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UniProtKB - A0A3Q2TZ07 (A0A3Q2TZ07_CHICK)

Entry version 10 (07 Oct 2020)
Sequence version 1 (10 Apr 2019)
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Protein

Anaphase-promoting complex subunit 1

Gene

ANAPC1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • molecular adaptor activity Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, MitosisARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin
R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-GGA-176412, Phosphorylation of the APC/C
R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A
R-GGA-2467813, Separation of Sister Chromatids
R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A3Q2TZ07, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1742 – 1899APC1_CInterPro annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni375 – 395DisorderedSequence analysisAdd BLAST21
Regioni525 – 544DisorderedSequence analysisAdd BLAST20
Regioni997 – 1022DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC1 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016757

Identification of Orthologs from Complete Genome Data

More...OMAi		AIAEWMQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR024990, Apc1
IPR041221, APC1_C

The PANTHER Classification System

More...PANTHERi		PTHR12827, PTHR12827, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12859, ANAPC1, 1 hit
PF18122, APC1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2TZ07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDHSEERAT MIAAGDLQEF IPRGREHCRR HPGAHNLQPR ELQPASELCS 
        60         70         80         90        100
SDGAAGLVGS LREVTIHERQ RESWQLRKGV SDFGEEVDYD EELYVASNMV 
       110        120        130        140        150
IWSKGSKTEA SAAYKAFSVD SPVLQALWCD FTIQQEKSDK ADVSGGKEIV 
       160        170        180        190        200
QKCVCILQSS CVNVHSIDGK DYVAALPFQV ANIWPTKFGL LLERSGSSHE 
       210        220        230        240        250
VPPSPPREPL PTMFSMLHPL DEITPLVCKS GAGVFGSARV QYVADYTLRI 
       260        270        280        290        300
VFVNAEPSIV MTYDTVQSLH TVWALRRVKP EEQNMVLKFS EQLGTPQNVA 
       310        320        330        340        350
ASSSLTAQLR SLSKGDSPMA SPFQNYSSIH SQSRSVSSPS MQSRSPSISN 
       360        370        380        390        400
MAALSRSHSP ALGVHSFSGV QRFNSSSNIQ SPRRHSITHS PESTCSDSFL 
       410        420        430        440        450
VTETEPIVPE LCIDHLWTEA ITKMREKNSQ ASKVFITTDL CGQKFLCFLV 
       460        470        480        490        500
ESQLQLRCVK FQESNDKSQL IFGSVTNIQA KDAAPVQGVD TLLVLEGSGN 
       510        520        530        540        550
LVLYSGIVRV GKVFIPGLPA PSLTMSNQMP RPSTPLDSVS TPSKTLNKHL 
       560        570        580        590        600
GPLEESMLLS PVPELRDSSK LHDSTYVEDC TFQQHGTFIH ALRDPVHNRV 
       610        620        630        640        650
TLELSSNTMV RITIPEIATS ELVKTCLQGV KAILPKEIAV QMLVKWYNAY 
       660        670        680        690        700
NAPGGPSYRL EWNLFVTCLM NMMGYNTEKL TWTRNLNVGG SPSPVSAPKK 
       710        720        730        740        750
ARPSETGSDE DWEYLLSSDY HRNFESHPLS RVLGLDPLEV LAPKDDFLQS 
       760        770        780        790        800
LSLDYSTLLF THIPAIFFVL HLVYEEFKLN LLMGEENRSL VVLLVQLARD 
       810        820        830        840        850
LKLEAYIDYY YRDYPALVKS SGQTCIIDQG FMHHPAFFSA EPPSIFQWLS 
       860        870        880        890        900
SCLKGGSVQP YPYLPGICER SKLVILSVAL YVLGDESAVS NEASPYLYKI 
       910        920        930        940        950
TSGQQKQQIE HDDNRCCFGH SASISSLAEK LIIWLTNIGF TLRDLETLPF 
       960        970        980        990       1000
GVALPIRDAI YYCREQPASD WPEAVCVLIG RQDLSRQACD GNLLKSKSSV 
      1010       1020       1030       1040       1050
GPVLSSDSPS GAESEEDEDG MNNMNDEVMS LIWSKDLRVQ EVRRLLQSAR 
      1060       1070       1080       1090       1100
PVRVNVVQMP EASDHDFIEE KENRLLQLCQ RTMALPVGRG MFTLFSYHPI 
      1110       1120       1130       1140       1150
PAEQLPIPKL NLTGRAPPRN STVDLNSGNI DVPPNMACWA SFHNGVAAGL 
      1160       1170       1180       1190       1200
KIAPASRIDS SWIIYNKPKN AEQANEYAGF LMALGLSGHL TKLATLNIHD 
      1210       1220       1230       1240       1250
YLTKGHEMTS IGLLLGVSAA KLGTMDMAIT RLLSIHIPAL LPPTSTELDV 
      1260       1270       1280       1290       1300
PHNVQVAAVI GIGLVYQGTA HRHTAEVLLA EIGRPPGPEM EYCTDRESYS 
      1310       1320       1330       1340       1350
LASGLALGMV CLGHGSNLIG MSDLNVPEQL YQYMVGGHRR FQAGMHREKH 
      1360       1370       1380       1390       1400
KSPSYQIKEG DTINVDVTCP GATLAFAMIY LKTNNRSIAD WLQAPDTMYL 
      1410       1420       1430       1440       1450
LDFVKPEFLL LRTLARCLIL WDDIMPSTEW VDSNVPQIIR ENSIPLHATE 
      1460       1470       1480       1490       1500
LPSSEDLSLE TLMQAHVYII AGACLSLGFR FAGSENKAAF NCLDKYATDF 
      1510       1520       1530       1540       1550
LKSLSAPTAS IIGHYNLETC LSVLLLSLAM VVAGSGNLKV LQLCRFMHKK 
      1560       1570       1580       1590       1600
TGGEMNYGFH LAHHMALGLL FLGGGRYSLS TSNSSIAALL CALYPHFPVH 
      1610       1620       1630       1640       1650
STDNRYHLQA LRHLYVLAAD PRLLIPVDVD SNTPCYALIE VTFKGTQWYA 
      1660       1670       1680       1690       1700
ETTEEMMAPT LLPELHLLKQ IRVKGPRYWE LLIDLSNETN HLKSILSKGG 
      1710       1720       1730       1740       1750
VLYVKLRAGQ LSYKEDPMGW RSFSAQTITH GNEARSFKPE DISAFTSDPA 
      1760       1770       1780       1790       1800
LLLFAEYFCK PTVNMGQKQE MLDFFSSILY ECVTQEKPEM LPTYIAIDQA 
      1810       1820       1830       1840       1850
VRRLERGEMS ETFELGQIKL VLEFFNSRCH QGRMSRNPNR GLFMNSEFLP 
      1860       1870       1880       1890       1900
VMKCTIDKAL DQWLQAGGDA CLRSYLSRQP KDESQQNMLA CFLVYHSVPM 
      1910       1920       1930       1940 
PGQLAAGGLD GITNFSEMLL KFKQWNVLVR ALLRLAPVLL KNPQSMVL
Length:1,948
Mass (Da):216,299
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6A020A713B0D8E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1C2U7E1C2U7_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,919Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2UIV9A0A3Q2UIV9_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,756Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2U7I1A0A3Q2U7I1_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AADN05000009 Genomic DNA No translation available.

NCBI Reference Sequences

More...RefSeqi		XP_419303.3, XM_419303.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254

Database of genes from NCBI RefSeq genomes

More...GeneIDi		421228

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000009 Genomic DNA No translation available.
RefSeqiXP_419303.3, XM_419303.5

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254
GeneIDi421228

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		64682

Phylogenomic databases

GeneTreeiENSGT00390000016757
OMAiAIAEWMQ

Enzyme and pathway databases

ReactomeiR-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin
R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-GGA-176412, Phosphorylation of the APC/C
R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A
R-GGA-2467813, Separation of Sister Chromatids
R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

ExpressionAtlasiA0A3Q2TZ07, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR024990, Apc1
IPR041221, APC1_C
PANTHERiPTHR12827, PTHR12827, 1 hit
PfamiView protein in Pfam
PF12859, ANAPC1, 1 hit
PF18122, APC1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2TZ07_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2TZ07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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