bcl2-associated agonist of cell death

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cysteine-type endopeptidase activator activity involved in apoptotic process Source: Ensembl
• phospholipid binding Source: Ensembl
• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl

GO - Biological processⁱ

• activation of cysteine-type endopeptidase activity Source: Ensembl
• ADP metabolic process Source: Ensembl
• ATP metabolic process Source: Ensembl
• cellular response to hypoxia Source: Ensembl
• cellular response to lipid Source: Ensembl
• cellular response to mechanical stimulus Source: Ensembl
• cellular response to nicotine Source: Ensembl
• cytokine-mediated signaling pathway Source: Ensembl
• extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
• extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
• glucose catabolic process Source: Ensembl
• glucose homeostasis Source: Ensembl
• intrinsic apoptotic signaling pathway in response to DNA damage Source: Ensembl
• pore complex assembly Source: Ensembl
• positive regulation of apoptotic process by virus Source: Ensembl
• positive regulation of B cell differentiation Source: Ensembl
• positive regulation of epithelial cell proliferation Source: Ensembl
• positive regulation of glucokinase activity Source: Ensembl
• positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
• positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress Source: Ensembl
• positive regulation of mitochondrial membrane potential Source: Ensembl
• positive regulation of release of cytochrome c from mitochondria Source: Ensembl
• positive regulation of T cell differentiation Source: Ensembl
• positive regulation of type B pancreatic cell development Source: Ensembl
• regulation of mitochondrial membrane permeability Source: Ensembl
• release of cytochrome c from mitochondria Source: Ensembl
• suppression by virus of host apoptotic process Source: Ensembl
• type B pancreatic cell proliferation Source: Ensembl

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: Ensembl
• protein phosphatase binding Source: Ensembl

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MFQIPEFEPS EQEDSSPANR GLGPSPTGDR PPGLLGEAGH QQGQPASRKH 
        60         70         80         90        100
HGGAGAETRS RHSSFPAGTD EDEGMEEEEL SPFRGRSSSA PPNLCAALRY 
       110        120        130        140        150
GRELRRMSDE FQGSFKGLPR PKSAGTATQM RQSPSWTRVI QSWWDRNLGR 

GGSAPSQ                                                

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ