Mothers against decapentaplegic homolog

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: Ensembl
• collagen binding Source: Ensembl
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• I-SMAD binding Source: Ensembl
• metal ion binding Source: UniProtKB-KW
• protein homodimerization activity Source: Ensembl
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
• RNA polymerase II transcription factor binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• sulfate binding Source: Ensembl
• transcription coactivator binding Source: Ensembl

GO - Biological processⁱ

• atrioventricular canal development Source: Ensembl
• atrioventricular valve formation Source: Ensembl
• axon guidance Source: Ensembl
• BMP signaling pathway Source: Ensembl
• brainstem development Source: Ensembl
• branching involved in ureteric bud morphogenesis Source: Ensembl
• cell population proliferation Source: Ensembl
• cellular iron ion homeostasis Source: Ensembl
• developmental growth Source: Ensembl
• embryonic digit morphogenesis Source: Ensembl
• endocardial cell differentiation Source: Ensembl
• endothelial cell activation Source: Ensembl
• epithelial to mesenchymal transition involved in endocardial cushion formation Source: Ensembl
• female gonad morphogenesis Source: Ensembl
• formation of anatomical boundary Source: Ensembl
• gastrulation with mouth forming second Source: Ensembl
• interleukin-6-mediated signaling pathway Source: Ensembl
• intracellular signal transduction Source: Ensembl
• in utero embryonic development Source: Ensembl
• left ventricular cardiac muscle tissue morphogenesis Source: Ensembl
• mesendoderm development Source: Ensembl
• metanephric mesenchyme morphogenesis Source: Ensembl
• negative regulation of cardiac muscle hypertrophy Source: Ensembl
• negative regulation of cardiac myofibril assembly Source: Ensembl
• negative regulation of cell death Source: Ensembl
• negative regulation of cell growth Source: Ensembl
• negative regulation of cell population proliferation Source: Ensembl
• negative regulation of ERK1 and ERK2 cascade Source: Ensembl
• negative regulation of transcription by RNA polymerase II Source: Ensembl
• nephrogenic mesenchyme morphogenesis Source: Ensembl
• neural crest cell differentiation Source: Ensembl
• neuron fate commitment Source: Ensembl
• outflow tract septum morphogenesis Source: Ensembl
• ovarian follicle development Source: Ensembl
• positive regulation of BMP signaling pathway Source: Ensembl
• positive regulation of cell proliferation involved in heart valve morphogenesis Source: Ensembl
• positive regulation of epithelial to mesenchymal transition Source: Ensembl
• positive regulation of follicle-stimulating hormone secretion Source: Ensembl
• positive regulation of histone H3-K4 methylation Source: Ensembl
• positive regulation of histone H3-K9 acetylation Source: Ensembl
• positive regulation of luteinizing hormone secretion Source: Ensembl
• positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
• positive regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
• positive regulation of SMAD protein signal transduction Source: Ensembl
• positive regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
• regulation of binding Source: Ensembl
• regulation of hair follicle development Source: Ensembl
• regulation of transforming growth factor beta2 production Source: Ensembl
• response to hypoxia Source: Ensembl
• sebaceous gland development Source: Ensembl
• secondary palate development Source: Ensembl
• seminiferous tubule development Source: Ensembl
• single fertilization Source: Ensembl
• SMAD protein complex assembly Source: Ensembl
• SMAD protein signal transduction Source: Ensembl
• somite rostral/caudal axis specification Source: Ensembl
• spermatogenesis Source: Ensembl
• transforming growth factor beta receptor signaling pathway Source: Ensembl
• uterus development Source: Ensembl
• ventricular septum morphogenesis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• I-SMAD binding Source: Ensembl
• protein homodimerization activity Source: Ensembl
• RNA polymerase II transcription factor binding Source: Ensembl
• R-SMAD binding Source: Ensembl
• transcription coactivator binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK 
        60         70         80         90        100
KDELDSLITA ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR 
       110        120        130        140        150
WPDLHKNELK HVKYCQYAFD LKCDSVCVNP YHYERVVSPG IDLSGLTLQS 
       160        170        180        190        200
NAPPSMLVKD EYVHDFEGQP SLSTEGHSIQ TIQHPPSNRA STETYSTPAL 
       210        220        230        240        250
LAPSESNATS TTNFPNIPVA STSQPASILA GSHSEGLLQI ASGPQPGQQQ 
       260        270        280        290        300
NGFTAQPATY HHNSTTTWTG SRSAPYTPNL PHHQNGHLQH HPPMPPHPGH 
       310        320        330        340        350
YWPVHNELAF QPPISNHPAP EYWCSIAYFE MDVQVGETFK VPSSCPIVTV 
       360        370        380        390        400
DGYVDPSGGD RFCLGQLSNV HRTEAIERAR LHIGKGVQLE CKGEGDVWVR 
       410        420        430        440        450
CLSDHAVFVQ SYYLDREAGR APGDAVHKIY PSAYIKVFDL RQCHRQMQQQ 
       460        470        480        490        500
AATAQAAAAA QAAAVAGNIP GPGSVGGIAP AISLSAAAGI GVDDLRRLCI 
       510        520        530        540        550
LRMSFVKGWG PDYPRQSIKE TPCWIEIHLH RALQLLDEVL HTMPIADPQP 

LD                                                     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ