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Entry version 7 (12 Aug 2020)
Sequence version 1 (10 Apr 2019)
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Protein
Submitted name:

epidermal growth factor receptor substrate 15-like 1 isoform X3

Gene

EPS15L1

Organism
Callorhinus ursinus (Northern fur seal)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) of the calcium-binding region(s) within the protein. One common calcium-binding motif is the EF-hand, but other calcium-binding motifs also exist.<p><a href='/help/ca_bind' target='_top'>More...</a></p>Calcium bindingi142 – 153PROSITE-ProRule annotationAdd BLAST12

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported
LigandCalciumPROSITE-ProRule annotationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
epidermal growth factor receptor substrate 15-like 1 isoform X3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EPS15L1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCallorhinus ursinus (Northern fur seal)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri34884 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaOtariidaeCallorhinus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000286641 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 74EHInterPro annotationAdd BLAST74
Domaini18 – 53EF-handInterPro annotationAdd BLAST36
Domaini97 – 185EHInterPro annotationAdd BLAST89
Domaini129 – 164EF-handInterPro annotationAdd BLAST36
Domaini244 – 279EF-handInterPro annotationAdd BLAST36
Domaini245 – 335EHInterPro annotationAdd BLAST91
Domaini280 – 313EF-handInterPro annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni191 – 230DisorderedSequence analysisAdd BLAST40
Regioni330 – 350DisorderedSequence analysisAdd BLAST21
Regioni587 – 831DisorderedSequence analysisAdd BLAST245

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili356 – 439Sequence analysisAdd BLAST84
Coiled coili447 – 537Sequence analysisAdd BLAST91
Coiled coili835 – 855Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi205 – 230PolarSequence analysisAdd BLAST26
Compositional biasi592 – 606PolyampholyteSequence analysisAdd BLAST15
Compositional biasi640 – 655PolyampholyteSequence analysisAdd BLAST16
Compositional biasi656 – 694PolarSequence analysisAdd BLAST39
Compositional biasi702 – 732PolarSequence analysisAdd BLAST31
Compositional biasi751 – 766Pro-richSequence analysisAdd BLAST16

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00052, EH, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR003903, UIM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12763, EF-hand_4, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00054, EFh, 3 hits
SM00027, EH, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473, SSF47473, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 4 hits
PS50031, EH, 3 hits
PS50330, UIM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q7QED2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPLLPLSQ QIPTGNPLYE SYYKQIWDLA DPEGKGFLDK QGFYVALRLV
60 70 80 90 100
ACAQSGHEVT LSNLNLNMPP PKFHDTSSPL MVTPPSAEAH WAVRVEEKAK
110 120 130 140 150
FDGIFESLLP ISGLLSGDKV KPVLMNSKLP LDVLGRVWDL SDIDKDGHLD
160 170 180 190 200
RDEFAVAMHL VYRALEKEPV PSVLPPSLIP PSKRKKTVFP GAVPVLPASP
210 220 230 240 250
PPKDSLRSTP SHGSVSSLNS TGSLSPKHSI KQTQPTVSWV VPVADKMRFD
260 270 280 290 300
EIFLKTDLDL DGYVSGQEVK EIFMHSGLTQ NLLAHIWALA DTRQTGKLSK
310 320 330 340 350
DQFALAMYFI QQKVSKGIDP PQVLSPDMVP PSERGTPIPD GSSSLGSGEF
360 370 380 390 400
TGVKELDDIS QEIAQLQREK YSLEQDIREK EEAIRQKSNE VQELQNDLDR
410 420 430 440 450
ETSSLQELEA QKQDAQDRLD EMDQQKAKLR DMLSDVRQKC QDETQMISSL
460 470 480 490 500
KTQIQSQESD LKSQEDDLNR AKSELNRLQQ EETQLEQSIQ AGKVQLETII
510 520 530 540 550
KSLKSTQDEI NQARSKLSEL HESHQEAHRT LEQYDEALDG AHGASLTNLA
560 570 580 590 600
DLSEGVSLTE RGGFGAMVKD DPFKNKALLF SNNAQELHPD PFQAEDPFKS
610 620 630 640 650
DPFKGADPFK GDPFQNDPFA EQQTASADPF GGDPFKESDP FRGSAPDDFF
660 670 680 690 700
KKQTKNDPFT SDPFTKNPSL PSKLDPFESS DPFSSSSVSS KGSGPFGTLD
710 720 730 740 750
PFGSGSFNSA EGFADFSQMS KPPTSGPFTS SFGGAGFSDD PFKSKQDTPA
760 770 780 790 800
LPPKKPAPPR PKPPSGKSTP VSQLGSADFP EPPDPFQPLG ADSSDPFQNK
810 820 830 840 850
KGFGDPFSGK DPFAPSSSAK PSKASSLGFA DFTSFGNEEQ QMAWAKRESE
860 870 880
KAEQERLARL RRQEQEDLEL AIALSKADMP AA
Length:882
Mass (Da):96,782
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52ED4573B3C21DE5
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_025740537.1, XM_025884752.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_025740537.1, XM_025884752.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00052, EH, 2 hits
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR000261, EH_dom
IPR003903, UIM_dom
PfamiView protein in Pfam
PF12763, EF-hand_4, 2 hits
SMARTiView protein in SMART
SM00054, EFh, 3 hits
SM00027, EH, 3 hits
SUPFAMiSSF47473, SSF47473, 3 hits
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 1 hit
PS50222, EF_HAND_2, 4 hits
PS50031, EH, 3 hits
PS50330, UIM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q7QED2_CALUR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q7QED2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: August 12, 2020
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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