UniProtKB - A0A3Q2TZ07 (A0A3Q2TZ07_CHICK)
Protein
Anaphase-promoting complex subunit 1
Gene
ANAPC1
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- molecular adaptor activity Source: GO_Central
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: GO_Central
- cell division Source: UniProtKB-KW
- metaphase/anaphase transition of mitotic cell cycle Source: GO_Central
- protein K11-linked ubiquitination Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, MitosisARBA annotation |
Enzyme and pathway databases
Reactomei | R-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-GGA-176412, Phosphorylation of the APC/C R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A R-GGA-2467813, Separation of Sister Chromatids R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: Anaphase-promoting complex subunit 1ARBA annotation |
Gene namesi | Name:ANAPC1Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- anaphase-promoting complex Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1742 – 1899 | APC1_CInterPro annotationAdd BLAST | 158 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 375 – 395 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 525 – 544 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 997 – 1022 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the APC1 family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00390000016757 |
OMAi | AIAEWMQ |
Family and domain databases
InterProi | View protein in InterPro IPR024990, Apc1 IPR041221, APC1_C |
PANTHERi | PTHR12827, PTHR12827, 1 hit |
Pfami | View protein in Pfam PF12859, ANAPC1, 1 hit PF18122, APC1_C, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
A0A3Q2TZ07-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDHSEERAT MIAAGDLQEF IPRGREHCRR HPGAHNLQPR ELQPASELCS
60 70 80 90 100
SDGAAGLVGS LREVTIHERQ RESWQLRKGV SDFGEEVDYD EELYVASNMV
110 120 130 140 150
IWSKGSKTEA SAAYKAFSVD SPVLQALWCD FTIQQEKSDK ADVSGGKEIV
160 170 180 190 200
QKCVCILQSS CVNVHSIDGK DYVAALPFQV ANIWPTKFGL LLERSGSSHE
210 220 230 240 250
VPPSPPREPL PTMFSMLHPL DEITPLVCKS GAGVFGSARV QYVADYTLRI
260 270 280 290 300
VFVNAEPSIV MTYDTVQSLH TVWALRRVKP EEQNMVLKFS EQLGTPQNVA
310 320 330 340 350
ASSSLTAQLR SLSKGDSPMA SPFQNYSSIH SQSRSVSSPS MQSRSPSISN
360 370 380 390 400
MAALSRSHSP ALGVHSFSGV QRFNSSSNIQ SPRRHSITHS PESTCSDSFL
410 420 430 440 450
VTETEPIVPE LCIDHLWTEA ITKMREKNSQ ASKVFITTDL CGQKFLCFLV
460 470 480 490 500
ESQLQLRCVK FQESNDKSQL IFGSVTNIQA KDAAPVQGVD TLLVLEGSGN
510 520 530 540 550
LVLYSGIVRV GKVFIPGLPA PSLTMSNQMP RPSTPLDSVS TPSKTLNKHL
560 570 580 590 600
GPLEESMLLS PVPELRDSSK LHDSTYVEDC TFQQHGTFIH ALRDPVHNRV
610 620 630 640 650
TLELSSNTMV RITIPEIATS ELVKTCLQGV KAILPKEIAV QMLVKWYNAY
660 670 680 690 700
NAPGGPSYRL EWNLFVTCLM NMMGYNTEKL TWTRNLNVGG SPSPVSAPKK
710 720 730 740 750
ARPSETGSDE DWEYLLSSDY HRNFESHPLS RVLGLDPLEV LAPKDDFLQS
760 770 780 790 800
LSLDYSTLLF THIPAIFFVL HLVYEEFKLN LLMGEENRSL VVLLVQLARD
810 820 830 840 850
LKLEAYIDYY YRDYPALVKS SGQTCIIDQG FMHHPAFFSA EPPSIFQWLS
860 870 880 890 900
SCLKGGSVQP YPYLPGICER SKLVILSVAL YVLGDESAVS NEASPYLYKI
910 920 930 940 950
TSGQQKQQIE HDDNRCCFGH SASISSLAEK LIIWLTNIGF TLRDLETLPF
960 970 980 990 1000
GVALPIRDAI YYCREQPASD WPEAVCVLIG RQDLSRQACD GNLLKSKSSV
1010 1020 1030 1040 1050
GPVLSSDSPS GAESEEDEDG MNNMNDEVMS LIWSKDLRVQ EVRRLLQSAR
1060 1070 1080 1090 1100
PVRVNVVQMP EASDHDFIEE KENRLLQLCQ RTMALPVGRG MFTLFSYHPI
1110 1120 1130 1140 1150
PAEQLPIPKL NLTGRAPPRN STVDLNSGNI DVPPNMACWA SFHNGVAAGL
1160 1170 1180 1190 1200
KIAPASRIDS SWIIYNKPKN AEQANEYAGF LMALGLSGHL TKLATLNIHD
1210 1220 1230 1240 1250
YLTKGHEMTS IGLLLGVSAA KLGTMDMAIT RLLSIHIPAL LPPTSTELDV
1260 1270 1280 1290 1300
PHNVQVAAVI GIGLVYQGTA HRHTAEVLLA EIGRPPGPEM EYCTDRESYS
1310 1320 1330 1340 1350
LASGLALGMV CLGHGSNLIG MSDLNVPEQL YQYMVGGHRR FQAGMHREKH
1360 1370 1380 1390 1400
KSPSYQIKEG DTINVDVTCP GATLAFAMIY LKTNNRSIAD WLQAPDTMYL
1410 1420 1430 1440 1450
LDFVKPEFLL LRTLARCLIL WDDIMPSTEW VDSNVPQIIR ENSIPLHATE
1460 1470 1480 1490 1500
LPSSEDLSLE TLMQAHVYII AGACLSLGFR FAGSENKAAF NCLDKYATDF
1510 1520 1530 1540 1550
LKSLSAPTAS IIGHYNLETC LSVLLLSLAM VVAGSGNLKV LQLCRFMHKK
1560 1570 1580 1590 1600
TGGEMNYGFH LAHHMALGLL FLGGGRYSLS TSNSSIAALL CALYPHFPVH
1610 1620 1630 1640 1650
STDNRYHLQA LRHLYVLAAD PRLLIPVDVD SNTPCYALIE VTFKGTQWYA
1660 1670 1680 1690 1700
ETTEEMMAPT LLPELHLLKQ IRVKGPRYWE LLIDLSNETN HLKSILSKGG
1710 1720 1730 1740 1750
VLYVKLRAGQ LSYKEDPMGW RSFSAQTITH GNEARSFKPE DISAFTSDPA
1760 1770 1780 1790 1800
LLLFAEYFCK PTVNMGQKQE MLDFFSSILY ECVTQEKPEM LPTYIAIDQA
1810 1820 1830 1840 1850
VRRLERGEMS ETFELGQIKL VLEFFNSRCH QGRMSRNPNR GLFMNSEFLP
1860 1870 1880 1890 1900
VMKCTIDKAL DQWLQAGGDA CLRSYLSRQP KDESQQNMLA CFLVYHSVPM
1910 1920 1930 1940
PGQLAAGGLD GITNFSEMLL KFKQWNVLVR ALLRLAPVLL KNPQSMVL
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE1C2U7 | E1C2U7_CHICK | Anaphase-promoting complex subunit ... | ANAPC1 | 1,919 | Annotation score: | ||
A0A3Q2UIV9 | A0A3Q2UIV9_CHICK | Anaphase-promoting complex subunit ... | ANAPC1 | 1,756 | Annotation score: | ||
A0A3Q2U7I1 | A0A3Q2U7I1_CHICK | Anaphase-promoting complex subunit ... | ANAPC1 | 1,924 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000009 Genomic DNA No translation available. |
RefSeqi | XP_419303.3, XM_419303.5 |
Genome annotation databases
Ensembli | ENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254 |
GeneIDi | 421228 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000009 Genomic DNA No translation available. |
RefSeqi | XP_419303.3, XM_419303.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSGALT00000097399; ENSGALP00000067663; ENSGALG00000008254 |
GeneIDi | 421228 |
Organism-specific databases
CTDi | 64682 |
Phylogenomic databases
GeneTreei | ENSGT00390000016757 |
OMAi | AIAEWMQ |
Enzyme and pathway databases
Reactomei | R-GGA-141430, Inactivation of APC/C via direct inhibition of the APC/C complex R-GGA-174048, APC/C:Cdc20 mediated degradation of Cyclin B R-GGA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-GGA-174154, APC/C:Cdc20 mediated degradation of Securin R-GGA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-GGA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-GGA-176407, Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase R-GGA-176408, Regulation of APC/C activators between G1/S and early anaphase R-GGA-176409, APC/C:Cdc20 mediated degradation of mitotic proteins R-GGA-176412, Phosphorylation of the APC/C R-GGA-179409, APC-Cdc20 mediated degradation of Nek2A R-GGA-2467813, Separation of Sister Chromatids R-GGA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-GGA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-GGA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Gene expression databases
ExpressionAtlasi | A0A3Q2TZ07, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR024990, Apc1 IPR041221, APC1_C |
PANTHERi | PTHR12827, PTHR12827, 1 hit |
Pfami | View protein in Pfam PF12859, ANAPC1, 1 hit PF18122, APC1_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3Q2TZ07_CHICK | |
Accessioni | A0A3Q2TZ07Primary (citable) accession number: A0A3Q2TZ07 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 10, 2019 |
Last sequence update: | April 10, 2019 | |
Last modified: | October 7, 2020 | |
This is version 10 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |