Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 5 (31 Jul 2019)
Sequence version 1 (10 Apr 2019)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Voltage-dependent T-type calcium channel subunit alpha

Gene

CACNA1I

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent T-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CACNA1IImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei121 – 141HelicalSequence analysisAdd BLAST21
Transmembranei208 – 232HelicalSequence analysisAdd BLAST25
Transmembranei345 – 366HelicalSequence analysisAdd BLAST22
Transmembranei372 – 397HelicalSequence analysisAdd BLAST26
Transmembranei726 – 748HelicalSequence analysisAdd BLAST23
Transmembranei804 – 826HelicalSequence analysisAdd BLAST23
Transmembranei1136 – 1154HelicalSequence analysisAdd BLAST19
Transmembranei1174 – 1196HelicalSequence analysisAdd BLAST23
Transmembranei1211 – 1239HelicalSequence analysisAdd BLAST29
Transmembranei1274 – 1293HelicalSequence analysisAdd BLAST20
Transmembranei1375 – 1397HelicalSequence analysisAdd BLAST23
Transmembranei1453 – 1470HelicalSequence analysisAdd BLAST18
Transmembranei1490 – 1509HelicalSequence analysisAdd BLAST20
Transmembranei1573 – 1600HelicalSequence analysisAdd BLAST28
Transmembranei1675 – 1696HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 408Ion_transInterPro annotationAdd BLAST331
Domaini604 – 831Ion_transInterPro annotationAdd BLAST228
Domaini1134 – 1407Ion_transInterPro annotationAdd BLAST274
Domaini1453 – 1706Ion_transInterPro annotationAdd BLAST254

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 51DisorderedSequence analysisAdd BLAST51
Regioni464 – 579DisorderedSequence analysisAdd BLAST116
Regioni836 – 899DisorderedSequence analysisAdd BLAST64
Regioni1706 – 1759DisorderedSequence analysisAdd BLAST54
Regioni1843 – 1864DisorderedSequence analysisAdd BLAST22
Regioni1901 – 1927DisorderedSequence analysisAdd BLAST27
Regioni2037 – 2067DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1406 – 1433Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18PolarSequence analysisAdd BLAST18
Compositional biasi25 – 43Pro-richSequence analysisAdd BLAST19
Compositional biasi532 – 546PolarSequence analysisAdd BLAST15
Compositional biasi1901 – 1917PolarSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K04856

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10037:SF209 PTHR10037:SF209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01629 TVDCCALPHA1

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q7T7Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAESSPPPSS SSATAPAAEP GVTEQPGPQS PPPSPPGPEE PLDGADPEVP
60 70 80 90 100
HPDLAPVAFF CLRQTTSPRN WCIKMVCNPW FECVSMLVIL LNCVTLGMYQ
110 120 130 140 150
PCDDMDCLSD RCKILQVFDD FIFVFFAMEM VLKMVALGIF GKKCYLGDTW
160 170 180 190 200
NRLDFFIVMA GMVEYSLDLQ NINLSAIRTV RVLRPLKAIN RVPSMRILVN
210 220 230 240 250
LLLDTLPMLG NVLLLCFFVF FIFGIIGVQL WAGLLRNRCF LEENFTIQGD
260 270 280 290 300
VALPPYYQPE EDDEMPFICS LSGDNGIMGC HEIPPLKEQG RECCLSKDDV
310 320 330 340 350
YDFGAGRQDL NASGLCVNWN RYYNVCRTGS ANPHKGAINF DNIGYAWIVI
360 370 380 390 400
FQVITLEGWV EIMYYVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ
410 420 430 440 450
FSETKQREHR LMLEQRQRYL SSSTVASYAE PGDCYEEIFQ YICHILRKAR
460 470 480 490 500
RRALGLYQAL QSRRQASAPG APTSTKPGPH TKEPRHYKLC PQHSPLDPTP
510 520 530 540 550
HTLVQPISAM LASDPASCPR CQHEESRRPS GPDSTDSGQE GSGSGGSGGG
560 570 580 590 600
SEEADGDGAR SSEDGASSGL GKEDEEEKAD GATRLCGDVW RETRAKLRGI
610 620 630 640 650
VDSKYFNRGI MMAILVNTVS MGIEHHEQPE ELTNILEICN VVFTSMFALE
660 670 680 690 700
MLLKLAAFGL FDYLRNPYNI FDSIIVIISI WEIVGQADGG LSVLRTFRLL
710 720 730 740 750
RVLKLVRFMP ALRRQLVVLM KTMDNVATFC MLLMLFIFIF SILGMHIFGC
760 770 780 790 800
KFSLRTDTGD TVPDRKNFDS LLWAIVTVFQ ILTQEDWNVV LYNGMASTSP
810 820 830 840 850
WASLYFVALM TFGNYVLFNL LVAILVEGFQ AEGDANRSYS DEDQSSSNME
860 870 880 890 900
DFDKLQEGLD GSGDPKLCPI PMTPNGHLDP NLPLGGHLGP AGAAAPAPRL
910 920 930 940 950
SLQPDPVLVA LGSRKSSVMS LGRMSYDQRS LSSSRSSYYG PWGRSGAWAS
960 970 980 990 1000
RRSSWNSLKH KPXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
1010 1020 1030 1040 1050
XXXXXXXXXX XXHRHRHHRR TLSLDTRDSM DLAELVPAVG AHPRAAWRAV
1060 1070 1080 1090 1100
GPAPGHEDCN GRMPSIAKDV FTKMDDRRDR GEDEEEIDYT LCFRVRKMID
1110 1120 1130 1140 1150
VYKPDWCEVR EDWSVYLFSP ENRFRVLCQT IIAHKLFDYV VLAFIFLNCI
1160 1170 1180 1190 1200
TIALERPQIE AGSTERIFLT VSNYIFTAIF VGEMTLKVVS LGLYFGEQAY
1210 1220 1230 1240 1250
LRSSWNVLDG FLVFVSIIDI VVSVASAGGA KILGVLRVLR LLRTLRPLRV
1260 1270 1280 1290 1300
ISRAPGLKLV VETLISSLKP IGNIVLICCA FFIIFGILGV QLFKGKFYHC
1310 1320 1330 1340 1350
LGVDTRNITN RSDCVAANYR WVHHKYNFDN LGQALMSLFV LASKDGWVNI
1360 1370 1380 1390 1400
MYNGLDAVAV DQQPWPTPHH PSLNLYFISF LLIVSFFVLN MFVGVVVENF
1410 1420 1430 1440 1450
HKCRQHQEAE EARRREEKRL RRLEKKRRKA QRLPYYATYC PTRLLIHSMC
1460 1470 1480 1490 1500
TSHYLDIFIT FIICLNVVTM SLEHYNQPTS LETALKYCNY MFTTVFVLEA
1510 1520 1530 1540 1550
VLKLVAFGLR RFFKDRWNQL DLAIVLLSVM GITLEEIEIN AALPINPTII
1560 1570 1580 1590 1600
RIMRVLRIAR VLKLLKMATG MRALLDTVVQ ALPQVGNLGL LFMLLFFIYA
1610 1620 1630 1640 1650
ALGVELFGKL VCNDENPCEG MSRHATFENF GMAFLTLFQV STGDNWNGIM
1660 1670 1680 1690 1700
KDTLRDCTHD ERSCLSSLQF VSPLYFVSFV LTAQFVLINV VVAVLMKHLD
1710 1720 1730 1740 1750
DSNKEAQEDA EMDAELELEM AHGLGPSPRP PSSSPGAPGR GPGGAGGSGG
1760 1770 1780 1790 1800
GDPEGRLCRR CYSPAQENLW LDSVSLIIKD SLEGELTIID NLSGSIFHHY
1810 1820 1830 1840 1850
SSPAGCEKCH HDKQEVQLAE TEAFSLNSDK SSSILLGDDL SLEDPTACPV
1860 1870 1880 1890 1900
GPKDSRGEPD TPEPMQVEEV AECFFPLSNT AVSSDPENFL WEKETVPSNP
1910 1920 1930 1940 1950
VRSWLKQESS RAAPPSPFSP DASSPLLPMP AEFFHPAVSA SQKGQDKGPG
1960 1970 1980 1990 2000
AGTLPKIALQ GSWASLRSPS VNCTLLRQVR ALPRLQELSW WGTSEWGLEV
2010 2020 2030 2040 2050
QVEMEGPVWG MGGLACRASS TALARAASWA CRRHGAQSRK ASRANSPPRG
2060 2070 2080 2090 2100
WGSLGSERSR SCPGSHSMVE AEPGLELVHL LTPAMCQAVC QARRPQQATE
2110 2120
YEIPLSWLIR YYSVYALQGC ERRDW
Length:2,125
Mass (Da):237,172
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33651C7EAB7494EC
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025873069.1, XM_026017284.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vvp:112933963

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025873069.1, XM_026017284.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

KEGGivvp:112933963

Phylogenomic databases

KOiK04856

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR030162 CACNA1I
IPR005821 Ion_trans_dom
IPR005445 VDCC_T_a1
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR10037:SF209 PTHR10037:SF209, 1 hit
PfamiView protein in Pfam
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01629 TVDCCALPHA1

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7T7Q3_VULVU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7T7Q3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: July 31, 2019
This is version 5 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again