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Entry version 3 (05 Jun 2019)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

collagen alpha-3(V) chain isoform X1

Gene

COL5A3

Organism
Vulpes vulpes (Red fox)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
collagen alpha-3(V) chain isoform X1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COL5A3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVulpes vulpes (Red fox)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9627 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeVulpes
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501878044930 – 1749Sequence analysisAdd BLAST1720

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1518 – 1748Fibrillar collagen NC1InterPro annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 305DisorderedSequence analysisAdd BLAST77
Regioni343 – 363DisorderedSequence analysisAdd BLAST21
Regioni389 – 434DisorderedSequence analysisAdd BLAST46
Regioni479 – 1496DisorderedSequence analysisAdd BLAST1018

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi248 – 268BasicSequence analysisAdd BLAST21
Compositional biasi274 – 305PolarSequence analysisAdd BLAST32
Compositional biasi400 – 427Pro-richSequence analysisAdd BLAST28
Compositional biasi661 – 682Pro-richSequence analysisAdd BLAST22
Compositional biasi877 – 894Pro-richSequence analysisAdd BLAST18
Compositional biasi968 – 988Pro-richSequence analysisAdd BLAST21
Compositional biasi1177 – 1194Pro-richSequence analysisAdd BLAST18
Compositional biasi1300 – 1314Pro-richSequence analysisAdd BLAST15
Compositional biasi1318 – 1333PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1370 – 1389Pro-richSequence analysisAdd BLAST20
Compositional biasi1433 – 1450Pro-richSequence analysisAdd BLAST18
Compositional biasi1477 – 1492Pro-richSequence analysisAdd BLAST16

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

CollagenImported, SignalSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51461 NC1_FIB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q7R824-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRRGLGQP RAGLCFVLAS LQLLLRTQAE DPVDVLKALG VRGGQAGVLD
60 70 80 90 100
GPGLCPQRAP EGDRAFRVGK ATILGIPTWE LFPDGHFPEN FSVLITLRGQ
110 120 130 140 150
PANQSVLLSI YDESGIRQLG LALGPALGLL GDSFSPLPQQ VNLMDGRWHR
160 170 180 190 200
VAVSVDGRMV TLVADCEPQP PILGQGPRFI SAAGLTVLGT QDLGEETFEG
210 220 230 240 250
DVQELLISPD PQAAFQACER YLPGCDNLDP IATGVPQSEP ETPPPRRKGK
260 270 280 290 300
GKGKKKGRGR KGKGRKKKNK ESLTPSPPPG SLENQTFTDI PNTETPASTL
310 320 330 340 350
PPTSTPLVIT TTVTIGLNAT MLEGGLDPDN GTELRTLKTK LAKEDQEGDG
360 370 380 390 400
PTMGPDFRAA EQPSQTQFQI FPGGGEKGAK GEPAVIEQGQ KFEGPPGAPG
410 420 430 440 450
PRGVIGPSGP PGPPGFPGDP GLPGPAGLPG MPGIDGIRGL PGTVIMMPFQ
460 470 480 490 500
FASSSLKGPP VSFQQAQAQA VLQQAQLSMK GPPGPVGLTG RPGPVGLPGY
510 520 530 540 550
PGQKGEMGDI GPQGPRGLQG PLGPPGQEGK MGRSGADGAR GLPGDTGPKG
560 570 580 590 600
DRGFDGLPGL PGEKGQRGDF GHVGQPGPPG EDGKKGAEGP PGPTGQAGEP
610 620 630 640 650
GPRGLIGPRG SPGPLGRPGV VGIDGAPGAK GNVGPPGEPG PPGQQGNPGS
660 670 680 690 700
QGLPGPQGPI GTPGEKGPPG NPGIPGVPGS DGPPGHPGHE GPTGEKGAQG
710 720 730 740 750
PPGSAGPPGY PGPRGVKGTS GNRGLQGEKG EQGEDGFPGF KGDGGPKGDR
760 770 780 790 800
GHPGPPGPRG EDGPEGLKGQ EGLAGEEGPP GSAGEKGKLG VPGLPGYPGR
810 820 830 840 850
PGPKGSTGFP GPLGPLGEKG KRGKAGQPGL EGERGPPGSR GERGQPGATG
860 870 880 890 900
QPGPKGDVGQ DGATGIPGEK GLPGLQGPPG FPGPKGPPGP QGKDGRPGHP
910 920 930 940 950
GQRGELGFQG QTGPPGPAGV VGPQGKTGEA GPLGERGPPG PPGPPGEQGL
960 970 980 990 1000
PGLEGREGIK GDLGPPGPLG KEGPPGPRGF PGPQGAPGDP GPIGLKGDKG
1010 1020 1030 1040 1050
PLGPVGANGS PGERGPVGPA GGIGLPGQSG GQGPVGPAGE KGSPGERGPP
1060 1070 1080 1090 1100
GPTGKDGIPG PLGLRGPPGA VGPSGEDGDK GEVGPPGNKG SKGDKGDAGP
1110 1120 1130 1140 1150
PGPTGVRGPV GHPGSPGADG AQGRRGPPGL FGQKGDDGVR GFVGVIGPPG
1160 1170 1180 1190 1200
LQGLPGPPGE KGEVGDVGSM GPHGAPGPRG PHGPSGPEGP PGLPGGVGQP
1210 1220 1230 1240 1250
GAVGEKGEPG EAGDPGPPGT PGLPGPKGEI GEKGDSGPSG AAGPPGKKGP
1260 1270 1280 1290 1300
PGEDGAKGNV GPTGLPGDLG PPGDPGVSGI DGSPGEKGDP GDVGGPGPPG
1310 1320 1330 1340 1350
ASGEPGPPGP PGKRGPSGRV GREGREGEKG AKGEPGPDGP PGMTGPVGAR
1360 1370 1380 1390 1400
GPPGRVGPEG LRGIPGPVGE PGLLGPPGQM GPPGPLGPSG LPGLKGDAGL
1410 1420 1430 1440 1450
KGEKGHIGLI GLIGPPGEAG EKGDQGLPGV QGPPGPKGEP GPPGPIGSLG
1460 1470 1480 1490 1500
HPGPPGVAGP LGQKGSKGSP GSFGPRGDTG PPGPPGPPGP PAELHGLRRR
1510 1520 1530 1540 1550
RRSLPGPGAL EAPEGGMEEV LASLTSLSFE LEQMRRPPGT AERPGLVCSE
1560 1570 1580 1590 1600
LYRNHPHLPD GEYWIDPNQG CARDALRVFC NFTAGGETCL YPDKKFETVK
1610 1620 1630 1640 1650
MASWSREKPG NWYSTFRRGK KFSYVDADGS PVSVVQMTFL KLLSATAHQS
1660 1670 1680 1690 1700
FTYTCQNSAA WLDEAAGDHG RSVRFLGANG EELSFNQTTA ATITVPYDGC
1710 1720 1730 1740
RLRKGQTKTL LEVSSSRVGF LPLWDVAAAD FGQTNQKFGF ELGPVCFSS
Length:1,749
Mass (Da):172,272
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEFAB69D3ED4E946B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3Q7SIE8A0A3Q7SIE8_VULVU
collagen alpha-3(V) chain isoform X...
COL5A3
1,439Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7R800A0A3Q7R800_VULVU
collagen alpha-3(V) chain isoform X...
COL5A3
1,606Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7RHB7A0A3Q7RHB7_VULVU
collagen alpha-3(V) chain isoform X...
COL5A3
1,429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q7R611A0A3Q7R611_VULVU
collagen alpha-3(V) chain isoform X...
COL5A3
1,471Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025841587.1, XM_025985802.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025841587.1, XM_025985802.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR013320 ConA-like_dom_sf
IPR000885 Fib_collagen_C
IPR001791 Laminin_G
PfamiView protein in Pfam
PF01410 COLFI, 1 hit
PF01391 Collagen, 4 hits
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078 Fib_collagen_C, 1 hit
SMARTiView protein in SMART
SM00038 COLFI, 1 hit
SM00210 TSPN, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51461 NC1_FIB, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7R824_VULVU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7R824
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: June 5, 2019
This is version 3 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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