarSequence analysisAdd BLAST16
Compositional biasi3231 – 3257PolarSequence analysisAdd BLAST27
Compositional biasi3265 – 3280PolarSequence analysisAdd BLAST16
Compositional biasi3503 – 3561PolarSequence analysisAdd BLAST59
Compositional biasi3594 – 3660PolarSequence analysisAdd BLAST67

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1180 – 1228CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q7WIK1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAGSS GAGVPGGAAA ASAASSSSAS SSSSSSSSAS
110 120 130 140 150
SGPALLRVGP GFDAALQVSA AIGTNLRRFR AVFGESGGGG GSGELTTQIP
160 170 180 190 200
CSWRTKGLIH DKKTEPFRLL AWSWCLNDEQ FLGFGSDEEV RVRSPTRSPS
210 220 230 240 250
VKTSPRKPRG RPRSGSDRNS AILSDPSVFS PLNKSETKSG DKIKKKDSKS
260 270 280 290 300
IEKKRGRPPT FPGVKIKITH GKDISELPKG SKEDSLKKIK RTPSATFQQA
310 320 330 340 350
TKIKKLRAGK LSPLKSKFKT GKLQIGRKGV QIVRRRGRPP STERIKTPSG
360 370 380 390 400
LLINSELEKP QKVRKDKEGT PPLTKEDKTV VRQSPRRIKP VRIIPSSKRT
410 420 430 440 450
DATIAKQLLQ RAKKGAQKKI EKEAAQLQGR KVKTQVKNIR QFIMPVVSAI
460 470 480 490 500
SSRIIKTPRR FIEDEDYDPP IKIARLESTP NSRFSATSCG SSEKSSAASQ
510 520 530 540 550
HSSQMSSDSS RSSSPSVDTS TDSQASEEIQ VLPEERSETP EVPTPLPISQ
560 570 580 590 600
SPENDSNDRR SRRYSVSERS FGSRTTKKLS TLQSAPQQQP SSSPPPPLLT
610 620 630 640 650
PPPPLQPASS ISDHTPWLMP PTIPLASPFL PASAAPMQGK RKSILREPTF
660 670 680 690 700
RWTSLKHSRS EPQYFSSAKY AKEGLIRKPI FDNFRPPPLT PEDVGFASGF
710 720 730 740 750
STSGTAASAR LFSPLHSGTR FDMHKRSPLL RAPRFTPSEA HSRIFESVTL
760 770 780 790 800
PSNRTSAGTS SSGVSNRKRK RKVFSPIRSE PRSPSHSMRT RSGRLSTAEL
810 820 830 840 850
SPLTPPSSVS SSLSISVSPL ATSALNPTFT FPSHSLTQSG ESAEKSQRPR
860 870 880 890 900
KQASAPAEPF SSGSPTPLFP WFTPGSQTER GRNKDKAPEE LSKDRDADKS
910 920 930 940 950
VEKDKSRERD REREKENKRE SRKEKRKKGS EIQSSSALYP VGRVSKDKVV
960 970 980 990 1000
GEDVATSSSA KKATGRKKSS SLDSGTDIAS VTLGDTTAVK TKILIKKGRG
1010 1020 1030 1040 1050
NLEKNNLDLG PTAPSLEKEK TLCLSTPSSS TVKHSTSSIG SMLAQADKLP
1060 1070 1080 1090 1100
MTDKRVASLL KKAKAQLCKI EKSKSLKQTD QPKAQGQESD SSETSVRGPR
1110 1120 1130 1140 1150
IKHVCRRAAV ALGRKRAVFP DDMPTLSALP WEEREKILSS MGNDDKSSIA
1160 1170 1180 1190 1200
GSEDAEPLAP PIKPIKPVTR NKAPQEPPVK KGRRSRRCGQ CPGCQVPEDC
1210 1220 1230 1240 1250
GVCTNCLDKP KFGGRNIKKQ CCKMRKCQNL QWMPSKAYLQ KQAKAVKKKE
1260 1270 1280 1290 1300
KKSKTSEKKE SKESNVGKSV VDSGQKPAPS AREDPAPKKS NSEPPPRKPI
1310 1320 1330 1340 1350
EEKSEEGNAS APVPESKQVT TPASRKSSKQ ASQPVPVTPP QPPNTAPPRK
1360 1370 1380 1390 1400
EVPKTTPSEP KKKQPPPPES GPEQSKQKKV APRPSIPVKQ KPKEKEKPPP
1410 1420 1430 1440 1450
VSKQENTGTL NILSTLSNGN SSKQKIPADG VHRIRVDFKE DCEAENVWEM
1460 1470 1480 1490 1500
GGLGILTSVP ITPRVVCFLC ASSGHVEFVY CQVCCEPFHK FCLEENERPL
1510 1520 1530 1540 1550
EDQLENWCCR RCKFCHVCGR QHQATKQLLE CNKCRNSYHP ECLGPNYPTK
1560 1570 1580 1590 1600
PTKKKKVWIC TKCVRCKSCG STTPGKGWDA QWSHDFSLCH DCAKLFAKGN
1610 1620 1630 1640 1650
FCPLCDKCYD DDDYESKMMQ CGKCDRWVHS KCENLSGTED EMYEILSNLP
1660 1670 1680 1690 1700
ESVAYTCVNC TERHPAEWRL ALEKELQSSL KQVLTALLNS RTTSHLLRYR
1710 1720 1730 1740 1750
QAAKPPDLNP ETEESIPSRS SPEGPDPPVL TEVSKQEDQQ PLDLEGVKRK
1760 1770 1780 1790 1800
MDQGNYTSVL EFSDDIVKII QAAINSDGGQ PEIKKANSMV KSFFIRQMER
1810 1820 1830 1840 1850
VFPWFSVKKS RFWEPNKVSS NSGMLPNAVL PPSLDHNYAQ WQEREENSHT
1860 1870 1880 1890 1900
EQPPLMKKII PAPKAKGPGE PDSPTPLHPP TPPILSTDRS REDSPELNPP
1910 1920 1930 1940 1950
PGVEDNRQCA LCLTYGDDSA NDAGRLLYIG QNEWTHVNCA LWSAEVFEDD
1960 1970 1980 1990 2000
DGSLKNVHMA VIRGKQLRCE FCQKPGATVG CCLTSCTSNY HFMCSRAKNC
2010 2020 2030 2040 2050
VFLDDKKVYC QRHRDLIKGE VVPENGFEVF RRVFVDFEGI SLRRKFLNGL
2060 2070 2080 2090 2100
EPENIHMMIG SMTIDCLGIL NDLSDCEDKL FPIGYQCSRV YWSTTDARKR
2110 2120 2130 2140 2150
CVYTCKIVEC RPPVVEPDIN STVEHDENRT IAHSPTSFAE ISSKESQNTA
2160 2170 2180 2190 2200
EIVSPPSPER PHSQTSGSCF YHVISKVPRI RTPSYSPTQR SPGCRPLPSA
2210 2220 2230 2240 2250
GSPTPTTHEI VTVGDPLLSS GLRSIGSRRH STSSLSPQRS KLRIMSPMRT
2260 2270 2280 2290 2300
GGTYSRNSVS SVSTIGTATD LESSAKAVDH VLGPLNSNTN LGQNTPTSSN
2310 2320 2330 2340 2350
LQRTVVTMGA KTSHLDGSSS SDMKHSSASD LASKSSSLKG EKTKVPSSKS
2360 2370 2380 2390 2400
SEGPAHTVTY PGLPKLAPQV PNTAPVELNA SKIGAFAELS SGPFSSKEAL
2410 2420 2430 2440 2450
SFPPLHLRGQ RNERDQHSDS NQAVNPPPDE DAGVKTLKLS GVSNRSSIIN
2460 2470 2480 2490 2500
EHVGSSSRDR RQKGKKSCKE TFKEKHSSKS FLEPGQVTTG EEGNLKPEFV
2510 2520 2530 2540 2550
GEVLTPEFMG QRPCNNVSSD KIGDKVLSIP GVPKAPSMQV EGSAKELQTP
2560 2570 2580 2590 2600
RKRTVKVTLT PLKMESEGQS KNTLKEGSPV SPLQIESASP TEPVAASESP
2610 2620 2630 2640 2650
GDGPVAQPSP NNTSSQDPQS NNYQNLPVQD RNLMLPDGPK PQEDGSFKRR
2660 2670 2680 2690 2700
YPRRSARARS NMFFGLTPLY GVRSYGEEDI PFYSSSTGKK RGKRSAEGQV
2710 2720 2730 2740 2750
DGADDLSTSD EDDLYYYNFT RTVISSGGDE RLASHNLFRE EEQCDLPKIS
2760 2770 2780 2790 2800
QLDGVDDGTE SDTSVTATTR KSSQIPKRNG KENGTENLKM ERPEDAGEKE
2810 2820 2830 2840 2850
HVIKSSVGHK NEPKMDNCHS VSRVKAQGQD SLEAQLSSLE SSRRVHTSTP
2860 2870 2880 2890 2900
SDKNLLDTYN AELLKSDSDN NNSDDCGNIL PSDIMDFVLK NTPSMQALGE
2910 2920 2930 2940 2950
SPESSSSELL NLGEGLGLDS NREKDMGLFE VFSQQLPTAE PVDSSVSSSI
2960 2970 2980 2990 3000
SAEEQFELPL ELPSDLSVLT TRSPTVPSQN PSRLAVISDS GEKRVTITEK
3010 3020 3030 3040 3050
SVASSEGDSA LLSPGVDPTP EGHMTPDHFI QGHMDADHIS SPPCGSVEQG
3060 3070 3080 3090 3100
HGNNQDLTRN SSTPGLQVPV SPTVPIQNQK YVPNSTESPG PSQISNAAVQ
3110 3120 3130 3140 3150
TTPPHLKPAT EKLIVVNQNM QPLYVLQTLP NGVTQKIQLT SSVSSTPNVM
3160 3170 3180 3190 3200
ETNTSVLGPM GSGLTLATGL NPSLPTSPSL FPPASKGLLP MPHHQHLHSF
3210 3220 3230 3240 3250
PAAAQSSFPP NISSPPSGLL IGVQPPPDPQ LLVSEASQRT DLSSTVATPS
3260 3270 3280 3290 3300
SGLKKRPISR LQTRKNKKLA PSSTPSTIAP SDVVSNMTLI NFTPSQLPNH
3310 3320 3330 3340 3350
PNLLDLGSLN TSSHRTVPNI IKRSKSGIMY FEQAPLLPQS VGGTAAAAAG
3360 3370 3380 3390 3400
TSTMSQDTGH LTAGPVSGLA SGSSVLNVVS MQTTTTPTSS ASVPGHVALT
3410 3420 3430 3440 3450
NPRLLGTPDI GSISNLLIKA SQQSLGMQDQ PVALPPSSAM FPQLGTSQAP
3460 3470 3480 3490 3500
AATMTAASSI CVLPSAQTAG ITAASPSGEA EEHYQLQHVN QLLASKTGIL
3510 3520 3530 3540 3550
PSQRELDSAP GTQGSNFTQT VDAPSSMGLE QNKALSSAMQ AGSASPGGSP
3560 3570 3580 3590 3600
SSGQQSASPS VPAPTKPKPK IKRFQLPLDK GNGKKHKASH LRTSSSEAHI
3610 3620 3630 3640 3650
PDQEANTTPL TSVTGTPGAE AEQQDTANVE QSSQKECGQP TGQVLPEIQA
3660 3670 3680 3690 3700
TQNPANEQES TEPKTVEEEE SNFSSPLMLW LQQEQKRKES IAEKKPKKGL
3710 3720 3730 3740 3750
VFEISSDDGF QICAESIEDA WKSLTDKVQE ARSNARLKQL SFAGVNGLRM
3760 3770 3780 3790 3800
LGILHDAVVF LIEQLSGAKH CRNYKFRFHK PEEANEPPLN PHGSARAEVH
3810 3820 3830 3840 3850
LRKSAFDMFN FLASKHRQPP EYNPNDEEEE EVQLKSARRA TSMDLPMPMR
3860 3870 3880 3890 3900
FRHLKKTSKE AVGVYRSPIH GRGLFCKRNI DAGEMVIEYA GNVIRSIQTD
3910 3920 3930 3940 3950
KREKYYDSKG IGCYMFRIDD SEVVDATMHG NAARFINHSC EPNCYSRVIN
3960 3970 3980 3990 4000
IDGQKHIVIF AMRKIYRGEE LTYDYKFPIE DASNKLPCNC GAKKCRKFLN
Length:4,000
Mass (Da):434,346
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i619869B426C582BC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q7VKA2A0A3Q7VKA2_URSAR
Histone-lysine N-methyltransferase
KMT2A
3,964Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7W977A0A3Q7W977_URSAR
Histone-lysine N-methyltransferase
KMT2A
3,967Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7X4E2A0A3Q7X4E2_URSAR
Histone-lysine N-methyltransferase
KMT2A
3,997Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7XFT9A0A3Q7XFT9_URSAR
Histone-lysine N-methyltransferase
KMT2A
3,734Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_026361423.1, XM_026505638.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
uah:113259992

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_026361423.1, XM_026505638.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

KEGGiuah:113259992

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7WIK1_URSAR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7WIK1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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