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UniProtKB - A0A3Q2I396 (A0A3Q2I396_HORSE)

Entry version 9 (07 Oct 2020)
Sequence version 2 (11 Dec 2019)
Previous versions | rss
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Protein
Submitted name:

Uncharacterized protein

Gene

ANK2

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANK2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEquus caballus (Horse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9796 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002281 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, CytoskeletonARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A3Q2I396, baseline

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 795ANK_REP_REGIONInterPro annotationAdd BLAST751
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 110ANKPROSITE-ProRule annotationAdd BLAST33
Repeati111 – 143ANKPROSITE-ProRule annotationAdd BLAST33
Repeati144 – 176ANKPROSITE-ProRule annotationAdd BLAST33
Repeati247 – 279ANKPROSITE-ProRule annotationAdd BLAST33
Repeati280 – 312ANKPROSITE-ProRule annotationAdd BLAST33
Repeati313 – 345ANKPROSITE-ProRule annotationAdd BLAST33
Repeati346 – 378ANKPROSITE-ProRule annotationAdd BLAST33
Repeati379 – 411ANKPROSITE-ProRule annotationAdd BLAST33
Repeati412 – 444ANKPROSITE-ProRule annotationAdd BLAST33
Repeati445 – 477ANKPROSITE-ProRule annotationAdd BLAST33
Repeati478 – 510ANKPROSITE-ProRule annotationAdd BLAST33
Repeati511 – 543ANKPROSITE-ProRule annotationAdd BLAST33
Repeati544 – 576ANKPROSITE-ProRule annotationAdd BLAST33
Repeati577 – 609ANKPROSITE-ProRule annotationAdd BLAST33
Repeati610 – 642ANKPROSITE-ProRule annotationAdd BLAST33
Repeati643 – 675ANKPROSITE-ProRule annotationAdd BLAST33
Repeati676 – 708ANKPROSITE-ProRule annotationAdd BLAST33
Repeati709 – 741ANKPROSITE-ProRule annotationAdd BLAST33
Repeati742 – 774ANKPROSITE-ProRule annotationAdd BLAST33
Domaini962 – 1117ZU5InterPro annotationAdd BLAST156
Domaini1119 – 1265ZU5InterPro annotationAdd BLAST147
Domaini3531 – 3615DeathInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 49DisorderedSequence analysisAdd BLAST49
Regioni1418 – 1447DisorderedSequence analysisAdd BLAST30
Regioni1610 – 1717DisorderedSequence analysisAdd BLAST108
Regioni1736 – 2102DisorderedSequence analysisAdd BLAST367
Regioni2154 – 2441DisorderedSequence analysisAdd BLAST288
Regioni2474 – 2759DisorderedSequence analysisAdd BLAST286
Regioni2773 – 2919DisorderedSequence analysisAdd BLAST147
Regioni2937 – 2982DisorderedSequence analysisAdd BLAST46
Regioni3030 – 3068DisorderedSequence analysisAdd BLAST39
Regioni3097 – 3426DisorderedSequence analysisAdd BLAST330
Regioni3511 – 3530DisorderedSequence analysisAdd BLAST20
Regioni3656 – 3675DisorderedSequence analysisAdd BLAST20
Regioni3688 – 3817DisorderedSequence analysisAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili3440 – 3460Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 48PolyampholyteSequence analysisAdd BLAST48
Compositional biasi1610 – 1634PolarSequence analysisAdd BLAST25
Compositional biasi1671 – 1698PolyampholyteSequence analysisAdd BLAST28
Compositional biasi1736 – 1764PolyampholyteSequence analysisAdd BLAST29
Compositional biasi1786 – 1865PolarSequence analysisAdd BLAST80
Compositional biasi1931 – 1945PolarSequence analysisAdd BLAST15
Compositional biasi1968 – 2001PolyampholyteSequence analysisAdd BLAST34
Compositional biasi2002 – 2017PolarSequence analysisAdd BLAST16
Compositional biasi2032 – 2087PolyampholyteSequence analysisAdd BLAST56
Compositional biasi2214 – 2248PolyampholyteSequence analysisAdd BLAST35
Compositional biasi2314 – 2343PolarSequence analysisAdd BLAST30
Compositional biasi2350 – 2364PolarSequence analysisAdd BLAST15
Compositional biasi2484 – 2518PolarSequence analysisAdd BLAST35
Compositional biasi2529 – 2587PolyampholyteSequence analysisAdd BLAST59
Compositional biasi2595 – 2610PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2618 – 2634PolarSequence analysisAdd BLAST17
Compositional biasi2658 – 2685PolarSequence analysisAdd BLAST28
Compositional biasi2686 – 2707PolyampholyteSequence analysisAdd BLAST22
Compositional biasi2721 – 2738PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2776 – 2791PolyampholyteSequence analysisAdd BLAST16
Compositional biasi2799 – 2815PolarSequence analysisAdd BLAST17
Compositional biasi2833 – 2868PolarSequence analysisAdd BLAST36
Compositional biasi2880 – 2919PolarSequence analysisAdd BLAST40
Compositional biasi2959 – 2982PolarSequence analysisAdd BLAST24
Compositional biasi3033 – 3064PolarSequence analysisAdd BLAST32
Compositional biasi3117 – 3131PolarSequence analysisAdd BLAST15
Compositional biasi3140 – 3154AcidicSequence analysisAdd BLAST15
Compositional biasi3156 – 3210PolarSequence analysisAdd BLAST55
Compositional biasi3226 – 3241PolyampholyteSequence analysisAdd BLAST16
Compositional biasi3255 – 3282PolarSequence analysisAdd BLAST28
Compositional biasi3322 – 3340PolarSequence analysisAdd BLAST19
Compositional biasi3342 – 3379PolyampholyteSequence analysisAdd BLAST38
Compositional biasi3404 – 3418PolarSequence analysisAdd BLAST15
Compositional biasi3688 – 3707PolarSequence analysisAdd BLAST20
Compositional biasi3732 – 3763PolarSequence analysisAdd BLAST32

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, Coiled coilSequence analysis, RepeatARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155279

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

A0A3Q2I396-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAASIKK VREAELDEKE KTLERERKKQ RKIPRERMER KRKSDSNASF 
        60         70         80         90        100
LRAARAGNLD KVVEYLKGGI DINTCNQNGL NALHLAAKEG HVGLVQELLG 
       110        120        130        140        150
RGSSVDSATK KGNTALHIAS LAGQAEVVKV LVKEGANINA QSQNGFTPLY 
       160        170        180        190        200
MAAQENHIDV VKYLLENGAN QSTATEDGFT PLAVALQQGH NQAVAILLEN 
       210        220        230        240        250
DTKGKVRLPA LHIAARKDDT KSAALLLQND HNADVQSKMM VNRTTESGFT 
       260        270        280        290        300
PLHIAAHYGN VNVATLLLNR GAAVDFTARN GITPLHVASK RGNTNMVKLL 
       310        320        330        340        350
LDRGGQIDAK TRDGLTPLHC AARSGHDQVV ELLLERGAPL LARTKNGLSP 
       360        370        380        390        400
LHMAAQGDHV ECVKHLLQHK APVDDVTLDY LTALHVAAHC GHYRVTKLLL 
       410        420        430        440        450
DKRANPNARA LNGFTPLHIA CKKNRIKVME LLVKYGASIQ AITESGLTPI 
       460        470        480        490        500
HVAAFMGHLN IVLLLLQNGA SPDVTNIRGE TALHMAARAG QVEVVRCLLR 
       510        520        530        540        550
NGALVDARAR EEQTPLHIAS RLGKTEIVQL LLQHMAHPDA ATTNGYTPLH 
       560        570        580        590        600
ISAREGQVDV ASVLLEAGAA HSLATKKGFT PLHVAAKYGS LDVAKLLLQR 
       610        620        630        640        650
RAAADSAGKN GYTPLHIAAK KNQMQIASTL LNYGAETNIV TKQGVTPLHL 
       660        670        680        690        700
ASQEGHTDMV TLLLDKGANI HMSTKSGLTS LHLAAQEDKV NVADILTKNG 
       710        720        730        740        750
ADQDAHTKLG YTPLIVACHY GNVKMVNFLL KQGADVNAKT KNGYTPLHQA 
       760        770        780        790        800
AQQGHTHIIN VLLQHGAKPN ATTANGNTAL AIAKRLGYIS VVDTLKVVTE 
       810        820        830        840        850
EVTTTTTTIT EKHKLNVPET MTEVLDVSDE EGDDTMTGDG GEYLRPEDLK 
       860        870        880        890        900
ELGDDSLPSS QFLDGMNYLR YSLEGGRSDS LRSFSSDRSH TLSHASYLRD 
       910        920        930        940        950
SAMIDDTVVI PSHQVSALAK EAERNSYRLS WGTENLDNVA LSSSPIHSGR 
       960        970        980        990       1000
TSPCLDRDNS SFLVSFMVDA RGGAMRGCRH NGLRIIIPPR KCTAPTRVTC 
      1010       1020       1030       1040       1050
RLVKRHRLAT MPPMVEGEGL ASRLIEVGPS GAQFLGPVIV EIPHFAALRG 
      1060       1070       1080       1090       1100
KERELVVLRS ENGDSWKEHY CEYTEDELNE ILNGMDEVLD SPEDLEKKRI 
      1110       1120       1130       1140       1150
CRIVTRDFPQ YFAVVSRIKQ DSNLIGPEGG VLSSTVVPQV QAVFPEGALT 
      1160       1170       1180       1190       1200
KRIRVGLQAQ PMHSELVKKI LGNKATFSPI VTLEPRRRKF HKPITMTIPV 
      1210       1220       1230       1240       1250
PKASSDVMLN GFGGDAPTLR LLCSITGGTT PAQWEDITGT TPLTFVNECV 
      1260       1270       1280       1290       1300
SFTTNVSARF WLIDCRQIQE SVTFASQVYR EIICVPYMAK FVVFAKSHDP 
      1310       1320       1330       1340       1350
IEARLRCFCM TDDKVDKTLE QQENFAEVAR SRDVEVLEGK PIYVDCFGNL 
      1360       1370       1380       1390       1400
VPLTKSGQHH IFSFFAFKEN RLPLFVKVRD TTQEPCGRLS FMKEPKSTRG 
      1410       1420       1430       1440       1450
LVHQAICNLN ITLPVYTKES ESDQEQEEEI DMTSEKNDET ESTETSVLKS 
      1460       1470       1480       1490       1500
HLVNEVPVLA SPDLLSEVSE MKQDLIKMTA ILTTDVSERA GSIKVKELVK 
      1510       1520       1530       1540       1550
AAEEEPGEPF EIVERVKEDL EKVNEILRSG TCTRDEASAP RARSERELVE 
      1560       1570       1580       1590       1600
EEWVIISDEE IEEARQKAPL EITEYPCVEV RIDKETKEEV EKDSTGLVNY 
      1610       1620       1630       1640       1650
LTEDLNSYVS PHGEQLQPAQ EMAGETSQAP AVGRSSENEG KDAHPDETQI 
      1660       1670       1680       1690       1700
PQKQQKPSLG IKKPVRRKLK EKQKQKEESL QASTEKTELT KGSSEESLDE 
      1710       1720       1730       1740       1750
DLGLAPEPVP AVKATSPLIE ETPIGSIKDK VKALQKRVED EQKGRSKLPI 
      1760       1770       1780       1790       1800
RVKGKEDVPK KIVHRTHPAV SPSLKAEKHT PASPASKTER HSSLSSSAKT 
      1810       1820       1830       1840       1850
ERHPPVSPSS KTEKHSPVSP SAKTERHSPV SSSSKTEKHS PVSPSTKTER 
      1860       1870       1880       1890       1900
HSPVSSSTKT ERHPPVSPSG KTDKRPPISP SGRPEKHSPV SPGRTEKRSP 
      1910       1920       1930       1940       1950
VSPAGRIERH PPVSALGKTE KHLPVSPSGK TEKQPPVSPT SKTERIEETM 
      1960       1970       1980       1990       2000
SVRELMKAFQ SGQDPSKHKA GLFEHKSAKQ KQPQEKGKVR VEKEKGQMLT 
      2010       2020       2030       2040       2050
QRETQRTESQ TIKRGQKILV TGASESKRGV RASSLGFKKE ETVGEKEKGV 
      2060       2070       2080       2090       2100
SHKTPEPVRS APEEESHKEN EVPKEKPAEE QGDMDLQISP DRKASTDFSD 
      2110       2120       2130       2140       2150
VIKQELEDNE KYQQFRLSEE PEKAQLHLDQ VLTSPFNTTF PLDYVKDEFL 
      2160       2170       2180       2190       2200
PALSLPSGAL DGSSESPKHE GVAGSPCGSL MEGTPQISSE ESYKHEGLAE 
      2210       2220       2230       2240       2250
TPETSPESLS FSPKKSEEPV REENETTKLE TPREIHLEKE HPSTKDVPDG 
      2260       2270       2280       2290       2300
SEEPGAAVTE GTEPSAECLL KEATLDPSKD TSSKQEGDYL DSNSVSLAKE 
      2310       2320       2330       2340       2350
TPKGLAEEAS CDEGQPTYVS SALKAQTDTE AQGSTTTKPS DETKASPLPD 
      2360       2370       2380       2390       2400
VSVKTGTGTE PKPQGVVRSP QGLELALPSR DSEVFSPGAD ESFAVSHKDS 
      2410       2420       2430       2440       2450
LEASPVLEDN SSHKTPDSLE PSPLKESPCR DSLESSPVEP KMKAGILSSH 
      2460       2470       2480       2490       2500
FPLPAAVAKT ELFTEVASMR SRLLRDPDGS AEDDSLEQTS LMESSGKSPL 
      2510       2520       2530       2540       2550
SPDTPSSEEI SYEVTPKATD ASTPKPAVIH ECAEEDDLEN GEKKRFTPEE 
      2560       2570       2580       2590       2600
EMFKMVTKIK TFDELEQEAK QKRDYRKEPK QEESSSSSEP DADSSADVDE 
      2610       2620       2630       2640       2650
PKHMESAEEE SEVPVAVTSE SRKASSSSES EPELTQLKKG ADSGLLPEPV 
      2660       2670       2680       2690       2700
IRVQPPSPLP SSIDSNSSPE EVQFQPIVSK QYTFKMNEDT QEESGKSEEE 
      2710       2720       2730       2740       2750
KVCESHLPED SQTVSTEGPD MSYDDLKRDD DQPKIYDDHG CEAGSPSSPA 
      2760       2770       2780       2790       2800
TPISSGLHSS CAHDISEQLV IHKEALPLQD AEEKDTEGEL DVSGLESPQV 
      2810       2820       2830       2840       2850
EGPSESSSSP SSLPRCLASE RKELDEDLVS PSSPTKVEAT KTDQAFESLP 
      2860       2870       2880       2890       2900
KDCSTEDSSI TPQTDRLSVD VPVSDPAETD EISDPQTISP YENVPSQSFF 
      2910       2920       2930       2940       2950
SSEESKTQTD ASHTSFHSSE VCSVTVTSSV AEVAVESSSS RTVSSKESNF 
      2960       2970       2980       2990       3000
EDQNMELESK QESTLWEMQS DGAPSSVEST IPNTSAVVGE KISKVIITKT 
      3010       3020       3030       3040       3050
DVDSDSWSEI REDDEAFEAR VKEEEQKIFG LMVDRQSQGT TPDTTPARTP 
      3060       3070       3080       3090       3100
TEEGTPTSEQ NPFLFQEGKL FEMTRSGAID MTKRSYADES FHFFQIGQES 
      3110       3120       3130       3140       3150
SEETLSEDMK GVSTGAEPPQ LETSAESLAL SQSKEPVDDE ADLLPDDLSE 
      3160       3170       3180       3190       3200
EVEEIPSSDA QLNSQMEISA SAETSTEDAT SAEPEDLPTT QVSDTPPKSS 
      3210       3220       3230       3240       3250
VKQTSCPDSP EPAVQVHLDF STVTRSVYSD REDDSPDSSP EEQKSVIEIP 
      3260       3270       3280       3290       3300
TAPMESVPST ESKSKIPIRT IPTSTPAPPS AEDENSLSED VPPSLDEESK 
      3310       3320       3330       3340       3350
EDETKPKSKI PVKAPVQRVE QQLLVLDSSL QKTVAPQGQD VTSRARDDRS 
      3360       3370       3380       3390       3400
KSESDADPLD SKAKSPVKTR SYTETETESG EKAEELELES EEGATRTKIF 
      3410       3420       3430       3440       3450
ASRLPVKSKS TTSSCREDTS PTKDSKEHFL DLYRNSIEFF EEISDEASKL 
      3460       3470       3480       3490       3500
VDRLTQSERE QELVSDDESS SALEVSVIEN LPPVETEHSI PEDIFDTRPI 
      3510       3520       3530       3540       3550
WDESIETLIE RIPDENGHDH AEDQQDEQER TEERLAYIAD HLGFSWTELA 
      3560       3570       3580       3590       3600
RELDFTEEQI HQIRIENPNS LQDQSHALLK YWLERDGKHA TDTSLIECLT 
      3610       3620       3630       3640       3650
KINRMDIVHL LETSTEPLQE HMSHSYAEIE QTITLDHSEG FSVLQEELCL 
      3660       3670       3680       3690       3700
AQQKQKEEEQ AASKEGEPCD QPPIVSEEDI SVGYSTFQDY IPKTDGDSST 
      3710       3720       3730       3740       3750
TELLPQTHKE EVQQDFSGKM QDLPEKSPPD HQQEYFVTTP GTEVSETQKA 
      3760       3770       3780       3790       3800
TAASGSPSKT PEEITTPPEE ERPYLQTPTP SEQGDSPIVQ EPEEPLAQRE 
      3810       3820       3830       3840       3850
ESPRKTSLVI VESADDQPQA FERLEEDAAF QKELTEELGE LEASSDDEAT 
      3860       3870       3880       3890       3900
VTTRVVRRRV IIQGDDMPDI PPESVTEEEY IDEHGHTVVK KVTRKIIKRY 
      3910       3920       3930       3940       3950
VSSDGTEKEE ITVQGLPQDP VDVEEGDGYS KVIKRVVLKS DTALSEVTLS 
      3960       3970       3980       3990       4000
EPSILSSSSQ FEAEPVEGRR VSKVVKTTMV HGERMEKHLG DSSLATDLPS 
      4010       4020       4030       4040       4050
AKDDFEEALS YTGSHMKVHS PSLVEREILK EDGSVIKRTV MSKASTRSRA 
      4060       4070       4080       4090 
VVKDQHGKHI HLEHLEDVPE ALDQGDLQRD LQQLLQHFCK EHLKQEAK
Length:4,098
Mass (Da):450,220
Last modified:December 11, 2019 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE4708483B725486
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SQK7F6SQK7_HORSE
Uncharacterized protein
ANK2
3,958Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6SQP2F6SQP2_HORSE
Uncharacterized protein
ANK2
4,137Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GU11A0A3Q2GU11_HORSE
Uncharacterized protein
ANK2
4,077Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2GZG4A0A3Q2GZG4_HORSE
Uncharacterized protein
ANK2
4,164Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2H3M0A0A3Q2H3M0_HORSE
Uncharacterized protein
ANK2
4,143Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HCE8A0A3Q2HCE8_HORSE
Uncharacterized protein
ANK2
4,156Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HHV3A0A3Q2HHV3_HORSE
Uncharacterized protein
ANK2
4,141Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A3Q2HPB7A0A3Q2HPB7_HORSE
Uncharacterized protein
ANK2
4,069Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSECAT00000037372; ENSECAP00000042294; ENSECAG00000024436

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsembliENSECAT00000037372; ENSECAP00000042294; ENSECAG00000024436

Phylogenomic databases

GeneTreeiENSGT00940000155279

Gene expression databases

ExpressionAtlasiA0A3Q2I396, baseline

Family and domain databases

Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR040745, Ankyrin_UPA
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR000906, ZU5_dom
PfamiView protein in Pfam
PF00023, Ank, 2 hits
PF12796, Ank_2, 6 hits
PF00531, Death, 1 hit
PF17809, UPA_2, 1 hit
PF00791, ZU5, 1 hit
PRINTSiPR01415, ANKYRIN
SMARTiView protein in SMART
SM00248, ANK, 22 hits
SM00005, DEATH, 1 hit
SM00218, ZU5, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF48403, SSF48403, 3 hits
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 19 hits
PS50017, DEATH_DOMAIN, 1 hit
PS51145, ZU5, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A3Q2I396_HORSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A3Q2I396
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 10, 2019
Last sequence update: December 11, 2019
Last modified: October 7, 2020
This is version 9 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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