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Entry version 12 (10 Feb 2021)
Sequence version 2 (11 Dec 2019)
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Protein
Submitted name:

Afadin, adherens junction formation factor

Gene

AFDN

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesionARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Afadin, adherens junction formation factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AFDNImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 31

Organism-specific databases

Vertebrate Gene Nomenclature Database

More...
VGNCi
VGNC:15143, AFDN

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 134Ras-associatingInterPro annotationAdd BLAST96
Domaini247 – 349Ras-associatingInterPro annotationAdd BLAST103
Domaini653 – 893DiluteInterPro annotationAdd BLAST241
Domaini992 – 1078PDZInterPro annotationAdd BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni129 – 195DisorderedSequence analysisAdd BLAST67
Regioni351 – 378DisorderedSequence analysisAdd BLAST28
Regioni525 – 580DisorderedSequence analysisAdd BLAST56
Regioni1092 – 1458DisorderedSequence analysisAdd BLAST367
Regioni1486 – 1513DisorderedSequence analysisAdd BLAST28
Regioni1554 – 1705DisorderedSequence analysisAdd BLAST152
Regioni1722 – 1884DisorderedSequence analysisAdd BLAST163

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi144 – 195PolyampholyteSequence analysisAdd BLAST52
Compositional biasi351 – 370PolyampholyteSequence analysisAdd BLAST20
Compositional biasi530 – 550PolarSequence analysisAdd BLAST21
Compositional biasi1115 – 1130PolarSequence analysisAdd BLAST16
Compositional biasi1139 – 1154PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1156 – 1194PolarSequence analysisAdd BLAST39
Compositional biasi1210 – 1231PolarSequence analysisAdd BLAST22
Compositional biasi1259 – 1285PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1287 – 1325PolarSequence analysisAdd BLAST39
Compositional biasi1345 – 1361Pro-richSequence analysisAdd BLAST17
Compositional biasi1391 – 1427PolyampholyteSequence analysisAdd BLAST37
Compositional biasi1499 – 1513PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1575 – 1665PolyampholyteSequence analysisAdd BLAST91
Compositional biasi1667 – 1696Pro-richSequence analysisAdd BLAST30
Compositional biasi1743 – 1757Pro-richSequence analysisAdd BLAST15
Compositional biasi1764 – 1783PolarSequence analysisAdd BLAST20
Compositional biasi1821 – 1835PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1853 – 1868PolarSequence analysisAdd BLAST16
Compositional biasi1869 – 1884PolyampholyteSequence analysisAdd BLAST16

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155237

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.42.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2L1F7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK
60 70 80 90 100
AAGNFATKCI RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG
110 120 130 140 150
EERRLDVDEK PLVVQLNWNK DDREGRFVLK NENDAFPPKK AQSNGPEKQE
160 170 180 190 200
KEGVIQNFKR TLSKKEKKEK KKREKEAMRQ ASDKDDRPFQ GDDIENSRLA
210 220 230 240 250
AEVYKDMPET SFTRTISNPE VVMKRRRQQK LEKRMQEFRS SDGRPDSGGT
260 270 280 290 300
LRIYADSLKP NIPYKTILLS TTDPADFAVA EALEKYGLEK ENPQDYCIAR
310 320 330 340 350
VMLPPGAQHS DDKGAKEVIL DEDECPLQIF REWPGDKGSL VFQLKRRPPD
360 370 380 390 400
YIPKKSKKHG DGKLAKGKER ADAASYGSAL PPDKLPYLVE LSPDGSDSRD
410 420 430 440 450
KPKLYRLQLS VTEVGTDKVD DSSIQLFGSG IQPHHCDLTN MDGVVTVTPR
460 470 480 490 500
SIDAETYVEG QRISETTVLQ SGMKVQFGAS HVFKFVDPSQ DHALAKRSVD
510 520 530 540 550
GGLTVKGPRH KPGVVQETTF DLGGDVHSGT ALPTSKSATR LDSDRVPSAS
560 570 580 590 600
STAERGMVKP MVREQQQDYR RQDSRTQDLP GPELILPASI EFRESAEDSF
610 620 630 640 650
LSAIINYTNS STVHFKLSPT YVLYMACRYV LSSQYRPDVS PTERTHKVIA
660 670 680 690 700
IVNKMVSMME GVIQKQKNIA GALAFWMANA SELLNFIKQD RDLSRITLDA
710 720 730 740 750
QDVLAHLVQM AFKYLVHCLQ SELNNYMPAF LDDPEENSLQ RPKIDDVLHT
760 770 780 790 800
LTGAMSLLRR CRVNAALTIQ LFSQLFHFIN MWLFNRLVTD PESGLCSHYW
810 820 830 840 850
GAIIRQQLGH VEAWAEKQGL ELAADCHLSR IVQATTLLTM DKYAPEDIPN
860 870 880 890 900
INSTCFKLNS LQLQALLQNY HCAPDEPFIP ADLIGSVVAV AENTADELAR
910 920 930 940 950
SDGRQVQLEE DPDLQLPFLL PEDGYSCDVV RNMPNGLQEF LDPLCQRGFC
960 970 980 990 1000
RLIPHARSPG TWTIYFEGAD YESHLMRENT ELAQPLRKEP EIITVTLKKQ
1010 1020 1030 1040 1050
NGMGLSIVAA KGAGQDKLGI YVKSVVKGGA ADVDGRLAAG DQLLSVDGRS
1060 1070 1080 1090 1100
LVGLSQERAA ELMTRTSSVV TLEVAKQGAI YHGLATLLNQ PSPMMQRISD
1110 1120 1130 1140 1150
RRGSGKPRPK SEGFELYNNS AQNGSPESPQ LPWAEYSEPK KLPGDDRLMK
1160 1170 1180 1190 1200
NRADHRSSPN VANQPPSPGG KSTYAPGTTA KITSVSTGNL CTEEQTPPPR
1210 1220 1230 1240 1250
PEAYPIPTQT YTREYFTFPA SKSQDRMAPP QNQWPSYEEK PHLHTDSSHS
1260 1270 1280 1290 1300
SSAIQRVTRS QEELREEKAY QLERHRIEAV MDHKSDSDMW INQSSSLGSS
1310 1320 1330 1340 1350
ASSQEHLDHS SKAGTPASTL TKSGPGRWKT PAAVPPMPVA VSQPIRTDLP
1360 1370 1380 1390 1400
PPPPPPPAHY ASELDGIPMD LPLPPPPSAS HLGPQSAQVA AAERKKREEH
1410 1420 1430 1440 1450
QRWYEKEKAR LEEERERKRR EQERKLGQMR TQALNPAQFP PAAVQQMKPE
1460 1470 1480 1490 1500
KPSTLQRPQE TVIRELQPQQ QPRTIERRDL QYITVSREEL SSGDSLSPDP
1510 1520 1530 1540 1550
WKRDAKEKLE KQQQMHIVDM LSKEIQELQG KPDRTAEEND RLRKLMLEWQ
1560 1570 1580 1590 1600
FQKRLQESKQ KDEDDEEEED DDVDTMLIMQ RLEAERRARL QDEERRRQQQ
1610 1620 1630 1640 1650
LEEMRKREAE DRARQEEERR QQEEERVRRD AEEKRRQEEG YYSRLEAERR
1660 1670 1680 1690 1700
RQHDEAERRL LEPEEPGLGR PPLPRGYEPP PPSPPAGAPP PPPQRGASFL
1710 1720 1730 1740 1750
QAQALSPDAL YTAKLVAYGE EEAEDGSLAG QHRGAGTSKS PGALPPAAPP
1760 1770 1780 1790 1800
LQPPRRPRPA SDGIFLSNSF QPPSASANST AHEAGQPPPP PKKPGVRAPS
1810 1820 1830 1840 1850
HSRGRGPNSY TGSAGTALGA HDAHRDSRER LSKSQDADAP GGSGAPENLT
1860 1870 1880
FKERQRLFSQ GQDVSNRVKA SRKLTELENE LNTK
Length:1,884
Mass (Da):211,550
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iED09F734F3FBC3B1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7CWJ4F7CWJ4_HORSE
Afadin, adherens junction formation...
AFDN
1,771Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H5Q7A0A3Q2H5Q7_HORSE
Afadin, adherens junction formation...
AFDN
1,842Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2I4X5A0A3Q2I4X5_HORSE
Afadin, adherens junction formation...
AFDN
1,751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2LRE1A0A3Q2LRE1_HORSE
Afadin, adherens junction formation...
AFDN
1,786Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSECAT00000060061; ENSECAP00000031097; ENSECAG00000014680

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000060061; ENSECAP00000031097; ENSECAG00000014680

Organism-specific databases

VGNCiVGNC:15143, AFDN

Phylogenomic databases

GeneTreeiENSGT00940000155237

Family and domain databases

CDDicd00060, FHA, 1 hit
cd15471, Myo5p-like_CBD_afadin, 1 hit
Gene3Di2.30.42.10, 1 hit
InterProiView protein in InterPro
IPR037977, CBD_Afadin
IPR002710, Dilute_dom
IPR000253, FHA_dom
IPR001478, PDZ
IPR036034, PDZ_sf
IPR000159, RA_dom
IPR008984, SMAD_FHA_dom_sf
IPR029071, Ubiquitin-like_domsf
PfamiView protein in Pfam
PF01843, DIL, 1 hit
PF00498, FHA, 1 hit
PF00595, PDZ, 1 hit
PF00788, RA, 2 hits
SMARTiView protein in SMART
SM01132, DIL, 1 hit
SM00240, FHA, 1 hit
SM00228, PDZ, 1 hit
SM00314, RA, 2 hits
SUPFAMiSSF49879, SSF49879, 1 hit
SSF50156, SSF50156, 1 hit
SSF54236, SSF54236, 2 hits
PROSITEiView protein in PROSITE
PS51126, DILUTE, 1 hit
PS50106, PDZ, 1 hit
PS50200, RA, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2L1F7_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2L1F7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: December 11, 2019
Last modified: February 10, 2021
This is version 12 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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