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Entry version 11 (10 Feb 2021)
Sequence version 1 (10 Apr 2019)
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Protein

Double minute 2 protein

Gene
N/A
Organism
Hippocampus comes (Tiger tail seahorse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.ARBA annotation EC:2.3.2.27

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseARBA annotation
Biological processUbl conjugation pathwayARBA annotation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Double minute 2 proteinARBA annotation (EC:2.3.2.27ARBA annotation)
Alternative name(s):
E3 ubiquitin-protein ligase Mdm2ARBA annotation
RING-type E3 ubiquitin transferase Mdm2ARBA annotation
p53-binding protein Mdm2ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHippocampus comes (Tiger tail seahorse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri109280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataSyngnathiariaSyngnathiformesSyngnathoideiSyngnathidaeHippocampus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000264820 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini328 – 357RanBP2-typeInterPro annotationAdd BLAST30
Domaini462 – 503RING-typeInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni148 – 225DisorderedSequence analysisAdd BLAST78
Regioni244 – 277DisorderedSequence analysisAdd BLAST34
Regioni380 – 420DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi148 – 171PolarSequence analysisAdd BLAST24
Compositional biasi246 – 277PolarSequence analysisAdd BLAST32
Compositional biasi392 – 420PolarSequence analysisAdd BLAST29

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MDM2/MDM4 family.ARBA annotation

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063539

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16783, mRING-HC-C2H2C4_MDM2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.245.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015459, MDM2_E3_ligase
IPR044080, MDM2_mRING-HC-C2H2C4
IPR016495, p53_neg-reg_MDM_2/4
IPR036885, SWIB_MDM2_dom_sf
IPR003121, SWIB_MDM2_domain
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR13844:SF15, PTHR13844:SF15, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02201, SWIB, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF006748, p53_MDM_2/4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47592, SSF47592, 2 hits
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A3Q2YMZ1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWRLYKSQP QSLPQLSLPP LCTLSLCTCT HGPLTGSPIA CMSTDNMDAS
60 70 80 90 100
DENKVVRPKL ELSTLLKLAG ATKDVLTFKE VMFYLGQYII QKQLFDKKQQ
110 120 130 140 150
HIVHCAQDAL GRILGVDTFS VKEPRVFFAM LSKNLVIVRS QEESTRSFAE
160 170 180 190 200
AASGSQTQQP TQESVAGSGP SSPNIRRRRR RRTRSSRSND AGPSHGLPGE
210 220 230 240 250
EKDNGSDVDE DDDGSEGAKR TRSDSYSLTF DDSLSWCVIG GLASGRDRRN
260 270 280 290 300
SQSSETPSNS ARSDATAAIA SDSDSDNFSV EFEVESIDSD DYNEDDDALS
310 320 330 340 350
ADDQVYELTI FEEEDDDDSF DEDTEITEAD YWSCEGCKES NPPLTRNCLR
360 370 380 390 400
CWRLRRDWLH SASLPAQPAA CVDAPALDAE DGVDVPDGKT AVSSSAPESQ
410 420 430 440 450
ESQEPPASRP PSSCSSSSQE KLWTCDSQPS SLANSQETVG TPELERSVSA
460 470 480 490 500
EMRLPESCLE PCLICQSRPK NGCIVHGKTG HLMTCYVCAR KLKKHNKLCP
510
VCRLPIQAVV FTYFS
Length:515
Mass (Da):56,524
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i97E5DF600B930D54
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_019753239.1, XM_019897680.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSHCOT00000009720; ENSHCOP00000019043; ENSHCOG00000004090

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
109532684

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hcq:109532684

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_019753239.1, XM_019897680.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSHCOT00000009720; ENSHCOP00000019043; ENSHCOG00000004090
GeneIDi109532684
KEGGihcq:109532684

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4193

Phylogenomic databases

GeneTreeiENSGT00530000063539

Family and domain databases

CDDicd16783, mRING-HC-C2H2C4_MDM2, 1 hit
Gene3Di1.10.245.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR015459, MDM2_E3_ligase
IPR044080, MDM2_mRING-HC-C2H2C4
IPR016495, p53_neg-reg_MDM_2/4
IPR036885, SWIB_MDM2_dom_sf
IPR003121, SWIB_MDM2_domain
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PANTHERiPTHR13844:SF15, PTHR13844:SF15, 1 hit
PfamiView protein in Pfam
PF02201, SWIB, 1 hit
PIRSFiPIRSF006748, p53_MDM_2/4, 1 hit
SUPFAMiSSF47592, SSF47592, 2 hits
SSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2YMZ1_HIPCM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2YMZ1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: February 10, 2021
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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