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Entry version 10 (07 Oct 2020)
Sequence version 1 (10 Apr 2019)
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Protein

Anaphase-promoting complex subunit 1

Gene

ANAPC1

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • molecular adaptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, MitosisARBA annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin
R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-GGA-176412, Phosphorylation of the APC/C
R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A
R-GGA-2467813, Separation of Sister Chromatids
R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1ARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A3Q2TZ07, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1742 – 1899APC1_CInterPro annotationAdd BLAST158

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni375 – 395DisorderedSequence analysisAdd BLAST21
Regioni525 – 544DisorderedSequence analysisAdd BLAST20
Regioni997 – 1022DisorderedSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC1 family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016757

Identification of Orthologs from Complete Genome Data

More...
OMAi
AIAEWMQ

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024990, Apc1
IPR041221, APC1_C

The PANTHER Classification System

More...
PANTHERi
PTHR12827, PTHR12827, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12859, ANAPC1, 1 hit
PF18122, APC1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2TZ07-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDHSEERAT MIAAGDLQEF IPRGREHCRR HPGAHNLQPR ELQPASELCS
60 70 80 90 100
SDGAAGLVGS LREVTIHERQ RESWQLRKGV SDFGEEVDYD EELYVASNMV
110 120 130 140 150
IWSKGSKTEA SAAYKAFSVD SPVLQALWCD FTIQQEKSDK ADVSGGKEIV
160 170 180 190 200
QKCVCILQSS CVNVHSIDGK DYVAALPFQV ANIWPTKFGL LLERSGSSHE
210 220 230 240 250
VPPSPPREPL PTMFSMLHPL DEITPLVCKS GAGVFGSARV QYVADYTLRI
260 270 280 290 300
VFVNAEPSIV MTYDTVQSLH TVWALRRVKP EEQNMVLKFS EQLGTPQNVA
310 320 330 340 350
ASSSLTAQLR SLSKGDSPMA SPFQNYSSIH SQSRSVSSPS MQSRSPSISN
360 370 380 390 400
MAALSRSHSP ALGVHSFSGV QRFNSSSNIQ SPRRHSITHS PESTCSDSFL
410 420 430 440 450
VTETEPIVPE LCIDHLWTEA ITKMREKNSQ ASKVFITTDL CGQKFLCFLV
460 470 480 490 500
ESQLQLRCVK FQESNDKSQL IFGSVTNIQA KDAAPVQGVD TLLVLEGSGN
510 520 530 540 550
LVLYSGIVRV GKVFIPGLPA PSLTMSNQMP RPSTPLDSVS TPSKTLNKHL
560 570 580 590 600
GPLEESMLLS PVPELRDSSK LHDSTYVEDC TFQQHGTFIH ALRDPVHNRV
610 620 630 640 650
TLELSSNTMV RITIPEIATS ELVKTCLQGV KAILPKEIAV QMLVKWYNAY
660 670 680 690 700
NAPGGPSYRL EWNLFVTCLM NMMGYNTEKL TWTRNLNVGG SPSPVSAPKK
710 720 730 740 750
ARPSETGSDE DWEYLLSSDY HRNFESHPLS RVLGLDPLEV LAPKDDFLQS
760 770 780 790 800
LSLDYSTLLF THIPAIFFVL HLVYEEFKLN LLMGEENRSL VVLLVQLARD
810 820 830 840 850
LKLEAYIDYY YRDYPALVKS SGQTCIIDQG FMHHPAFFSA EPPSIFQWLS
860 870 880 890 900
SCLKGGSVQP YPYLPGICER SKLVILSVAL YVLGDESAVS NEASPYLYKI
910 920 930 940 950
TSGQQKQQIE HDDNRCCFGH SASISSLAEK LIIWLTNIGF TLRDLETLPF
960 970 980 990 1000
GVALPIRDAI YYCREQPASD WPEAVCVLIG RQDLSRQACD GNLLKSKSSV
1010 1020 1030 1040 1050
GPVLSSDSPS GAESEEDEDG MNNMNDEVMS LIWSKDLRVQ EVRRLLQSAR
1060 1070 1080 1090 1100
PVRVNVVQMP EASDHDFIEE KENRLLQLCQ RTMALPVGRG MFTLFSYHPI
1110 1120 1130 1140 1150
PAEQLPIPKL NLTGRAPPRN STVDLNSGNI DVPPNMACWA SFHNGVAAGL
1160 1170 1180 1190 1200
KIAPASRIDS SWIIYNKPKN AEQANEYAGF LMALGLSGHL TKLATLNIHD
1210 1220 1230 1240 1250
YLTKGHEMTS IGLLLGVSAA KLGTMDMAIT RLLSIHIPAL LPPTSTELDV
1260 1270 1280 1290 1300
PHNVQVAAVI GIGLVYQGTA HRHTAEVLLA EIGRPPGPEM EYCTDRESYS
1310 1320 1330 1340 1350
LASGLALGMV CLGHGSNLIG MSDLNVPEQL YQYMVGGHRR FQAGMHREKH
1360 1370 1380 1390 1400
KSPSYQIKEG DTINVDVTCP GATLAFAMIY LKTNNRSIAD WLQAPDTMYL
1410 1420 1430 1440 1450
LDFVKPEFLL LRTLARCLIL WDDIMPSTEW VDSNVPQIIR ENSIPLHATE
1460 1470 1480 1490 1500
LPSSEDLSLE TLMQAHVYII AGACLSLGFR FAGSENKAAF NCLDKYATDF
1510 1520 1530 1540 1550
LKSLSAPTAS IIGHYNLETC LSVLLLSLAM VVAGSGNLKV LQLCRFMHKK
1560 1570 1580 1590 1600
TGGEMNYGFH LAHHMALGLL FLGGGRYSLS TSNSSIAALL CALYPHFPVH
1610 1620 1630 1640 1650
STDNRYHLQA LRHLYVLAAD PRLLIPVDVD SNTPCYALIE VTFKGTQWYA
1660 1670 1680 1690 1700
ETTEEMMAPT LLPELHLLKQ IRVKGPRYWE LLIDLSNETN HLKSILSKGG
1710 1720 1730 1740 1750
VLYVKLRAGQ LSYKEDPMGW RSFSAQTITH GNEARSFKPE DISAFTSDPA
1760 1770 1780 1790 1800
LLLFAEYFCK PTVNMGQKQE MLDFFSSILY ECVTQEKPEM LPTYIAIDQA
1810 1820 1830 1840 1850
VRRLERGEMS ETFELGQIKL VLEFFNSRCH QGRMSRNPNR GLFMNSEFLP
1860 1870 1880 1890 1900
VMKCTIDKAL DQWLQAGGDA CLRSYLSRQP KDESQQNMLA CFLVYHSVPM
1910 1920 1930 1940
PGQLAAGGLD GITNFSEMLL KFKQWNVLVR ALLRLAPVLL KNPQSMVL
Length:1,948
Mass (Da):216,299
Last modified:April 10, 2019 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC6A020A713B0D8E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1C2U7E1C2U7_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,919Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2UIV9A0A3Q2UIV9_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,756Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2U7I1A0A3Q2U7I1_CHICK
Anaphase-promoting complex subunit ...
ANAPC1
1,924Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AADN05000009 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_419303.3, XM_419303.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
421228

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN05000009 Genomic DNA No translation available.
RefSeqiXP_419303.3, XM_419303.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254
GeneIDi421228

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
64682

Phylogenomic databases

GeneTreeiENSGT00390000016757
OMAiAIAEWMQ

Enzyme and pathway databases

ReactomeiR-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex
R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B
R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C
R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin
R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase
R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins
R-GGA-176412, Phosphorylation of the APC/C
R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A
R-GGA-2467813, Separation of Sister Chromatids
R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP)
R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6
R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation

Gene expression databases

ExpressionAtlasiA0A3Q2TZ07, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR024990, Apc1
IPR041221, APC1_C
PANTHERiPTHR12827, PTHR12827, 1 hit
PfamiView protein in Pfam
PF12859, ANAPC1, 1 hit
PF18122, APC1_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2TZ07_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2TZ07
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: April 10, 2019
Last modified: October 7, 2020
This is version 10 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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