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Entry version 10 (10 Feb 2021)
Sequence version 1 (10 Apr 2019)
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Protein

HGF/SF receptor

Gene

MET

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, ReceptorImportedARBA annotation, Transferase, Tyrosine-protein kinaseARBA annotation
LigandATP-bindingARBA annotation, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
HGF/SF receptorARBA annotation (EC:2.7.10.1ARBA annotation)
Alternative name(s):
Hepatocyte growth factor receptorARBA annotation
Proto-oncogene c-MetARBA annotation
Scatter factor receptorARBA annotation
Tyrosine-protein kinase MetARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:METImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei936 – 960HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501868084829 – 1274HGF/SF receptorSequence analysisAdd BLAST1246

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation, PhosphoproteinARBA annotation, Ubl conjugationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 520SemaInterPro annotationAdd BLAST490
Domaini1083 – 1274Protein kinaseInterPro annotationAdd BLAST192

Keywords - Domaini

RepeatARBA annotation, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR011009, Kinase-like_dom_sf
IPR031148, Plexin
IPR002165, Plexin_repeat
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR22625, PTHR22625, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109, TYRKINASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00219, TyrKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF101912, SSF101912, 1 hit
SSF56112, SSF56112, 1 hit
SSF81296, SSF81296, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS51004, SEMA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

A0A3Q7SVW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLTMKAPAV LAPGILVLLF TLVQKSYGEC KEALVKSEMN VNMKYQLPNF
60 70 80 90 100
TAETPIQNVV LHKHHIYLGA VNYIYVLNDK DLQKVAEYKT GPVLEHPDCS
110 120 130 140 150
PCQDCSHKAN LSGGVWEDNI NMALLVDTYY DDQLISCGSV HRGTCQRHIL
160 170 180 190 200
PPSNIADIQS EVHCMYSSQA DEEPSQCPDC VVSALGTKVL ISEKDRFINF
210 220 230 240 250
FVGNTINSSD HPDHSLHSIS VRRLKETQDG FKFLTDQSYI DVLPEFRDSY
260 270 280 290 300
PIKYVHAFES NHFIYFLTVQ RETLDAQTFH TRIIRFCSVD SGLHSYMEMP
310 320 330 340 350
LECILTEKRR KRSTREEVFN ILQAAYVSKP GAHLAKQIGA NLNDDILYGV
360 370 380 390 400
FAQSKPDSAE PMNRSAVCAF PIKYVNEFFN KIVNKNNVRC LQHFYGPNHE
410 420 430 440 450
HCFNRTLLRN SSGCEARNDE YRTEFTTALQ RVDLFMGQFN QVLLTSISTF
460 470 480 490 500
IKGDLTIANL GTSEGRFMQV VVSRSGLSTP HVNFRLDSHP VSPAAIVEHP
510 520 530 540 550
LNQNGYTLVV TGKKITRIPL NGLGCEHFQS CSQCLSAPPF VQCGWCHDRC
560 570 580 590 600
VHLEECPTGA WTQEVCLPAI YEVFPTSAPL EGGTVLTVCG WDFGFRRNNK
610 620 630 640 650
FDLKKTKVFL GNESCTLTLS ESTTNMLKCT VGPAVNEHFN ISIIISNGRG
660 670 680 690 700
TAQYSTFSYV DPIITSISPS YGPKNGGTLL TLTGKYLNSG NSRHISIGGK
710 720 730 740 750
TCTLKSVSDS ILECYTPAQA TATEFPIKLK IDLANREMNS FSYQEDPIVY
760 770 780 790 800
AIHPTKSFIS GGSTITAVGK NLNSVSVLRM VIDVHETRRN FTVACQHRSN
810 820 830 840 850
SEIICCTTPS LQQLNLQLPL KTKAFFMLDG IHSKYFDLIY VHNPVFKPFE
860 870 880 890 900
KPVMISIGNE NVLKIKGNDI DPEAVKGEVL KVGNKSCETI YSDSKAVLCK
910 920 930 940 950
VPYDLLKLNN ELNIEWKQAV SSTVLGKVIV QPDQNFTGLI AGAISISTIV
960 970 980 990 1000
LLLLGLFLWL KRKKQIKDLG SELVRYDARV HTPHLDRLVS ARSVSPTTEM
1010 1020 1030 1040 1050
VSNESVDYRA TFPEDQFPNS SQNGSCRQVQ YPLTDLSPML TSGDSDISSP
1060 1070 1080 1090 1100
LLQNTVHIDL SALNPELVQA VQHVVIGPSS LIVHFNEVIG RGHFGCVYHG
1110 1120 1130 1140 1150
TLLDNDDKKI HCAVKSLNRI TDIGEVSQFL TEGIIMKDFS HPNVLSLLGI
1160 1170 1180 1190 1200
CLRSEGSPLV VLPYMKHGDL RNFIRNETHN PTVKDLIGFG LQVAKGMKYL
1210 1220 1230 1240 1250
ASKKFVHRDL AARNCMLDEK FTVKVADFGL ARDMYDKEYY SVHNKTGAKL
1260 1270
PVKWMALESL QTQKFTTKSD VVTY
Length:1,274
Mass (Da):142,267
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8751F7FDF7F1983
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q7UKU6A0A3Q7UKU6_VULVU
HGF/SF receptor
MET
1,227Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025867934.1, XM_026012149.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSVVUT00000018807; ENSVVUP00000014345; ENSVVUG00000010494

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vvp:112929871

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025867934.1, XM_026012149.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSVVUT00000018807; ENSVVUP00000014345; ENSVVUG00000010494
KEGGivvp:112929871

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR002909, IPT_dom
IPR011009, Kinase-like_dom_sf
IPR031148, Plexin
IPR002165, Plexin_repeat
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR016201, PSI
IPR001627, Semap_dom
IPR036352, Semap_dom_sf
IPR001245, Ser-Thr/Tyr_kinase_cat_dom
IPR008266, Tyr_kinase_AS
IPR020635, Tyr_kinase_cat_dom
IPR015943, WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625, PTHR22625, 1 hit
PfamiView protein in Pfam
PF07714, PK_Tyr_Ser-Thr, 1 hit
PF01437, PSI, 1 hit
PF01403, Sema, 1 hit
PF01833, TIG, 3 hits
PRINTSiPR00109, TYRKINASE
SMARTiView protein in SMART
SM00429, IPT, 4 hits
SM00423, PSI, 1 hit
SM00630, Sema, 1 hit
SM00219, TyrKc, 1 hit
SUPFAMiSSF101912, SSF101912, 1 hit
SSF56112, SSF56112, 1 hit
SSF81296, SSF81296, 3 hits
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00109, PROTEIN_KINASE_TYR, 1 hit
PS51004, SEMA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7SVW1_VULVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7SVW1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: February 10, 2021
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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