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Entry version 9 (07 Oct 2020)
Sequence version 1 (10 Apr 2019)
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Protein

Histone-lysine N-methyltransferase

Gene

KMT2A

Organism
Callorhinus ursinus (Northern fur seal)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei3856S-adenosyl-L-methionineUniRule annotation1
Binding sitei3858S-adenosyl-L-methionineUniRule annotation1
Binding sitei3900S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi3926ZincUniRule annotation1
Metal bindingi3974ZincUniRule annotation1
Binding sitei3975S-adenosyl-L-methionineUniRule annotation1
Metal bindingi3976ZincUniRule annotation1
Metal bindingi3981ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1181 – 1229CXXC-typePROSITE-ProRule annotationAdd BLAST49

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulatorUniRule annotationARBA annotation, DNA-bindingARBA annotation, MethyltransferaseUniRule annotationImportedARBA annotation, Transferase
Biological processTranscription, Transcription regulationUniRule annotationARBA annotation
LigandMetal-binding, S-adenosyl-L-methionineUniRule annotationARBA annotation, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseUniRule annotation (EC:2.1.1.354UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KMT2AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallorhinus ursinus (Northern fur seal)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34884 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOtariidaeCallorhinus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286641 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1181 – 1229CXXC-typeInterPro annotationAdd BLAST49
Domaini1465 – 1516PHD-typeInterPro annotationAdd BLAST52
Domaini1513 – 1567PHD-typeInterPro annotationAdd BLAST55
Domaini1600 – 1664PHD-typeInterPro annotationAdd BLAST65
Domaini1740 – 1785BromoInterPro annotationAdd BLAST46
Domaini1907 – 2015PHD-typeInterPro annotationAdd BLAST109
Domaini2055 – 2111FYR N-terminalInterPro annotationAdd BLAST57
Domaini3683 – 3764FYR C-terminalInterPro annotationAdd BLAST82
Domaini3846 – 3962SETInterPro annotationAdd BLAST117
Domaini3970 – 3986Post-SETInterPro annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 81DisorderedSequence analysisAdd BLAST81
Regioni189 – 266DisorderedSequence analysisAdd BLAST78
Regioni358 – 378DisorderedSequence analysisAdd BLAST21
Regioni479 – 632DisorderedSequence analysisAdd BLAST154
Regioni747 – 979DisorderedSequence analysisAdd BLAST233
Regioni1072 – 1101DisorderedSequence analysisAdd BLAST30
Regioni1139 – 1200DisorderedSequence analysisAdd BLAST62
Regioni1234 – 1425DisorderedSequence analysisAdd BLAST192
Regioni1700 – 1742DisorderedSequence analysisAdd BLAST43
Regioni1843 – 1906DisorderedSequence analysisAdd BLAST64
Regioni2144 – 2167DisorderedSequence analysisAdd BLAST24
Regioni2182 – 2206DisorderedSequence analysisAdd BLAST25
Regioni2313 – 2354DisorderedSequence analysisAdd BLAST42
Regioni2407 – 2496DisorderedSequence analysisAdd BLAST90
Regioni2511 – 2655DisorderedSequence analysisAdd BLAST145
Regioni2684 – 2712DisorderedSequence analysisAdd BLAST29
Regioni2750 – 2821DisorderedSequence analysisAdd BLAST72
Regioni2839 – 2858DisorderedSequence analysisAdd BLAST20
Regioni3000 – 3080DisorderedSequence analysisAdd BLAST81
Regioni3205 – 3282DisorderedSequence analysisAdd BLAST78
Regioni3493 – 3660DisorderedSequence analysisAdd BLAST168
Regioni3802 – 3825DisorderedSequence analysisAdd BLAST24
Regioni3923 – 3924S-adenosyl-L-methionine bindingUniRule annotation2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili407 – 427Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi37 – 58Pro-richSequence analysisAdd BLAST22
Compositional biasi218 – 237PolarSequence analysisAdd BLAST20
Compositional biasi238 – 260PolyampholyteSequence analysisAdd BLAST23
Compositional biasi359 – 378PolyampholyteSequence analysisAdd BLAST20
Compositional biasi479 – 529PolarSequence analysisAdd BLAST51
Compositional biasi569 – 589PolarSequence analysisAdd BLAST21
Compositional biasi590 – 610Pro-richSequence analysisAdd BLAST21
Compositional biasi747 – 765PolarSequence analysisAdd BLAST19
Compositional biasi781 – 844PolarSequence analysisAdd BLAST64
Compositional biasi858 – 879PolarSequence analysisAdd BLAST22
Compositional biasi880 – 932PolyampholyteSequence analysisAdd BLAST53
Compositional biasi958 – 979PolarSequence analysisAdd BLAST22
Compositional biasi1080 – 1095PolarSequence analysisAdd BLAST16
Compositional biasi1283 – 1306PolyampholyteSequence analysisAdd BLAST24
Compositional biasi1312 – 1335PolarSequence analysisAdd BLAST24
Compositional biasi1336 – 1351Pro-richSequence analysisAdd BLAST16
Compositional biasi1403 – 1425PolarSequence analysisAdd BLAST23
Compositional biasi1859 – 1884Pro-richSequence analysisAdd BLAST26
Compositional biasi2313 – 2351PolarSequence analysisAdd BLAST39
Compositional biasi2440 – 2454PolarSequence analysisAdd BLAST15
Compositional biasi2455 – 2481PolyampholyteSequence analysisAdd BLAST27
Compositional biasi2564 – 2595PolarSequence analysisAdd BLAST32
Compositional biasi2606 – 2631PolarSequence analysisAdd BLAST26
Compositional biasi2758 – 2783PolarSequence analysisAdd BLAST26
Compositional biasi2784 – 2821PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3048 – 3080PolarSequence analysisAdd BLAST33
Compositional biasi3205 – 3220PolarSequence analysisAdd BLAST16
Compositional biasi3233 – 3259PolarSequence analysisAdd BLAST27
Compositional biasi3267 – 3282PolarSequence analysisAdd BLAST16
Compositional biasi3493 – 3547PolarSequence analysisAdd BLAST55
Compositional biasi3582 – 3646PolarSequence analysisAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1181 – 1229CXXC-typePROSITE-ProRule annotationAdd BLAST49

Keywords - Domaini

BromodomainPROSITE-ProRule annotation, Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotationARBA annotation

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45838:SF2, PTHR45838:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF010354, Methyltransferase_trithorax, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q7R5K2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHSCRWRFP ARPGTTGGGG GGGRRGLGGA PRQRVPALLL PPGPPVGGGG
60 70 80 90 100
PGAPPSPPAV AAAAAAAAGS SGAGVPGGAA AASAASSSSA SSSSSSSSSA
110 120 130 140 150
SSGPALLRVG PGFDAALQVS AAIGTNLRRF RAVFGESGGG GGSGELTTQI
160 170 180 190 200
PCSWRTKGLI HDKKTEPFRL LAWSWCLNDE QFLGFGSDEE VRVRSPTRSP
210 220 230 240 250
SVKTSPRKPR GRPRSGSDRN SAILSDPSVF SPLNKSETKS GDKIKKKDSK
260 270 280 290 300
SIEKKRGRPP TFPGVKIKIT HGKDISELPK GSKEDSLKKI KRTPSATFQQ
310 320 330 340 350
ATKIKKLRAG KLSPLKSKFK TGKLQIGRKG VQIVRRRGRP PSTERIKTPS
360 370 380 390 400
GLLINSELEK PQKVRKDKEG TPPLTKEDKT VVRQSPRRIK PVRIIPSSKR
410 420 430 440 450
TDATIAKQLL QRAKKGAQKK IEKEAAQLQG RKVKTQVKNI RQFIMPVVSA
460 470 480 490 500
ISSRIIKTPR RFIEDEDYDP PIKIARLEST PNSRFSATSC GSSEKSSAAS
510 520 530 540 550
QHSSQMSSDS SRSSSPSVDT STDSQASEEI QVLPEERSET PEVHTPLPIS
560 570 580 590 600
QSPENDSNDR RSRRYSVSER SFGSRTTKKL STLQSAPQQQ PSSSPPPPLL
610 620 630 640 650
TPPPPLQPAS GISDHTPWLM PPTIPLASPF LPASAAPMQG KRKSILREPT
660 670 680 690 700
FRWTSLKHSR SEPQYFSSAK YAKEGLIRKP IFDNFRPPPL TPEDVGFASG
710 720 730 740 750
FSASGTAASA RLFSPLHSGT RFDMHKRSPL LRAPRFTPSE AHSRIFESVT
760 770 780 790 800
LPSNRTSAGT SSSGVSNRKR KRKVFSPIRS EPRSPSHSMR TRSGRLSTAE
810 820 830 840 850
LSPLTPPSSV SSSLSISVSP LATSALNPTF TFPSHSLTQS GESAEKSQRP
860 870 880 890 900
RKQASAPAEP FSSGSPTPLF PWFTPGSQTE RGRNKDKAPE ELSKDRDADK
910 920 930 940 950
SVEKDKSRER DREREKENKR ESRKEKRKKG SEIQSSSALY PVGRVSKDKV
960 970 980 990 1000
VGEDVATSSS AKKATGRKKS SSLDSGTDIA SVTLGDTTAV KTKILIKKGR
1010 1020 1030 1040 1050
GNLEKNNLDL GPTAPSLEKE KTLCLSTPSS STVKHSTSSI GSMLAQADKL
1060 1070 1080 1090 1100
PMTDKRVASL LKKAKAQLCK IEKSKSLKQT DQPKAQGQES DSSETSVRGP
1110 1120 1130 1140 1150
RIKHVCRRAA VALGRKRAVF PDDMPTLSAL PWEEREKILS SMGNDDKSSI
1160 1170 1180 1190 1200
AGSEDAEPLA PPIKPIKPVT RNKAPQEPPV KKGRRSRRCG QCPGCQVPED
1210 1220 1230 1240 1250
CGVCTNCLDK PKFGGRNIKK QCCKMRKCQN LQWMPSKAYL QKQAKAVKKK
1260 1270 1280 1290 1300
EKKSKTSEKK ESKESSVGKS VVDSGQKPAP SAREDPAPKK SNSEPPPRKP
1310 1320 1330 1340 1350
IEEKSEEGNA SAPVPESKQV TTPASRKSSK QASQPVPVTP PQPPSTAPPR
1360 1370 1380 1390 1400
KEVPKTTPSE PKKKQPPPPE SGPEQSKQKK VAPRPSIPVK QKPKEKEKPP
1410 1420 1430 1440 1450
PVSKQENTGT LNILSTLSNG NSSKQKIPAD GVHRIRVDFK EDCEAENVWE
1460 1470 1480 1490 1500
MGGLGILTSV PITPRVVCFL CASSGHVEFV YCQVCCEPFH KFCLEENERP
1510 1520 1530 1540 1550
LEDQLENWCC RRCKFCHVCG RQHQATKQLL ECNKCRNSYH PECLGPNYPT
1560 1570 1580 1590 1600
KPTKKKKVWI CTKCVRCKSC GSTTPGKGWD AQWSHDFSLC HDCAKLFAKG
1610 1620 1630 1640 1650
NFCPLCDKCY DDDDYESKMM QCGKCDRWVH SKCENLSGTE DEMYEILSNL
1660 1670 1680 1690 1700
PESVAYTCVN CTERHPAEWR LALEKELQIS LKQVLTALLN SRTTSHLLRY
1710 1720 1730 1740 1750
RQAAKPPDLN PETEESIPSR SSPEGPDPPV LTEVSKQEDQ QPLDLEGVKR
1760 1770 1780 1790 1800
KMDQGNYTSV LEFSDDIVKI IQAAINSDGG QPEIKKANSM VKSFFIRQME
1810 1820 1830 1840 1850
RVFPWFSVKK SRFWEPNKVS SNSGMLPNAV LPPSLDHNYA QWQEREENSH
1860 1870 1880 1890 1900
TEQPPLMKKI IPAPKPKGPG EPDSPTPLHP PTPPILSTDR SREDSPELNP
1910 1920 1930 1940 1950
PPGIEDNRQC ALCLTYGDDS ANDAGRLLYI GQNEWTHVNC ALWSAEVFED
1960 1970 1980 1990 2000
DDGSLKNVHM AVIRGKQLRC EFCQKPGATV GCCLTSCTSN YHFMCSRAKN
2010 2020 2030 2040 2050
CVFLDDKKVY CQRHRDLIKG EVVPENGFEV FRRVFVDFEG ISLRRKFLNG
2060 2070 2080 2090 2100
LEPENIHMMI GSMTIDCLGI LNDLSDCEDK LFPIGYQCSR VYWSTTDARK
2110 2120 2130 2140 2150
RCVYTCKIVE CRPPVVEPDI NSTVEHDENR TIAHSPTSFA EIASKESQNT
2160 2170 2180 2190 2200
AEIVSPPSPD RPHSQTSGSC FYHVISKVPR IRTPSYSPTQ RSPGCRPLPS
2210 2220 2230 2240 2250
AGSPTPTTHE IVTVGDPLLS SGLRSIGSRR HSTSSLSPQR SKLRIMSPMR
2260 2270 2280 2290 2300
TGGTYSRNSV SSVSTIGTAT DLESSAKAVD HVLGPLNSNT NLGQNTSTSS
2310 2320 2330 2340 2350
NLQRTVVTMG AKTSHLDGSS SSEMKHSSAS DLASKGSSLK GEKTKVPSSK
2360 2370 2380 2390 2400
SLEGSAHAVA YPGIPKLAPQ VHNTTPGELN ASKIGTFAEL SSGPFSSKEA
2410 2420 2430 2440 2450
LSFPPLHLRG QRNDRDQHTD SNQSVNPPPD EDAGVKTLKL SGVSNRSSIL
2460 2470 2480 2490 2500
NEHVGSSSRD RRQKGKKSCK ETFKEKHSSK SFLEPGQVST GEEGNLKPEF
2510 2520 2530 2540 2550
VDEVLTPEFM GQRPCNNVSS DKIGDKGLSI PGAPKAPSMQ VEGSAKELQT
2560 2570 2580 2590 2600
PRKRTVKVTL TPLKMESEGQ SKNTLKEGSP VSPLQIESAS PPTEPVAASE
2610 2620 2630 2640 2650
SPGDGPVAQP SPNDTSSQDP QSNNYQNLPV QDRNLMLPDG PKPQEDGSFK
2660 2670 2680 2690 2700
RRYPRRSARA RSNMFFGLTP LYGVRSYGEE DIPFYSSSTG KKRGKRSAEG
2710 2720 2730 2740 2750
QVDGADDLST SDEDDLYYYN FTRTVISSGG DERLASHNLF REEEQCDLPK
2760 2770 2780 2790 2800
ISQLDGVDDG TESDTSVTAT TRKSSQIPKR NGKENGTENL KIERPEDASE
2810 2820 2830 2840 2850
KEHVLKSSVG HKNEPKVDNC HSVSRVKAQG QDSLEAQLSS LEPSRRVHTS
2860 2870 2880 2890 2900
TPSDKNLLDT YSTELLKSDS DNNNSDDCGN ILPSDIMDFV LKNTPSMQAL
2910 2920 2930 2940 2950
GESPESSSSE LLNLGEGLGL DSNREKDMGL FEVFSQQLPT AEPVDSSVSS
2960 2970 2980 2990 3000
SISAEEQFEL PLELPSDLSV LTTRSPTVPS QNASRLAVIS DSGEKRVTIT
3010 3020 3030 3040 3050
EKSVASSEGD SALLSPGVDP TPEGHMTPDH FIQGHMDADH ISSPPCGSVE
3060 3070 3080 3090 3100
QGHGNNQDLT RNSSTPGLQV PVSPTVPIQN QKYVPNSTES PGPSQISNAA
3110 3120 3130 3140 3150
VQTTPPHLKP ATEKLIVVNQ NMQPLYVLQT LPNGVTQKIQ LTSSVSSTPN
3160 3170 3180 3190 3200
VMETNTSVLG PMGSGLTLAT GLNPSLPTSP SLFPPASKGL LPMPHHQHLH
3210 3220 3230 3240 3250
SFPAAAQSSF PPNISSPPSG LLIGVQPPPD PQLLVSEASQ RTDLSTTVAT
3260 3270 3280 3290 3300
PSSGLKKRPI SRLQTRKNKK LAPSSTPSTI APSDVVSNMT LINFTPSQLP
3310 3320 3330 3340 3350
NHPNLLDLGS LNTSSHRTVP NIIKRSKSGI MYFEQAPLLP QSAAAAGAST
3360 3370 3380 3390 3400
VSQDTSHLTA GPGSGLASGA SVLNVVSMQT TTAPTSSASV PGHVALTNPR
3410 3420 3430 3440 3450
LLSAPDIGSI SNLLIKASQQ SLGMQDQPVA LPPSAGMFPQ LGAAASSICV
3460 3470 3480 3490 3500
LPSAQTAGVA AASPSGEAEE HYQLQRVNQL LASKTGILPS QRELDSAAGT
3510 3520 3530 3540 3550
QGSTFAQTGD ASNSMGLEQN KALSSAMQAS PASPGGSPSS GQPSASPAVP
3560 3570 3580 3590 3600
APTKPKPKIK RFQLPLDKGN GKKHKVSHLR TSSSEAHIPD QEASTTSLTS
3610 3620 3630 3640 3650
VTGTPGAEAE QQDTANVEQS KECGQPTGQV LPEIQATQNP ANEQEGTEPK
3660 3670 3680 3690 3700
TVEEEESNFS SPLMLWLQQE QKRKESIAEK KPKKGLVFEI SSDDGFQICA
3710 3720 3730 3740 3750
ESIEDAWKSL TDKVQEARSN ARLKQLSFAG VNGLRMLGIL HDAVVFLIEQ
3760 3770 3780 3790 3800
LSGAKHCRNY KFRFHKPEEA NEPPLNPHGS ARAEVHLRKS AFDMFNFLAS
3810 3820 3830 3840 3850
KHRQPPEYNP NDEEEEEVQL KSARRATSMD LPMPMRFRHL KKTSKEAVGV
3860 3870 3880 3890 3900
YRSPIHGRGL FCKRNIDAGE MVIEYAGNVI RSIQTDKREK YYDSKGIGCY
3910 3920 3930 3940 3950
MFRIDDSEVV DATMHGNAAR FINHSCEPNC YSRVINIDGQ KHIVIFAMRK
3960 3970 3980
IYRGEELTYD YKFPIEDASN KLPCNCGAKK CRKFLN
Length:3,986
Mass (Da):432,631
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2883CE897A81CBE8
GO

Sequence databases

NCBI Reference Sequences

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RefSeqi
XP_025749852.1, XM_025894067.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025749852.1, XM_025894067.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd15693, ePHD_KMT2A, 1 hit
cd15588, PHD1_KMT2A, 1 hit
cd15590, PHD2_KMT2A, 1 hit
Gene3Di3.30.40.10, 3 hits
InterProiView protein in InterPro
IPR001487, Bromodomain
IPR036427, Bromodomain-like_sf
IPR034732, EPHD
IPR003889, FYrich_C
IPR003888, FYrich_N
IPR037927, KMT2A
IPR041958, KMT2A_ePHD
IPR042023, KMT2A_PHD1
IPR042025, KMT2A_PHD2
IPR016569, MeTrfase_trithorax
IPR003616, Post-SET_dom
IPR001214, SET_dom
IPR002857, Znf_CXXC
IPR011011, Znf_FYVE_PHD
IPR001965, Znf_PHD
IPR019787, Znf_PHD-finger
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR45838:SF2, PTHR45838:SF2, 1 hit
PfamiView protein in Pfam
PF05965, FYRC, 1 hit
PF05964, FYRN, 1 hit
PF00628, PHD, 2 hits
PF00856, SET, 1 hit
PF02008, zf-CXXC, 1 hit
PIRSFiPIRSF010354, Methyltransferase_trithorax, 2 hits
SMARTiView protein in SMART
SM00297, BROMO, 1 hit
SM00542, FYRC, 1 hit
SM00541, FYRN, 1 hit
SM00249, PHD, 4 hits
SM00508, PostSET, 1 hit
SM00317, SET, 1 hit
SUPFAMiSSF47370, SSF47370, 1 hit
SSF57903, SSF57903, 2 hits
PROSITEiView protein in PROSITE
PS50014, BROMODOMAIN_2, 1 hit
PS51805, EPHD, 1 hit
PS51543, FYRC, 1 hit
PS51542, FYRN, 1 hit
PS50868, POST_SET, 1 hit
PS50280, SET, 1 hit
PS51058, ZF_CXXC, 1 hit
PS50016, ZF_PHD_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7R5K2_CALUR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7R5K2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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