Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 8 (02 Dec 2020)
Sequence version 1 (10 Apr 2019)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

PDZ domain-containing protein 2

Gene

PDZD2

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
PDZ domain-containing protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PDZD2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini94 – 160PDZInterPro annotationAdd BLAST67
Domaini334 – 419PDZInterPro annotationAdd BLAST86
Domaini584 – 670PDZInterPro annotationAdd BLAST87
Domaini726 – 796PDZInterPro annotationAdd BLAST71
Domaini2364 – 2436PDZInterPro annotationAdd BLAST73
Domaini2489 – 2574PDZInterPro annotationAdd BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 316DisorderedSequence analysisAdd BLAST133
Regioni439 – 503DisorderedSequence analysisAdd BLAST65
Regioni676 – 722DisorderedSequence analysisAdd BLAST47
Regioni825 – 851DisorderedSequence analysisAdd BLAST27
Regioni877 – 925DisorderedSequence analysisAdd BLAST49
Regioni1005 – 1026DisorderedSequence analysisAdd BLAST22
Regioni1063 – 1581DisorderedSequence analysisAdd BLAST519
Regioni1641 – 1680DisorderedSequence analysisAdd BLAST40
Regioni1705 – 1946DisorderedSequence analysisAdd BLAST242
Regioni1958 – 2009DisorderedSequence analysisAdd BLAST52
Regioni2094 – 2182DisorderedSequence analysisAdd BLAST89
Regioni2200 – 2220DisorderedSequence analysisAdd BLAST21
Regioni2277 – 2307DisorderedSequence analysisAdd BLAST31
Regioni2447 – 2480DisorderedSequence analysisAdd BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi185 – 202PolarSequence analysisAdd BLAST18
Compositional biasi278 – 294PolyampholyteSequence analysisAdd BLAST17
Compositional biasi302 – 316PolyampholyteSequence analysisAdd BLAST15
Compositional biasi676 – 711PolarSequence analysisAdd BLAST36
Compositional biasi825 – 846PolarSequence analysisAdd BLAST22
Compositional biasi1084 – 1113PolarSequence analysisAdd BLAST30
Compositional biasi1407 – 1427PolarSequence analysisAdd BLAST21
Compositional biasi1465 – 1530PolarSequence analysisAdd BLAST66
Compositional biasi1544 – 1558PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1562 – 1578PolarSequence analysisAdd BLAST17
Compositional biasi1797 – 1811PolarSequence analysisAdd BLAST15
Compositional biasi1897 – 1911PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1912 – 1934Pro-richSequence analysisAdd BLAST23
Compositional biasi2128 – 2160PolarSequence analysisAdd BLAST33
Compositional biasi2452 – 2469PolarSequence analysisAdd BLAST18

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00595, PDZ, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228, PDZ, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50156, SSF50156, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106, PDZ, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q7RCQ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPITQDNAML HLPLLYQWLQ NSLREGGDGP EQRLCQAAIQ KLQEYIQLNF
60 70 80 90 100
AVDESVVPPD RSPPGMEICT VYLTKELGDT ETVGLSFGNI PVFGDYGEKR
110 120 130 140 150
RGGKKRKTHP GPVLDVGCIW VTELRKNSPA GKSGKVRLRD EILSLNGQLM
160 170 180 190 200
VGVDVSGASY LAEQCWNGGF IYLIMLRRFK HKVQSPYNGN GSSSTEPAET
210 220 230 240 250
PTLELGDQTV KKGKRARKFG VISKPPTHKA TEEPKSSAGC ELENDPVSEL
260 270 280 290 300
DNGPDPDLGN GHALELENGP ESLKELAGSH LDGSEADRGT EPRIPKTDAS
310 320 330 340 350
LPANNDKRRF SKSGKTDFQS SDCLAREEVG RIWKMELLKE SDGLGIQVSG
360 370 380 390 400
GRGSKRSPHA IVVTQVKEGG AAHRDGRLSL GDELLVINGH LLVGLSHEEA
410 420 430 440 450
VAILRSATGM VQLVVASKET SAEDLLRLTS KSLPDLTSSV EDVSSWTDNE
460 470 480 490 500
DQEPDGEEDG SSSVQGAMPG TDEPQDSCGP DESKGNLESP KQGSSKMKLK
510 520 530 540 550
SRLSGGVHRL ESVEEYNELM LRNGDPRVRM LEVSRDGRKH SLPQLLDSTG
560 570 580 590 600
TSQEYHIVKK STRSLSTTQV ESPWRLIRPS VISIIGLYKE KGKGLGFSIA
610 620 630 640 650
GGRDCIRGQM GIFVKTIFPN GSAAEDGRLK EGDEILDVNG IPIKGLTFQE
660 670 680 690 700
AIHTFKQIRS GLFVLTVRTK LLSPSLTPCS TPTHMSRSSS PNFNTSGGSS
710 720 730 740 750
ATGSDEGSSS SLGRKAPGPK DRIVMEVTLN KEPRVGLGIG ACCLALENSP
760 770 780 790 800
PGIYIHSLAP GSVAKMESNL SRGDQILEVN SVNVRHAALS KVHTILSKCP
810 820 830 840 850
PGPVRLVIGR HPNPKISEQE MDLVIARSTY QESKEASSSP GSGTPLKSPS
860 870 880 890 900
LAKKDALITE AEASHYFAHG VPGSLSDFVV AGSEDEDPPG GGCGASEDSG
910 920 930 940 950
LPPSTPAPRE PGKPRANSLV SLGSQRSSGL FHKQVTIARQ TSLPGSPQAL
960 970 980 990 1000
RNPLLRQRRV GCYDTDDASD EEEFDGEGDC ISLPGTLSDP SRPLTEDSSR
1010 1020 1030 1040 1050
HVLVTSSKAT GLNNQGEHPQ KTMVSKASSV PLFGSSLSLE ERVPEGVGDT
1060 1070 1080 1090 1100
PSHAAHLLAS AEAAKGGSGC PRRKELSGSR SSPKLEYKAD TSPQCLVNTD
1110 1120 1130 1140 1150
TPRLPQQKND NLGSRHKPVA RVSPHHKRPE ADARPSNPET ADLTDGADDP
1160 1170 1180 1190 1200
CVQAAPVKEI RTGFQPGGTA EKESLGKLTV QEGHVPATWG PASAPLHPDA
1210 1220 1230 1240 1250
GHCTENLLGA TPEPGQQPGT GLDGPPGQKG AAHPDPGEPS ADTGHARRPE
1260 1270 1280 1290 1300
DPGKPVSPGG SESEDRGQVR LGQERGSSPG KTAAPEASSP RRAAAHRGGR
1310 1320 1330 1340 1350
EADGASPAST VLARGLLVSQ EDTQRVPGDH SKAPQTTGVL VPEAPRGSQR
1360 1370 1380 1390 1400
APQARPAPPS PADKAEGACG GVAGHCCPGE QGGSPVTDID KLLKELGGAS
1410 1420 1430 1440 1450
EPRLQSPQKG DRVSQEGRSQ GQPPAGAGSG SSRHAEPVMG DQTPTPRRAR
1460 1470 1480 1490 1500
AAAGQPPHPP WASQPSVLDS INPDKHFTVN KSFLSNYSRN FSSFHEDSLS
1510 1520 1530 1540 1550
LSGLGDSTEP SLSSMYGDAE DSSSDPESLT EAPRAATRDN WSPPRSRRAS
1560 1570 1580 1590 1600
HKEDTTESEE EPIEICSTNG SPNPPSATAH APAQAAPCPV LAKVLPLKHS
1610 1620 1630 1640 1650
ALSQVVGNPC ERASFVPGTS RLSIPNASQP FSLLDVSSQE HERHADRGMA
1660 1670 1680 1690 1700
QNPGPSREEI VEATGASSAV ESRQPPNTAR HVHNLTVTLS NLNMVNGLEH
1710 1720 1730 1740 1750
ELLGNEIPHK KQETTVSATE NRSPFSGDVP KNGESPLANL HISESEDLDD
1760 1770 1780 1790 1800
LLQKPKMTSR RPIMAWFKEI NKNNHGTHSQ GKTEKEQPVV PARSPDSKGQ
1810 1820 1830 1840 1850
VSGSSHRKGV AGPQSPLQPK VSLENKDPPK KGAVETLVSN GQKPKSGPKL
1860 1870 1880 1890 1900
KRLSIKSKSK ASTEAPVANM TKAGGADPRK PLISPQASHR MLSKAVAHRV
1910 1920 1930 1940 1950
HAPEHQEPDQ DGPASPRPPP SGLESRPPAA PGSPKAPTAE TGTWAFVAPH
1960 1970 1980 1990 2000
AAAKALPEQG ACGRWHPARP ATRTYSMPAQ FASHFGREAQ ASSGGPPEAR
2010 2020 2030 2040 2050
ASRGGVLGLA DGQGVYSVKP LLETSRTVPA TDGAAALSVQ ESSCQVTDKI
2060 2070 2080 2090 2100
KVTRRHYHSE QNYESTSFFS VKQRIKSFEN LANSDRLVAK SGAAPFLSAG
2110 2120 2130 2140 2150
GKPPVGRRSS GSSASGSLGH PGDPTARSLR RSLSSCSESP SEAGALGPQL
2160 2170 2180 2190 2200
TKSPSSTALT VPRPHAAAAG DQGXXXXXXX XXXXXXXXXX XXXXXXXXXX
2210 2220 2230 2240 2250
XXXAGRRAQP SPLSRSKLQE LRALSMPDLD KLRSEDFRAG PAAVLFRTEL
2260 2270 2280 2290 2300
EIVPRRPPAS ATGGLNGPTA LSCPVRPAAG ACPAGSSPKA MEPGAPSSAH
2310 2320 2330 2340 2350
LAGEAARDLP SGKGWSVNLD QLLVSAGDQQ RLQSVLSSVG SKSTVLTLIQ
2360 2370 2380 2390 2400
EARAQSENKE DVCFIVLNKK EGSGLGFTVA GGTDVEPKSI VVHRVCSQGA
2410 2420 2430 2440 2450
ASQEGTVNRG DFLLSVNGAS LAGLAHGDVL KILHQAQLHR DVLVVIKRGN
2460 2470 2480 2490 2500
DQPGPSSRQE ANGKGSFSRK TSPLEPGIGR SVPSHDALCV EVLKTSAGLG
2510 2520 2530 2540 2550
LSLDGGKSSV AGDGPLFIKR VYKGGAAEQA GTIEAGDEIL AINGKPLVGL
2560 2570 2580
MHFDAWNIMK SVPEGPVQLV IRKPGILPET STSSNTH
Length:2,587
Mass (Da):272,660
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i74AC5FAF0B2A53B7
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025839906.1, XM_025984121.1

Genome annotation databases

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vvp:112908619

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025839906.1, XM_025984121.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Genome annotation databases

KEGGivvp:112908619

Family and domain databases

Gene3Di2.30.42.10, 6 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 5 hits
SMARTiView protein in SMART
SM00228, PDZ, 6 hits
SUPFAMiSSF50156, SSF50156, 6 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7RCQ8_VULVU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7RCQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: December 2, 2020
This is version 8 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again