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Entry version 10 (10 Feb 2021)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1

Gene

LOC112932168

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransducerARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
guanine nucleotide-binding protein G(S) subunit alpha isoforms XLas isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC112932168Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    MembraneARBA annotation

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 259DisorderedSequence analysisAdd BLAST259
    Regioni281 – 541DisorderedSequence analysisAdd BLAST261
    Regioni558 – 602DisorderedSequence analysisAdd BLAST45
    Regioni646 – 671DisorderedSequence analysisAdd BLAST26

    Coiled coil

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili671 – 691Sequence analysisAdd BLAST21

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi346 – 362PolyampholyteSequence analysisAdd BLAST17
    Compositional biasi527 – 541BasicSequence analysisAdd BLAST15
    Compositional biasi571 – 602PolyampholyteSequence analysisAdd BLAST32

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the G-alpha family. G(s) subfamily.ARBA annotation

    Keywords - Domaini

    Coiled coilSequence analysis

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00066, G-alpha, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.400.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR000367, Gprotein_alpha_S
    IPR001019, Gprotein_alpha_su
    IPR011025, GproteinA_insert
    IPR027417, P-loop_NTPase

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10218, PTHR10218, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00503, G-alpha, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00318, GPROTEINA
    PR00443, GPROTEINAS

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00275, G_alpha, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF47895, SSF47895, 1 hit
    SSF52540, SSF52540, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51882, G_ALPHA, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

    A0A3Q7UU41-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MGVRNCLDGN NMSGQRDIPL ELGEQPEQPS LEAPGAAAPS PGPGAAEEME
    60 70 80 90 100
    TQPPHSEPIP VETEGEACGP PEVSRPNFQD LGETVKEAGA HGAYSPPPEE
    110 120 130 140 150
    AMPFEVEQPS SGGFWPTPEQ PGDTTGAHAG LEVSRPSLME SGAFDDARPG
    160 170 180 190 200
    LGGYSPPPEE AMPFEFEQPA QGGCNQPPLQ VSDLAPGGPG AGVYTTPPQE
    210 220 230 240 250
    PRALKPANAG FRGDRSPPPE EAMPFEFDGA AFGDDSPPPG LPRAIPQIDG
    260 270 280 290 300
    GGGGGGESAA AAVPSAVLLA PAANEPPLWV PGAIGSPSRE AVRPPPHFAG
    310 320 330 340 350
    DSPPMEISGP PLEIGSAPVG VDDAPVNMDS PPIALDGPPI EVSRAPVKRA
    360 370 380 390 400
    RAEGERPPVE GEAAEMEGGS AAAAAEGGKV SSPGDGAPAA RAKPASPAAG
    410 420 430 440 450
    AAAAAPDAPA AGAAPAAPDA PAAGAAAPAA RAAPAAGAAA PASRAAPASR
    460 470 480 490 500
    AAPAAPASGA RPKLRFLRPP SPEIQAADPP TPQPPRAFAW RGRSGRSRDD
    510 520 530 540 550
    DEGSVSSDDD HSSDESDDGT SGCRRWLQPR RNRRRRKPRR NLLRNFLMQA
    560 570 580 590 600
    FGGCFGRAES PQPKAAHSPK VKKIPLAEKR RQMRKEALEK RAQKRAEKKR
    610 620 630 640 650
    SKLIDKQLQE EKMGYMCTHR LLLLGAGESG KSTIVKQMRI LHVNGFNGEG
    660 670 680 690 700
    GEEDPQAARS NSDGSEKATK VQDIKNNLKE AIETIVAAMS NLVPPVELAN
    710 720 730 740 750
    PENQFRVDYI LSVMNVPDFD FPPEFYEHAK ALWEDEGVRA CYERSNEYQL
    760 770 780 790 800
    IDCAQYFLDK IDVIKQADYV PSDQDLLRCR VLTSGIFETK FQVDKVNFHM
    810 820 830 840 850
    FDVGGQRDER RKWIQCFNDV TAIIFVVASS SYNMVIREDN QTNRLQEALN
    860 870 880 890 900
    LFKSIWNNRW LRTISVILFL NKQDLLAEKV LAGKSKIEDY FPEFARYTTP
    910 920 930 940 950
    EDATPEPGED PRVTRAKYFI RDEFLRISTA SGDGRHYCYP HFTCAVDTEN
    960 970
    IRRVFNDCRD IIQRMHLRQY ELL
    Length:973
    Mass (Da):104,423
    Last modified:April 10, 2019 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B32C689DFF72945
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A3Q7UU45A0A3Q7UU45_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    394Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7T1P8A0A3Q7T1P8_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    395Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7TZP3A0A3Q7TZP3_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    380Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7UC71A0A3Q7UC71_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    379Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7TMA8A0A3Q7TMA8_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    957Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7TZN8A0A3Q7TZN8_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    972Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A3Q7UC66A0A3Q7UC66_VULVU
    guanine nucleotide-binding protein ...
    LOC112932168
    958Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Sequence databases

    NCBI Reference Sequences

    More...
    RefSeqi
    XP_025870800.1, XM_026015015.1

    Genome annotation databases

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    vvp:112932168

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    RefSeqiXP_025870800.1, XM_026015015.1

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Genome annotation databases

    KEGGivvp:112932168

    Family and domain databases

    CDDicd00066, G-alpha, 1 hit
    Gene3Di1.10.400.10, 1 hit
    InterProiView protein in InterPro
    IPR000367, Gprotein_alpha_S
    IPR001019, Gprotein_alpha_su
    IPR011025, GproteinA_insert
    IPR027417, P-loop_NTPase
    PANTHERiPTHR10218, PTHR10218, 1 hit
    PfamiView protein in Pfam
    PF00503, G-alpha, 1 hit
    PRINTSiPR00318, GPROTEINA
    PR00443, GPROTEINAS
    SMARTiView protein in SMART
    SM00275, G_alpha, 1 hit
    SUPFAMiSSF47895, SSF47895, 1 hit
    SSF52540, SSF52540, 1 hit
    PROSITEiView protein in PROSITE
    PS51882, G_ALPHA, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7UU41_VULVU
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7UU41
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
    Last sequence update: April 10, 2019
    Last modified: February 10, 2021
    This is version 10 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteomeImported
    UniProt is an ELIXIR core data resource
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