UniProtKB - A0A3Q2HTD4 (A0A3Q2HTD4_HORSE)
Protein
Submitted name:
5'-nucleotidase, cytosolic II
Gene
NT5C2
Organism
Equus caballus (Horse)
Status
Functioni
Cofactori
Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 63 | NucleophileUniRule annotation | 1 | |
Metal bindingi | 63 | MagnesiumUniRule annotation | 1 | |
Active sitei | 65 | Proton donorUniRule annotation | 1 | |
Metal bindingi | 65 | Magnesium; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 138 | Allosteric activator 1UniRule annotation | 1 | |
Binding sitei | 173 | Allosteric activator 2UniRule annotation | 1 | |
Metal bindingi | 370 | MagnesiumUniRule annotation | 1 | |
Binding sitei | 373 | Allosteric activator 2UniRule annotation | 1 | |
Binding sitei | 455 | Allosteric activator 1; via carbonyl oxygenUniRule annotation | 1 | |
Binding sitei | 472 | Allosteric activator 2UniRule annotation | 1 |
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseARBA annotation |
Ligand | MagnesiumUniRule annotationARBA annotation, Metal-bindingUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: 5'-nucleotidase, cytosolic IIImported |
Gene namesi | Name:NT5C2Imported |
Organismi | Equus caballus (Horse)Imported |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:20913, NT5C2 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 556 – 583 | DisorderedSequence analysisAdd BLAST | 28 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 567 – 583 | AcidicSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the 5'(3')-deoxyribonucleotidase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000162369 |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR008380, HAD-SF_hydro_IG_5-nucl IPR023214, HAD_sf IPR016695, Pur_nucleotidase |
PANTHERi | PTHR12103, PTHR12103, 1 hit |
Pfami | View protein in Pfam PF05761, 5_nucleotid, 1 hit |
PIRSFi | PIRSF017434, Purine_5'-nucleotidase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02244, HAD-IG-Ncltidse, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
A0A3Q2HTD4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRAWNSAYKQ NKMTSWSDRL QNAADMPANM DKHALKKYRR EAFHRVFVNR
60 70 80 90 100
SLAMEKIKCF GFDMDYTLAV YKSPEYESLG FELTVERLVS IGYPQELLSF
110 120 130 140 150
AYDSTFPTRG LVFDTLYGNL LKVDAYGNLL VCAHGFNFIR GSQVAAQKRP
160 170 180 190 200
ETREQYPNKF IQRDDTERFY ILNTLFNLPE TYLLACLVDF FTNCPRYTSC
210 220 230 240 250
ETGFKDGDLF MSYRSMFQDV RDAVDWVHYK GSLKEKTLEN LEKYVVKDGK
260 270 280 290 300
LPLLLSRMKE VGKVFLATNS DYKYTDKIMT YLFDFPHGPK PGSSHRPWQS
310 320 330 340 350
YFDLILVDAR KPLFFGEGTV LRQVDTKTGK LKIGTYTGPL QHGIVYSGGS
360 370 380 390 400
SDTICDLLGA KGKDILYIGD HIFGDILKSK KRQGWRTFLV IPELAQELHV
410 420 430 440 450
WTDKSSLFEE LQSLDVFLAE LYKHLDSSSN ERPDISSIQR RIKKVTHDMD
460 470 480 490 500
MCYGMMGSLF RSGSRQTLFA SQVMRYADLY AASFINLLYY PFSYLFRAAH
510 520 530 540 550
VLMPHESTVE HIHVDINEME SPLATRNRTS VDFKDTDYKR HQLTRSISEI
560 570 580
KPPNLFPLAP QEITHCHDED DDEEEEEEEE EEE
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2HN48 | A0A3Q2HN48_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 600 | Annotation score: | ||
F6TVA0 | F6TVA0_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 586 | Annotation score: | ||
A0A3Q2GVX1 | A0A3Q2GVX1_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 543 | Annotation score: | ||
A0A3Q2HJ75 | A0A3Q2HJ75_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 614 | Annotation score: | ||
A0A3Q2I3E1 | A0A3Q2I3E1_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 532 | Annotation score: | ||
A0A3Q2I5Y9 | A0A3Q2I5Y9_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 522 | Annotation score: | ||
A0A5F5PSS9 | A0A5F5PSS9_HORSE | 5'-nucleotidase, cytosolic II | NT5C2 | 557 | Annotation score: |
Genome annotation databases
Ensembli | ENSECAT00000038520; ENSECAP00000037453; ENSECAG00000022574 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSECAT00000038520; ENSECAP00000037453; ENSECAG00000022574 |
Organism-specific databases
VGNCi | VGNC:20913, NT5C2 |
Phylogenomic databases
GeneTreei | ENSGT00940000162369 |
Gene expression databases
ExpressionAtlasi | A0A3Q2HTD4, baseline |
Family and domain databases
Gene3Di | 3.40.50.1000, 2 hits |
InterProi | View protein in InterPro IPR036412, HAD-like_sf IPR008380, HAD-SF_hydro_IG_5-nucl IPR023214, HAD_sf IPR016695, Pur_nucleotidase |
PANTHERi | PTHR12103, PTHR12103, 1 hit |
Pfami | View protein in Pfam PF05761, 5_nucleotid, 1 hit |
PIRSFi | PIRSF017434, Purine_5'-nucleotidase, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit |
TIGRFAMsi | TIGR02244, HAD-IG-Ncltidse, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A3Q2HTD4_HORSE | |
Accessioni | A0A3Q2HTD4Primary (citable) accession number: A0A3Q2HTD4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | April 10, 2019 |
Last sequence update: | December 11, 2019 | |
Last modified: | October 7, 2020 | |
This is version 9 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |