Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 3 (05 Jun 2019)
Sequence version 1 (10 Apr 2019)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

cadherin EGF LAG seven-pass G-type receptor 3 isoform X4

Gene

LOC112911950

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer
LigandCalciumSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
cadherin EGF LAG seven-pass G-type receptor 3 isoform X4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LOC112911950Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2552 – 2576HelicalSequence analysisAdd BLAST25
Transmembranei2588 – 2608HelicalSequence analysisAdd BLAST21
Transmembranei2614 – 2636HelicalSequence analysisAdd BLAST23
Transmembranei2657 – 2677HelicalSequence analysisAdd BLAST21
Transmembranei2697 – 2718HelicalSequence analysisAdd BLAST22
Transmembranei2739 – 2760HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 38Sequence analysisAdd BLAST38
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501875841439 – 3330Sequence analysisAdd BLAST3292

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1429 ↔ 1438PROSITE-ProRule annotation
Disulfide bondi1467 ↔ 1476PROSITE-ProRule annotation
Disulfide bondi1754 ↔ 1763PROSITE-ProRule annotation
Disulfide bondi2016 ↔ 2025PROSITE-ProRule annotation
Disulfide bondi2083 ↔ 2095PROSITE-ProRule annotation
Disulfide bondi2085 ↔ 2102PROSITE-ProRule annotation
Disulfide bondi2104 ↔ 2113PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1381 – 1439EGF-likeInterPro annotationAdd BLAST59
Domaini1441 – 1477EGF-likeInterPro annotationAdd BLAST37
Domaini1481 – 1520EGF-likeInterPro annotationAdd BLAST40
Domaini1521 – 1725LAM_G_DOMAINInterPro annotationAdd BLAST205
Domaini1728 – 1764EGF-likeInterPro annotationAdd BLAST37
Domaini1770 – 1950LAM_G_DOMAINInterPro annotationAdd BLAST181
Domaini1952 – 1985EGF-likeInterPro annotationAdd BLAST34
Domaini1988 – 2026EGF-likeInterPro annotationAdd BLAST39
Domaini2083 – 2130Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini2115 – 2193G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST79
Domaini2491 – 2543GPSInterPro annotationAdd BLAST53
Domaini2553 – 2790G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni96 – 116DisorderedSequence analysisAdd BLAST21
Regioni152 – 174DisorderedSequence analysisAdd BLAST23
Regioni214 – 283DisorderedSequence analysisAdd BLAST70
Regioni2371 – 2393DisorderedSequence analysisAdd BLAST23
Regioni2903 – 2959DisorderedSequence analysisAdd BLAST57
Regioni2995 – 3024DisorderedSequence analysisAdd BLAST30
Regioni3105 – 3158DisorderedSequence analysisAdd BLAST54
Regioni3178 – 3258DisorderedSequence analysisAdd BLAST81
Regioni3275 – 3330DisorderedSequence analysisAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2932 – 2959PolyampholyteSequence analysisAdd BLAST28
Compositional biasi2996 – 3017PolarSequence analysisAdd BLAST22
Compositional biasi3125 – 3140PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3180 – 3194Pro-richSequence analysisAdd BLAST15
Compositional biasi3275 – 3320PolarSequence analysisAdd BLAST46

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Laminin EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00205 CADHERIN
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111418 SSF111418, 1 hit
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q7RQH0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRRGVMARR PLWWSLRGPT TPLLLLLLLV SLFPLSREEL EVDGGQGWDP
60 70 80 90 100
GVAAATGPGA RIGGGTLALC PETPGVQEDG EPGLGMREPV FVGLRGGRKS
110 120 130 140 150
AQSGRGPPKQ PDAGLGAKYG VQALDSRGRE TGQGTGSLLC WRTEVSSCEQ
160 170 180 190 200
AGPLRRDSLS PEALSPEVPS LENSPPFPSD LLVWPRGYKP VSSQRNAGRG
210 220 230 240 250
TPKKVGTMRC CGELWAPRRR GQGERTATPR AERTAPQPEC SPRAAGSGPG
260 270 280 290 300
LDSAPLTERT APAPGSAPRE SRTAPEPTPE RMRSRALFRR RFLPQSPGPR
310 320 330 340 350
PPGVLAHPRV WRIPTTNRVR PRRAANRHPQ FPQYNYQALV PENEAAGTTV
360 370 380 390 400
LRVVAQDPDA GEAGRLVYSL AALMNSRSLE LFSIDPLSGL IRTEAALDRE
410 420 430 440 450
SMERHYLRVT AQDHGSPRLS ATTMVAVTVT DRNDHAPVFE QAQYRETLRE
460 470 480 490 500
NVEEGYPILQ LRATDGDAPP NANLRYRFVG PPAARAAASA AFEIDPRSGL
510 520 530 540 550
ISTSGRVDRE HMESYELVVE ASDQGQEPGP RSATVRVHIT VLDENDNAPQ
560 570 580 590 600
FSEKRYVAQV REDVRPHTVV LRVTATDRDK DANGLVHYNI ISGNSRGHFA
610 620 630 640 650
IDSLTGEIQV VAPLDFEAER EYALRIRAQD AGRPPLSNNT GLVSIQVVDI
660 670 680 690 700
NDHTPIFVST PFQVSVLENA PLGHSVIHIQ AVDADHGENA RLEYSLTGMA
710 720 730 740 750
PDMPFVINSA TGWVSVSGPL DRESVEHYFF GVEARDHGTP PLSASASVTV
760 770 780 790 800
TVLDVNDNRP EFTMKEYHLR LNEDAAVGTT VVSVTAVDRD ANSAISYQIT
810 820 830 840 850
GGNTRNRFAI STQGGVGLVT LALPLDYKQE RYFKLVLTAS DRALHDHCYV
860 870 880 890 900
HINITDANTH RPVFQSAHYS VSVNEDRPVG STVVVISASD DDVGENARIT
910 920 930 940 950
YLLEDNLPQF RIDADSGAIT LQAPLDYEDQ VTYTLAITAR DNGIPQKADT
960 970 980 990 1000
TYVEVMVNDV NDNAPQFVAS HYTGLVSEDA PPFTSVLQIS ATDRDAHANG
1010 1020 1030 1040 1050
RVQYTFQNGE DGDGDFTIEP TSGIVRTVRR LDREAVPVYE LTAYAVDRGV
1060 1070 1080 1090 1100
PPLRTPVSIQ VTVQDVNDNA PVFPAEEFEV RVKENSIVGS VVAQITAVDP
1110 1120 1130 1140 1150
DEGPNAHIMY QIVEGNIPEL FQMDIFSGEL TALIDLDYEA RQEYVIVVQA
1160 1170 1180 1190 1200
TSAPLVSRAT VHVRLVDQND NSPVLNNFQI LFNNYVSNRS DTFPSGVIGR
1210 1220 1230 1240 1250
IPAYDPDVSD HLFYSFERGN ELQLLVVNQT SGELRLSRKL DNNRPLVASM
1260 1270 1280 1290 1300
LVTVTDGLHS VTAQCVLRVV IITEELLANS LTVRLENMWQ ERFLSPLLGH
1310 1320 1330 1340 1350
FLEGVAAVLA TPAEDVFIFN IQNDTDVGGT VLNVSFSALA PRGAGAGAAG
1360 1370 1380 1390 1400
PWFSSEELQE QLYVRRAALA ARSLLDVLPF DDNVCLREPC ENYMKCVSVL
1410 1420 1430 1440 1450
RFDSSAPFLA SASTLFRPIQ PIAGLRCRCP PGFTGDFCET ELDLCYSNPC
1460 1470 1480 1490 1500
RNGGACARRE GGYTCVCRPR FTGEDCELDT EAGRCVPGIC RNGGTCADGP
1510 1520 1530 1540 1550
DGGFRCQCPA GGAFEGPRCE VAARSFPPSS FVMFRGLRQR FHLTLSLSFA
1560 1570 1580 1590 1600
TVQPSGLLFY NGRLNEKHDF LALELVAGQV RLTYSTGESN TVVSPTVPGG
1610 1620 1630 1640 1650
LSDGQWHTVH LRYYNKPRTD ALGGAQGPSK DKVAVLSVDD CDVAVALQFG
1660 1670 1680 1690 1700
AEIGNYSCAA AGMQTSSKKS LDLTGPLLLG GVPNLPENFP VSHKEFIGCM
1710 1720 1730 1740 1750
RDLYIDGRRV DMAAFVANNG TMAGCQAKLH FCDSGPCKNS GFCSERWGGF
1760 1770 1780 1790 1800
SCDCPVGFGG KDCRLTMAHP HHFRGNGTLT WDFGNDMAVS VPWYLGLAFR
1810 1820 1830 1840 1850
TRATQGVLMQ VQAGPHSTLL CQLDRGLLSV MVTRGSGRAA HLLLDQVTVS
1860 1870 1880 1890 1900
DGRWHDLRLE LQEEPGGRRG HHVLMVSLDF SLFQDTMAVG SELQGLKVKR
1910 1920 1930 1940 1950
LHVGGLPPSS EEEVPQGLVG CIQGVWLGST PSGSPTLLPP SHRVNVEPGC
1960 1970 1980 1990 2000
VVPNACASGP CPPHADCRDL WQTFSCTCWP GYYGPGCVDA CLLNPCQNQG
2010 2020 2030 2040 2050
SCRHLPGAPH GYTCDCVGGY FGHHCEHRMD QQCPRGWWGS PTCGPCNCDV
2060 2070 2080 2090 2100
HKGFDPNCNK TNGQCHCKEF HYRPQGSDSC LPCDCYPVGS TSRSCAPHSG
2110 2120 2130 2140 2150
QCPCRPGALG RQCNSCDSPF AEVTASGCRV LYDACPKSLR SGVWWPQTKF
2160 2170 2180 2190 2200
GMLASVPCPR GALGLRGAGA AVRLCDEDRG WLEPDLFNCT SPAFRELNLL
2210 2220 2230 2240 2250
LDGLELNKTA LDTVEAKKLA QRLREVTGHT EHYFSQDVRV TARLLAHLLA
2260 2270 2280 2290 2300
FESHQQGFGL TATQDAHFNE NLLWAGSALL APETGDLWAA LGQRAPGGSP
2310 2320 2330 2340 2350
GSAGLVQHLE EYAATLARNM ELTYLNPVGL VTPNIMLSID RMEHPSPTRG
2360 2370 2380 2390 2400
TRRYPRYHSN LFRGQDAWDP HTHVLLPSQS PRPSPPAVLP TGSGNMENIT
2410 2420 2430 2440 2450
TSSVAPPPAP LEPEPEPGIS IVILLVYRTL GGLLPAQFQA ERRGARLPQN
2460 2470 2480 2490 2500
PVMNSPVVSV AVFHRRNFLR GVLESPISLE FRLLQTANRS KAICVQWDPP
2510 2520 2530 2540 2550
GPADQHGMWT ARDCELVHRN GSHARCRCSR TGTFGVLMDA SPRERLEGDL
2560 2570 2580 2590 2600
ELLAVFTHVV MAVSVAALLL TAAVLLSLRS LKSNMRGIHA NVAAALGVAE
2610 2620 2630 2640 2650
LLFLLGIHRT HNQLVCTAVA ILLHYFFLST FAWLLVQGLH LYRMQVEPRN
2660 2670 2680 2690 2700
VDRGAMRFYH ALGWGVPAVL LGLAVGLDPE GYGNPDFCWI SIHEPLIWSF
2710 2720 2730 2740 2750
AGPVILVIVM NGTMLLLAAR TSCATGQREA KKTSMLRSLR SCFLLLLLVS
2760 2770 2780 2790 2800
ASWLFGLLAV NHSVLAFHYL HAALSGLQGL AVLLLFCILN ADARAAWTPA
2810 2820 2830 2840 2850
CLGRKAAPEE ARPAPGTGHG AYNNTALFEE SGLIRITLGA STVSSVSSAR
2860 2870 2880 2890 2900
SGRTQDQDSQ RGRGYLRDNV LVRHGSAADH TDHSLQAHAG PTDLDVAMFH
2910 2920 2930 2940 2950
RDAGGAADSD SDSDLSLEEE RSLSIPSSES EDNGRTRGRF QRPLRRAAQS
2960 2970 2980 2990 3000
ERLLTHPKDV DGNDLLSYWP ALGECEATPC ALQTWGSERR LGLDTSKDAA
3010 3020 3030 3040 3050
NNNQPDLALT SGDETSLGRA QRQRKGILKN RLQYPLVPQT RGAPELSWCR
3060 3070 3080 3090 3100
AATLGHRAVP AASYGRIYAG GATGSLSQPA SRYSSREQLD LLLRRQLSRE
3110 3120 3130 3140 3150
RLEEAPAPIL RPLSRPGSQE RLDAAPGRLE PRDRGSTLPR RQPPRDYPGA
3160 3170 3180 3190 3200
RAGRFGSRDA LDLGAPCEWL STLPLPHSAR DLDPQPPPLP LSPQRQLSRD
3210 3220 3230 3240 3250
PLLPSRPLDS LSRRSNSGEQ LDRVPSRHPS REGLGPPPQL LRVREDPASG
3260 3270 3280 3290 3300
PSHGPSTEQL DILSSILASF NSSALSSSVQ SSSTPSGPHT TATPSATASA
3310 3320 3330
LGPSTSRSAT SHSISELSPD SEVPRSEGHS
Length:3,330
Mass (Da):361,166
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12888985DC9B3A9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q7RFN8A0A3Q7RFN8_VULVU
cadherin EGF LAG seven-pass G-type ...
LOC112911950
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RGR4A0A3Q7RGR4_VULVU
cadherin EGF LAG seven-pass G-type ...
LOC112911950
3,324Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RGP3A0A3Q7RGP3_VULVU
cadherin EGF LAG seven-pass G-type ...
LOC112911950
3,480Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7SQK1A0A3Q7SQK1_VULVU
cadherin EGF LAG seven-pass G-type ...
LOC112911950
3,481Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RGP9A0A3Q7RGP9_VULVU
cadherin EGF LAG seven-pass G-type ...
LOC112911950
3,476Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RFM2A0A3Q7RFM2_VULVU
solute carrier family 26 member 6 i...
LOC112911950
759Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RGS6A0A3Q7RGS6_VULVU
solute carrier family 26 member 6 i...
LOC112911950
760Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7SQQ4A0A3Q7SQQ4_VULVU
solute carrier family 26 member 6 i...
LOC112911950
739Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025844461.1, XM_025988676.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025844461.1, XM_025988676.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR002126 Cadherin-like_dom
IPR015919 Cadherin-like_sf
IPR020894 Cadherin_CS
IPR013320 ConA-like_dom_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR032471 GAIN_dom_N
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR002049 Laminin_EGF
IPR001791 Laminin_G
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00028 Cadherin, 8 hits
PF00008 EGF, 2 hits
PF16489 GAIN, 1 hit
PF01825 GPS, 1 hit
PF02793 HRM, 1 hit
PF00053 Laminin_EGF, 1 hit
PF02210 Laminin_G_2, 2 hits
PRINTSiPR00205 CADHERIN
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00112 CA, 9 hits
SM00181 EGF, 6 hits
SM00179 EGF_CA, 5 hits
SM00180 EGF_Lam, 1 hit
SM00303 GPS, 1 hit
SM00008 HormR, 1 hit
SM00282 LamG, 2 hits
SUPFAMiSSF111418 SSF111418, 1 hit
SSF49313 SSF49313, 9 hits
SSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS00232 CADHERIN_1, 6 hits
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 6 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50025 LAM_G_DOMAIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7RQH0_VULVU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7RQH0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: June 5, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again